膽固醇-聚乙二醇-胺基CLS-PEG-NH2/CHOL-PEG-NH2利用非常穩(wěn)定的化學鍵，通過醚鍵或酰胺鍵將膽固醇和胺連接到聚乙二醇上。與在水溶液中容易水解的酯鍵不同，膽固醇和PEG之間的醚鍵具有化學穩(wěn)定性。膽固醇是一種膜成分，具有調(diào)節(jié)膜流動性、彈性和滲透性的功能。當?shù)鞍踪|(zhì)嵌入膜中時，它填補了其他脂質(zhì)物種堆積形成的空隙。為華生物膽固醇聚乙二醇氨基CLS-PEG-NH2的應(yīng)用：CLS-PEG-NH2（膽固醇聚乙二醇胺）是一種具有良好水溶性的親脂性脂質(zhì)PEG綴合物。PEG膽固醇衍生物可用于制備脂質(zhì)體以改善包封藥物的循環(huán)時間，它們也可用于非病毒轉(zhuǎn)染試劑。聚乙二醇化膽固醇作為一種兩親性脂質(zhì)衍生物，可用于制備脂質(zhì)體和其他膠束作為藥物傳遞系統(tǒng)，用于藥物修飾或緩釋藥物研發(fā)，新型材料探究。

用水溶性單甲氧基聚乙二醇2000 (mPEG2000)通過小分子的胺與膽固醇連接,制備mPEG2000修飾的膽固醇衍生物。該衍生物可以作為多種制劑的輔料,如作為表面活性劑用來制備水溶液分散體：納米乳劑,納米脂質(zhì)體；也可以作為載體成分之一用來制備能分散于水的膠束、固體脂質(zhì)納米粒；還可以作為長循環(huán)納米、溫度或pH敏感性納米載體的成分之一。

注意事項：CLS-PEG-NH2（膽固醇聚乙二醇胺）材料易吸潮，取用前需放置室溫后再打開包裝取用防止吸潮，吸潮后活性會降低直至完全失去活性，請務(wù)必保持干燥，同時盡量避免頻繁的溶解和凍干。

Cholesterol polyethylene glycol amine cls-peg-nh2 / chol-peg-nh2 uses very stable chemical bonds to connect cholesterol and amine to polyethylene glycol through ether or amide bonds. Unlike the ester bond that is easily hydrolyzed in aqueous solution, the ether bond between cholesterol and peg is chemically stable. Cholesterol is a membrane component with the function of regulating membrane fluidity, elasticity and permeability. When the protein is embedded in the membrane, it fills the gap formed by the accumulation of other lipid species. Application of cholesterol polyethylene glycol amino cls-peg-nh2 of Weihua biology: cls-peg-nh2 (cholesterol polyethylene glycol amine) is a lipophilic lipid peg conjugate with good water solubility. Peg cholesterol derivatives can be used to prepare liposomes to improve the circulation time of encapsulated drugs, and they can also be used as non viral transfection reagents. As an amphiphilic lipid derivative, pegylated cholesterol can be used to prepare liposomes and other micelles as drug delivery systems, for drug modification or sustained-release drug development, and for new material exploration.

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Water soluble monomethoxy polyethylene glycol 2000 (mpeg2000) was linked to cholesterol through small molecule amine to prepare mpeg2000 modified cholesterol derivatives. The derivatives can be used as excipients of various preparations, such as surfactants to prepare aqueous dispersion: nano emulsions, nano liposomes; It can also be used as one of the carrier components to prepare micelles and solid lipid nanoparticles that can be dispersed in water; It can also be used as one of the components of long cycle nano, temperature or pH sensitive nanocarriers.

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Precautions: cls-peg-nh2 (cholesterol polyethylene glycol amine) material is easy to absorb moisture. Before taking it, it needs to be placed at room temperature before opening the package to prevent moisture absorption. After moisture absorption, the activity will decrease until it completely loses its activity. Please keep it dry and try to avoid frequent dissolution and lyophilization.