Timeline

What Is Your Research Question?

你的科研問(wèn)題是什么？

Try to find rules by which nerves are wired up in the cerebral cortex (outermost layer).

Which Method Did You Employ?

你運(yùn)用了哪些方法？

1. image data with electron microscopes.
2. extract nerve cell network by machine learning and human annotators.d

What Are Your Findings?

你的發(fā)現(xiàn)是什么？

In the medial entorhinal cortex, axons and their synapses are embedded in a triad circuit motif with cellular feed-forward inhibition.

What Is the Relevance of Your Findings?

有哪些內(nèi)容有關(guān)于你的發(fā)現(xiàn)？

1. highly precise networks, which challenge old assumptions.
2. circuit motifs.
3. synchronous activity.

Your Outlook for the Future?

你對(duì)于未來(lái)的展望？

1. Some circuit motifs are already found in rats. What about apes and humans?
2. How do you combine context with sensory input in algorithms?
3. Could alteration of the rules of human circuits lead to disease?

Publication

1. Helene Schmidt, Anjali Gour, Jakob Straehle, Kevin M. Boergens, Michael Brecht and Moritz Helmstaedter.?"Axonal Synapse Sorting in Medial Entorhinal Cortex."?Nature?549?(2017):?469-475.
2. Kevin M. Boergens, Manuel Berning, Tom Bocklisch, Dominic Br?unlein, Florian Drawitsch, Johannes Frohnhofen, Tom Herold, Philipp Otto, Norman Rzepka, D. W. Werkmeister, G. Wiese, H. Wissler and Moritz Helmstaedter.?"webKnossos: Efficient Online 3D Data Annotation for Connectomics."?Nature Methods?14,?7?(2017):?691-694.
3. Benedikt Staffler, Manuel Berning, Kevin M. Boergens, Anjali Gour, Patrick van der Smagt and Moritz Helmstaedter.?"SynEM, Automated Synapse Detection for Connectomics."?eLife?6?(2017).

Researcher

Moritz Helmstaedter is Director at the Max Planck Institute for Brain Research. Before this appointment, he was the Research Group Leader and Principal Investigator at the Max Planck Institute of Neurobiology. His research field is connectomics, the mapping of neuronal circuits using electron microscopy and machine learning.