產(chǎn)品名稱：

活性氧IFN-γ (mouse, recombinant)，Type II Interferon，Interferon-γ

產(chǎn)地：西安

規(guī)格：1mg 5mg 10mg

純度：99%

用途：僅用于科研

狀態(tài)：固體/粉末

儲藏條件：冷藏-20℃

溫馨提示：僅用于科研，不能用于人體實驗！

說明：提供使用說明，核磁圖譜，包裝，價格，產(chǎn)地，制備方法，應(yīng)用，穩(wěn)定性，溶解度，簡單合成等各種信息　　

Interferon γ (IFN-γ) is a cytokine and type II interferon with roles in innate and adaptive immunity. It is initially produced by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response to pathogens, and then by CD4+ T helper (Th1) cells and CD8+ cytotoxic effector T cells as adaptive antigen-specific immunity is developed. IFN-γ production is induced in response to pathogen-induced secretion of IL-12 and IL-18 by macrophages and is inhibited by IL-4, IL-10, TGF-β, and various glucocorticoids. It facilitates amplification of antigen presentation, the production of reactive oxygen species (ROS), and the induction of antiviral and antibacterial responses by binding to the interferon γ receptor extracellular domain IFNGR1 to induce signal transduction and gene transcription.In addition to its role in infectious disease, IFN-γ enhances the antigenicity of tumor cells, making them more susceptible to IFN-γ-stimulated immune effector cells. It induces tumor cell apoptosis and necroptosis and inhibits tumor angiogenesis in vitro and in vivo. However, IFN-γ-induced removal of highly antigenic tumor cells can leave behind a population with reduced immunogenicity that can evade immune detection and enhance metastasis. Knockdown of Ifnγ improves insulin resistance in a mouse model of high-fat diet-induced obesity and increases susceptibility to various pathogens in mice.Cayman's IFN-γ (mouse, recombinant) protein can be used for ELISA and cell-based assay applications. This protein consists of 133 amino acids, has a calculated molecular weight of 15.5 kDa, and a predicted N-terminus of His23 after signal peptide cleavage.

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編輯：XAQYBIO HAO，2023年4月28日。