產(chǎn)品名稱：ATTO 647 Maleimide

AT 647 Maleimide

中文名稱：AT 647馬來酰亞胺

化學(xué)式：C40H51N4O6S+

分子量：715.93

純度：95%

保存條件：避光，干燥，-20℃保存

注意事項(xiàng)：取用一定要干燥，避免頻繁的溶解和凍干。

用途：僅用于科學(xué)研究或者工業(yè)應(yīng)用等非醫(yī)療目的，非藥用，非食用

結(jié)構(gòu)式：

供應(yīng)商：西安凱新生物科技有限公司

Atto 647 belongs to a new generation of fluorescent labels for the red spectral region with high molecular absorption (120.000) and quantum yield (0.20) as well as sufficient stoke′s shift (excitation maximum 645 nm, emission maximum 669 nm). Atto 647 is characterized by a high photostability. The dye is designed for application in the area of life science, e.g. labeling of DNA, RNA or proteins. Atto The dye is very stable under physiological pH-values and in buffers up to pH 8.5. However, it slowly degrades at higher pH. Atto 647 maleimide shows excellent solubility in polar solvents like DMF, DMSO or acetonitrile. After coupling to a substrate the dye moiety is electrically neutral.

Maleimide is a cyclic dicarboximide in which the two carboacyl groups on nitrogen together with the nitogen itself form a 1H-pyrrole-2,5-dione structure. It has a role as an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor. It is a dicarboximide and a member of maleimides. It is functionally related to a maleic acid. It derives from a hydride of a 1H-pyrrole.

Atto 647屬于新一代紅色光譜區(qū)熒光標(biāo)記，具有高分子吸收（120.000）和量子產(chǎn)率（0.20）以及足夠的斯托克位移（激發(fā)645 nm，發(fā)射669 nm）。Atto 647具有高光穩(wěn)定性的特點(diǎn)。該染料設(shè)計(jì)用于生命科學(xué)領(lǐng)域，例如標(biāo)記DNA、RNA或蛋白質(zhì)。Atto染料在生理pH值和pH值高達(dá)8.5的緩沖液中非常穩(wěn)定。但是，在較高的pH值下，染料會(huì)緩慢降解。Atto 647馬來酰亞胺在極性溶劑（如DMF、DMSO或乙腈）中表現(xiàn)出良好的溶解度。在耦合到襯底后，染料部分是電中性的。

馬來酰亞胺是一種環(huán)狀二羧基，其中氮上的兩個(gè)碳?；c氮本身形成1H-吡咯-2,5-二酮結(jié)構(gòu)。它具有EC5.99.1.3[DNA拓?fù)洚悩?gòu)酶（ATP水解）]抑制劑的作用。它是二羧肟和馬來酰亞胺的成員。它在功能上與順丁烯二酸有關(guān)。它來源于1H吡咯的氫化物。

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