【文獻速遞】【Nchem】【2022年】【2-6月】
聲明：本專欄主要對生命科學領域的一些期刊文章標題進行翻譯，所有內容均由本人手工整理翻譯。由于本人專業(yè)為生物分析相關，其他領域如果出現(xiàn)翻譯錯誤請諒解。
使DNA編碼的文庫多樣化
Discovering ligands that modulate the function of biomolecules can be achieved by using DNA-encoded libraries that link the function of a synthetic molecule to an amplifiable nucleic acid tag. Such technologies do not make full use of the principles of Darwinian selection, but now a team led by Nicolas Winssinger has developed a strategy to assemble libraries of macrocyclic-like structures (Dsuprabodies) that undergo iterative cycles of selection, amplification and diversification. The method was validated with selections against streptavidin and used to discover a potent and selective binder for the protein PD-L1. The cover image shows an artistic representation of a suprabody interacting with PD-L1.
發(fā)現(xiàn)調節(jié)生物分子功能的配體可以通過使用將合成分子的功能與可擴增的核酸標簽聯(lián)系起來的DNA編碼文庫來實現(xiàn)。這些技術沒有充分利用達爾文選擇的原則，但現(xiàn)在由Nicolas Winssinger領導的團隊開發(fā)了一種策略來組裝經(jīng)歷選擇、放大和多樣化迭代循環(huán)的類大環(huán)結構（Dsuprabodies）。該方法通過針對鏈霉親和素的選擇進行驗證，并用于發(fā)現(xiàn)蛋白質PD-L1的有效和選擇性結合劑。封面圖片展示了超體與PD-L1相互作用的藝術表現(xiàn)。
1.A mating mechanism to generate diversity for the Darwinian selection of DNA-encoded synthetic molecules.
為DNA編碼的合成分子的達爾文式選擇產生多樣性的交配機制。
2.Observation of robust energy transfer in the photosynthetic protein allophycocyanin using single-molecule pump–probe spectroscopy.
用單分子泵探針光譜法觀察光合蛋白異花青中的強大能量傳遞。
3.Amino-oxetanes as amide isosteres by an alternative defluorosulfonylative coupling of sulfonyl fluorides.
氨基氧烷通過磺酰氟的另一種去氟磺化偶聯(lián)作為酰胺類異物。
4.Cyanide as a primordial reductant enables a protometabolic reductive glyoxylate pathway.
氰化物作為原始還原劑實現(xiàn)了原生代謝還原糖醛酸的途徑。
5.A chiral interlocking auxiliary strategy for the synthesis of mechanically planar chiral rotaxanes.
一種手性聯(lián)鎖輔助策略，用于合成機械平面手性羅丹。
6.Directing-group-free catalytic dicarbofunctionalization of unactivated alkenes.
未被激活的烯類的無指導基團的催化二重功能化。
7.Deciphering how naturally occurring sequence features impact the phase behaviours of disordered prion-like domains.
解讀自然發(fā)生的序列特征如何影響無序的朊病毒樣結構的相行為。
8.Continuous, autonomous subsurface cargo shuttling by nature-inspired meniscus-climbing systems.
自然啟發(fā)的半月板爬行系統(tǒng)的連續(xù)、自主的表面下貨物穿梭。
9.Arene radiofluorination enabled by photoredox-mediated halide interconversion.
光氧化劑介導的鹵化物相互轉化實現(xiàn)了烯的放射性氟化。
10.Release of linker histone from the nucleosome driven by polyelectrolyte competition with a disordered protein.
聚電解質與無序蛋白的競爭驅動核糖體中連接組蛋白的釋放。
11.Ultrafast energy transfer between π-stacked aromatic rings upon inner-valence ionization.
內價電離時π型堆疊芳香環(huán)之間的超快能量轉移。
電子轉移的新扭曲
Understanding and controlling the rate at which electrons are transferred across solid–liquid interfaces is critical to developing efficient processes for the interconversion of electrical and chemical energy. Now, Bediako and colleagues have shown that the interfacial electrochemical kinetics of two stacked layers of graphene can be modified by varying the ‘twist’ angle between them, with the greatest enhancement observed near the ‘magic angle’ (~1.1°). The cover depicts an artistic representation of electron transfer from twisted bilayer graphene to Ru(NH3)6 3+ — the redox-active molecule used in these studies.
了解和控制電子在固-液界面上傳輸?shù)乃俾蕦τ陂_發(fā)電能和化學能相互轉換的高效過程至關重要?，F(xiàn)在，Bediako及其同事表明，可以通過改變它們之間的“扭曲”角來修改兩層堆疊石墨烯的界面電化學動力學，在“魔角”(~1.1°) 附近觀察到最大增強。封面描繪了電子從扭曲的雙層石墨烯轉移到Ru(NH3)6 3+（這些研究中使用的氧化還原活性分子）的藝術表現(xiàn)。
1.Tunable angle-dependent electrochemistry at twisted bilayer graphene with moiré flat bands.
扭曲的雙層石墨烯的可調控角度依賴的電化學與摩爾平帶。
2.Phase-separating peptides for direct cytosolic delivery and redox-activated release of macromolecular therapeutics.
相分離肽用于大分子治療藥物的直接細胞傳遞和氧化還原激活釋放。
3.Tricyclic cell-penetrating peptides for efficient delivery of functional antibodies into cancer cells.
三環(huán)細胞穿透肽用于將功能性抗體有效送入癌細胞。
4.Towards high-performance sustainable polymers via isomerization-driven irreversible ring-opening polymerization of five-membered thionolactones.
通過異構化驅動的五元噻吩內酯的不可逆開環(huán)聚合實現(xiàn)高性能可持續(xù)聚合物。
5.Concurrent control over sequence and dispersity in multiblock copolymers.
多嵌段共聚物中序列和分散性的同時控制。
6.Engineering an efficient and enantioselective enzyme for the Morita–Baylis–Hillman reaction.
為Morita-Baylis-Hillman反應設計一種高效的對映選擇性酶。
7.A photosensitizer–polyoxometalate dyad that enables the decoupling of light and dark reactions for delayed on-demand solar hydrogen production.
一種光敏劑-多氧金屬酸鹽的組合，使光和暗反應脫鉤，用于延遲的按需太陽能制氫。
8.Stabilization of intermediate spin states in mixed-valent diiron dichalcogenide complexes.
混合價二鐵二氯化物復合物中中間自旋態(tài)的穩(wěn)定化。
9.Scalable and selective deuteration of (hetero)arenes.
可擴展的、有選擇性的（雜）烯類的脫硫。
10.A terminal neptunium(V)–mono(oxo) complex.
終端镎（V）-單（氧）復合物。
11.An RNA-cleaving threose nucleic acid enzyme capable of single point mutation discrimination.
一種能夠識別單點突變的RNA裂解蘇糖核酸酶。
Two-dimensional layers of boron atoms have been grown on a variety of surfaces, typically noble metals. Borophene sheets can form different polymorphs with different properties, which is attractive for applications, but for practical use larger flakes with weaker metal–substrate interactions are required. Now, Rongting Wu, Sohrab Ismail-Beigi, Ivan Bo?ovi? and co-workers have synthesized micrometre-scale single-crystalline borophene on a square-lattice Cu(100) surface. The cover image depicts a continuous transition from the experimental scanning tunnelling microscopy (STM) topography, to the simulated STM image, to the atomic model of this borophene polymorph that adopts a rectangular unit cell.
硼原子的二維層已經(jīng)生長在各種表面上，通常是貴金屬。硼烯片可以形成具有不同性質的不同多晶型物，這對應用很有吸引力，但對于實際應用來說，需要更大的薄片和更弱的金屬-基材相互作用?，F(xiàn)在，Rongting Wu、Sohrab Ismail-Beigi、Ivan Bo?ovi?及其同事在方晶格Cu(100)表面上合成了微米級單晶硼烯。封面圖片描繪了從實驗掃描隧道顯微鏡(STM)形貌到模擬STM圖像，再到采用矩形晶胞的這種硼烯多晶型物的原子模型的連續(xù)過渡。
1.Micrometre-scale single-crystalline borophene on a square-lattice Cu(100) surface.
方格Cu(100)表面上的微米級單晶硼烯。
2.Direct conversion of white phosphorus to versatile phosphorus transfer reagents via oxidative onioation.
白磷通過氧化反應直接轉化為多功能的磷轉移試劑。
3.A 9.2-GHz clock transition in a Lu(II) molecular spin qubit arising from a 3,467-MHz hyperfine interaction.
Lu(II)分子自旋量子軌道中由3,467-MHz超正弦相互作用產生的9.2-GHz時鐘轉換。
4.Reversible C–C bond formation using palladium catalysis.
利用鈀的催化作用形成可逆的C-C鍵。
5.Charge-density reduction promotes ribozyme activity in RNA–peptide coacervates via RNA fluidization and magnesium partitioning.
電荷密度降低通過RNA流化和鎂分配促進RNA-肽共存物中核酸酶的活性。
6.Fast CO2 hydration kinetics impair heterogeneous but improve enzymatic CO2 reduction catalysis.
快速的二氧化碳水化動力學損害了異質性但改善了酶法二氧化碳還原催化。
7.Catalytic remote hydrohalogenation of internal alkenes.
催化內部烯類的遠程氫鹵化。
8.Self-assembly of polyoxometalate clusters into two-dimensional clusterphene structures featuring hexagonal pores.
多氧金屬簇的自組裝成具有六方孔的二維簇芬結構。
9.Quantum–classical simulations of rhodopsin reveal excited-state population splitting and its effects on quantum efficiency.
熒光素的量子經(jīng)典模擬揭示了激發(fā)態(tài)群體分裂及其對量子效率的影響。
10.Total synthesis of nine longiborneol sesquiterpenoids using a functionalized camphor strategy.
采用功能化樟腦策略全合成九種長角鯊烯類化合物。
11.Multilayer stacks of polycyclic aromatic hydrocarbons.
多環(huán)芳烴的多層堆疊。
12.Stereodefined alkenes with a fluoro-chloro terminus as a uniquely enabling compound class.
帶有氟-氯末端的立體定義的烯類是一個獨特的使能化合物類別。
Photocatalysis is often limited by the molecular integrity of the photocatalyst and although instability can be managed by replacing the inactive photocatalyst with a new one, repairing the damaged system can be a more cost-effective strategy. Now, Rau, Dietzek-Ivan?i? and colleagues have shown that a hydrogen-evolving photocatalyst that contains photoactive and catalytic components connected by an aromatic bridging ligand can be repaired. The bridge is inactivated through hydrogenation, which inhibits intramolecular electron transfer and prevents the system functioning as a photocatalyst. The inactivated bridge can be repaired by reoxidation, however, which restores the photocatalytic function. The cover depicts the photocatalyst working as desired on the left and undergoing bridge repairs on the right.
光催化通常受到光催化劑分子完整性的限制，雖然可以通過用新的光催化劑替換非活性光催化劑來控制不穩(wěn)定性，但修復受損系統(tǒng)可能是一種更具成本效益的策略。現(xiàn)在，Rau、Dietzek-Ivan?i?及其同事表明，可以修復一種放氫光催化劑，該催化劑包含通過芳香橋接配體連接的光活性和催化成分。該橋通過氫化作用失活，從而抑制分子內電子轉移并阻止系統(tǒng)發(fā)揮光催化劑的作用。然而，失活的橋可以通過再氧化進行修復，從而恢復光催化功能。封面左側描繪了光催化劑按預期工作，右側描繪了正在進行橋梁修復的情況。
1.Active repair of a dinuclear photocatalyst for visible-light-driven hydrogen production.
二核光催化劑的活性修復，用于可見光驅動的氫氣生產。
2.Porous covalent organic nanotubes and their assembly in loops and toroids.
多孔共價有機納米管及其在環(huán)形和環(huán)形中的組裝。
3.Frequency chasing of individual megadalton ions in an Orbitrap analyser improves precision of analysis in single-molecule mass spectrometry.
在Orbitrap分析儀中對單個兆質子的追頻提高了單分子質譜分析的精度。
4.Atomic control of active-site ensembles in ordered alloys to enhance hydrogenation selectivity.
原子控制有序合金中的活性位點組合以提高氫化的選擇性。
5.Insights from an information thermodynamics analysis of a synthetic molecular motor.
合成分子馬達的信息熱力學分析的啟示。
6.Mapping partial wave dynamics in scattering resonances by rotational de-excitation collisions.
通過旋轉去激發(fā)碰撞繪制散射共振中的部分波動力學圖。
7.Fermi-phase-induced interference in the reaction between Cl and vibrationally excited CH3D.
Cl和振動激發(fā)的CH3D反應中的費米相誘導干擾。
8.Cobalt(II)–tetraphenylporphyrin-catalysed carbene transfer from acceptor–acceptor iodonium ylides via N-enolate–carbene radicals.
鈷(II)-四苯基卟啉催化的受體-受體碘化物通過N-烯醇-碳烯自由基的碳烯轉移。
9.Single-particle combinatorial multiplexed liposome fusion mediated by DNA.
由DNA介導的單顆粒組合式多路脂質體融合。
a，目標脂質體與PLL-PEG（聚（L-賴氨酸）-g-聚（乙二醇））鈍化表面的典型顯微照片。 不同的強度源自脂質體的多分散尺寸分布。 卡通表示說明了在單粒子水平上監(jiān)測的隨機融合事件，可用于使用TIRF顯微鏡和自動數(shù)據(jù)分析以隨機和多路復用的方式檢測數(shù)千個單獨的DNA可編程脂質體融合事件。t代表目標脂質體。貨物脂質體的內腔數(shù)字代表不同的貨物群體。t-1、t-2、...代表融合的隨機序列，導致不同的產品脂質體。比例尺，10μm。b，目標脂質體，每個載有六個LiNA序列（紅色，標記為A-F），被固定在表面上。自由擴散的貨物脂質體，每個都用六種互補的LiNA（藍色，A'-F'）中的一種功能化，用最多三種類型的熒光標記脂質的不同比例進行條形碼標記。這導致6個不同的條形碼表示為相對RGB比率，它們很容易擴展到10個不同的條形碼和多達11個互補的LiNA序列對（參見補充圖 5 和 6）。
10.Stereocontrolled 1,3-nitrogen migration to access chiral α-amino acids.
立體控制的1,3-氮遷移以獲得手性α-氨基酸。
11.Cold photo-carving of halogen-bonded co-crystals of a dye and a volatile co-former using visible light.
利用可見光對染料和揮發(fā)性共成型物的鹵素鍵合晶體進行冷光雕刻。
Stability issues currently prevent the practical application of nickel-rich layered oxides as cathodes in next-generation lithium batteries. Now, Kang, Park and colleagues have studied the solid-state synthesis of LiNi0.6Co0.2Mn0.2O2 (NCM622) using multiscale in situ techniques and show that kinetic competition between precursor decomposition and lithiation leads to spatially heterogeneous intermediates and the formation of detrimental defects. The image on the cover depicts the heterogeneous intermediates captured during the synthesis of NCM622 from a precursor mixture of transition-metal hydroxides and lithium hydroxides. The lithium atoms are shown as blue spheres, transition-metal atoms (Ni, Co and Mn) as brown spheres, and hydrogen and oxygen atoms are white and red, respectively.
目前，穩(wěn)定性問題阻礙了富鎳層狀氧化物作為陰極在下一代鋰電池中的實際應用?，F(xiàn)在，Kang、Park 及其同事使用多尺度原位技術研究了LiNi0.6Co0.2Mn0.2O2 (NCM622)的固態(tài)合成，并表明前體分解和鋰化之間的動力學競爭導致空間異質中間體和有害物質的形成缺陷。封面圖片描繪了在從過渡金屬氫氧化物和氫氧化鋰的前體混合物合成NCM622過程中捕獲的非均相中間體。鋰原子顯示為藍色球體，過渡金屬原子（Ni、Co 和 Mn）顯示為棕色球體，氫原子和氧原子分別顯示為白色和紅色。
1.In situ multiscale probing of the synthesis of a Ni-rich layered oxide cathode reveals reaction heterogeneity driven by competing kinetic pathways.
對富含鎳的層狀氧化物陰極合成的原位多尺度探測揭示了由競爭的動力學途徑驅動的反應異質性。
2.Environmental conditions drive self-organization of reaction pathways in a prebiotic reaction network.
環(huán)境條件驅動了前生物反應網(wǎng)絡中反應途徑的自我組織。
3.Low-valent tungsten redox catalysis enables controlled isomerization and carbonylative functionalization of alkenes.
低價鎢的氧化還原催化作用使烯烴的異構化和羰基化得到控制。
4.E- and Z-trisubstituted macrocyclic alkenes for natural product synthesis and skeletal editing.
E-和Z-三取代的大環(huán)烯用于天然產品合成和骨架編輯。
5.Parallel transmission in a synthetic nerve.
合成神經(jīng)中的平行傳輸。
6.Anisotropic dynamics of resonant scattering between a pair of cold aligned diatoms.
一對冷排列的硅藻之間的共振散射的各向異性動力學。
7.Glory scattering in deeply inelastic molecular collisions.
深度非彈性分子碰撞中的光輝散射。
8.Photogearing as a concept for translation of precise motions at the nanoscale.
作為納米級精確運動轉換概念的光齒輪。
9.Serial crystallography captures dynamic control of sequential electron and proton transfer events in a flavoenzyme.
串行晶體學捕捉到一個黃酶中電子和質子連續(xù)轉移事件的動態(tài)控制。
10.Halogen-bond-assisted radical activation of glycosyl donors enables mild and stereoconvergent 1,2-cis-glycosylation.
鹵素鍵輔助的糖基供體的自由基活化使1,2-順式糖基化變得溫和和立體逆轉。
11.Fabrication of devices featuring covalently linked MoS2–graphene heterostructures.
以共價連接的MoS2-石墨烯異質結構為特征裝置的制造。
12.Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria.
生物合成基因簇的全球分析揭示了昆蟲病原線蟲-共生細菌中保守和獨特的天然產物。
