CalBioreagents?Id蛋白（Id=抑制DNA結(jié)合）是針對(duì)人類(lèi)和小鼠Id1、Id2、Id3和Id4開(kāi)發(fā)的一系列兔單克隆抗體。Id蛋白是轉(zhuǎn)錄的負(fù)性調(diào)節(jié)因子，Id1和Id3可能在血管生成中發(fā)揮中心作用。這些試劑適用于福爾馬林固定的石蠟包埋組織的IHC和蛋白質(zhì)印跡。一起來(lái)看下CalBioreagents/艾美捷?ID蛋白單克隆抗體相關(guān)案例分析：

?

CalBioreagents/艾美捷??ID蛋白單克隆抗體（cat#：M082）

?

蛋白質(zhì)家族，Id1，Id2，Id3和Id4。這些蛋白質(zhì)最初是作為蛋白質(zhì)被發(fā)現(xiàn)的參與細(xì)胞的陰性控制區(qū)別Id蛋白起著陰性作用通過(guò)物理機(jī)制調(diào)節(jié)轉(zhuǎn)錄與一組轉(zhuǎn)錄因子的相互作用被稱(chēng)為bHLH（堿性螺旋-環(huán)-螺旋）蛋白質(zhì)。Id蛋白與bHLH蛋白在細(xì)胞內(nèi)相互作用阻止DNA與HLH結(jié)合的方式蛋白質(zhì)。由于這項(xiàng)活動(dòng)蛋白質(zhì)被命名為Id（DNA抑制劑）綁定）。Id蛋白也被發(fā)現(xiàn)與與其他一些蛋白質(zhì)如Rb，Ets，Paz、MIDA-1和SREBP-1c。Id蛋白可能在協(xié)調(diào)基因方面發(fā)揮中心作用表達(dá)、細(xì)胞增殖、腫瘤發(fā)生和血管生成。

?

Id蛋白被發(fā)現(xiàn)是在許多類(lèi)型中過(guò)度表達(dá)，包括膠質(zhì)母細(xì)胞瘤髓母細(xì)胞瘤神經(jīng)母細(xì)胞瘤，胰腺癌、甲狀腺癌、鱗狀細(xì)胞癌細(xì)胞癌，乳腺癌，子宮內(nèi)膜癌癌癥、宮頸癌、黑色素瘤和網(wǎng)膜母細(xì)胞瘤。越來(lái)越多的人證據(jù)表明Id1和Id3在血管生成。Id1-/-，Id3中的實(shí)驗(yàn)-/-敲除小鼠表明，隨著Id的丟失表達(dá)：無(wú)血管生成，無(wú)血管生成腫瘤的后續(xù)生長(zhǎng)。

?

CalBioreagents/艾美捷??ID蛋白單克隆抗體相關(guān)研究：

ANALYTE ????TYPE ??DESCRIPTION ??APPLICATION ??PART # ?PKG

Id1?Rabbit Monoclonal?Anti-Mouse Id1 Clone 37-2?WB, IHC?M082 ?50 ug

Id1?Rabbit Monoclonal?Anti-Mouse Id1 Clone 37-2?WB, IHC?M083?100 ug

Id1?Rabbit Monoclonal?Anti-Mouse Id1 Clone 37-2?WB, IHC?M084?1 mg

Id1?Rabbit Monoclonal?Anti-Human/Mouse Id1 Clone 195-14?WB, IHC?M085?50 ug

Id1?Rabbit Monoclonal?Anti-Human/Mouse Id1 Clone 195-14?WB, IHC?M086?100 ug

Id1?Rabbit Monoclonal?Anti-Human/Mouse Id1 Clone 195-14?WB, IHC?M087?1 mg

Id1?Rabbit Monoclonal?Anti-Human Id1 Clone 5-3?WB?M088?50 ug

Id1?Rabbit Monoclonal?Anti-Human Id1 Clone 5-3?WB?M089?100 ug

Id1?Rabbit Monoclonal?Anti-Human Id1 Clone 5-3?WB?M090?1 mg

Id2?Rabbit Monoclonal?Anti Human/Mouse Id2 Clone 9-2-8?WB, IHC?M213?50 ug

Id2?Rabbit Monoclonal?Anti Human/Mouse Id2 Clone 9-2-8?WB, IHC?M214?100 ug

Id2?Rabbit Monoclonal?Anti Human/Mouse Id2 Clone 9-2-8?WB, IHC?M215 ??1 mg

Id3?Rabbit Monoclonal?Anti-Human/Mouse Id3 Clone 6-1?WB?M094 ??50 ug

Id3?Rabbit Monoclonal?Anti-Human/Mouse Id3 Clone 6-1?WB?M095?100 ug

Id3?Rabbit Monoclonal?Anti-Human/Mouse Id3 Clone 6-1?WB?M096?1 mg

Id3?Rabbit Monoclonal?Anti-Human/Mouse Id3 Clone 16-1?WB?M097?50 ug

Id3?Rabbit Monoclonal?Anti-Human/Mouse Id3 Clone 16-1?WB?M098 ???100 ug

Id3?Rabbit Monoclonal?Anti-Human/Mouse Id3 Clone 16-1?WB?M099?1 mg

Id3?Rabbit Monoclonal?Anti-Human/Mouse Id3 Clone 17-3?WB, IHC (IHC for Human only) M100?50 ug

Id3?Rabbit Monoclonal?Anti-Human/Mouse Id3 Clone 17-3?WB, IHC (IHC for Human only)?M101?100 ug

Id3?Rabbit Monoclonal?Anti-Human/Mouse Id3 Clone 17-3?WB, IHC (IHC for Human only)?M102?1 mg

Id3?Rabbit Monoclonal?Anti-Human/Mouse Id3 Clone 42-1?WB?M103?50 ug

Id3?Rabbit Monoclonal?Anti-Human/Mouse Id3 Clone 42-1?WB?M104?100 ug

Id3?Rabbit Monoclonal?Anti-Human/Mouse Id3 Clone 42-1?WB?M105?1 mg

Id4?Rabbit Monoclonal?Anti-Human/Mouse Id4 Clone 82-12?WB, IHC?M106?50 ug

Id4?Rabbit Monoclonal?Anti-Human/Mouse Id4 Clone 82-12?WB, IHC?M107?100 mg

Id4?Rabbit Monoclonal?Anti-Human/Mouse Id4 Clone 82-12?WB, IHC?M108?1 mg

?

艾美捷科技是CalBioreagents的中國(guó)代理商，為科研工作者提供優(yōu)質(zhì)的產(chǎn)品與服務(wù)。

?