品牌：為華生物

產(chǎn)地：中國廣州

PCL分子量?1000 2000 5000 10000 12000 15000 20000 40000?

PEG分子量 2000、3400、5000

PDI ＜1.05

外觀：灰白色/棕色固體或粘稠液體

常用溶劑：水，DCM(二氯甲烷溶解性好）

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PCL-PEG-COOH是一種最常用的藥物封裝可生物降解聚合物藥物增溶和藥,聚（ε-己內(nèi)酯）-嵌段聚（乙二醇）-羧酸（PCL-PEG-COOH）是一種功能性兩親嵌段共聚物（ABC），一端是親水鏈段-羧基聚乙二醇，一端是親油鏈段-聚己內(nèi)酯。其在PEG嵌段末端具有羧基，PCL-PEG是用于藥物遞送的最常用的可生物降解ABC聚合物之一。通過調(diào)整分子量或者親水/親油鏈段的比值，PCL-PEG-COOH可以作為不同種類的藥物載體材料，并且可以提供藥物的水溶性以及包封率和載藥量。可以用于制備膠束、微球、微囊、囊泡，用于實現(xiàn)藥物的緩釋、控釋，也可以用于親水性較好的組織工程支架材料。羧基功能化PEG可以用來修飾蛋白、抗體、多肽等等。羧基可以和氨基反應(yīng)形成穩(wěn)定的酰胺鍵，也可以和羥基形成酯鍵。羧基化PEG在生物工程領(lǐng)域有著廣泛的應(yīng)用，粒子表面改性，生物分子聚乙二醇化等。

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Pcl-peg-cooh is one of the most commonly used drug encapsulation biodegradable polymers for drug solubilization and drug, poly（ ε- Caprolactone) - block poly (ethylene glycol) - carboxylic acid (pcl-peg-cooh) is a functional amphiphilic block copolymer (ABC). One end is hydrophilic segment carboxy polyethylene glycol and the other end is lipophilic segment polycaprolactone. PCL-PEG is one of the most commonly used biodegradable ABC polymers for drug delivery. By adjusting the molecular weight or the ratio of hydrophilic / lipophilic segments, pcl-peg-cooh can be used as different kinds of drug carrier materials, and can provide the water solubility, encapsulation efficiency and drug loading of drugs. It can be used to prepare micelles, microspheres, microcapsules and vesicles, to achieve sustained-release and controlled release of drugs, and can also be used as tissue engineering scaffold materials with good hydrophilicity. Carboxyl functionalized peg can be used to modify proteins, antibodies, polypeptides and so on. Carboxyl group can react with the amino group to form stable amide bond, and can also form ester bond with the hydroxyl group. Carboxylated peg has been widely used in the field of bioengineering, such as particle surface modification and PEGylation of biomolecules.