【文獻速遞】【NBE】【2022年】【4-6月】
聲明：本專欄主要對生命科學領(lǐng)域的一些期刊文章標題進行翻譯，所有內(nèi)容均由本人手工整理翻譯。由于本人專業(yè)為生物分析相關(guān)，其他領(lǐng)域如果出現(xiàn)翻譯錯誤請諒解。
由血管流動連接的成熟多器官組織
This issue highlights that forced mitophagy can reduce mtDNA heteroplasmy in mitochondrial replacement therapy, a multi-organ chip with matured tissues, the maturation of human cardiac microtissues on a chip, methods for the expansion of human atrial myocytes, for the reprogramming of fibroblasts into cardiovascular progenitor cells and for the conversion of quiescent cardiomyocytes into pacemaker cells, and organoids recapitulating neural-tube morphogenesis, programmatically patterned from the orthogonal differentiation of pluripotent stem cells, derived from pluripotent stem cells with genetically ablated cilia, or used for the screening of modulators of gut epithelia.
本期強調(diào)強制線粒體自噬可以減少線粒體替代療法中的mtDNA異質(zhì)性、具有成熟組織的多器官芯片、芯片上人類心臟微組織的成熟、人心房肌細胞的擴增方法、用于將成纖維細胞重編程為心血管祖細胞以及將靜止心肌細胞轉(zhuǎn)化為起搏細胞和類器官重演神經(jīng)管形態(tài)發(fā)生、從多能干細胞的正交分化中以編程方式模式化、源自具有基因消融纖毛的多能干細胞或用于腸道上皮調(diào)節(jié)劑的篩選。
1.Reduction of mtDNA heteroplasmy in mitochondrial replacement therapy by inducing forced mitophagy.
通過誘導強制線粒體自噬減少線粒體替代療法中的線粒體DNA異質(zhì)性。
2.A multi-organ chip with matured tissue niches linked by vascular flow.
具有由血管流動連接的成熟組織壁龕的多器官芯片。
3.Metabolically driven maturation of human-induced-pluripotent-stem-cell-derived cardiac microtissues on microfluidic chips.
人誘導多能干細胞衍生的心臟微組織在微流控芯片上的代謝驅(qū)動成熟。
4.Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation.
人心房肌細胞的條件永生化，用于產(chǎn)生心房顫動的體外模型。
5.Reprogramming of fibroblasts into expandable cardiovascular progenitor cells via small molecules in xeno-free conditions.
在無異種條件下，通過小分子將成纖維細胞重編程為可擴展的心血管祖細胞。
6.Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats.
生物材料誘導的靜態(tài)心肌細胞轉(zhuǎn)化為大鼠的起搏器細胞。
7.Production of human spinal-cord organoids recapitulating neural-tube morphogenesis.
人類脊髓類器官的生產(chǎn)重演神經(jīng)管形態(tài)發(fā)生。
8.Orthogonally induced differentiation of stem cells for the programmatic patterning of vascularized organoids and bioprinted tissues.
正交誘導干細胞分化，用于血管化類器官和生物打印組織的程序化模式化。
9.Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated cilia.
模擬人體組織中的纖毛病表型，這些組織源自具有基因消融纖毛的多能干細胞。
10.Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation.
通過腸干細胞分化的類器官模型篩選腸上皮細胞組成的調(diào)節(jié)劑。
This issue highlights performance and functionality enhancements in hardware and software for a range of imaging modalities, including Cerenkov luminescence imaging, light-sheet microscopy, photoacoustic computed tomography, ultrasound localization microscopy, chemical exchange saturation transfer magnetic resonance imaging, magnetic resonance fingerprinting, and a number of optical-imaging techniques.
本期重點介紹了一系列成像模式的硬件和軟件的性能和功能增強，包括切倫科夫發(fā)光成像、光片顯微鏡、光聲計算機斷層掃描、超聲定位顯微鏡、化學交換飽和轉(zhuǎn)移磁共振成像、磁共振指紋識別和一些光學成像技術(shù)。
1.Prospective testing of clinical Cerenkov luminescence imaging against standard-of-care nuclear imaging for tumour location.
針對腫瘤位置的標準核成像對臨床切倫科夫發(fā)光成像的前瞻性測試。
2.High-speed light-sheet microscopy for the in-situ acquisition of volumetric histological images of living tissue.
高速光片顯微鏡，用于活組織體積組織學圖像的原位采集。。
3.Massively parallel functional photoacoustic computed tomography of the human brain.
人腦的大量平行功能的光聲計算機斷層掃描。
4.Diagnostic assessment of glaucoma and non-glaucomatous optic neuropathies via optical texture analysis of the retinal nerve fibre layer.
通過視網(wǎng)膜神經(jīng)纖維層的光學結(jié)構(gòu)分析，對青光眼和非青光眼性視神經(jīng)病變的診斷評估。
5.Performance benchmarking of microbubble-localization algorithms for ultrasound localization microscopy.
超聲定位顯微鏡的微泡定位算法的性能基準測試。
6.In vivo lensless microscopy via a phase mask generating diffraction patterns with high-contrast contours.
通過相位掩模產(chǎn)生具有高對比度輪廓衍射圖的體內(nèi)無透鏡顯微鏡。
7.A phosphorescent probe for in vivo imaging in the second near-infrared window.
在第二個近紅外窗口中進行體內(nèi)成像的磷光探針。
8.Simultaneous visualization of multiple radionuclides in vivo.
在體內(nèi)同時可視化多個放射性核素。
9.Quantitative imaging of apoptosis following oncolytic virotherapy by magnetic resonance fingerprinting aided by deep learning.
在深度學習的幫助下，通過磁共振指紋圖譜對溶瘤病毒療法后細胞凋亡的定量成像。
10.In vivo tracking of unlabelled mesenchymal stromal cells by mannose-weighted chemical exchange saturation transfer MRI.
通過甘露糖加權(quán)化學交換飽和轉(zhuǎn)移MRI對未標記的間充質(zhì)基質(zhì)細胞進行體內(nèi)跟蹤。
11.Linking the genotypes and phenotypes of cancer cells in heterogenous populations via real-time optical tagging and image analysis.
通過實時光學標記和圖像分析將癌細胞的基因型和表型聯(lián)系起來。
This issue highlights the restoration of glucose homeostasis via ultrasound-mediated stimulation of hepatoportal nerves, an endovascular implant for peripheral-nerve stimulation, an analysis of the performance of compression and amplification algorithms for hearing aids, a cutaneous mechanoneural interface for eliciting tactile feedback through electrical stimulation, an organic implant for wireless peripheral-nerve stimulation, deep brain stimulation by near-infrared light via injected photothermal transducers, and modular hardware and software for the remote operation of wireless networks for the study of rodent behaviour.
本期重點介紹了通過超聲介導的肝門脈神經(jīng)刺激恢復(fù)葡萄糖穩(wěn)態(tài)、用于周圍神經(jīng)刺激的血管內(nèi)植入物、助聽器壓縮和放大算法的性能分析、用于通過電刺激引發(fā)觸覺反饋的皮膚機械神經(jīng)接口、用于無線周圍神經(jīng)刺激的有機植入物、通過注入的光熱換能器產(chǎn)生近紅外光刺激大腦深部和用于研究嚙齒動物行為的無線網(wǎng)絡(luò)遠程操作的模塊化硬件和軟件。
1.Stimulation of the hepatoportal nerve plexus with focused ultrasound restores glucose homoeostasis in diabetic mice, rats and swine.
用聚焦的超聲刺激肝臟神經(jīng)叢，可在糖尿病小鼠，大鼠和豬中恢復(fù)葡萄糖穩(wěn)態(tài)。
2.A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves.
無線毫米磁電植入物，用于周圍神經(jīng)的血管內(nèi)刺激。
3.Compression and amplification algorithms in hearing aids impair the selectivity of neural responses to speech.
助聽器中的壓縮和放大算法會損害神經(jīng)對語音反應(yīng)的選擇性。
4.A cutaneous mechanoneural interface for neuroprosthetic feedback.
用于神經(jīng)假體反饋的皮膚機械神經(jīng)接口。
5.Chronic electrical stimulation of peripheral nerves via deep-red light transduced by an implanted organic photocapacitor.
通過植入的有機光電容器轉(zhuǎn)換的深紅光對周圍神經(jīng)進行慢性電刺激。
6.Tether-free photothermal deep-brain stimulation in freely behaving mice via wide-field illumination in the near-infrared-II window.
通過近紅外-II窗口中的寬視場照明，自由行為小鼠的無系繩光熱深部腦刺激。。
7.Scalable and modular wireless-network infrastructure for large-scale behavioural neuroscience.
大規(guī)模行為神經(jīng)科學的可擴展和模塊化無線網(wǎng)絡(luò)基礎(chǔ)架構(gòu)。
