產(chǎn)品名稱：DSPE-PEG-Azide

DSPE-PEG-N3

中文名稱：磷脂-聚乙二醇-疊氮

品牌：為華生物

產(chǎn)地：廣州

分子量：1k，2k，3.4k，5k，10k 其他分子量可定制

純度：95%

存儲條件：≤4℃低溫干燥保存

外觀: 固體或黏稠液體，取決于分子量

溶于大部分有機溶劑，如：DCM、DMF、DMSO、THF等等。在水中有很好的溶解性

1,2-二硬脂酰-sn-甘油-3-磷酸乙醇胺（DSPE）共軛聚乙二醇，DSPE-PEG是一種兼具親水性和疏水性的磷脂-PEG共軛物。聚乙二醇化磷脂是一種優(yōu)良的脂質(zhì)體形成材料，可用于藥物遞送、基因轉(zhuǎn)染和疫苗遞送。DSPE-PEG-N3產(chǎn)品可用于使用點擊化學制備聚乙二醇化脂質(zhì)體。疊氮化物在有或沒有銅催化劑的水溶液中很容易與炔烴或環(huán)氰基反應。磷脂的聚乙二醇化提高了膠囊藥物的血液循環(huán)時間和穩(wěn)定性。

2-Distearoyl-sn-Glycero-3-Phosphoethanolamine(DSPE)共軛聚乙二醇是磷脂和聚乙二醇結(jié)合，具有親水性和疏水性。聚乙二醇化磷脂能有效改善血液循環(huán)時間和穩(wěn)定封裝藥物。這些材料還可用于靶向給藥通過修改與目標表面配體如抗體、多肽。

疊氮（-N3）能與水溶液中銅催化的炔烴的反應被還原成胺基。聚乙二醇可以增加溶解度和穩(wěn)定性。減少多肽和蛋白質(zhì)的免疫原性，它也能抑制帶電分子在修飾表面的非特異性結(jié)合。

1,2-distearoyl-sn-glycerol-3-phosphate ethanolamine (DSPE) conjugated polyethylene glycol, DSPE-PEG is a phospholipid PEG conjugate with both hydrophilicity and hydrophobicity. PEGylated phospholipid is an excellent liposome forming material, which can be used for drug delivery, gene transfection and vaccine delivery. DSPE-PEG-N3 products can be used to prepare polyethylene glycol liposomes using click chemistry. Azides react easily with alkynes or cyclocyanides in aqueous solutions with or without copper catalysts. The PEG of phospholipid improves the blood circulation time and stability of the capsule drug.

Azide (- N3) can react with copper catalyzed alkynes in aqueous solution and be reduced to amino groups. Polyethylene glycol can increase solubility and stability. Reduce the immunogenicity of peptides and proteins, and it can also inhibit the non-specific binding of charged molecules on the modified surfaces.

DSPE-PEG-Succinyl

DSPE-PEG -Carboxylic Acid

DSPE-PEG-Maleimide

DSPE-PEG -TPP

DSPE-PEG-?Cyanur

DSPE-PEG-?Amine

DSPE-PEG-Biotin