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【熱門產(chǎn)品推薦】替利組單抗,Teplizumab, AntibodySystem Laboratories

2023-06-15 10:44 作者:AtaGenix-普健生物  | 我要投稿

替利組單抗,Teplizumab,CAS: 876387-05-2,AntibodySystem Laboratories

貨號(hào):DHC27703

產(chǎn)品鏈接:http://www.atagenix.com/product_detail-75401.html

別名:A-031 / MGA031, PRV-031, CAS: 876387-05-2

簡(jiǎn)介:MGTeplizumab (MGA-031)是一種Fc受體型、非結(jié)合類型的抗-人CD3的單克隆抗體。Teplizumab 可緩解β細(xì)胞的功能喪失。Teplizumab可用于type 1型糖尿病的研究。

貨號(hào):DHC27703

產(chǎn)品品牌:Antibodysystem

通用名:Teplizumab

純度:>95% by SDS-PAGE.

濃度:1mg/ml

Formulationicon:0.01M PBS, pH 7.4.

內(nèi)毒素:Please contact with the lab for this information.

別名:MGA-031 / MGA031, PRV-031

靶點(diǎn);物種:Human CD3E

種類:Humanized

受體鑒定:IgG1-kappa

CAS: 876387-05-2

存儲(chǔ)條件:

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.

參考文獻(xiàn):

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Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals. PMID: 33658358

Teplizumab. PMID: 36795904

Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial. PMID: 21719095

Safety and Efficacy of Teplizumab for Treatment of Type One Diabetes Mellitus: A Systematic Review and Meta-Analysis. PMID: 33302842

Teplizumab: First Approval. PMID: 36877454

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Teplizumab Improves Beta Cell Function, Delays Type 1 Diabetes. PMID: 33847731

Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders. PMID: 23835333

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The Deterrence of Rapid Metabolic Decline Within 3 Months After Teplizumab Treatment in Individuals at High Risk for Type 1 Diabetes. PMID: 34551936

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Teplizumab treatment may improve C-peptide responses in participants with type 1 diabetes after the new-onset period: a randomised controlled trial. PMID: 23086558

Teplizumab induces human gut-tropic regulatory cells in humanized mice and patients. PMID: 22277969

Changing the landscape for type 1 diabetes: the first step to prevention. PMID: 31533907

Recent Advances in Immune-based Therapies for Type 1 Diabetes. PMID: 35533645

Treatment of type 1 diabetes with teplizumab: clinical and immunological follow-up after 7 years from diagnosis. PMID: 30569273

Changes in T-cell subsets identify responders to FcR-nonbinding anti-CD3 mAb (teplizumab) in patients with type 1 diabetes. PMID: 26518356

Association possible entre l’acidocétose diabétique et l’utilisation d’un inhibiteur du sodium-glucose co-transporteur 2 chez un jeune de 17 ans atteint de diabète de type 2. PMID: 34782384

Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years. PMID: 19443276

Partial exhaustion of CD8 T cells and clinical response to teplizumab in new-onset type 1 diabetes. PMID: 28664195

Timing of Immunotherapy in Type 1 Diabetes: The Earlier, the Better? PMID: 34261674

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Immunomodulators: Cell savers. PMID: 22616095

Traveling down the Long Road to Type 1 Diabetes Mellitus Prevention. PMID: 31180193

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Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes. PMID: 32833543

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Anti-CD3 drug keeps diabetes at bay. PMID: 31578500

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Anti-CD3 Antibody for the Prevention of Type 1 Diabetes: A Story of Perseverance. PMID: 31523950

Prospects for therapeutic tolerance in humans. PMID: 24378931

Enforcing the checkpoints: harnessing T-cell exhaustion for therapy of T1D. PMID: 31157632

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An improved clinical model to predict stimulated C-peptide in children with recent-onset type 1 diabetes. PMID: 30556344

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improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes. PMID: 15919798

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