COOH-PEG-COOH聚乙二醇二羧酸是官能化的聚乙二醇（cooh-peg-cooh），是一種雙功能PEG衍生物。COOH-PEG-COOH聚乙二醇二羧酸PH值：2.1 (100g/l, H2O)，閃點(diǎn)：華氏：572 °F攝氏：300 °C，密度：1.191 g/mL at 25 °C

COOH-PEG-COOH是一類同雙官能團(tuán)修飾劑，可用于修飾蛋白質(zhì)、氨基或其他酸反應(yīng)的化學(xué)基團(tuán)的肽和其他材料?？捎糜诎邢蛩幬镅芯坎V泛應(yīng)用于蛋白載體及配基的交聯(lián)等。PEG末端的羥端基被羧基取代，主要強(qiáng)調(diào)利用羧基和羥基發(fā)生酯化反應(yīng)形成酯鍵,與氨基發(fā)生的親和取代反應(yīng)形成酰胺等的羧基特性，從而有效地將PEG鏈接到所需材料或小分子藥物及多肽上去，以達(dá)到反應(yīng)的目的。

COOH-PEG-COOH is a kind of bifunctional modifier, which can be used to modify peptides and other materials of proteins, amino groups or other acid reaction chemical groups. It can be used in targeted drug research and widely used in protein carriers and cross-linking of ligands. The hydroxyl terminal group at the end of PEG is replaced by carboxyl group, which mainly emphasizes the carboxyl group characteristics of ester bond formed by esterification reaction between carboxyl group and hydroxyl group, and amide formed by affinity substitution reaction with amino group, so as to effectively link peg to the required materials or small molecule drugs and polypeptides to achieve the purpose of reaction.

PEG修飾可提高溶解度和穩(wěn)定性，減少蛋白質(zhì)和肽的免疫原性。它也可以抑制電荷的分子改性表面的非特異性結(jié)合。

注意事項(xiàng)：材料COOH-PEG-COOH聚乙二醇二羧酸易吸潮，取用前需放置室溫后再打開包裝取用防止吸潮，吸潮后活性會(huì)降低直至完全失去活性，請(qǐng)務(wù)必保持干燥，同時(shí)盡量避免頻繁的溶解和凍干。