關(guān)鍵詞

免疫檢查點 單抗 合胞病毒 系統(tǒng)性紅斑狼瘡 DNA ?

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#今日行業(yè)熱點#

①Lancet：Pembrolizumab in combination with gemcitabine and cisplatin compared with gemcitabine and cisplatin alone for patients with advanced biliary tract cancer (KEYNOTE-966): a randomised, double-blind, placebo-controlled, phase 3 trial

臨床試驗：免疫檢查點抑制劑派姆單抗聯(lián)合吉西他濱和順鉑用于晚期膽道癌患者的Ⅲ期隨機(jī)、對照試驗

DOI :10.1016/S0140-6736(23)00727-4

②Lancet：The link between respiratory syncytial virus infection during infancy and asthma during childhood

嬰兒期呼吸道合胞病毒感染與兒童期哮喘之間的聯(lián)系

DOI :10.1016/S0140-6736(23)00672-4

③Trends in Cancer：Bone marrow microenvironment: roles and therapeutic implications in obesity-associated cancer

綜述：肥胖期間BMME（骨髓微環(huán)境）對癌癥的影響及其在應(yīng)對癌癥策略方面的意義

DOI :10.1016/j.trecan.2023.03.007

④Nature Communications：DNA-binding mechanism and evolution of replication protein A

同源核苷酸復(fù)制蛋白A（RPA）DNA結(jié)合機(jī)制及其進(jìn)化

DOI :10.1038/s41467-023-38048-w

⑤Clinical Immunology：Serum proteome and metabolome uncover novel biomarkers for the assessment of disease activity and diagnosing of systemic lupus erythematosus

血清蛋白質(zhì)組學(xué)和代謝組學(xué)中發(fā)現(xiàn)用于評估自身免疫性疾病系統(tǒng)性紅斑狼瘡（SLE）的新生物標(biāo)記物

DOI :10.1016/j.clim.2023.109330

⑥Clinical Immunology：Manufacturing regulatory T cells for adoptive cell therapy in immune diseases: A critical appraisal

綜述：應(yīng)對免疫疾病的巨噬細(xì)胞調(diào)節(jié)性T細(xì)胞(Tregs)及其用于臨床前和臨床試驗的方法與結(jié)果

DOI :10.1016/j.clim.2023.109328
⑦全球唯一用于IgA腎病的靶向腸道的黏膜免疫調(diào)節(jié)劑口服靶向布地奈德遲釋膠囊在海南獲批落地，將應(yīng)用于臨床使用

⑧甲苯磺酸ZG2001片用于KRAS突變的晚期實體瘤臨床試驗申請獲美FDA批準(zhǔn)

⑨創(chuàng)新生物藥BL-M11D1（CD33-ADC）獲國家藥監(jiān)局批準(zhǔn)開展用于復(fù)發(fā)或難治性急性髓系白血病的臨床試驗

⑩中國臨床腫瘤學(xué)會（CSCO）2023CSCO指南發(fā)布，注射用紫杉醇聚合物膠束獲推入選，用于非鱗癌非小細(xì)胞肺癌（NSCLC）

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