貨號(hào)：DHC21901
產(chǎn)品鏈接：http://www.antibodysystem.com/product/188.html
寄主物種：Human
形式：Liquid
存儲(chǔ)緩沖區(qū)：0.01M?PBS,?pH?7.4.
濃度：1?mg/ml
純度：>95%?by?SDS-PAGE.
克隆性：Monoclonal
應(yīng)用：Research?Grade?Biosimilar
介紹：Abituzumab是一種人源化抗?integrin?αV?單克隆抗體?(IgG2?型)。Abituzumab?能有效減少?FAK、?Akt?和?ERK?的磷酸化。Abituzumab?可用于癌癥，尤其是前列腺癌的研究。
儲(chǔ)存：Use?a?manual?defrost?freezer?and?avoid?repeated?freeze-thaw?cycles.Store?at?+4°C?short?term?(1-2?weeks).Store?at?-20?°C?12?months.?Store?at?-80°C?long?term.
Hotline：027-65279366
參考文獻(xiàn)：
Abituzumab?Targeting?of?αV-Class?Integrins?Inhibits?Prostate?Cancer?Progression.?PMID:?28314844
STRATUS:?A?Phase?II?Study?of?Abituzumab?in?Patients?With?Systemic?Sclerosis-associated?Interstitial?Lung?Disease.?PMID:?33004536
Abituzumab?combined?with?cetuximab?plus?irinotecan?versus?cetuximab?plus?irinotecan?alone?for?patients?with?KRAS?wild-type?metastatic?colorectal?cancer:?the?randomised?phase?I/II?POSEIDON?trial.?PMID:?25319061
Differential?Effect?on?Bone?Lesions?of?Targeting?Integrins:?Randomized?Phase?II?Trial?of?Abituzumab?in?Patients?with?Metastatic?Castration-Resistant?Prostate?Cancer.?PMID:?26839144
Integrins?as?A?New?Target?for?Cancer?Treatment.?PMID:?30451118
Integration?of?NMR?Spectroscopy?in?an?Analytical?Workflow?to?Evaluate?the?Effects?of?Oxidative?Stress?on?Abituzumab:?Beyond?the?Fingerprint?of?mAbs.?PMID:?37278511
Integrin?Inhibitors?in?Prostate?Cancer.?PMID:?29415418
Integrins?as?Therapeutic?Targets:?Successes?and?Cancers.?PMID:?28832494
A?novel?therapeutic?option?for?castration-resistant?prostate?cancer:?after?or?before?chemotherapy??PMID:?23838638
Ongoing?clinical?trials?and?treatment?options?for?patients?with?systemic?sclerosis-associated?interstitial?lung?disease.?PMID:?29893938
Enhanced?drug?targeting?by?attachment?of?an?anti?alphav?integrin?antibody?to?doxorubicin?loaded?human?serum?albumin?nanoparticles.?PMID:?20031203
Safety,?tolerability,?and?pharmacokinetics?of?the?novel?αv-integrin?antibody?EMD?525797?(DI17E6)?in?healthy?subjects?after?ascending?single?intravenous?doses.?PMID:?24242902
A?multicenter?phase?1?study?of?EMD?525797?(DI17E6),?a?novel?humanized?monoclonal?antibody?targeting?αv?integrins,?in?progressive?castration-resistant?prostate?cancer?with?bone?metastases?after?chemotherapy.?PMID:?23791392