關(guān)鍵詞

猴痘 免疫分析 尼古丁 胰島素 微環(huán)境 單細(xì)胞測序 特瑞普利單抗

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#今日行業(yè)熱點#

①Lancet：Mpox neglect and the smallpox niche: a problem for Africa, a problem for the world

由對人畜共患病毒性疾病猴痘（Mpox）的忽視可能引發(fā)的潛在后果及生態(tài)位風(fēng)險

DOI :10.1016/S0140-6736(23)00588-3

②Biosensors & Bioelectronics：Highly selective and quantitative in situ monitoring of cell surface proteins by SERS immunoassay system

利用SERS免疫分析的納米探針對細(xì)胞表面蛋白（CSP）進(jìn)行高選擇性和定量的原位監(jiān)測

DOI :10.1016/j.bios.2023.115366

③Pharmacological Research：Epigenetic and Long-Term Effects of Nicotine on Biology, Behavior, and Health

綜述：與尼古丁(或吸煙)相關(guān)的表觀遺傳信號改變是疾病和健康挑戰(zhàn)的促發(fā)因素

DOI :10.1016/j.phrs.2023.106741

④Biomaterials：Affordable oral proinsulin bioencapsulated in plant cells regulates blood sugar levels similar to natural insulin

在植物細(xì)胞中設(shè)計的胰島素原可調(diào)節(jié)血糖水平類似于天然胰島素的水平

DOI :10.1016/j.biomaterials.2023.122142

⑤Cell Reports：Glioblastoma cell fate is differentially regulated by the microenvironments of the tumor bulk and infiltrative margin

膠質(zhì)母細(xì)胞瘤細(xì)胞（GBM）受到腫瘤體積和浸潤邊緣的微環(huán)境的不同調(diào)控

DOI :10.1016/j.celrep.2023.112472

⑥Cell Reports：Glial progenitor heterogeneity and key regulators revealed by single-cell RNA sequencing provide insight to regeneration in spinal cord injury

單細(xì)胞RNA測序揭示了脊髓損傷前后膠質(zhì)祖細(xì)胞異質(zhì)性和關(guān)鍵調(diào)控因子

DOI :10.1016/j.celrep.2023.112486

⑦重組抗胰島素樣生長因子1受體（IGF-1R）抗體用于甲狀腺眼病（TED）的III期臨床研究（RESTORE）完成首例受試者給藥

⑧特瑞普利（Toripalimab）單抗用于廣泛期小細(xì)胞肺癌（SCLC）III期臨床研究（ENTENTORCH）達(dá)到主要研究終點

⑨布魯頓氏酪氨酸激酶（BTK）小分子抑制劑澤布替尼用于慢性淋巴細(xì)胞白血病（CLL）/小淋巴細(xì)胞淋巴瘤（SLL）及華氏巨球蛋白血癥（WM）等多項注冊申請獲中國國家藥品監(jiān)督管理局（NMPA）批準(zhǔn)

⑩靶向前列腺特異性膜抗原（PSMA）的177Lu-LNC1003獲FDA臨床試驗批準(zhǔn)，將用于PSMA陽性表達(dá)的晚期前列腺癌

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