聲明：本專欄主要對生命科學(xué)領(lǐng)域的一些期刊文章標(biāo)題進行翻譯，所有內(nèi)容均由本人手工整理翻譯。由于本人專業(yè)為生物分析相關(guān)，其他領(lǐng)域如果出現(xiàn)翻譯錯誤請諒解。

1.Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis.

由一個基因座編碼的Kastor和Polluks多肽合作調(diào)節(jié)VDAC和精子生成。

2.Bacterial N4-methylcytosine as an epigenetic mark in eukaryotic DNA.

細(xì)菌的N4-甲基胞嘧啶作為真核生物DNA的表觀遺傳標(biāo)記。

3.Leveraging the multivalent p53 peptide-MdmX interaction to guide the improvement of small molecule inhibitors.

利用多價p53肽-MdmX的相互作用來指導(dǎo)小分子抑制劑的改進。

4.HPV infection alters vaginal microbiome through down-regulating host mucosal innate peptides used by Lactobacilli as amino acid sources.

HPV感染通過下調(diào)乳酸菌作為氨基酸來源的宿主粘膜先天性肽而改變陰道微生物組。

5.LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer.

LKB1驅(qū)動停滯和C/EBP介導(dǎo)的重編程到肺癌中的肺泡II型命運。

6.Single-cell gene fusion detection by scFusion.

scFusion的單細(xì)胞基因融合檢測。

7.SIRT1 selectively exerts the metabolic protective effects of hepatocyte nicotinamide phosphoribosyltransferase.

SIRT1選擇性地發(fā)揮肝細(xì)胞煙酰胺磷酸核苷轉(zhuǎn)移酶的代謝保護作用。

8.Cryo-EM structure of translesion DNA synthesis polymerase ζ with a base pair mismatch.

帶有堿基對錯配的易位DNA合成聚合酶ζ的低溫冷凍電鏡結(jié)構(gòu)。

9.Structure and assembly of the S-layer in C. difficile.

艱難梭菌中S層的結(jié)構(gòu)和組裝。

10.AP-4-mediated axonal transport controls endocannabinoid production in neurons.

AP-4介導(dǎo)的軸突運輸控制著神經(jīng)元中的內(nèi)源性大麻素的產(chǎn)生。

11.Inhibition of SRP-dependent protein secretion by the bacterial alarmone (p)ppGpp.

細(xì)菌報警素(p)ppGpp對SRP依賴性蛋白質(zhì)分泌的抑制。

12.Natural variation in Glume Coverage 1 causes naked grains in sorghum.

Glume Coverage 1的自然變異導(dǎo)致高粱的裸露谷物。

13.Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.

Tirzepatide和肽20在GIP、GLP-1或胰高血糖素受體上的多重藥理作用的結(jié)構(gòu)見解。

14.A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6.

通過S.cerevisiae ORC-DNA-Cdc6的自抑制進行起源許可控制的機制。

15.Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER+ breast cancer.

YAP對雌激素受體α的轉(zhuǎn)錄抑制揭示了Hippo途徑作為ER+乳腺癌的治療目標(biāo)。

16.Phosphoproteomic profiling of T cell acute lymphoblastic leukemia reveals targetable kinases and combination treatment strategies.

T細(xì)胞急性淋巴細(xì)胞白血病的磷蛋白組學(xué)分析揭示了可靶向的激酶和聯(lián)合治療策略。

17.Understanding self-assembly at molecular level enables controlled design of DNA G-wires of different properties.

了解分子水平的自組裝可以控制設(shè)計不同性質(zhì)的DNA G線。

18.A putative cap binding protein and the methyl phosphate capping enzyme Bin3/MePCE function in telomerase biogenesis.

一種推定的帽結(jié)合蛋白和甲基磷酸酯蓋帽酶Bin3/MePCE在端粒酶生物生成中的功能。

19.Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2.

Formylpeptide受體FPR1和FPR2對formylpeptide和各種激動劑的分子識別。

20.Increased fMRI connectivity upon chemogenetic inhibition of the mouse prefrontal cortex.

小鼠前額葉皮層化學(xué)遺傳抑制后fMRI連接性增加。

21.Investigation of Cas9 antibodies in the human eye.

對人眼中Cas9抗體的調(diào)查。

22.Quantifying arousal and awareness in altered states of consciousness using interpretable deep learning.

利用可解釋的深度學(xué)習(xí)量化意識改變狀態(tài)下的喚醒和意識。

23.Different gut microbial communities correlate with efficacy of albendazole-ivermectin against soil-transmitted helminthiases.

不同的腸道微生物群落與阿苯達(dá)唑-伊維菌素對土壤傳播蠕蟲病的療效相關(guān)。

24.Structural basis of adenylyl cyclase 9 activation.

腺苷酸環(huán)化酶9激活的結(jié)構(gòu)基礎(chǔ)。

25.Modelling Chlamydia and HPV co-infection in patient-derived ectocervix organoids reveals distinct cellular reprogramming.

在患者來源的宮頸器官中建立衣原體和HPV共同感染的模型，揭示了不同的細(xì)胞重編程。

26.A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.

一個快速肌球蛋白超級增強子通過與肌球蛋白基因的競爭性相互作用決定了肌肉纖維的表型。

27.Single-cell profiling of human subventricular zone progenitors identifies SFRP1 as a target to re-activate progenitors.

人類腦室下區(qū)祖細(xì)胞的單細(xì)胞分析確定了SFRP1是重新激活祖細(xì)胞的目標(biāo)。

28.Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes.

識別不同的細(xì)胞毒顆粒作為T淋巴細(xì)胞中超分子攻擊顆粒的起源。

29.Tuning the rate of aggregation of hIAPP into amyloid using small-molecule modulators of assembly.

使用小分子組裝調(diào)節(jié)劑調(diào)整hIAPP聚集成淀粉樣蛋白的速度。

30.Opposite forms of adaptation in mouse visual cortex are controlled by distinct inhibitory microcircuits.

小鼠視覺皮層中相反的適應(yīng)形式由不同的抑制性微電路控制。

31.Osteoblast-derived vesicles induce a switch from bone-formation to bone-resorption in vivo.

成骨細(xì)胞源性囊泡誘導(dǎo)體內(nèi)從骨形成到骨吸收的轉(zhuǎn)換。

32.Circulating microbial content in myeloid malignancy patients is associated with disease subtypes and patient outcomes.

髓系惡性腫瘤患者的循環(huán)微生物含量與疾病亞型和患者預(yù)后有關(guān)。

33.Targeting ferroptosis protects against experimental (multi)organ dysfunction and death.

靶向鐵蛋白酶可防止實驗性（多）器官功能障礙和死亡。

34.Multilateral benefit-sharing from digital sequence information will support both science and biodiversity conservation.

數(shù)字序列信息的多邊利益共享將支持科學(xué)和生物多樣性保護。

35.Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis.

尖銳濕疣的綜合分子和臨床分析將22q11.21的局域擴增與轉(zhuǎn)移聯(lián)系起來。

36.Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection.

非肺炎SARS-CoV-2感染的早期病毒遏制中的保護性免疫軌跡。

37.Uncovering interpretable potential confounders in electronic medical records.

揭示電子醫(yī)療記錄中可解釋的潛在混雜因素.

38.Evidence for a trap-and-flip mechanism in a proton-dependent lipid transporter.

質(zhì)子依賴性脂質(zhì)轉(zhuǎn)運體中捕獲和翻轉(zhuǎn)機制的證據(jù)。

39.Biosynthetic gene cluster profiling predicts the positive association between antagonism and phylogeny in Bacillus.

生物合成基因簇分析預(yù)測了芽孢桿菌的拮抗作用和系統(tǒng)發(fā)育之間的正相關(guān)。

40.Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma.

蛋白質(zhì)組學(xué)分析揭示CDK6上調(diào)是多發(fā)性骨髓瘤來那度胺的可靶向耐藥機制。

41.Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission.

防止SARS-CoV-2輸入和傳播的檢疫措施的基因組學(xué)評估。

42.Small Cajal body-associated RNA 2 (scaRNA2) regulates DNA repair pathway choice by inhibiting DNA-PK.

小Cajal體相關(guān)RNA 2（scaRNA2）通過抑制DNA-PK調(diào)節(jié)DNA修復(fù)途徑選擇。

43.Kindlin-2 haploinsufficiency protects against fatty liver by targeting Foxo1 in mice.

Kindlin-2單倍體功能通過靶向小鼠的Foxo1保護脂肪肝。

44.Neutrophil extracellular traps promote metastasis in gastric cancer patients with postoperative abdominal infectious complications.

中性粒細(xì)胞外陷阱促進胃癌患者術(shù)后腹腔感染性并發(fā)癥的轉(zhuǎn)移。

45.Fine-scale heterogeneity in population density predicts wave dynamics in dengue epidemics.

人口密度的精細(xì)異質(zhì)性預(yù)示著登革熱疫情的波浪動態(tài)。

46.High-throughput identification and quantification of single bacterial cells in the microbiota.

微生物群中單個細(xì)菌細(xì)胞的高通量鑒定和量化.

47.Identification and establishment of type IV interferon and the characterization of interferon-υ including its class II cytokine receptors IFN-υR1 and IL-10R2.

IV型干擾素的鑒定和建立以及干擾素-υ的特征，包括其II類細(xì)胞因子受體IFN-υR1和IL-10R2。

48.Acetylcholine deficiency disrupts extratelencephalic projection neurons in the prefrontal cortex in a mouse model of Alzheimer’s disease.

乙酰膽堿的缺乏破壞了阿爾茨海默病小鼠模型中前額葉皮質(zhì)的腦外投射神經(jīng)元。

49.Multi-parameter photon-by-photon hidden Markov modeling.

多參數(shù)逐個光子的隱馬爾可夫模型。

50.Menin directs regionalized decidual transformation through epigenetically setting PTX3 to balance FGF and BMP signaling.

Menin通過表觀遺傳學(xué)設(shè)置PTX3來平衡FGF和BMP信號，指導(dǎo)區(qū)域化蛻膜轉(zhuǎn)化。

51.Dicer promotes genome stability via the bromodomain transcriptional co-activator BRD4.

Dicer通過溴域轉(zhuǎn)錄共激活物BRD4促進基因組穩(wěn)定。

52.Short- and long-read metagenomics of urban and rural South African gut microbiomes reveal a transitional composition and undescribed taxa.

南非城市和農(nóng)村腸道微生物組的短讀和長讀元基因組學(xué)揭示了過渡性組成和未描述的分類群。

53.White matter myelination during early infancy is linked to spatial gradients and myelin content at birth.

嬰兒早期的白質(zhì)髓鞘化與出生時的空間梯度和髓鞘含量有關(guān)。

54.Cooperative multivalent receptor binding promotes exposure of the SARS-CoV-2 fusion machinery core.

合作的多價受體結(jié)合促進了SARS-CoV-2融合機制核心的暴露。

55.Virtual intracranial EEG signals reconstructed from MEG with potential for epilepsy surgery.

由腦電圖重建的虛擬顱內(nèi)腦電信號具有癲癇手術(shù)的潛力。

56.Randomized controlled trial for time-restricted eating in healthy volunteers without obesity.

無肥胖癥的健康志愿者限時進食的隨機對照試驗。

57.Rad52 mediates class-switch DNA recombination to IgD.

Rad52介導(dǎo)類開關(guān)DNA重組到IgD。

58.Disentangling the recognition complexity of a protein hub using a nanopore.

利用納米孔解讀蛋白質(zhì)樞紐的識別復(fù)雜性。

59.A hemimetabolous wing development suggests the wing origin from lateral tergum of a wingless ancestor.

翅膀的半代謝發(fā)育表明翅膀起源于無翼祖先的側(cè)肢。

60.Nuclear genome of Bulinus truncatus, an intermediate host of the carcinogenic human blood fluke Schistosoma haematobium.

致癌的人類血吸蟲血吸蟲的中間宿主Bulinus truncatus的核基因組。

61.Atmospheric dryness reduces photosynthesis along a large range of soil water deficits.

大氣干燥在很大的土壤缺水范圍內(nèi)降低了光合作用。

62.Multichannel optogenetics combined with laminar recordings for ultra-controlled neuronal interrogation.

多通道光遺傳學(xué)與層狀記錄相結(jié)合的超控神經(jīng)元審訊。

63.Microbial-driven preterm labour involves crosstalk between the innate and adaptive immune response.

微生物驅(qū)動的早產(chǎn)涉及先天和適應(yīng)性免疫反應(yīng)之間的串?dāng)_。

64.Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins.

8-oxoG的全球和轉(zhuǎn)錄耦合修復(fù)是由核苷酸切除修復(fù)蛋白啟動的。

65.Specific length and structure rather than high thermodynamic stability enable regulatory mRNA stem-loops to pause translation.

特定的長度和結(jié)構(gòu)而非高熱力學(xué)穩(wěn)定性使調(diào)節(jié)性mRNA干環(huán)能夠暫停翻譯。

66.Effect of biannual azithromycin distribution on antibody responses to malaria, bacterial, and protozoan pathogens in Niger.

兩年一次的阿奇霉素分配對尼日爾的瘧疾、細(xì)菌和原生動物病原體的抗體反應(yīng)的影響。

67.Genome binning of viral entities from bulk metagenomics data.

來自大宗元基因組學(xué)數(shù)據(jù)的病毒實體的基因組分級。

68.High-pH structure of EmrE reveals the mechanism of proton-coupled substrate transport.

EmrE的高pH結(jié)構(gòu)揭示了質(zhì)子偶聯(lián)底物運輸?shù)臋C制。

69.The insect somatostatin pathway gates vitellogenesis progression during reproductive maturation and the post-mating response.

昆蟲體液蛋白途徑在生殖成熟和交配后的反應(yīng)過程中對卵黃發(fā)生的進展進行把關(guān)。

70.PyUUL provides an interface between biological structures and deep learning algorithms.

PyUUL為生物結(jié)構(gòu)和深度學(xué)習(xí)算法提供了一個接口。

71.ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1.

ATF-4和硫化氫信號介導(dǎo)對翻譯或mTORC1抑制的長壽反應(yīng)。

72.Kansl1 haploinsufficiency impairs autophagosome-lysosome fusion and links autophagic dysfunction with Koolen-de Vries syndrome in mice.

Kansl1單倍體功能損害自噬體-溶酶體融合，并將自噬功能障礙與小鼠Koolen-de Vries綜合征聯(lián)系起來。

73.ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis.

ASPP2在形態(tài)發(fā)生過程中維持機械壓力下的假層狀上皮的完整性。

74.Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo signaling recruiting SAV1 to cell-cell contact sites.

細(xì)胞粘附分子KIRREL1是Hippo信號的反饋調(diào)節(jié)器，將SAV1招募到細(xì)胞-細(xì)胞接觸點。

75.A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.

人類線粒體大亞基的一個后期組裝檢查點。

76.CPEB1 directs muscle stem cell activation by reprogramming the translational landscape.

CPEB1通過重塑翻譯格局指導(dǎo)肌肉干細(xì)胞的激活。

77.Spatiotemporal dynamics of clonal selection and diversification in normal endometrial epithelium.

正常子宮內(nèi)膜上皮細(xì)胞中克隆選擇和多樣化的時空動態(tài)。

78.Nanoscale rules governing the organization of glutamate receptors in spine synapses are subunit specific.

脊柱突觸中谷氨酸受體組織的納米級規(guī)則是亞單位特異的。

79.The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development.

組蛋白去甲基化酶Kdm6b調(diào)控小鼠脊柱運動神經(jīng)元發(fā)育過程中的亞型多樣化。

80.Development and characterization of functional antibodies targeting NMDA receptors.

靶向NMDA受體的功能性抗體的開發(fā)和特征。

81.Heterotypic interactions drive antibody synergy against a malaria vaccine candidate.

異型相互作用驅(qū)動針對瘧疾候選疫苗的抗體協(xié)同作用。

82.Genome-wide functional screens enable the prediction of high activity CRISPR-Cas9 and -Cas12a guides in Yarrowia lipolytica.

全基因組功能篩選使人們能夠預(yù)測脂質(zhì)體中的高活性CRISPR-Cas9和-Cas12a指南。

83.TrkB agonist antibody ameliorates fertility deficits in aged and cyclophosphamide-induced premature ovarian failure model mice.

TrkB激動劑抗體改善了老年和環(huán)磷酰胺誘導(dǎo)的卵巢早衰模型小鼠的生育障礙。

84.Rough and smooth variants of Mycobacterium abscessus are differentially controlled by host immunity during chronic infection of adult zebrafish.

成年斑馬魚慢性感染期間，膿腫分枝桿菌的粗糙和光滑變體受到宿主免疫力的不同控制。

85.T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10.

膠質(zhì)母細(xì)胞瘤微環(huán)境中的T細(xì)胞功能障礙是由釋放白細(xì)胞介素-10的骨髓細(xì)胞介導(dǎo)的。

86.Prognostic tools and candidate drugs based on plasma proteomics of patients with severe COVID-19 complications.

基于嚴(yán)重COVID-19并發(fā)癥患者血漿蛋白組學(xué)的預(yù)知工具和候選藥物.

87.Forest fragmentation impacts the seasonality of Amazonian evergreen canopies.

森林破碎化影響亞馬遜常綠樹冠的季節(jié)性。

88.Recurrent chromosome reshuffling and the evolution of neo-sex chromosomes in parrots.

鸚鵡中反復(fù)出現(xiàn)的染色體重組和新性染色體的進化。

89.TRPC3 shapes the ER-mitochondria Ca2+ transfer characterizing tumour-promoting senescence.

TRPC3塑造了ER-mitochondria Ca2+轉(zhuǎn)移的特點，促進了腫瘤的衰老。

90.CytofIn enables integrated analysis of public mass cytometry datasets using generalized anchors.

CytofIn利用廣義錨對公共質(zhì)譜數(shù)據(jù)集進行綜合分析。

91.RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity.

RIF1-ASF1介導(dǎo)的高階染色質(zhì)結(jié)構(gòu)保障了基因組的完整性。

92.Protease-controlled secretion and display of intercellular signals.

蛋白酶控制的細(xì)胞間信號的分泌和顯示。

93.Stratification of hospitalized COVID-19 patients into clinical severity progression groups by immuno-phenotyping and machine learning.

通過免疫表型和機器學(xué)習(xí)將住院的COVID-19患者分層為臨床嚴(yán)重程度進展組。

94.Stroke induces disease-specific myeloid cells in the brain parenchyma and pia.

中風(fēng)誘導(dǎo)腦實質(zhì)和皮亞區(qū)的疾病特異性骨髓細(xì)胞。

95.A cattle graph genome incorporating global breed diversity.

納入全球品種多樣性的牛圖基因組。

96.Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists.

新型胰島素受體部分激動劑的功能選擇性信號和廣泛的代謝益處。

97.Hypoxia-induced macropinocytosis represents a metabolic route for liver cancer.

低氧誘導(dǎo)的巨細(xì)胞增多癥代表了肝癌的代謝途徑。

98.Dihydroceramide- and ceramide-profiling provides insights into human cardiometabolic disease etiology.

二氫甘油酰胺和神經(jīng)酰胺分析提供了對人類心臟代謝疾病病因的深入了解。

99.Chemical reversible crosslinking enables measurement of RNA 3D distances and alternative conformations in cells.

化學(xué)可逆交聯(lián)能夠測量RNA的三維距離和細(xì)胞中的替代構(gòu)象。

100.Atomically unveiling the structure-activity relationship of biomacromolecule-metal-organic frameworks symbiotic crystal.

原子揭示了生物大分子-金屬-有機框架共生晶體的結(jié)構(gòu)-活性關(guān)系。

101.Dual clathrin and integrin signaling systems regulate growth factor receptor activation.

雙重凝集素和整合素信號系統(tǒng)調(diào)節(jié)生長因子受體的激活。

102.The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system.

AUTOTAC化學(xué)生物學(xué)平臺，通過自噬-溶酶體系統(tǒng)定向降解蛋白質(zhì)。

103.Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial.

早期生活中的抗生素對發(fā)育中的嬰兒腸道微生物組和抵抗組的影響：一項隨機試驗。

104.Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains.

早期肺泡巨噬細(xì)胞反應(yīng)和IL-1R依賴的T細(xì)胞引物決定了結(jié)核分枝桿菌菌株的傳播性。

105.Brain-wide visual habituation networks in wild type and fmr1 zebrafish.

野生型和fmr1斑馬魚的全腦視覺習(xí)慣網(wǎng)絡(luò)。

106.CRISPR-assisted rational flux-tuning and arrayed CRISPRi screening of an L-proline exporter for L-proline hyperproduction.

CRISPR輔助下的合理通量調(diào)控和陣列式CRISPRi篩選L-脯氨酸出口者的L-脯氨酸超生。

107.Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression.

Lin28B高的乳腺癌細(xì)胞通過外泌體促進肺部轉(zhuǎn)移前生態(tài)位的免疫抑制，并支持癌癥的發(fā)展。

108.A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis.

Hexokinase 2的非催化性支架活動有助于EMT和轉(zhuǎn)移。

109.Differential V2-directed antibody responses in non-human primates infected with SHIVs or immunized with diverse HIV vaccines.

感染SHIVs或用不同HIV疫苗免疫的非人靈長類動物的差異性V2導(dǎo)向抗體反應(yīng)。

110.Population antibody responses following COVID-19 vaccination in 212,102 individuals.

在212,102人中接種COVID-19疫苗后的群體抗體反應(yīng)。

111.RETRACTED ARTICLE: Pharmacological perturbation of CXCL1 signaling alleviates neuropathogenesis in a model of HEVA71 infection.

被撤回的文章： 藥理擾亂CXCL1信號，緩解HEVA71感染模型中的神經(jīng)發(fā)病機制。

112.Proteomic analysis of archival breast cancer clinical specimens identifies biological subtypes with distinct survival outcomes.

對存檔乳腺癌臨床標(biāo)本的蛋白質(zhì)組學(xué)分析確定了具有不同生存結(jié)果的生物亞型。

113.Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength.

肌肉中與疾病相關(guān)的蛋白酶LONP1的損失損害了線粒體功能，導(dǎo)致骨骼肌質(zhì)量和力量下降。

114.Xrn1 is a deNADding enzyme modulating mitochondrial NAD-capped RNA.

Xrn1是一種調(diào)節(jié)線粒體NAD封頂RNA的去NADding酶。

115.Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription.

La Crosse病毒聚合酶的結(jié)構(gòu)快照揭示了Peribunyaviridae復(fù)制和轉(zhuǎn)錄的機制。

116.An efficient urine peptidomics workflow identifies chemically defined dietary gluten peptides from patients with celiac disease.

高效的尿液肽組學(xué)工作流程識別乳糜瀉患者的化學(xué)定義飲食麩皮肽。

117.Disruption of the grid cell network in a mouse model of early Alzheimer’s disease.

早期阿爾茨海默病小鼠模型中網(wǎng)格細(xì)胞網(wǎng)絡(luò)的破壞。

118.Cell specific peripheral immune responses predict survival in critical COVID-19 patients.

細(xì)胞特異性外周免疫反應(yīng)預(yù)測危重癥COVID-19患者的生存率。

119.Organic anion transporter 1 is an HDAC4-regulated mediator of nociceptive hypersensitivity in mice.

有機陰離子轉(zhuǎn)運體1是HDAC4調(diào)控的小鼠痛覺超敏的媒介。

120.IL-22 initiates an IL-18-dependent epithelial response circuit to enforce intestinal host defence.

IL-22啟動IL-18依賴性上皮反應(yīng)回路，強制腸道宿主防御。

121.Global patterns in functional rarity of marine fish.

海洋魚類功能稀有性的全球模式。

122.Re-engineered BCG overexpressing cyclic di-AMP augments trained immunity and exhibits improved efficacy against bladder cancer.

過度表達(dá)環(huán)狀二AMP的再造卡介苗增強了訓(xùn)練有素的免疫力，對膀胱癌表現(xiàn)出更好的療效。

123.TLR4 is a regulator of trained immunity in a murine model of Duchenne muscular dystrophy.

TLR4是杜氏肌肉萎縮癥小鼠模型中訓(xùn)練有素的免疫力的調(diào)節(jié)器。

124.The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern.

口服蛋白酶抑制劑（PF-07321332）可保護敘利亞倉鼠免受SARS-CoV-2變體的感染，值得關(guān)注。

125.Cancer patient survival can be parametrized to improve trial precision and reveal time-dependent therapeutic effects.

癌癥患者的生存期可以被參數(shù)化，以提高試驗的精確性，并揭示與時間有關(guān)的治療效果。

126.HSL1 and BAM1/2 impact epidermal cell development by sensing distinct signaling peptides.

HSL1和BAM1/2通過感知不同的信號肽影響表皮細(xì)胞的發(fā)育。

127.Using language in social media posts to study the network dynamics of depression longitudinally.

利用社交媒體帖子中的語言，縱向研究抑郁癥的網(wǎng)絡(luò)動態(tài)。

128.Structural basis for SARS-CoV-2 Delta variant recognition of ACE2 receptor and broadly neutralizing antibodies.

SARS-CoV-2 Delta變體識別ACE2受體和廣義中和抗體的結(jié)構(gòu)基礎(chǔ)。

129.Gut metagenome associations with extensive digital health data in a volunteer-based Estonian microbiome cohort.

基于志愿者的愛沙尼亞微生物群隊列中，腸道元基因組與大量數(shù)字健康數(shù)據(jù)的關(guān)聯(lián)。

130.AusTrakka: Fast-tracking nationalized genomics surveillance in response to the COVID-19 pandemic.

AusTrakka：為應(yīng)對COVID-19大流行，快速跟蹤國家化基因組學(xué)監(jiān)測。

131.Recruitment of two Ndc80 complexes via the CENP-T pathway is sufficient for kinetochore functions.

兩個Ndc80復(fù)合物通過CENP-T途徑的招募對激振子功能是足夠的。

132.Mesenchymal stem cells transfer mitochondria to allogeneic Tregs in an HLA-dependent manner improving their immunosuppressive activity.

間質(zhì)干細(xì)胞以HLA依賴性的方式將線粒體轉(zhuǎn)移到異體Tregs，提高了其免疫抑制活性。

133.Local and global crosstalk among heterochromatin marks drives DNA methylome patterning in Arabidopsis.

異染色質(zhì)標(biāo)記之間的局部和整體串?dāng)_驅(qū)動擬南芥的DNA甲基組模式。

134.Structural basis of neuropeptide Y signaling through Y1 receptor.

神經(jīng)肽Y通過Y1受體信號傳導(dǎo)的結(jié)構(gòu)基礎(chǔ)。

135.Structural insights into the Venus flytrap mechanosensitive ion channel Flycatcher1.

對維納斯捕蠅草機械敏感離子通道Flycatcher1的結(jié)構(gòu)見解。

136.Humoral and cellular responses after a third dose of SARS-CoV-2 BNT162b2 vaccine in patients with lymphoid malignancies.

淋巴性惡性腫瘤患者第三劑SARS-CoV-2 BNT162b2疫苗后的體液和細(xì)胞反應(yīng)。

137.EBV miRNAs BART11 and BART17-3p promote immune escape through the enhancer-mediated transcription of PD-L1.

EBV miRNAs BART11和BART17-3p通過增強子介導(dǎo)的PD-L1轉(zhuǎn)錄促進免疫逃逸。

138.Dynamic FMR1 granule phase switch instructed by m6A modification contributes to maternal RNA decay.

由m6A修飾指示的動態(tài)FMR1顆粒相切換有助于母體RNA的衰變。

139.Synthetic virions reveal fatty acid-coupled adaptive immunogenicity of SARS-CoV-2 spike glycoprotein.

合成病毒揭示了SARS-CoV-2穗狀糖蛋白的脂肪酸偶聯(lián)適應(yīng)性免疫原性。

140.A deep-learning system bridging molecule structure and biomedical text with comprehension comparable to human professionals.

一個連接分子結(jié)構(gòu)和生物醫(yī)學(xué)文本的深度學(xué)習(xí)系統(tǒng)，其理解力堪比人類專業(yè)人士。

141.Clinical and biomarker analyses of sintilimab versus chemotherapy as second-line therapy for advanced or metastatic esophageal squamous cell carcinoma: a randomized, open-label phase 2 study (ORIENT-2).

辛硫磷與化療作為晚期或轉(zhuǎn)移性食管鱗狀細(xì)胞癌二線治療的臨床和生物標(biāo)志物分析：一項隨機、開放標(biāo)簽的2期研究（ORIENT-2）。

142.Genetic associations with carotid intima-media thickness link to atherosclerosis with sex-specific effects in sub-Saharan Africans.

與頸動脈內(nèi)膜厚度有關(guān)的遺傳關(guān)聯(lián)與撒哈拉以南非洲人的動脈粥樣硬化有性別上的影響。

143.Droplet-based screening of phosphate transfer catalysis reveals how epistasis shapes MAP kinase interactions with substrates.

基于液滴的磷酸鹽轉(zhuǎn)移催化篩查揭示了外顯性如何形成MAP激酶與底物的相互作用。

144.Genomic variants affecting homoeologous gene expression dosage contribute to agronomic trait variation in allopolyploid wheat.

影響同源基因表達(dá)劑量的基因組變異有助于異源多倍體小麥的農(nóng)藝性狀變化。

145.PEBP balances apoptosis and autophagy in whitefly upon arbovirus infection.

PEBP平衡白粉虱感染蟲媒病毒后的細(xì)胞凋亡和自噬。

146.Allosteric control of Ubp6 and the proteasome via a bidirectional switch.

通過雙向開關(guān)對Ubp6和蛋白酶體的異生控制。

147.Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer.

BRCA1/2突變的高級別漿液性卵巢癌的單細(xì)胞腫瘤-免疫微環(huán)境。

148.Rhizosphere bacteriome structure and functions.

根瘤菌群的結(jié)構(gòu)和功能。

149.Protein nanowires with tunable functionality and programmable self-assembly using sequence-controlled synthesis.

利用序列控制的合成技術(shù)實現(xiàn)可調(diào)節(jié)功能和可編程自組裝的蛋白質(zhì)納米線。

150.Development of a skin- and neuro-attenuated live vaccine for varicella.

水痘皮膚和神經(jīng)強化活疫苗的開發(fā).

151.Colocalized, bidirectional optogenetic modulations in freely behaving mice with a wireless dual-color optoelectronic probe.

用無線雙色光電探針對自由行為的小鼠進行同位、雙向的光遺傳學(xué)調(diào)控。

152.The spatial transcriptomic landscape of the healing mouse intestine following damage.

損傷后小鼠腸道愈合的空間轉(zhuǎn)錄組景觀。

153.Coordinated hippocampal-thalamic-cortical communication crucial for engram dynamics underneath systems consolidation.

協(xié)調(diào)的海馬-丘腦-皮層交流對系統(tǒng)鞏固下的恩格動態(tài)至關(guān)重要。

154.Lapcin, a potent dual topoisomerase I/II inhibitor discovered by soil metagenome guided total chemical synthesis.

土壤元基因組指導(dǎo)下的全化學(xué)合成發(fā)現(xiàn)的強效雙拓?fù)洚悩?gòu)酶I/II抑制劑Lapcin。

155.Heterogeneous repolarization creates ventricular tachycardia circuits in healed myocardial infarction scar.

異質(zhì)復(fù)極化在愈合的心肌梗塞瘢痕中形成室性心動過速回路。

156.Micro-mechanical blood clot testing using smartphones.

利用智能手機進行微機械血凝塊檢測。

157.Small RNA pathways in the nematode Ascaris in the absence of piRNAs.

沒有piRNA的情況下線蟲Ascaris的小RNA途徑。

158.Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain.

單細(xì)胞RNA測序揭示了小鼠脊髓小膠質(zhì)細(xì)胞對周圍神經(jīng)損傷的時間和性別特異性反應(yīng)，并將載脂蛋白與慢性疼痛聯(lián)系起來。

159.Data-informed discovery of hydrolytic nanozymes.

基于數(shù)據(jù)信息的水解納米酶的發(fā)現(xiàn)。

160.Machine learning-based integration develops an immune-derived lncRNA signature for improving outcomes in colorectal cancer.

基于機器學(xué)習(xí)的整合開發(fā)了一個免疫衍生的lncRNA簽名，以改善結(jié)腸直腸癌的結(jié)果。

161.Comparative metabolomics with Metaboseek reveals functions of a conserved fat metabolism pathway in C. elegans.

Metaboseek的比較代謝組學(xué)揭示了優(yōu)雅動物中一個保守的脂肪代謝途徑的功能。

162.Pluripotency factors determine gene expression repertoire at zygotic genome activation.

多能性因子決定了子代基因組激活時的基因表達(dá)劇目。

163.Whole-cell modeling in yeast predicts compartment-specific proteome constraints that drive metabolic strategies.

酵母中的全細(xì)胞模型預(yù)測了驅(qū)動代謝策略的區(qū)間特異性蛋白質(zhì)組限制。

164.In vivo CRISPR screens reveal a HIF-1α-mTOR-network regulates T follicular helper versus Th1 cells.

體內(nèi)CRISPR篩選顯示HIF-1α-mTOR-網(wǎng)絡(luò)調(diào)節(jié)T濾泡輔助細(xì)胞與Th1細(xì)胞。

165.Pervasive misannotation of microexons that are evolutionarily conserved and crucial for gene function in plants.

在植物中普遍存在的對基因功能具有進化保守性和關(guān)鍵性的微外顯子的錯誤注解。

166.Overlooked and widespread pennate diatom-diazotroph symbioses in the sea.

海洋中被忽視的廣泛的筆狀硅藻-重氮菌共生體。

167.GLI transcriptional repression is inert prior to Hedgehog pathway activation.

GLI轉(zhuǎn)錄抑制在Hedgehog途徑激活之前是惰性的。

168.Structures of highly flexible intracellular domain of human α7 nicotinic acetylcholine receptor.

人類α7尼古丁乙酰膽堿受體的高度靈活的細(xì)胞內(nèi)結(jié)構(gòu)。

169.Defining molecular glues with a dual-nanobody cannabidiol sensor.

用雙納米體大麻酚傳感器定義分子膠粘劑。

170.Whole exome sequencing in Alopecia Areata identifies rare variants in KRT82.

脫發(fā)癥患者的全外顯子組測序確定了KRT82的罕見變異。

171.Schizophrenia-associated SAP97 mutations increase glutamatergic synapse strength in the dentate gyrus and impair contextual episodic memory in rats.

精神分裂癥相關(guān)的SAP97突變增加了大鼠齒狀回的谷氨酸突觸強度，損害了大鼠的情境性記憶。

172.A mammalian methylation array for profiling methylation levels at conserved sequences.

哺乳動物甲基化陣列用于分析保守序列的甲基化水平。

173.Cotranslational N-degron masking by acetylation promotes proteome stability in plants.

乙酰化對N-egron的共翻譯掩蔽促進了植物的蛋白質(zhì)組穩(wěn)定性。

174.SM-Omics is an automated platform for high-throughput spatial multi-omics.

SM-Omics是一個用于高通量空間多組學(xué)的自動化平臺。

175.Copy number amplification of ENSA promotes the progression of triple-negative breast cancer via cholesterol biosynthesis.

ENSA的拷貝數(shù)擴增通過膽固醇的生物合成促進三陰性乳腺癌的進展。

176.Superior Colliculus to VTA pathway controls orienting response and influences social interaction in mice.

上丘腦至VTA通路控制定向反應(yīng)并影響小鼠的社會互動。

177.Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes.

小分子SWELL1復(fù)合物的誘導(dǎo)改善了小鼠2型糖尿病的血糖控制和非酒精性脂肪肝的病情。

178.Mark-release-recapture experiment in Burkina Faso demonstrates reduced fitness and dispersal of genetically-modified sterile malaria mosquitoes.

在布基納法索進行的標(biāo)記-釋放-捕捉實驗表明，經(jīng)基因改造的不育瘧疾蚊子的健身性和擴散性降低。

179.Glutaredoxin 1 controls monocyte reprogramming during nutrient stress and protects mice against obesity and atherosclerosis in a sex-specific manner.

谷胱甘肽1控制營養(yǎng)壓力下的單核細(xì)胞重編程，并以性別特異的方式保護小鼠免受肥胖和動脈硬化的影響。

180.The microbiome of the buffalo digestive tract.

水牛消化道的微生物組。

181.Deciphering spatial genomic heterogeneity at a single cell resolution in multiple myeloma.

破譯多發(fā)性骨髓瘤單細(xì)胞分辨率下的空間基因組異質(zhì)性。

182.Hyperuniformity and phase enrichment in vortex and rotor assemblies.

渦旋和轉(zhuǎn)子組件中的超均勻性和相位富集。

183.Engineering and exploiting synthetic allostery of NanoLuc luciferase.

設(shè)計和利用NanoLuc熒光素酶的合成異構(gòu)體。

184.Neutralization against Omicron SARS-CoV-2 from previous non-Omicron infection.

對以前非Omicron感染的Omicron SARS-CoV-2的中和。

185.Spatiotemporal expression of regulatory kinases directs the transition from mitosis to cellular morphogenesis in Drosophila.

調(diào)節(jié)性激酶的時空表達(dá)指導(dǎo)果蠅從有絲分裂到細(xì)胞形態(tài)發(fā)生的過渡。

186.Chemically Induced Chromosomal Interaction (CICI) method to study chromosome dynamics and its biological roles.

用化學(xué)誘導(dǎo)染色體相互作用（CICI）方法研究染色體動態(tài)及其生物學(xué)作用。

187.A platform for oncogenomic reporting and interpretation.

腫瘤基因組學(xué)報告和解釋的平臺。

188.The induction of peripheral trained immunity in the pancreas incites anti-tumor activity to control pancreatic cancer progression.

誘導(dǎo)胰腺外周訓(xùn)練的免疫力煽動抗腫瘤活性以控制胰腺癌的發(fā)展。

189.Translocated Legionella pneumophila small RNAs mimic eukaryotic microRNAs targeting the host immune response.

轉(zhuǎn)化的嗜肺軍團菌小RNA模擬真核微RNA，針對宿主免疫反應(yīng)。

190.Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target.

人類膠質(zhì)瘤和免疫細(xì)胞的單細(xì)胞分析確定了S100A4為免疫療法的目標(biāo)。

191.A SIMPLI (Single-cell Identification from MultiPLexed Images) approach for spatially-resolved tissue phenotyping at single-cell resolution.

一種SIMPLI(從 MultiPLexed 圖像中識別單細(xì)胞)方法用于單細(xì)胞分辨率的空間分辨組織表型。

192.Versioning biological cells for trustworthy cell engineering.

為值得信賴的細(xì)胞工程提供生物細(xì)胞版本。

193.Human transcription factor protein interaction networks.

人類轉(zhuǎn)錄因子蛋白質(zhì)相互作用網(wǎng)絡(luò)。

194.Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling.

利用DNA甲基化增強外周血的細(xì)胞解構(gòu)，用于高分辨率的免疫分析。

195.A diencephalic circuit in rats for opioid analgesia but not positive reinforcement.

大鼠腦膜回路對阿片類藥物鎮(zhèn)痛的作用，但不是正強化作用。

196.Sonogenetic control of mammalian cells using exogenous Transient Receptor Potential A1 channels.

利用外源性瞬時受體電位A1通道對哺乳動物細(xì)胞進行聲學(xué)控制。

197.Immune signature of acute pharyngitis in a Streptococcus pyogenes human challenge trial.

化膿性鏈球菌人體挑戰(zhàn)試驗中急性咽喉炎的免疫特征。

198.Development and validation of a prognostic and predictive 32-gene signature for gastric cancer.

胃癌預(yù)后和預(yù)測的32個基因特征的開發(fā)和驗證.

199.An optogenetic approach for regulating human parathyroid hormone secretion.

一種調(diào)節(jié)人類甲狀旁腺激素分泌的光遺傳學(xué)方法。

200.Prime editing efficiency and fidelity are enhanced in the absence of mismatch repair.

在沒有錯配修復(fù)的情況下，主編輯的效率和保真度得到提高。

201.Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development.

動態(tài)Runx1染色質(zhì)邊界影響造血發(fā)育中的基因表達(dá)。

202.Histone H3K4me3 modification is a transgenerational epigenetic signal for lipid metabolism in Caenorhabditis elegans.

組蛋白H3K4me3修飾是優(yōu)雅凱諾蟲脂質(zhì)代謝的跨代表觀遺傳信號。

203.UINMF performs mosaic integration of single-cell multi-omic datasets using nonnegative matrix factorization.

UINMF使用非負(fù)矩陣分解法對單細(xì)胞多組學(xué)數(shù)據(jù)集進行鑲嵌式整合。

204.Lymphocyte infiltration and thyrocyte destruction are driven by stromal and immune cell components in Hashimoto’s thyroiditis.

淋巴細(xì)胞浸潤和甲狀腺細(xì)胞破壞是由橋本甲狀腺炎的基質(zhì)和免疫細(xì)胞成分驅(qū)動的。

205.Perspectives in machine learning for wildlife conservation.

機器學(xué)習(xí)在野生動物保護中的應(yīng)用前景.

206.Combining p53 mRNA nanotherapy with immune checkpoint blockade reprograms the immune microenvironment for effective cancer therapy.

將p53 mRNA納米療法與免疫檢查點阻斷相結(jié)合，重新規(guī)劃免疫微環(huán)境，以實現(xiàn)有效的癌癥治療。

207.Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis.

硒磷酸酯合成酶1的缺失通過調(diào)節(jié)氧化還原平衡而加劇骨關(guān)節(jié)炎。

208.Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance.

咖啡因阻斷SREBP2誘導(dǎo)的肝臟PCSK9表達(dá)以增強LDLR介導(dǎo)的膽固醇清除。

209.Genomic epidemiology of SARS-CoV-2 under an elimination strategy in Hong Kong.

香港消除策略下SARS-CoV-2的基因組流行病學(xué)。

210.Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor.

TARP調(diào)控GluA1/2-γ8 AMPA受體的機制。

211.SMAP is a pipeline for sample matching in proteogenomics.

SMAP是一個用于蛋白質(zhì)基因組學(xué)中樣本匹配的管道。

212.Physiological synaptic activity and recognition memory require astroglial glutamine.

生理突觸活動和識別記憶需要星形細(xì)胞的谷氨酰胺。

213.Giant sponge grounds of Central Arctic seamounts are associated with extinct seep life.

中北極海山的巨型海綿地與已滅絕的滲水生物有關(guān)。

214.Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity.

內(nèi)源性甲醛清除細(xì)胞谷胱甘肽，導(dǎo)致氧化還原破壞和細(xì)胞毒性。

215.Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.

溶血磷脂酸和1-磷酸鞘氨醇對脂質(zhì)GPCRs的不同激活機制。

216.Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission.

英國某大學(xué)SARS-CoV-2的基因組流行病學(xué)確定了傳播的動態(tài)。

217.Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer.

免疫獼猴體內(nèi)誘導(dǎo)的中和抗體可識別閉塞開放的HIV-1包膜三聚體上的CD4結(jié)合位點。

218.Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.

雜亂樣激酶 2通過客戶模仿鎖定ASF1組蛋白伴侶。

219.Amylin-Calcitonin receptor signaling in the medial preoptic area mediates affiliative social behaviors in female mice.

胰淀素-降鈣素受體在內(nèi)側(cè)視前區(qū)的信號傳遞介導(dǎo)了雌性小鼠的附屬社會行為。

220.In vivo mitochondrial base editing via adeno-associated viral delivery to mouse post-mitotic tissue.

通過腺相關(guān)病毒傳遞到小鼠有絲分裂后組織的體內(nèi)線粒體堿基編輯。

221.Alternative splicing in seasonal plasticity and the potential for adaptation to environmental change.

季節(jié)性可塑性中的替代剪接和對環(huán)境變化的適應(yīng)潛力。

222.A Mediator-cohesin axis controls heterochromatin domain formation.

介體粘連蛋白軸控制異染色質(zhì)域的形成。

223.Hippocampal ensembles represent sequential relationships among an extended sequence of nonspatial events.

海馬集合體代表了非空間事件擴展序列中的順序關(guān)系。

224.Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants.

δ型和卡帕型SARS-CoV-2變體中穗狀蛋白適應(yīng)性增強的結(jié)構(gòu)和生物化學(xué)原理。

225.Protein sequence design with a learned potential.

具有學(xué)習(xí)潛力的蛋白質(zhì)序列設(shè)計。

226.Cooperation in alternating interactions with memory constraints.

有記憶約束的交替相互作用中的合作。

227.Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance.

β細(xì)胞特異性Insr缺失促進胰島素過度分泌，并在全球胰島素抵抗之前改善葡萄糖耐量。

228.Enhanced germline stem cell longevity in Drosophila diapause.

果蠅絕育期中生殖干細(xì)胞壽命的增強。

229.Reconstituting the complete biosynthesis of D-lysergic acid in yeast.

在酵母中重建D-麥角酸的完整生物合成。

230.Cryo-EM structures of human bradykinin receptor-Gq proteins complexes.

人類緩激肽受體-Gq蛋白復(fù)合體的低溫電鏡結(jié)構(gòu)。

231.Spatial-temporal dynamics of a microbial cooperative behavior resistant to cheating.

抵抗作弊的微生物合作行為的空間-時間動態(tài)。

232.Mesenchymal-epithelial crosstalk shapes intestinal regionalisation via Wnt and Shh signalling.

間質(zhì)-上皮串?dāng)_通過Wnt和Shh信號塑造腸道區(qū)域化。

233.Coat proteins of necroviruses target 14-3-3a to subvert MAPKKKα-mediated antiviral immunity in plants.

壞死病毒的衣殼蛋白以14-3-3a為目標(biāo)，顛覆植物中MAPKKKα介導(dǎo)的抗病毒免疫力。

234.Primate anterior insular cortex represents economic decision variables proposed by prospect theory.

靈長類前島皮層代表前景理論提出的經(jīng)濟決策變量。

235.Live-dead assay on unlabeled cells using phase imaging with computational specificity.

使用具有計算特異性的相位成像技術(shù)對未標(biāo)記的細(xì)胞進行活體死亡檢測。

236.An archaellum filament composed of two alternating subunits.

一個由兩個交替的亞單位組成的弓形絲。

237.Presynaptic NMDARs on spinal nociceptor terminals state-dependently modulate synaptic transmission and pain.

脊柱痛覺終端上的突觸前NMDARs狀態(tài)依賴性地調(diào)節(jié)突觸傳遞和疼痛。

238.Genome-wide association meta-analysis identifies 29 new acne susceptibility loci.

全基因組關(guān)聯(lián)元分析發(fā)現(xiàn)29個新的痤瘡易感位點。

239.Somatic PMK-1/p38 signaling links environmental stress to germ cell apoptosis and heritable euploidy.

體內(nèi)PMK-1/p38信號將環(huán)境壓力與生殖細(xì)胞凋亡和遺傳性優(yōu)生性聯(lián)系起來。

240.The olfactory gating of visual preferences to human skin and visible spectra in mosquitoes.

蚊子對人類皮膚和可見光譜的視覺偏好的嗅覺門控。

241.Placental genomics mediates genetic associations with complex health traits and disease.

胎盤基因組學(xué)介導(dǎo)了與復(fù)雜健康特征和疾病的基因關(guān)聯(lián)。

242.Bacterial filamentation as a mechanism for cell-to-cell spread within an animal host.

細(xì)菌絲狀物作為動物宿主內(nèi)細(xì)胞間傳播的機制。

243.Induction of tier-2 neutralizing antibodies in mice with a DNA-encoded HIV envelope native like trimer.

用DNA編碼的HIV包膜原生型三聚體誘導(dǎo)小鼠的第2級中和抗體。

244.ROCK1 mechano-signaling dependency of human malignancies driven by TEAD/YAP activation.

由TEAD/YAP激活驅(qū)動的人類惡性腫瘤的ROCK1機械信號依賴性。

245.Population-level deficit of homozygosity unveils CPSF3 as an intellectual disability syndrome gene.

群體水平的同源性缺失揭開了CPSF3作為智力障礙綜合征基因的面紗。

246.The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress.

腸道激素尿囊素C/生長抑素調(diào)節(jié)營養(yǎng)壓力下的食物攝入和代謝平衡。

247.A neomorphic variant in SP7 alters sequence specificity and causes a high-turnover bone disorder.

SP7中的一個新形態(tài)變體改變了序列特異性，導(dǎo)致了高周轉(zhuǎn)的骨質(zhì)紊亂。

248.Sculpting tissues by phase transitions.

通過相變雕塑組織。

249.Endothelial cell-specific expression of serine/threonine kinase 11 modulates dendritic cell differentiation.

內(nèi)皮細(xì)胞特異性表達(dá)絲氨酸/蘇氨酸激酶11調(diào)控樹突狀細(xì)胞分化。

250.A role for ColV plasmids in the evolution of pathogenic Escherichia coli ST58.

ColV質(zhì)粒在致病性大腸桿菌ST58進化中的作用。

251.Genetically stable CRISPR-based kill switches for engineered microbes.

基因穩(wěn)定的基于CRISPR的工程微生物的殺傷開關(guān)。

252.A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis.

RNase MRP中與疾病相關(guān)的lncRNA突變抑制了核糖體的合成。

253.Genomic insights into the evolution of Echinochloa species as weed and orphan crop.

對稗草物種作為雜草和孤兒作物的進化的基因組見解。

254.Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth.

Gαi2誘導(dǎo)的conductin/axin2縮合體抑制Wnt/β-catenin信號傳遞并抑制癌癥生長。

255.Graph-based pan-genome reveals structural and sequence variations related to agronomic traits and domestication in cucumber.

基于圖形的泛基因組揭示了與黃瓜農(nóng)藝性狀和馴化有關(guān)的結(jié)構(gòu)和序列變異。

256.The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom’s syndrome helicase for efficient disruption of D-loops.

拓?fù)洚悩?gòu)酶IIIalpha-RMI1-RMI2復(fù)合物為人類布魯姆綜合癥螺旋酶定向，以有效破壞D環(huán)。

257.TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models.

TNF拮抗劑使膠原蛋白誘導(dǎo)的關(guān)節(jié)炎小鼠模型中的滑膜成纖維細(xì)胞對鐵質(zhì)細(xì)胞死亡敏感。

258.Cyclin B/CDK1 and Cyclin A/CDK2 phosphorylate DENR to promote mitotic protein translation and faithful cell division.

Cyclin B/CDK1和Cyclin A/CDK2磷酸化DENR以促進有絲分裂蛋白翻譯和忠實的細(xì)胞分裂。

259.Mitochondrial protein import determines lifespan through metabolic reprogramming and de novo serine biosynthesis.

線粒體蛋白導(dǎo)入通過代謝重編程和新的絲氨酸生物合成決定了壽命的長短。

260.Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis.

受體交互蛋白激酶2（RIPK2）穩(wěn)定c-Myc，是前列腺癌轉(zhuǎn)移的一個治療目標(biāo)。

261.Multiple expansions of globally uncommon SARS-CoV-2 lineages in Nigeria.

尼日利亞全球不常見的SARS-CoV-2系的多重擴展。

262.An instructive role for Interleukin-7 receptor α in the development of human B-cell precursor leukemia.

白細(xì)胞介素-7受體α在人類B細(xì)胞前體白血病發(fā)展中的指導(dǎo)性作用。

263.Arabidopsis guard cell chloroplasts import cytosolic ATP for starch turnover and stomatal opening.

擬南芥守護細(xì)胞葉綠體導(dǎo)入細(xì)胞膜ATP用于淀粉周轉(zhuǎn)和氣孔開放。

264.Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice.

許旺細(xì)胞內(nèi)體CGRP信號引起小鼠眶周機械性痛覺。

265.Hemoglobin in the blood acts as a chemosensory signal via the mouse vomeronasal system.

血液中的血紅蛋白通過小鼠回聲系統(tǒng)充當(dāng)化學(xué)感應(yīng)信號。

266.Constructing neural network models from brain data reveals representational transformations linked to adaptive behavior.

從大腦數(shù)據(jù)中構(gòu)建神經(jīng)網(wǎng)絡(luò)模型，揭示了與適應(yīng)性行為有關(guān)的表征性轉(zhuǎn)變。

267.Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis.

一種HIV抗體的吞噬作用與病毒的減少有關(guān)，而不考慮補體裂解的增強。

268.Tracking cryptic SARS-CoV-2 lineages detected in NYC wastewater.

追蹤紐約市廢水中檢測到的隱性SARS-CoV-2系。

269.Temporal dynamics of the neural representation of hue and luminance polarity.

色調(diào)和亮度極性的神經(jīng)表征的時間動態(tài)。

270.Characterising within-hospital SARS-CoV-2 transmission events using epidemiological and viral genomic data across two pandemic waves.

利用流行病學(xué)和病毒基因組數(shù)據(jù)對兩次大流行的SARS-CoV-2院內(nèi)傳播事件進行定性。

271.Circadian lipid and hepatic protein rhythms shift with a phase response curve different than melatonin.

晝夜脂質(zhì)和肝臟蛋白節(jié)律的轉(zhuǎn)變，其相位反應(yīng)曲線與褪黑激素不同。

272.TAZ links exercise to mitochondrial biogenesis via mitochondrial transcription factor A.

TAZ通過線粒體轉(zhuǎn)錄因子A將運動與線粒體生物生成聯(lián)系起來。

273.The selection force weakens with age because ageing evolves and not vice versa.

選擇力隨著年齡的增長而減弱，因為老化是進化的，而不是反過來。

274.Inferring protein expression changes from mRNA in Alzheimer’s dementia using deep neural networks.

利用深度神經(jīng)網(wǎng)絡(luò)從mRNA推斷阿爾茨海默氏癥的蛋白質(zhì)表達(dá)變化。

275.Assortative mating biases marker-based heritability estimators.

基于標(biāo)記的遺傳性估計器的同種交配偏差。

276.Direct-laser writing for subnanometer focusing and single-molecule imaging.

用于亞納米聚焦和單分子成像的直接激光寫入。

277.Dendritic autophagy degrades postsynaptic proteins and is required for long-term synaptic depression in mice.

樹突自噬降解突觸后蛋白，是小鼠長期突觸抑制的必要條件。

278.Myeloid cell interferon responses correlate with clearance of SARS-CoV-2.

髓細(xì)胞干擾素反應(yīng)與SARS-CoV-2的清除相關(guān)。

279.Deep phenotyping of Alzheimer’s disease leveraging electronic medical records identifies sex-specific clinical associations.

利用電子病歷對阿爾茨海默病進行深度表型，確定了性別特異的臨床關(guān)聯(lián)。

280.The IGFBP3/TMEM219 pathway regulates beta cell homeostasis.

IGFBP3/TMEM219途徑調(diào)控β細(xì)胞的平衡。

281.A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments.

哺乳動物細(xì)胞特異性的泛CRISPR分析確定了用于基因組規(guī)模實驗的超緊湊sgRNA子集。

282.Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells.

原發(fā)性腫瘤相關(guān)巨噬細(xì)胞激活了傳播性腫瘤細(xì)胞的入侵和休眠程序。

283.Broadly neutralizing anti-HIV-1 antibodies tether viral particles at the surface of infected cells.

廣義中和抗HIV-1抗體將病毒顆粒拴在受感染細(xì)胞的表面。

284.Buxus and Tetracentron genomes help resolve eudicot genome history.

Buxus和Tetracentron的基因組有助于解決eudicot基因組歷史。

285.Molecular mechanism of Arp2/3 complex inhibition by Arpin.

Arp2/3復(fù)合物被Arpin抑制的分子機制。

286.Manipulation of RNA polymerase III by Herpes Simplex Virus-1.

單純皰疹病毒-1對RNA聚合酶III的操縱。

287.A robust method for collider bias correction in conditional genome-wide association studies.

條件性全基因組關(guān)聯(lián)研究中對撞機偏差校正的穩(wěn)健方法。

288.CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations.

CRISPR-Cas9誘導(dǎo)體內(nèi)靶點和非靶點的大型結(jié)構(gòu)變異，并跨代分離。

289.Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate.

常規(guī)Wnt信號的構(gòu)成性激活破壞了脈絡(luò)叢上皮的命運。

290.Gut microbiome of the largest living rodent harbors unprecedented enzymatic systems to degrade plant polysaccharides.

最大的活體嚙齒動物的腸道微生物群擁有前所未有的降解植物多糖的酶系統(tǒng)。

291.Event boundaries shape temporal organization of memory by resetting temporal context.

事件邊界通過重新設(shè)置時間背景來塑造記憶的時間組織。

292.A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase.

AT-527對SARS-CoV-2聚合酶的雙重作用機制。

293.Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy.

用于心臟基因治療的細(xì)菌電壓門控鈉通道平臺。

294.Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology.

罕見的SLC13A1變體與椎間盤紊亂有關(guān)，突出了硫酸鹽在椎間盤病變中的作用。

295.A population-based cohort study of obesity, ethnicity and COVID-19 mortality in 12.6 million adults in England.

英國1260萬成年人的肥胖、種族和COVID-19死亡率的人群隊列研究。

296.Lima1 mediates the pluripotency control of membrane dynamics and cellular metabolism.

Lima1介導(dǎo)了膜動態(tài)和細(xì)胞代謝的多能性控制。

297.PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides.

PplD是鏈球菌鼠李多糖的細(xì)胞壁連接單元的去N-乙?；浮?/p>

298.Generation of the organotypic kidney structure by integrating pluripotent stem cell-derived renal stroma.

通過整合多能干細(xì)胞衍生的腎臟基質(zhì)生成器官型腎臟結(jié)構(gòu)。

299.Automatic mapping of multiplexed social receptive fields by deep learning and GPU-accelerated 3D videography.

通過深度學(xué)習(xí)和GPU加速的3D攝像技術(shù)自動繪制多路社會接收場圖。

300.Cyclic AMP signalling and glucose metabolism mediate pH taxis by African trypanosomes.

環(huán)磷酸腺苷信號和葡萄糖代謝介導(dǎo)非洲錐蟲的pH計。

301.Electron transfer-triggered imaging of EGFR signaling activity.

EGFR信號活動的電子轉(zhuǎn)移觸發(fā)成像。

302.A neural circuit linking learning and sleep in Drosophila long-term memory.

果蠅長期記憶中連接學(xué)習(xí)和睡眠的神經(jīng)回路。

303.PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation.

PPM1D突變是新發(fā)彌漫性中線膠質(zhì)瘤形成的致癌驅(qū)動因素。

304.Impacts of rapid mass vaccination against SARS-CoV2 in an early variant of concern hotspot.

快速大規(guī)模接種SARS-CoV2疫苗對早期變異關(guān)注熱點的影響。

305.Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.

最小真核生物核糖體結(jié)構(gòu)中對基因組衰變的適應(yīng)性。

306.Inhibition of base editors with anti-deaminases derived from viruses.

用來自病毒的抗脫氨酶抑制堿基編輯。

307.Catalytic trajectory of a dimeric nonribosomal peptide synthetase subunit with an inserted epimerase domain.

具有插入外聚酶結(jié)構(gòu)域的二聚體非核糖體肽合成酶亞單位的催化軌跡。

308.Multiplexed nanomaterial-assisted laser desorption/ionization for pan-cancer diagnosis and classification.

用于泛癌診斷和分類的多重納米材料輔助激光解吸/離子化。

309.ΔNp63 regulates a common landscape of enhancer associated genes in non-small cell lung cancer.

ΔNp63調(diào)控非小細(xì)胞肺癌中增強子相關(guān)基因的共同景觀。

310.SARS-CoV-2 genomes from Saudi Arabia implicate nucleocapsid mutations in host response and increased viral load.

來自沙特阿拉伯的SARS-CoV-2基因組暗示核苷酸突變與宿主反應(yīng)和病毒負(fù)荷增加有關(guān)。

311.Relative effects of land conversion and land-use intensity on terrestrial vertebrate diversity.

土地轉(zhuǎn)換和土地使用強度對陸生脊椎動物多樣性的相對影響。

312.Cost-effectiveness of routine adolescent vaccination with an M72/AS01E-like tuberculosis vaccine in South Africa and India.

南非和印度青少年常規(guī)接種M72/AS01E類結(jié)核病疫苗的成本效益。

313.The mouse metallomic landscape of aging and metabolism.

衰老和代謝的小鼠金屬組學(xué)景觀。

314.Nationally representative SARS-CoV-2 antibody prevalence estimates after the first epidemic wave in Mexico.

墨西哥第一波疫情后具有全國代表性的SARS-CoV-2抗體流行率的估計。

315.Matrix condition mediates the effects of habitat fragmentation on species extinction risk.

基質(zhì)條件介導(dǎo)了棲息地破碎化對物種滅絕風(fēng)險的影響。

316.The DNA methylome of cervical cells can predict the presence of ovarian cancer.

宮頸細(xì)胞的DNA甲基組可以預(yù)測卵巢癌的存在。

317.Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity.

藥用IRE1/XBP1s激活促進肥胖癥的系統(tǒng)適應(yīng)性重塑。