聲明：本專欄主要對(duì)生命科學(xué)領(lǐng)域的一些期刊文章標(biāo)題進(jìn)行翻譯，所有內(nèi)容均由本人手工整理翻譯。由于本人專業(yè)為生物分析相關(guān)，其他領(lǐng)域如果出現(xiàn)翻譯錯(cuò)誤請(qǐng)諒解。

1.Reconstruction of a catalogue of genome-scale metabolic models with enzymatic constraints using GECKO 2.0.

使用GECKO 2.0重建具有酶學(xué)約束的基因組尺度的代謝模型目錄。

2.Simple synthesis of massively parallel RNA microarrays via enzymatic conversion from DNA microarrays.

通過(guò)對(duì)DNA芯片的酶促轉(zhuǎn)換，簡(jiǎn)單合成大規(guī)模并行的RNA芯片。

3.Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state.

通過(guò)改變構(gòu)象狀態(tài)對(duì)PPM1D絲氨酸/蘇氨酸磷酸酶進(jìn)行異生抑制。

4.An essential role for tungsten in the ecology and evolution of a previously uncultivated lineage of anaerobic, thermophilic Archaea.

鎢在厭氧、嗜熱古菌的生態(tài)學(xué)和進(jìn)化中的重要作用。

5.Endowing universal CAR T-cell with immune-evasive properties using TALEN-gene editing.

利用TALEN基因編輯技術(shù)賦予通用CAR T細(xì)胞以免疫破壞特性。

6.Comparative genomics of Acinetobacter baumannii and therapeutic bacteriophages from a patient undergoing phage therapy.

鮑曼不動(dòng)桿菌和治療性噬菌體的比較基因組學(xué)，來(lái)自于一個(gè)接受噬菌體治療的病人。

7.Tight junction channel regulation by interclaudin interference.

細(xì)胞間干擾的緊密連接通道調(diào)節(jié)。

8.Trans-cellular tunnels induced by the fungal pathogen Candida albicans facilitate invasion through successive epithelial cells without host damage.

真菌病原體白色念珠菌誘導(dǎo)的跨細(xì)胞隧道有利于在沒(méi)有宿主損傷的情況下通過(guò)連續(xù)的上皮細(xì)胞入侵。

9.Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots.

內(nèi)臟、腹部皮下和臀部脂肪庫(kù)的遺傳基礎(chǔ)。

10.Effect of vaccination on household transmission of SARS-CoV-2 Delta variant of concern.

疫苗接種對(duì)SARS-CoV-2 Delta變體家庭傳播的影響值得關(guān)注。

11.CD8+T cell responsiveness to anti-PD-1 is epigenetically regulated by Suv39h1 in melanomas.

CD8+T細(xì)胞對(duì)抗PD-1的反應(yīng)性在黑色素瘤中受到Suv39h1的表觀調(diào)節(jié)。

12.Inactivation of the Hippo tumor suppressor pathway promotes melanoma.

Hippo腫瘤抑制通路的失活促進(jìn)黑色素瘤的發(fā)生。

13.Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277.

ML277調(diào)控KCNQ1通道電流的結(jié)構(gòu)和電生理學(xué)基礎(chǔ)。

14.Reply to: Pitfalls in using phenanthroline to study the causal relationship between promoter nucleosome acetylation and transcription.

回復(fù)：?使用菲羅啉研究啟動(dòng)子核糖體乙?；娃D(zhuǎn)錄之間因果關(guān)系的陷阱。

15.Pitfalls in using phenanthroline to study the causal relationship between promoter nucleosome acetylation and transcription.

使用菲羅啉研究啟動(dòng)子核糖體乙?；娃D(zhuǎn)錄之間的因果關(guān)系的陷阱。

16.Pervasive translation of circular RNAs driven by short IRES-like elements.

由短的IRES樣元素驅(qū)動(dòng)的環(huán)狀RNA的普遍翻譯。

17.Vertex protein PduN tunes encapsulated pathway performance by dictating bacterial metabolosome morphology.

頂點(diǎn)蛋白PduN通過(guò)支配細(xì)菌代謝體的形態(tài)來(lái)調(diào)整封裝途徑的性能。

18.A guided multiverse study of neuroimaging analyses.

神經(jīng)影像分析的指導(dǎo)下的多宇宙研究。

19.The genetic heterogeneity and drug resistance mechanisms of relapsed refractory multiple myeloma.

復(fù)發(fā)難治性多發(fā)性骨髓瘤的遺傳異質(zhì)性和耐藥機(jī)制。

20.Rhythmic interactions between the mediodorsal thalamus and prefrontal cortex precede human visual perception.

丘腦內(nèi)側(cè)和前額葉皮層之間的節(jié)律性相互作用先于人類視覺(jué)感知。

21.The genetic architecture of pneumonia susceptibility implicates mucin biology and a relationship with psychiatric illness.

肺炎易感性的遺傳結(jié)構(gòu)牽涉到粘液蛋白生物學(xué)以及與精神病的關(guān)系。

22.Limited effects of m6A modification on mRNA partitioning into stress granules.

m6A修飾對(duì)mRNA分配到應(yīng)激顆粒的有限影響。

23.SARS-CoV-2 antibody trajectories after a single COVID-19 vaccination with and without prior infection.

單次COVID-19疫苗接種后的SARS-CoV-2抗體軌跡，有無(wú)先前感染。

24.WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage.

WASp調(diào)節(jié)單鏈DNA上的RPA功能以應(yīng)對(duì)復(fù)制壓力和DNA損傷。

25.Distinct nociception processing in the dysgranular and barrel regions of the mouse somatosensory cortex.

小鼠體感皮層障礙區(qū)和桶狀區(qū)的不同痛覺(jué)處理。

26.Regulation of age-associated insulin resistance by MT1-MMP-mediated cleavage of insulin receptor.

MT1-MMP介導(dǎo)的胰島素受體裂解對(duì)年齡相關(guān)的胰島素抵抗的調(diào)節(jié)。

27.Host lung microbiota promotes malaria-associated acute respiratory distress syndrome.

宿主肺部微生物群促進(jìn)瘧疾相關(guān)的急性呼吸窘迫綜合征。

28.Heat-fueled enzymatic cascade for selective oxyfunctionalization of hydrocarbons.

碳?xì)浠衔镞x擇性氧功能化的熱助推酶級(jí)聯(lián)反應(yīng)。

29.TPGS-based and S-thanatin functionalized nanorods for overcoming drug resistance in Klebsiella pneumonia.

基于TPGS和S-thanatin的功能化納米棒克服肺炎克雷伯菌的抗藥性.

30.Deep learning to diagnose Hashimoto’s thyroiditis from sonographic images.

深度學(xué)習(xí)從聲像圖中診斷橋本甲狀腺炎.

31.Reply to: “Steller’s sea cow uncertain history illustrates importance of ecological context when interpreting demographic histories from genomes”.

回復(fù)：?"斯特勒海牛不確定的歷史說(shuō)明了從基因組解釋人口歷史時(shí)生態(tài)環(huán)境的重要性"。

32.Network-based machine learning approach to predict immunotherapy response in cancer patients.

基于網(wǎng)絡(luò)的機(jī)器學(xué)習(xí)方法來(lái)預(yù)測(cè)癌癥患者的免疫治療反應(yīng)。

33.Structural basis for mitoguardin-2 mediated lipid transport at ER-mitochondrial membrane contact sites.

mitoguardin-2在ER-mitochondrial膜接觸點(diǎn)介導(dǎo)脂質(zhì)運(yùn)輸?shù)慕Y(jié)構(gòu)基礎(chǔ)。

34.Lsm7 phase-separated condensates trigger stress granule formation.

Lsm7相分離的凝集物引發(fā)應(yīng)激顆粒的形成。

35.The genomic basis of the plant island syndrome in Darwin’s giant daisies.

達(dá)爾文巨型雛菊的植物島嶼綜合征的基因組基礎(chǔ)。

36.The impact of rare germline variants on human somatic mutation processes.

罕見(jiàn)生殖系變體對(duì)人類體細(xì)胞突變過(guò)程的影響。

37.SpySwitch enables pH- or heat-responsive capture and release for plug-and-display nanoassembly.

SpySwitch實(shí)現(xiàn)了pH值或熱反應(yīng)的捕獲和釋放，用于插拔式納米組裝。

38.Pancreatic α and β cells are globally phase-locked.

胰腺α和β細(xì)胞是全球鎖相的。

39.SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination.

SHLD1對(duì)53BP1依賴的V(D)J重組是可有可無(wú)的，但對(duì)生產(chǎn)性的類轉(zhuǎn)換重組至關(guān)重要。

40.Immunogenicity and reactogenicity of SARS-CoV-2 vaccines BNT162b2 and CoronaVac in healthy adolescents.

SARS-CoV-2疫苗BNT162b2和CoronaVac對(duì)健康青少年的免疫原性和反應(yīng)原性。

41.Evolution and activation mechanism of the flavivirus class II membrane-fusion machinery.

黃病毒II類膜融合機(jī)制的演變和激活機(jī)制。

42.Senescent cells limit p53 activity via multiple mechanisms to remain viable.

衰老的細(xì)胞通過(guò)多種機(jī)制限制p53的活性以保持活力。

43.A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery.

在沒(méi)有mATG8結(jié)合機(jī)制的情況下，降解型到分泌型的自噬開(kāi)關(guān)介導(dǎo)了線粒體的清除。

44.MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma.

MYCN驅(qū)動(dòng)的脂肪酸攝取是神經(jīng)母細(xì)胞瘤的一個(gè)代謝弱點(diǎn)。

45.Maternal immune response and placental antibody transfer after COVID-19 vaccination across trimester and platforms.

COVID-19疫苗接種后的母體免疫反應(yīng)和胎盤抗體轉(zhuǎn)移跨越三個(gè)月和平臺(tái)。

46.Learning representations of chromatin contacts using a recurrent neural network identifies genomic drivers of conformation.

使用遞歸神經(jīng)網(wǎng)絡(luò)學(xué)習(xí)染色質(zhì)接觸的表征，確定構(gòu)象的基因組驅(qū)動(dòng)因素。

47.Clonal reconstruction from co-occurrence of vector integration sites accurately quantifies expanding clones in vivo.

從載體整合點(diǎn)的共同出現(xiàn)中進(jìn)行克隆重建，準(zhǔn)確地量化了體內(nèi)的擴(kuò)展克隆。

48.Lentivector cryptic splicing mediates increase in CD34+ clones expressing truncated HMGA2 in human X-linked severe combined immunodeficiency.

慢病毒隱性剪接介導(dǎo)了人類X連鎖嚴(yán)重聯(lián)合免疫缺陷癥中表達(dá)截?cái)嗟腍MGA2的CD34+克隆的增加。

49.Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors.

固體腫瘤細(xì)胞中谷氨酰胺的缺失賦予了對(duì)核糖體RNA合成抑制劑的抗性。

50.Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records.

10個(gè)英國(guó)縱向研究和電子健康記錄中的長(zhǎng)期COVID負(fù)擔(dān)和風(fēng)險(xiǎn)因素。

51.High-dimensional profiling reveals Tc17 cell enrichment in active Crohn’s disease and identifies a potentially targetable signature.

高維分析揭示了Tc17細(xì)胞在活動(dòng)性克羅恩病中的富集，并確定了一個(gè)潛在的目標(biāo)特征。

52.Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity.

死于鐵中毒的癌細(xì)胞阻礙了樹(shù)突狀細(xì)胞介導(dǎo)的抗腫瘤免疫力。

53.Context-aware deconvolution of cell–cell communication with Tensor-cell2cell.

用Tensor-cell2cell對(duì)細(xì)胞-細(xì)胞通訊進(jìn)行上下文感知的去卷積。

54.GenomicSuperSignature facilitates interpretation of RNA-seq experiments through robust, efficient comparison to public databases.

GenomicSuperSignature通過(guò)與公共數(shù)據(jù)庫(kù)進(jìn)行有力、有效的比較，促進(jìn)了對(duì)RNA-seq實(shí)驗(yàn)的解釋。

55.G1/S restriction point coordinates phasic gene expression and cell differentiation.

G1/S限制點(diǎn)協(xié)調(diào)了階段性基因表達(dá)和細(xì)胞分化。

56.The importance of DNAPKcs for blunt DNA end joining is magnified when XLF is weakened.

當(dāng)XLF被削弱時(shí)，DNAPKcs對(duì)鈍性DNA末端連接的重要性被放大。

57.Laboratory evolution of synthetic electron transport system variants reveals a larger metabolic respiratory system and its plasticity.

合成電子運(yùn)輸系統(tǒng)變體的實(shí)驗(yàn)室進(jìn)化揭示了一個(gè)更大的代謝呼吸系統(tǒng)及其可塑性。

58.Light-induced charge generation in polymeric nanoparticles restores vision in advanced-stage retinitis pigmentosa rats.

聚合物納米顆粒中光誘導(dǎo)的電荷生成可恢復(fù)晚期視網(wǎng)膜色素變性大鼠的視力。

59.A patatin-like phospholipase mediates Rickettsia parkeri escape from host membranes.

一種類似蛋白酶的磷脂酶介導(dǎo)帕克特氏菌從宿主膜上逃脫。

60.Poor outcome of pediatric patients with acute myeloid leukemia harboring high FLT3/ITD allelic ratios.

攜帶高FLT3/ITD等位基因的兒童急性骨髓性白血病患者的不良后果。

61.Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency.

人類VLCAD缺乏癥中突變酶的膜靶向缺陷的結(jié)構(gòu)基礎(chǔ)。

62.Frequency and mechanisms of LINE-1 retrotransposon insertions at CRISPR/Cas9 sites.

CRISPR/Cas9位點(diǎn)上LINE-1逆轉(zhuǎn)錄紡子插入的頻率和機(jī)制。

63.Common genetic variation associated with Mendelian disease severity revealed through cryptic phenotype analysis.

通過(guò)隱性表型分析揭示與孟德?tīng)柤膊?yán)重程度相關(guān)的常見(jiàn)遺傳變異。

64.Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer.

組合免疫療法克服三陰性乳腺癌中MYC驅(qū)動(dòng)的免疫規(guī)避。

65.Hsp multichaperone complex buffers pathologically modified Tau.

Hsp多介質(zhì)復(fù)合體緩沖病理改變的Tau。

66.The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia.

22q11.2區(qū)域調(diào)控與精神分裂癥有關(guān)的突觸前基因產(chǎn)物。

67.Osteocyte CIITA aggravates osteolytic bone lesions in myeloma.

骨細(xì)胞CIITA加重骨髓瘤的溶骨性病變。

68.Molecular mechanics underlying flat-to-round membrane budding in live secretory cells.

活體分泌細(xì)胞中平膜向圓膜出芽的分子力學(xué)原理。

69.Warming-induced increase in carbon uptake is linked to earlier spring phenology in temperate and boreal forests.

暖化誘導(dǎo)的碳吸收增加與溫帶和北方森林的春季物候?qū)W提前有關(guān)。

70.A GPCR-based yeast biosensor for biomedical, biotechnological, and point-of-use cannabinoid determination.

基于GPCR的酵母生物傳感器用于生物醫(yī)學(xué)、生物技術(shù)和使用點(diǎn)的大麻素測(cè)定。

71.Recovery of neural dynamics criticality in personalized whole-brain models of stroke.

在個(gè)性化的中風(fēng)全腦模型中恢復(fù)神經(jīng)動(dòng)力學(xué)的臨界點(diǎn)。

72.POLYRETINA restores light responses in vivo in blind G?ttingen minipigs.

POLYRETINA恢復(fù)了哥廷根迷你豬體內(nèi)的光反應(yīng)。

73.Echolocation-related reversal of information flow in a cortical vocalization network.

皮質(zhì)發(fā)聲網(wǎng)絡(luò)中與回聲定位有關(guān)的信息流的逆轉(zhuǎn)。

74.Existing function in primary visual cortex is not perturbed by new skill acquisition of a non-matched sensory task.

初級(jí)視覺(jué)皮層的現(xiàn)有功能不受非匹配的感覺(jué)任務(wù)的新技能獲取的干擾。

75.Occult polyclonality of preclinical pancreatic cancer models drives in vitro evolution.

臨床前胰腺癌模型的隱性多克隆性驅(qū)動(dòng)體外進(jìn)化。

76.Detection of SARS-CoV-2 intra-host recombination during superinfection with Alpha and Epsilon variants in New York City.

在紐約市Alpha和Epsilon變體的超級(jí)感染中檢測(cè)SARS-CoV-2的宿主內(nèi)重組。

77.FANCM promotes class I interfering crossovers and suppresses class II non-interfering crossovers in wheat meiosis.

FANCM促進(jìn)小麥減數(shù)分裂中的I類干擾性交叉，抑制II類非干擾性交叉。

78.Microtubule disassembly by caspases is an important rate-limiting step of cell extrusion.

卡西普酶對(duì)微管的分解是細(xì)胞擠壓的一個(gè)重要限速步驟。

79.Emergent properties as by-products of prebiotic evolution of aminoacylation ribozymes.

氨基?；颂呛怂崦傅男屡d特性是生物前進(jìn)化的副產(chǎn)品。

80.Mucin induces CRISPR-Cas defense in an opportunistic pathogen.

粘液蛋白誘導(dǎo)機(jī)會(huì)主義病原體的CRISPR-Cas防御。

81.The force required to remove tubulin from the microtubule lattice by pulling on its α-tubulin C-terminal tail.

通過(guò)拉動(dòng)其α-管蛋白的C端尾巴將管蛋白從微管格子中移除所需的力。

82.Structural mechanism of protein recognition by the FW domain of autophagy receptor Nbr1.

自噬受體Nbr1的FW結(jié)構(gòu)域識(shí)別蛋白質(zhì)的結(jié)構(gòu)機(jī)制。

83.Assembly dynamics of FtsZ and DamX during infection-related filamentation and division in uropathogenic E. coli.

FtsZ和DamX在尿毒癥大腸桿菌感染相關(guān)成絲和分裂過(guò)程中的組裝動(dòng)力學(xué)。

84.Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation.

用咪唑類吲哚靶向真菌膜平衡，損害唑類抗性和生物膜形成。

85.COVID-19 disease severity in US Veterans infected during Omicron and Delta variant predominant periods.

美國(guó)退伍軍人在Omicron和Delta變體主導(dǎo)時(shí)期感染的COVID-19疾病嚴(yán)重程度。

86.Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing.

Wiskott-Aldrich綜合征蛋白形成核凝聚物并調(diào)控替代剪接。

87.Ru(II) photocages enable precise control over enzyme activity with red light.

Ru(II)光籠能夠用紅光精確控制酶的活性。

88.Age and sex-specific risks of myocarditis and pericarditis following Covid-19 messenger RNA vaccines.

Covid-19信使RNA疫苗后心肌炎和心包炎的年齡和性別特定風(fēng)險(xiǎn)。

89.Cell surface glycan engineering reveals that matriglycan alone can recapitulate dystroglycan binding and function.

細(xì)胞表面糖類工程顯示，單獨(dú)的基質(zhì)聚糖可以重現(xiàn)抗肌萎縮聚糖的結(jié)合和功能。

90.Chain flexibility of medicinal lipids determines their selective partitioning into lipid droplets.

藥用脂質(zhì)的鏈的靈活性決定了它們?cè)谥|(zhì)液滴中的選擇性分配。

91.Spatiotemporal analysis of glioma heterogeneity reveals COL1A1 as an actionable target to disrupt tumor progression.

膠質(zhì)瘤異質(zhì)性的時(shí)空分析顯示COL1A1是破壞腫瘤進(jìn)展的一個(gè)可操作的目標(biāo)。

92.DNA damage-induced transcription stress triggers the genome-wide degradation of promoter-bound Pol II.

DNA損傷誘導(dǎo)的轉(zhuǎn)錄壓力引發(fā)了啟動(dòng)子結(jié)合的Pol II的全基因組降解。

93.Endothelial cell heterogeneity and microglia regulons revealed by a pig cell landscape at single-cell level.

內(nèi)皮細(xì)胞異質(zhì)性和小膠質(zhì)細(xì)胞調(diào)節(jié)器在單細(xì)胞水平上被豬細(xì)胞景觀所揭示。

94.Sizing up DNA nanostructure assembly with native mass spectrometry and ion mobility.

用原生質(zhì)譜和離子遷移率對(duì)DNA納米結(jié)構(gòu)組裝進(jìn)行測(cè)定。

95.Coordination of metal center biogenesis in human cytochrome c oxidase.

人類細(xì)胞色素c氧化酶中金屬中心生物生成的協(xié)調(diào)。

96.A glycine-rich PE_PGRS protein governs mycobacterial actin-based motility.

一個(gè)富含甘氨酸的PE_PGRS蛋白控制著霉菌基于肌動(dòng)蛋白的運(yùn)動(dòng)。

97.A microfluidic optimal experimental design platform for forward design of cell-free genetic networks.

用于無(wú)細(xì)胞遺傳網(wǎng)絡(luò)正向設(shè)計(jì)的微流控最佳實(shí)驗(yàn)設(shè)計(jì)平臺(tái)。

98.The encephalomyocarditis virus Leader promotes the release of virions inside extracellular vesicles via the induction of secretory autophagy.

腦膜炎病毒Leader通過(guò)誘導(dǎo)分泌型自噬促進(jìn)細(xì)胞外囊泡內(nèi)病毒的釋放。

99.A structural and functional subdivision in central orbitofrontal cortex.

中部眶額皮層的結(jié)構(gòu)和功能分區(qū)。

100.Insights into the mechanism of action of the arbitrium communication system in SPbeta phages.

洞察SPbeta噬菌體中的套圈通信系統(tǒng)的作用機(jī)制。

101.Construction of a synthetic Saccharomyces cerevisiae pan-genome neo-chromosome.

合成的釀酒酵母泛基因組新染色體的構(gòu)建。

102.Contribution of low population immunity to the severe Omicron BA.2 outbreak in Hong Kong.

低人口免疫力對(duì)香港嚴(yán)重的Omicron BA.2疫情的貢獻(xiàn)。

103.Porphyrin as a versatile visible-light-activatable organic/metal hybrid photoremovable protecting group.

卟啉作為一種多功能的可見(jiàn)光可激活的有機(jī)/金屬混合光可移動(dòng)的保護(hù)基。

104.Results of the phase I CCTG IND.231 trial of CX-5461 in patients with advanced solid tumors enriched for DNA-repair deficiencies.

CX-5461在富含DNA修復(fù)缺陷的晚期實(shí)體瘤患者中的I期CCTG IND.231試驗(yàn)的結(jié)果。

105.Neutralization of Omicron BA.1, BA.2, and BA.3 SARS-CoV-2 by 3 doses of BNT162b2 vaccine.

3劑BNT162b2疫苗對(duì)Omicron BA.1, BA.2,?和BA.3 SARS-CoV-2的中和作用。

106.Substrate binding in the mitochondrial ADP/ATP carrier is a step-wise process guiding the structural changes in the transport cycle.

線粒體ADP/ATP載體中的底物結(jié)合是一個(gè)指導(dǎo)運(yùn)輸循環(huán)結(jié)構(gòu)變化的分步過(guò)程。

107.Engineering substrate specificity of HAD phosphatases and multienzyme systems development for the thermodynamic-driven manufacturing sugars.

HAD磷酸酶的底物特異性工程和熱力學(xué)驅(qū)動(dòng)的制造糖類的多酶系統(tǒng)開(kāi)發(fā)。

108.Transcription factor-driven coordination of cell cycle exit and lineage-specification in vivo during granulocytic differentiation.

轉(zhuǎn)錄因子驅(qū)動(dòng)的細(xì)胞周期退出和體內(nèi)粒細(xì)胞分化過(guò)程中的線狀特化的協(xié)調(diào)。

109.Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR.

大循環(huán)穩(wěn)定其與14-3-3的相互作用增加CFTR的質(zhì)膜定位和活性。

110.Probing TDP-43 condensation using an in silico designed aptamer.

使用計(jì)算機(jī)設(shè)計(jì)的適體探測(cè)?TDP-43?凝聚。

111.Bateman gradients from first principles.

來(lái)自第一原理的貝特曼梯度。

112.HOX epimutations driven by maternal SMCHD1/LRIF1 haploinsufficiency trigger homeotic transformations in genetically wildtype offspring.

由母體SMCHD1/LRIF1單倍體不足驅(qū)動(dòng)的HOX外顯子引發(fā)基因野生型后代的順行性轉(zhuǎn)變。

113.Coiled-coil heterodimer-based recruitment of an exonuclease to CRISPR/Cas for enhanced gene editing.

基于盤狀線圈的異構(gòu)體對(duì)CRISPR/Cas的外切酶進(jìn)行招募以增強(qiáng)基因編輯。

114.Gut virome profiling identifies a widespread bacteriophage family associated with metabolic syndrome.

腸道病毒譜分析確定了一個(gè)與代謝綜合征有關(guān)的廣泛的噬菌體家族。

115.The obligate intracellular bacterium Orientia tsutsugamushi differentiates into a developmentally distinct extracellular state.

強(qiáng)制性細(xì)胞內(nèi)細(xì)菌Orientia tsutsugamushi分化為發(fā)育不同的細(xì)胞外狀態(tài)。

116.A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge.

一種廣譜中和抗體保護(hù)敘利亞倉(cāng)鼠免受SARS-CoV-2 Omicron挑戰(zhàn)。

117.An intein-split transactivator for intersectional neural imaging and optogenetic manipulation.

一種用于交叉神經(jīng)成像和光遺傳學(xué)操作的內(nèi)含肽分裂反式激活因子。

118.Mnemonic construction and representation of temporal structure in the hippocampal formation.

海馬形成中記憶的構(gòu)建和時(shí)間結(jié)構(gòu)的表示。

119.hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells.

hnRNPH1招募PTBP2和SRSF3以調(diào)控生殖細(xì)胞的替代剪接。

120.In situ 3D bioprinting with bioconcrete bioink.

用生物混凝土生物墨水進(jìn)行原位3D生物打印。

121.Peripherally restricted transthyretin-based delivery system for probes and therapeutics avoiding opioid-related side effects.

基于外周限制性轉(zhuǎn)甲狀腺素的探針和治療藥物的輸送系統(tǒng)，避免了阿片類藥物的相關(guān)副作用。

122.Advancing our understanding of genetic risk factors and potential personalized strategies for pelvic organ prolapse.

推進(jìn)我們對(duì)盆腔器官脫垂的遺傳風(fēng)險(xiǎn)因素和潛在個(gè)性化策略的理解。

123.High-resolution mass measurements of single budding yeast reveal linear growth segments.

單個(gè)發(fā)芽酵母的高分辨率質(zhì)量測(cè)量揭示了線性生長(zhǎng)段。

124.RNase III-CLASH of multi-drug resistant Staphylococcus aureus reveals a regulatory mRNA 3′UTR required for intermediate vancomycin resistance.

多重耐藥金黃色葡萄球菌的RNase III-CLASH揭示了中間萬(wàn)古霉素抗性所需的調(diào)節(jié)性mRNA 3′UTR。

125.RNase III CLASH in MRSA uncovers sRNA regulatory networks coupling metabolism to toxin expression.

MRSA的RNase III CLASH發(fā)現(xiàn)了連接代謝和毒素表達(dá)的sRNA調(diào)節(jié)網(wǎng)絡(luò)。

126.Branched actin networks are organized for asymmetric force production during clathrin-mediated endocytosis in mammalian cells.

哺乳動(dòng)物細(xì)胞中克拉特林介導(dǎo)的內(nèi)吞過(guò)程中，分支的肌動(dòng)蛋白網(wǎng)絡(luò)被組織起來(lái)以產(chǎn)生不對(duì)稱的力量。

127.Host control and the evolution of cooperation in host microbiomes.

宿主控制和宿主微生物組中合作的進(jìn)化。

128.Dissociation between individual differences in self-reported pain intensity and underlying fMRI brain activation.

自我報(bào)告的疼痛強(qiáng)度的個(gè)體差異與基礎(chǔ)fMRI大腦激活之間的關(guān)聯(lián)。

129.Kir2.1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transporters.

Kir2.1介導(dǎo)的膜電位通過(guò)調(diào)節(jié)營(yíng)養(yǎng)物質(zhì)轉(zhuǎn)運(yùn)體促進(jìn)營(yíng)養(yǎng)物質(zhì)的獲取和炎癥的發(fā)生。

130.Cyclic microchip assay for measurement of hundreds of functional proteins in single neurons.

用于測(cè)量單個(gè)神經(jīng)元中數(shù)百種功能蛋白的循環(huán)芯片檢測(cè)。

131.The antenna of far-red absorbing cyanobacteria increases both absorption and quantum efficiency of Photosystem II.

吸收遠(yuǎn)紅的藍(lán)藻的觸角增加了光系統(tǒng)II的吸收和量子效率。

132.NANOG initiates epiblast fate through the coordination of pluripotency genes expression.

NANOG通過(guò)協(xié)調(diào)多能性基因的表達(dá)來(lái)啟動(dòng)外胚層命運(yùn)。

133.Binding and structural basis of equine ACE2 to RBDs from SARS-CoV, SARS-CoV-2 and related coronaviruses.

馬匹ACE2與SARS-CoV、SARS-CoV-2和相關(guān)冠狀病毒的RBDs的結(jié)合和結(jié)構(gòu)基礎(chǔ)。

134.Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance.

定義SARS-CoV-2主要蛋白酶的底物包膜以預(yù)測(cè)和避免抗藥性。

135.A scalable, open-source implementation of a large-scale mechanistic model for single cell proliferation and death signaling.

一個(gè)可擴(kuò)展的、開(kāi)源的單細(xì)胞增殖和死亡信號(hào)的大規(guī)模機(jī)制模型的實(shí)現(xiàn)。

136.Innate immune responses against the fungal pathogen Candida auris.

針對(duì)真菌病原體Candida auris的先天免疫反應(yīng)。

137.MicroRNA-21 promotes pancreatic β cell function through modulating glucose uptake.

MicroRNA-21通過(guò)調(diào)節(jié)葡萄糖攝取促進(jìn)胰腺β細(xì)胞功能。

138.A multi-ethnic polygenic risk score is associated with hypertension prevalence and progression throughout adulthood.

多民族多基因風(fēng)險(xiǎn)評(píng)分與高血壓患病率和整個(gè)成年后的發(fā)展有關(guān)。

139.Islet autoantibody seroconversion in type-1 diabetes is associated with metagenome-assembled genomes in infant gut microbiomes.

1型糖尿病患者的胰島自身抗體血清轉(zhuǎn)換與嬰兒腸道微生物組的元基因組有關(guān)。

140.Structural basis of template strand deoxyuridine promoter recognition by a viral RNA polymerase.

病毒性RNA聚合酶識(shí)別模板鏈脫氧尿苷啟動(dòng)子的結(jié)構(gòu)基礎(chǔ)。

141.Mapping the conformational energy landscape of Abl kinase using ClyA nanopore tweezers.

使用ClyA納米孔鑷子繪制Abl激酶的構(gòu)象能量圖。

142.Revealing the human mucinome.

揭示人類粘液組的情況。

143.Optimal CD8+ T cell effector function requires costimulation-induced RNA-binding proteins that reprogram the transcript isoform landscape.

最佳的CD8+T細(xì)胞效應(yīng)功能需要成本刺激誘導(dǎo)的RNA結(jié)合蛋白來(lái)重新規(guī)劃轉(zhuǎn)錄本的異構(gòu)體景觀。

144.Global stable-isotope tracing metabolomics reveals system-wide metabolic alternations in aging Drosophila.

全球穩(wěn)定同位素追蹤代謝組學(xué)揭示了衰老果蠅的全系統(tǒng)代謝變化。

145.Satellite repeat transcripts modulate heterochromatin condensates and safeguard chromosome stability in mouse embryonic stem cells.

衛(wèi)星重復(fù)轉(zhuǎn)錄物調(diào)節(jié)小鼠胚胎干細(xì)胞中的異染色質(zhì)凝聚物并保障染色體穩(wěn)定性。

146.Inhibition of negative feedback for persistent epithelial cell–cell junction contraction by p21-activated kinase 3.

p21激活的激酶3對(duì)持久性上皮細(xì)胞-細(xì)胞交界處收縮的負(fù)反饋的抑制。

147.Forest Fire Clustering for single-cell sequencing combines iterative label propagation with parallelized Monte Carlo simulations.

用于單細(xì)胞測(cè)序的Forest Fire Clustering結(jié)合了迭代標(biāo)簽傳播和并行蒙特卡洛模擬。

148.HarmonizR enables data harmonization across independent proteomic datasets with appropriate handling of missing values.

HarmonizR能夠在獨(dú)立的蛋白質(zhì)組數(shù)據(jù)集之間進(jìn)行數(shù)據(jù)協(xié)調(diào)，并對(duì)缺失值進(jìn)行適當(dāng)處理。

149.EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment.

EphB4和ephrinB2在頭頸部腫瘤微環(huán)境中作用相反。

150.SARS-CoV-2 Omicron variant causes mild pathology in the upper and lower respiratory tract of hamsters.

SARS-CoV-2 Omicron變體在倉(cāng)鼠上、下呼吸道引起輕度病變。

151.Diagonal integration of multimodal single-cell data: potential pitfalls and paths forward.

多模態(tài)單細(xì)胞數(shù)據(jù)的對(duì)角線整合：潛在的陷阱和前進(jìn)的道路。

152.A global forum on synthetic biology: the need for international engagement.

關(guān)于合成生物學(xué)的全球論壇：需要國(guó)際參與。

153.Chromosome-level and haplotype-resolved genome provides insight into the tetraploid hybrid origin of patchouli.

染色體水平和單倍型解析的基因組為了解廣藿香的四倍體雜交起源提供了線索。

154.Complex regulation of Gephyrin splicing is a determinant of inhibitory postsynaptic diversity.

Gephyrin拼接的復(fù)雜調(diào)節(jié)是抑制性突觸后多樣性的決定因素。

155.Peptide fusion improves prime editing efficiency.

肽融合提高了質(zhì)粒編輯效率。

156.Bioorthogonally activatable cyanine dye with torsion-induced disaggregation for in vivo tumor imaging.

用于體內(nèi)腫瘤成像的具有扭轉(zhuǎn)誘導(dǎo)分解作用的生物正交可激活的青色染料。

157.A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes.

2型糖尿病患者BCAA分解代謝的藥理激活的隨機(jī)安慰劑對(duì)照臨床試驗(yàn)。

158.RIViT-seq enables systematic identification of regulons of transcriptional machineries.

RIViT-seq能夠系統(tǒng)地識(shí)別轉(zhuǎn)錄機(jī)制的調(diào)節(jié)子。

159.The architecture and operating mechanism of a cnidarian stinging organelle.

刺胞器的結(jié)構(gòu)和運(yùn)行機(jī)制。

160.3D structure and in situ arrangements of CatSper channel in the sperm flagellum.

精子鞭毛中CatSper通道的三維結(jié)構(gòu)和原位排列。

161.Comparative parallel multi-omics analysis during the induction of pluripotent and trophectoderm states.

在誘導(dǎo)多能體和滋養(yǎng)體狀態(tài)的過(guò)程中進(jìn)行比較性的平行多組學(xué)分析。

162.Asynchronous glutamate release is enhanced in low release efficacy synapses and dispersed across the active zone.

異步谷氨酸釋放在低釋放效能的突觸中得到加強(qiáng)，并分散在整個(gè)活動(dòng)區(qū)。

163.Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its conformational conversion.

全長(zhǎng)人SOD1形成的淀粉樣纖維的冷凍電鏡結(jié)構(gòu)揭示了其構(gòu)象轉(zhuǎn)換。

164.Bifurcation drives the evolution of assembly-line biosynthesis.

分叉推動(dòng)了流水線生物合成的進(jìn)化。

165.Core and rod structures of a thermophilic cyanobacterial light-harvesting phycobilisome.

嗜熱型藍(lán)藻采光藻體的核心和桿狀結(jié)構(gòu)。

166.Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction.

內(nèi)源性大麻素合成酶DAGLB的缺陷導(dǎo)致了早發(fā)性帕金森病和小鼠黑質(zhì)多巴胺能神經(jīng)元的功能障礙。

167.FUNDC2 promotes liver tumorigenesis by inhibiting MFN1-mediated mitochondrial fusion.

FUNDC2通過(guò)抑制MFN1介導(dǎo)的線粒體融合促進(jìn)肝臟腫瘤的發(fā)生。

168.The chromatin remodeller ATRX facilitates diverse nuclear processes, in a stochastic manner, in both heterochromatin and euchromatin.

染色質(zhì)重塑劑ATRX以隨機(jī)的方式在異染色質(zhì)和超染色質(zhì)中促進(jìn)各種核過(guò)程。

169.ZFP281-BRCA2 prevents R-loop accumulation during DNA replication.

ZFP281-BRCA2在DNA復(fù)制過(guò)程中防止R環(huán)的積累。

170.Functional but not obligatory link between microsaccades and neural modulation by covert spatial attention.

微動(dòng)與隱蔽空間注意的神經(jīng)調(diào)控之間存在功能性但非強(qiáng)制性的聯(lián)系。

171.A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants.

全球脂質(zhì)圖揭示了SARS-CoV-2變體之間保守的宿主依賴性因素。

172.Context-dependent enhancer function revealed by targeted inter-TAD relocation.

有針對(duì)性的TAD間遷移揭示了上下文依賴的增強(qiáng)器功能。

173.Adipocyte-derived kynurenine promotes obesity and insulin resistance by activating the AhR/STAT3/IL-6 signaling.

脂肪細(xì)胞衍生的犬尿喹啉通過(guò)激活A(yù)hR/STAT3/IL-6信號(hào)傳導(dǎo)促進(jìn)肥胖和胰島素抵抗。

174.Addressing challenges with real-world synthetic control arms to demonstrate the comparative effectiveness of Pralsetinib in non-small cell lung cancer.

應(yīng)對(duì)現(xiàn)實(shí)世界中合成控制臂的挑戰(zhàn)，以證明普拉西尼在非小細(xì)胞肺癌中的比較有效性。

175.ARID1A loss derepresses a group of human endogenous retrovirus-H loci to modulate BRD4-dependent transcription.

ARID1A的缺失解除了對(duì)一組人類內(nèi)源性逆轉(zhuǎn)錄病毒-H位點(diǎn)的抑制，以調(diào)節(jié)BRD4依賴的轉(zhuǎn)錄。

176.Unmixing for ultra-high-plex fluorescence imaging.

超高倍數(shù)熒光成像的未混合.

177.A hexa-species transcriptome atlas of mammalian embryogenesis delineates metabolic regulation across three different implantation modes.

哺乳動(dòng)物胚胎發(fā)育的六種轉(zhuǎn)錄組圖譜勾勒出三種不同植入模式下的代謝調(diào)節(jié)。

178.Therapeutic efficacy of combined active and passive immunization in ART-suppressed, SHIV-infected rhesus macaques.

主動(dòng)和被動(dòng)聯(lián)合免疫對(duì)受ART抑制的SHIV感染獼猴的治療效果。

179.T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles.

T細(xì)胞跨突觸囊泡與構(gòu)成性細(xì)胞外囊泡不同，攜帶更多的效應(yīng)物內(nèi)容。

180.Disentangling the genetic basis of rhizosphere microbiome assembly in tomato.

解讀番茄根瘤微生物群組裝的遺傳基礎(chǔ)。

181.The impact of species-wide gene expression variation on Caenorhabditis elegans complex traits.

物種范圍內(nèi)的基因表達(dá)變異對(duì)優(yōu)雅凱諾蟲復(fù)雜性狀的影響。

182.Single-cell profiling of the antigen-specific response to BNT162b2 SARS-CoV-2 RNA vaccine.

對(duì)BNT162b2 SARS-CoV-2 RNA疫苗的抗原特異性反應(yīng)的單細(xì)胞分析。

183.Phasing analysis of lung cancer genomes using a long read sequencer.

使用長(zhǎng)讀測(cè)序儀對(duì)肺癌基因組進(jìn)行相位分析。

184.The 3D architecture of the pepper genome and its relationship to function and evolution.

辣椒基因組的三維結(jié)構(gòu)及其與功能和進(jìn)化的關(guān)系。

185.GPI-anchored FGF directs cytoneme-mediated bidirectional contacts to regulate its tissue-specific dispersion.

GPI錨定的FGF指導(dǎo)細(xì)胞膜介導(dǎo)的雙向接觸以調(diào)節(jié)其組織特異性分散。

186.A sound approach to advancing healthcare systems: the future of biomedical acoustics.

推進(jìn)醫(yī)療保健系統(tǒng)的合理方法：生物醫(yī)學(xué)聲學(xué)的未來(lái)。

187.Ly6D+Siglec-H+ precursors contribute to conventional dendritic cells via a Zbtb46+Ly6D+ intermediary stage.

Ly6D+Siglec-H+前體通過(guò)Zbtb46+Ly6D+中間階段對(duì)常規(guī)樹(shù)突狀細(xì)胞的貢獻(xiàn)。

188.Light-sheet photonic force optical coherence elastography for high-throughput quantitative 3D micromechanical imaging.

光片式光子力光學(xué)相干彈性成像技術(shù)用于高通量定量三維微機(jī)械成像。

189.Identifying plant genes shaping microbiota composition in the barley rhizosphere.

識(shí)別塑造大麥根莖層微生物群組成的植物基因。

190.Catalytical nano-immunocomplexes for remote-controlled sono-metabolic checkpoint trimodal cancer therapy.

催化性納米免疫復(fù)合物用于遠(yuǎn)程控制的超聲代謝檢查點(diǎn)三聯(lián)體癌癥治療。

191.Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue.

腦組織中GPCR型谷氨酸受體激活的協(xié)調(diào)化學(xué)遺傳學(xué)。

192.Pilot study of bempegaldesleukin in combination with nivolumab in patients with metastatic sarcoma.

Bempegaldesleukin與nivolumab聯(lián)合治療轉(zhuǎn)移性肉瘤患者的試驗(yàn)研究。

193.Terahertz thermal curve analysis for label-free identification of pathogens.

太赫茲熱曲線分析用于病原體的無(wú)標(biāo)簽鑒定。

194.Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma.

軟組織和骨肉瘤患者管理中的臨床基因組分析。

195.Structural basis of rapid actin dynamics in the evolutionarily divergent Leishmania parasite.

進(jìn)化分化的利什曼寄生蟲中快速肌動(dòng)蛋白動(dòng)態(tài)的結(jié)構(gòu)基礎(chǔ)。

196.Sex-specific multi-level 3D genome dynamics in the mouse brain.

小鼠大腦中的性別特異性多層次三維基因組動(dòng)態(tài)。

197.Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase.

遠(yuǎn)程實(shí)體癌通過(guò)宿主煙酰胺-N-甲基轉(zhuǎn)移酶重構(gòu)肝臟氮素代謝。

198.Disease modeling by efficient genome editing using a near PAM-less base editor in vivo.

利用體內(nèi)近乎無(wú)PAM的堿基編輯器進(jìn)行高效基因組編輯的疾病建模。

199.Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets.

軟組織和骨肉瘤的臨床測(cè)序勾勒出不同的基因組圖譜和潛在的治療目標(biāo)。

200.Pre-existing antibody levels negatively correlate with antibody titers after a single dose of BBV152 vaccination.

預(yù)先存在的抗體水平與單劑量BBV152疫苗接種后的抗體滴度呈負(fù)相關(guān)。

201.Distributed genetic architecture across the hippocampal formation implies common neuropathology across brain disorders.

分布在整個(gè)海馬形成的遺傳結(jié)構(gòu)意味著整個(gè)大腦疾病的共同神經(jīng)病理學(xué)。

202.Complete biosynthetic pathway to the antidiabetic drug acarbose.

抗糖尿病藥物阿卡波糖的完整生物合成途徑。

203.Genetic subtypes of smoldering multiple myeloma are associated with distinct pathogenic phenotypes and clinical outcomes.

多發(fā)性骨髓瘤的遺傳亞型與不同的致病表型和臨床結(jié)果有關(guān)。

204.Structural remodeling of ribosome associated Hsp40-Hsp70 chaperones during co-translational folding.

共同翻譯折疊過(guò)程中核糖體相關(guān)Hsp40-Hsp70伴侶的結(jié)構(gòu)重塑。

205.CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes.

CXCL4與TLR8協(xié)同促進(jìn)TBK1-IRF5的激活、表觀基因組重塑和人類單核細(xì)胞的炎癥反應(yīng)。

206.ChIP-Hub provides an integrative platform for exploring plant regulome.

ChIP-Hub為探索植物調(diào)控組提供了一個(gè)綜合平臺(tái)。

207.A role for ascorbate conjugates of (+)-catechin in proanthocyanidin polymerization.

(+)-兒茶素的抗壞血酸共軛物在原花青素聚合中的作用。

208.Ursodeoxycholic acid reduces antitumor immunosuppression by inducing CHIP-mediated TGF-β degradation.

熊去氧膽酸通過(guò)誘導(dǎo)CHIP介導(dǎo)的TGF-β降解減少抗腫瘤免疫抑制。

209.Morphological pseudotime ordering and fate mapping reveal diversification of cerebellar inhibitory interneurons.

形態(tài)學(xué)上的假時(shí)排序和命運(yùn)圖譜揭示了小腦抑制性神經(jīng)元的多樣化。

210.Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery.

可編程益生菌在有效口服后調(diào)節(jié)炎癥和腸道微生物群以治療炎癥性腸病。

211.Brain-wide reconstruction of inhibitory circuits after traumatic brain injury.

創(chuàng)傷性腦損傷后全腦抑制性電路的重建。

212.A multifunctional system for genome editing and large-scale interspecies gene transfer.

一個(gè)用于基因組編輯和大規(guī)模種間基因轉(zhuǎn)移的多功能系統(tǒng)。

213.Cas9-induced large deletions and small indels are controlled in a convergent fashion.

Cas9誘導(dǎo)的大缺失和小缺失以一種收斂的方式被控制。

214.Influenza A virus undergoes compartmentalized replication in vivo dominated by stochastic bottlenecks.

甲型流感病毒在體內(nèi)經(jīng)歷了以隨機(jī)瓶頸為主導(dǎo)的區(qū)塊化復(fù)制。

215.SpG and SpRY variants expand the CRISPR toolbox for genome editing in zebrafish.

SpG和SpRY變體擴(kuò)展了斑馬魚基因組編輯的CRISPR工具箱。

216.Identification, discrimination and heterogeneity of fibroblasts.

成纖維細(xì)胞的識(shí)別、鑒別和異質(zhì)性。

217.Large-scale genomic analyses reveal insights into pleiotropy across circulatory system diseases and nervous system disorders.

大規(guī)模的基因組分析揭示了對(duì)跨循環(huán)系統(tǒng)疾病和神經(jīng)系統(tǒng)疾病的多態(tài)性的見(jiàn)解。

218.Compact IF2 allows initiator tRNA accommodation into the P site and gates the ribosome to elongation.

緊湊的IF2允許啟動(dòng)子tRNA容納到P位點(diǎn)，并為核糖體的延伸提供了門檻。

219.Anatomy of Omicron BA.1 and BA.2 neutralizing antibodies in COVID-19 mRNA vaccinees.

剖析COVID-19 mRNA疫苗接種者的Omicron BA.1和BA.2中和抗體。

220.Gene expression signatures of individual ductal carcinoma in situ lesions identify processes and biomarkers associated with progression towards invasive ductal carcinoma.

個(gè)別導(dǎo)管原位癌病變的基因表達(dá)特征確定了與侵襲性導(dǎo)管癌進(jìn)展相關(guān)的過(guò)程和生物標(biāo)志物。

221.Asgard archaea shed light on the evolutionary origins of the eukaryotic ubiquitin-ESCRT machinery.

阿斯加德古菌揭示了真核生物泛素-ESCRT機(jī)制的進(jìn)化起源。

222.Neurotoxic amyloidogenic peptides in the proteome of SARS-COV2: potential implications for neurological symptoms in COVID-19.

SARS-COV2蛋白質(zhì)組中的神經(jīng)毒性淀粉樣肽：對(duì)COVID-19的神經(jīng)系統(tǒng)癥狀的潛在影響。

223.Ribosome profiling reveals multiple roles of SecA in cotranslational protein export.

核糖體分析揭示了SecA在共翻譯蛋白輸出中的多種作用。

224.Triiodothyronine (T3) promotes brown fat hyperplasia via thyroid hormone receptor α mediated adipocyte progenitor cell proliferation.

三碘甲狀腺素（T3）通過(guò)甲狀腺激素受體α介導(dǎo)的脂肪細(xì)胞祖細(xì)胞增殖促進(jìn)棕色脂肪增生。

225.Linking individual differences in human primary visual cortex to contrast sensitivity around the visual field.

將人類初級(jí)視覺(jué)皮層的個(gè)體差異與視野周圍的對(duì)比敏感度聯(lián)系起來(lái)。

226.High throughput, label-free isolation of circulating tumor cell clusters in meshed microwells.

高通量、無(wú)標(biāo)簽分離網(wǎng)狀微孔中的循環(huán)腫瘤細(xì)胞群。

227.Defect engineering of layered double hydroxide nanosheets as inorganic photosensitizers for NIR-III photodynamic cancer therapy.

層狀雙氫氧化物納米片的缺陷工程作為無(wú)機(jī)光敏劑用于NIR-III光動(dòng)力癌癥治療。

228.Dynamic interaction of BRCA2 with telomeric G-quadruplexes underlies telomere replication homeostasis.

BRCA2與端粒G-四聯(lián)體的動(dòng)態(tài)互動(dòng)是端粒復(fù)制平衡的基礎(chǔ)。

229.Variants in ASPH cause exertional heat illness and are associated with malignant hyperthermia susceptibility.

ASPH中的變體引起勞累性熱病，并與惡性高熱病的易感性有關(guān)。

230.A long-acting interleukin-7, rhIL-7-hyFc, enhances CAR T cell expansion, persistence, and anti-tumor activity.

一種長(zhǎng)效白細(xì)胞介素-7，rhIL-7-hyFc，增強(qiáng)了CAR T細(xì)胞的擴(kuò)展、持久性和抗腫瘤活性。

231.A proteogenomic signature of age-related macular degeneration in blood.

血液中年齡相關(guān)性黃斑變性的蛋白質(zhì)基因組特征。

232.Plasmodium falciparum 7G8 challenge provides conservative prediction of efficacy of PfNF54-based PfSPZ Vaccine in Africa.

惡性瘧原蟲7G8挑戰(zhàn)為非洲基于PfNF54的PfSPZ疫苗的療效提供了保守的預(yù)測(cè)。

233.NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility.

NUP62定位于ALS/FTLD的病理集合體，有助于TDP-43的不溶性。

234.Enhancing bioreactor arrays for automated measurements and reactive control with ReacSight.

用ReacSight加強(qiáng)生物反應(yīng)器陣列的自動(dòng)測(cè)量和反應(yīng)性控制。

235.Mechanism of glycogen synthase inactivation and interaction with glycogenin.

糖原合成酶失活的機(jī)制和與糖原蛋白的相互作用。

236.Structural basis of resistance to herbicides that target acetohydroxyacid synthase.

對(duì)針對(duì)乙酰羥酸合成酶的除草劑產(chǎn)生抗性的結(jié)構(gòu)基礎(chǔ)。

237.Photoredox catalytic radical fluorosulfonylation of olefins enabled by a bench-stable redox-active fluorosulfonyl radical precursor.

光氧化催化自由基氟磺化烯烴的作用，由一個(gè)穩(wěn)定的氧化還原活性的氟磺化自由基前體促成。

238.Antigen glycosylation regulates efficacy of CAR T cells targeting CD19.

抗原糖基化調(diào)節(jié)靶向CD19的CAR T細(xì)胞的療效。

239.A highly conserved core bacterial microbiota with nitrogen-fixation capacity inhabits the xylem sap in maize plants.

具有固氮能力的高度保守的核心細(xì)菌微生物群棲息在玉米植物的木質(zhì)部汁液中。

240.Expansion of cytotoxic tissue-resident CD8+ T cells and CCR6+CD161+ CD4+ T cells in the nasal mucosa following mRNA COVID-19 vaccination.

mRNA COVID-19疫苗接種后細(xì)胞毒性組織駐留CD8+T細(xì)胞和CCR6+CD161+CD4+T細(xì)胞在鼻粘膜的擴(kuò)增。

241.Exploring the cellular landscape of circular RNAs using full-length single-cell RNA sequencing.

利用全長(zhǎng)的單細(xì)胞RNA測(cè)序技術(shù)探索環(huán)狀RNA的細(xì)胞景觀。

242.Stable choice coding in rat frontal orienting fields across model-predicted changes of mind.

大鼠額葉定向區(qū)的穩(wěn)定選擇編碼跨越模型預(yù)測(cè)的心智變化。

243.Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder.

Orgo-Seq整合了單細(xì)胞和批量轉(zhuǎn)錄組數(shù)據(jù)，以確定與自閉癥譜系障礙相關(guān)的細(xì)胞類型特定驅(qū)動(dòng)基因。

244.Deep learning driven biosynthetic pathways navigation for natural products with BioNavi-NP.

利用BioNavi-NP進(jìn)行深度學(xué)習(xí)驅(qū)動(dòng)的天然產(chǎn)品生物合成路徑導(dǎo)航。

245.Cis- and trans-resveratrol have opposite effects on histone serine-ADP-ribosylation and tyrosine induced neurodegeneration.

順式和反式白藜蘆醇對(duì)組蛋白絲氨酸-ADP-核苷酸化和酪氨酸誘導(dǎo)的神經(jīng)退行性有相反的影響。

246.Embryo-scale epithelial buckling forms a propagating furrow that initiates gastrulation.

胚胎規(guī)模的上皮屈曲形成了一個(gè)傳播溝，啟動(dòng)了胃腸發(fā)育。

247.Evolution of sexual systems, sex chromosomes and sex-linked gene transcription in flatworms and roundworms.

扁形蟲和蛔蟲的性系統(tǒng)、性染色體和性連鎖基因轉(zhuǎn)錄的進(jìn)化。

248.Parallel ventral hippocampus-lateral septum pathways differentially regulate approach-avoidance conflict.

平行的腹側(cè)海馬-側(cè)隔膜通路不同程度地調(diào)節(jié)接近-回避沖突。

249.Imaging translational control by Argonaute with single-molecule resolution in live cells.

在活細(xì)胞中以單分子分辨率對(duì)Argonaute的翻譯控制進(jìn)行成像。

250.Factors shaping the abundance and diversity of the gut archaeome across the animal kingdom.

塑造整個(gè)動(dòng)物王國(guó)的腸道考古組的豐度和多樣性的因素。

251.Excess ribosomal protein production unbalances translation in a model of Fragile X Syndrome.

過(guò)多的核糖體蛋白生產(chǎn)使脆性X綜合征模型中的翻譯失衡。

252.Results of the phase IIa RADICAL trial of the FGFR inhibitor AZD4547 in endocrine resistant breast cancer.

FGFR抑制劑AZD4547治療內(nèi)分泌耐藥乳腺癌的IIa期RADICAL試驗(yàn)結(jié)果。

253.Deep neural network trained on gigapixel images improves lymph node metastasis detection in clinical settings.

在千兆像素圖像上訓(xùn)練的深度神經(jīng)網(wǎng)絡(luò)改善了臨床上的淋巴結(jié)轉(zhuǎn)移檢測(cè)。

254.Microfluidics for understanding model organisms.

用于理解模型生物的微流控技術(shù)。

255.Airway Prevotella promote TLR2-dependent neutrophil activation and rapid clearance of Streptococcus pneumoniae from the lung.

氣道普雷沃特菌促進(jìn)TLR2依賴性中性粒細(xì)胞的激活和肺部肺炎鏈球菌的快速清除。

256.Controlling synthetic membraneless organelles by a red-light-dependent singlet oxygen-generating protein.

用一種依賴紅光的單線態(tài)氧生成蛋白控制合成的無(wú)膜細(xì)胞器。

257.Structural Basis for pH-gating of the K+ channel TWIK1 at the selectivity filter.

K+通道TWIK1在選擇性過(guò)濾器處的pH門控的結(jié)構(gòu)基礎(chǔ)。

258.Mechanically active integrins target lytic secretion at the immune synapse to facilitate cellular cytotoxicity.

機(jī)械活躍的整合素在免疫突觸中以細(xì)胞分泌為目標(biāo)，促進(jìn)細(xì)胞毒性的產(chǎn)生。

259.Large-scale multi-omics analysis suggests specific roles for intragenic cohesin in transcriptional regulation.

大規(guī)模的多組學(xué)分析表明基因內(nèi)協(xié)同蛋白在轉(zhuǎn)錄調(diào)控中的特定作用。

260.Comparison of methods and resources for cell-cell communication inference from single-cell RNA-Seq data.

從單細(xì)胞RNA-Seq數(shù)據(jù)推斷細(xì)胞-細(xì)胞通訊的方法和資源比較。

261.A single-cell transcriptomic atlas characterizes the silk-producing organ in the silkworm.

一個(gè)單細(xì)胞轉(zhuǎn)錄組圖譜描述了家蠶產(chǎn)絲器官的特征。

262.Mitigation of SARS-CoV-2 transmission at a large public university.

緩解SARS-CoV-2在一所大型公立大學(xué)的傳播。

263.Lactobacillus rhamnosus colonisation antagonizes Candida albicans by forcing metabolic adaptations that compromise pathogenicity.

鼠李糖乳桿菌定植通過(guò)迫使代謝適應(yīng)性損害致病性來(lái)對(duì)抗白色念珠菌。

264.Efferocytosis requires periphagosomal Ca2+-signaling and TRPM7-mediated electrical activity.

吞噬作用需要吞噬體周圍的Ca2+信號(hào)傳導(dǎo)和TRPM7介導(dǎo)的電活動(dòng)。

265.Watching right and wrong nucleotide insertion captures hidden polymerase fidelity checkpoints.

觀察正確和錯(cuò)誤的核苷酸插入捕捉到隱藏的聚合酶保真度檢查點(diǎn)。

266.SMYD5 catalyzes histone H3 lysine 36 trimethylation at promoters.

SMYD5催化啟動(dòng)子的組蛋白H3賴氨酸36三甲基化。

267.Drought-exposure history increases complementarity between plant species in response to a subsequent drought.

干旱暴露史增加了植物物種之間對(duì)后續(xù)干旱反應(yīng)的互補(bǔ)性。

268.An in vitro model of neuronal ensembles.

一個(gè)體外的神經(jīng)元集合體模型。

269.Physiological adaptive traits are a potential allele reservoir for maize genetic progress under challenging conditions.

生理適應(yīng)性狀是挑戰(zhàn)性條件下玉米遺傳進(jìn)展的潛在等位基因庫(kù)。

270.A Catharanthus roseus Fe(II)/α-ketoglutarate-dependent dioxygenase catalyzes a redox-neutral reaction responsible for vindolinine biosynthesis.

一種長(zhǎng)春花的Fe(II)/α-酮戊二酸依賴性二氧酶催化氧化還原中性反應(yīng)，負(fù)責(zé)藤本植物的生物合成。

271.Dynamic mRNA degradome analyses indicate a role of histone H3K4 trimethylation in association with meiosis-coupled mRNA decay in oocyte aging.

動(dòng)態(tài)mRNA降解組分析表明組蛋白H3K4三甲基化在卵母細(xì)胞衰老過(guò)程中與減數(shù)分裂耦合的mRNA衰減有關(guān)的作用。

272.Norepinephrine potentiates and serotonin depresses visual cortical responses by transforming eligibility traces.

去甲腎上腺素通過(guò)轉(zhuǎn)化資格痕跡增強(qiáng)和5-羥色胺抑制視覺(jué)皮質(zhì)反應(yīng)。

273.Transformation of dolutegravir into an ultra-long-acting parenteral prodrug formulation.

將多諾德格拉維轉(zhuǎn)化為超長(zhǎng)效腸外原藥制劑。

274.Molecularly cleavable bioinks facilitate high-performance digital light processing-based bioprinting of functional volumetric soft tissues.

分子可裂解的生物墨水促進(jìn)了高性能的基于數(shù)字光處理的功能性體積軟組織的生物打印。

275.Evolutionary action of mutations reveals antimicrobial resistance genes in Escherichia coli.

突變的進(jìn)化作用揭示了大腸桿菌的抗微生物基因。

276.Cerebellar stimulation prevents Levodopa-induced dyskinesia in mice and normalizes activity in a motor network.

小腦刺激可防止左旋多巴引起的小鼠運(yùn)動(dòng)障礙，并使運(yùn)動(dòng)網(wǎng)絡(luò)的活動(dòng)正常化。

277.Profiling Fusobacterium infection at high taxonomic resolution reveals lineage-specific correlations in colorectal cancer.

在高分類分辨率下對(duì)鐮刀菌感染進(jìn)行剖析，揭示了結(jié)直腸癌中的線粒體特異性關(guān)聯(lián)。

278.Extracellular release of two peptidases dominates generation of the trypanosome quorum-sensing signal.

細(xì)胞外釋放的兩種肽酶主導(dǎo)了錐蟲法定量感應(yīng)信號(hào)的產(chǎn)生。

279.Waning effectiveness of the third dose of the BNT162b2 mRNA COVID-19 vaccine.

BNT162b2 mRNA COVID-19疫苗第三劑的有效性減弱。

280.Malaria oocysts require circumsporozoite protein to evade mosquito immunity.

瘧疾卵囊需要環(huán)孢子蟲蛋白來(lái)逃避蚊子的免疫。

281.Effectiveness of BBIBP-CorV vaccine against severe outcomes of COVID-19 in Abu Dhabi, United Arab Emirates.

阿拉伯聯(lián)合酋長(zhǎng)國(guó)阿布扎比BBIBP-CorV疫苗對(duì)COVID-19嚴(yán)重后果的有效性。

282.Structural basis of ligand binding modes of human EAAT2.

人類EAAT2配體結(jié)合模式的結(jié)構(gòu)基礎(chǔ)。

283.Longitudinal evidence that Event Related Potential measures of self-regulation do not predict everyday goal pursuit.

縱向證據(jù)表明，自我調(diào)控的事件相關(guān)電位測(cè)量不能預(yù)測(cè)日常目標(biāo)的追求。

284.Association between resting-state functional brain connectivity and gene expression is altered in autism spectrum disorder.

自閉癥譜系障礙中靜止?fàn)顟B(tài)腦功能連接和基因表達(dá)之間的關(guān)聯(lián)被改變。

285.Proteomic and functional analyses of the periodic membrane skeleton in neurons.

神經(jīng)元中周期性膜骨架的蛋白質(zhì)組學(xué)和功能分析。

286.Robust and accurate estimation of paralog-specific copy number for duplicated genes using whole-genome sequencing.

利用全基因組測(cè)序?qū)χ貜?fù)基因的準(zhǔn)系譜特異性拷貝數(shù)進(jìn)行了穩(wěn)健而準(zhǔn)確的估計(jì)。

287.Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci.

不同形式的疝氣的全面全基因組關(guān)聯(lián)研究確定了80多個(gè)相關(guān)位點(diǎn)。

288.Disease-economy trade-offs under alternative epidemic control strategies.

替代流行病控制策略下的疾病-經(jīng)濟(jì)權(quán)衡。

289.Rapid, adaptable and sensitive Cas13-based COVID-19 diagnostics using ADESSO.

使用ADESSO進(jìn)行快速、適應(yīng)性強(qiáng)且敏感的基于Cas13的COVID-19診斷。

290.Computational identification of HCV neutralizing antibodies with a common HCDR3 disulfide bond motif in the antibody repertoires of infected individuals.

計(jì)算識(shí)別感染者抗體重現(xiàn)中具有共同HCDR3二硫鍵圖案的HCV中和抗體。

291.Genome-wide mapping of individual replication fork velocities using nanopore sequencing.

利用納米孔測(cè)序技術(shù)繪制單個(gè)復(fù)制叉速度的全基因組圖譜。

292.The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis.

EXTL3的結(jié)構(gòu)有助于解釋雙域外植體蛋白在硫酸肝素合成中的不同作用。

293.Targeting parvalbumin promotes M2 macrophage polarization and energy expenditure in mice.

靶向小清蛋白促進(jìn)小鼠M2巨噬細(xì)胞的極化和能量消耗。

294.Striatal hub of dynamic and stabilized prediction coding in forebrain networks for olfactory reinforcement learning.

前腦網(wǎng)絡(luò)中嗅覺(jué)強(qiáng)化學(xué)習(xí)的動(dòng)態(tài)和穩(wěn)定的預(yù)測(cè)編碼的紋狀體樞紐。

295.RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition.

RNF43 G659fs是一種致癌性結(jié)直腸癌突變，使腫瘤細(xì)胞對(duì)PI3K/mTOR抑制敏感。

296.Control of CRK-RAC1 activity by the miR-1/206/133 miRNA family is essential for neuromuscular junction function.

miR-1/206/133 miRNA家族對(duì)CRK-RAC1活性的控制對(duì)神經(jīng)肌肉接頭功能至關(guān)重要。

297.Ligand recognition and biased agonism of the D1 dopamine receptor.

D1多巴胺受體的配體識(shí)別和偏向激動(dòng)作用。

298.Hippocampal representations switch from errors to predictions during acquisition of predictive associations.

海馬表征在獲得預(yù)測(cè)性關(guān)聯(lián)過(guò)程中從錯(cuò)誤到預(yù)測(cè)的轉(zhuǎn)換。

299.Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1.

人類極長(zhǎng)鏈脂肪酸轉(zhuǎn)運(yùn)體ABCD1的底物識(shí)別和轉(zhuǎn)運(yùn)的結(jié)構(gòu)基礎(chǔ)。

300.Defining TCRγδ lymphoproliferative disorders by combined immunophenotypic and molecular evaluation.

通過(guò)聯(lián)合免疫表型和分子評(píng)估定義TCRγδ淋巴增生性疾病.

301.Taf2 mediates DNA binding of Taf14.

Taf2介導(dǎo)Taf14的DNA結(jié)合。

302.Global relationships in tree functional traits.

樹(shù)木功能性狀的全球關(guān)系。

303.Short- and long-read metagenomics expand individualized structural variations in gut microbiomes.

短讀和長(zhǎng)讀元基因組學(xué)拓展了腸道微生物組的個(gè)體化結(jié)構(gòu)變化。

304.Leukocyte cell-derived chemotaxin 2 is an antiviral regulator acting through the proto-oncogene MET.

白細(xì)胞衍生的趨化素2是一個(gè)通過(guò)原癌基因MET作用的抗病毒調(diào)節(jié)器。

305.Efficient aqueous remote loading of peptides in poly(lactic-co-glycolic acid).

聚(乳酸-co-glycolic acid)中多肽的高效水性遠(yuǎn)程裝載。

306.Deep learning enables reference-free isotropic super-resolution for volumetric fluorescence microscopy.

深度學(xué)習(xí)實(shí)現(xiàn)了體積熒光顯微鏡的無(wú)參照物各向同性超分辨率。

307.Altered predictive control during memory suppression in PTSD.

PTSD記憶抑制過(guò)程中的預(yù)測(cè)控制改變.

308.Immune monitoring and treatment in immune-mediated inflammatory diseases.

免疫介導(dǎo)的炎癥性疾病的免疫監(jiān)測(cè)和治療。

===================================

由于字?jǐn)?shù)限制，關(guān)注我的個(gè)人公眾號(hào)“遠(yuǎn)夢(mèng)研”查看更多。