聲明：本專(zhuān)欄主要對(duì)生命科學(xué)領(lǐng)域的一些期刊文章標(biāo)題進(jìn)行翻譯，所有內(nèi)容均由本人手工整理翻譯。由于本人專(zhuān)業(yè)為生物分析相關(guān)，其他領(lǐng)域如果出現(xiàn)翻譯錯(cuò)誤請(qǐng)諒解。

1.Integrated proteomic and transcriptomic landscape of macrophages in mouse tissues.

小鼠組織中巨噬細(xì)胞的綜合蛋白質(zhì)組和轉(zhuǎn)錄組景觀。

2.Deciphering the heterogeneity of the Lyve1+ perivascular macrophages in the mouse brain.

解讀小鼠大腦中Lyve1+血管周?chē)奘杉?xì)胞的異質(zhì)性。

3.A Shigella sonnei clone with extensive drug resistance associated with waterborne outbreaks in China.

一個(gè)具有廣泛抗藥性的志賀氏菌克隆與中國(guó)的水傳播疾病爆發(fā)有關(guān)。

4.Host-dependent resistance of Group A Streptococcus to sulfamethoxazole mediated by a horizontally-acquired reduced folate transporter.

A組鏈球菌對(duì)磺胺甲噁唑的依賴(lài)性抗性由水平獲得的還原葉酸轉(zhuǎn)運(yùn)體介導(dǎo)。

5.Structures of the R-type human CAV2.3 channel reveal conformational crosstalk of the intracellular segments.

R型人類(lèi)CAV2.3通道的結(jié)構(gòu)顯示了細(xì)胞內(nèi)段的構(gòu)象串聯(lián)。

6.HTLV-1 infection of donor-derived T cells might promote acute graft-versus-host disease following liver transplantation.

HTLV-1感染供體來(lái)源的T細(xì)胞可能會(huì)促進(jìn)肝移植后的急性移植物抗宿主疾病。

7.Spatially resolved proteomics via tissue expansion.

通過(guò)組織擴(kuò)張的空間分辨率蛋白質(zhì)組學(xué)。

8.Analysis of the first genetic engineering attribution challenge.

對(duì)第一個(gè)基因工程歸屬挑戰(zhàn)的分析。

9.Cell type diversity in a developing octopus brain.

發(fā)育中的章魚(yú)大腦的細(xì)胞類(lèi)型多樣性。

10.The E3 ubiquitin ligase WWP2 regulates pro-fibrogenic monocyte infiltration and activity in heart fibrosis.

E3泛素連接酶WWP2調(diào)控心臟纖維化中促纖維化單核細(xì)胞的浸潤(rùn)和活動(dòng)。

11.Self-cleaving guide RNAs enable pharmacological selection of precise gene editing events in vivo.

自裂導(dǎo)引RNA使體內(nèi)精確基因編輯事件的藥理選擇成為可能。

12.Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential.

原發(fā)性前列腺癌中廣泛的雄性激素受體增強(qiáng)子異質(zhì)性是轉(zhuǎn)錄多樣性和轉(zhuǎn)移潛力的基礎(chǔ)。

13.Automated high-throughput genome editing platform with an AI learning in situ prediction model.

帶有人工智能學(xué)習(xí)原位預(yù)測(cè)模型的自動(dòng)化高通量基因組編輯平臺(tái)。

14.Whole-exome sequencing study identifies rare variants and genes associated with intraocular pressure and glaucoma.

全外顯子組測(cè)序研究確定了與眼內(nèi)壓和青光眼有關(guān)的罕見(jiàn)變體和基因。

15.Membrane-mediated protein interactions drive membrane protein organization.

膜介導(dǎo)的蛋白質(zhì)相互作用驅(qū)動(dòng)膜蛋白組織。

16.Time-resolved β-lactam cleavage by L1 metallo-β-lactamase.

L1金屬β-內(nèi)酰胺酶的時(shí)間分辨β-內(nèi)酰胺裂解。

17.Perfluorodecalin-based oxygenated emulsion as a topical treatment for chemical burn to the eye.

以全氟萘烷為基礎(chǔ)的含氧乳液作為眼部化學(xué)燒傷的局部治療方法。

18.Global distribution and climate sensitivity of the tropical montane forest nitrogen cycle.

熱帶山地森林氮素循環(huán)的全球分布和氣候敏感性.

19.A nuclease-mimetic platinum nanozyme induces concurrent DNA platination and oxidative cleavage to overcome cancer drug resistance.

一種核酸酶模擬鉑金納米酶誘導(dǎo)同時(shí)進(jìn)行的DNA排異和氧化裂解，以克服癌癥藥物抗性。

20.Post-covid medical complaints following infection with SARS-CoV-2 Omicron vs Delta variants.

感染SARS-CoV-2 Omicron與Delta變體后的醫(yī)療投訴。

21.Polymer nanoparticles pass the plant interface.

聚合物納米顆粒通過(guò)植物界面。

22.Human visual consciousness involves large scale cortical and subcortical networks independent of task report and eye movement activity.

人類(lèi)的視覺(jué)意識(shí)涉及大規(guī)模的皮質(zhì)和皮質(zhì)下網(wǎng)絡(luò)，與任務(wù)報(bào)告和眼動(dòng)活動(dòng)無(wú)關(guān)。

23.HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation.

HSP90-CDC37-PP5形成了一個(gè)激酶去磷酸化的結(jié)構(gòu)平臺(tái)。

24.Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma.

四重基因工程的自然殺傷細(xì)胞使多抗原靶向?qū)Χ喟l(fā)性骨髓瘤具有持久的抗腫瘤活性。

25.IL6 supports long-term expansion of hepatocytes in vitro.

IL6支持肝細(xì)胞在體外的長(zhǎng)期擴(kuò)張。

26.Evolutionary origins of the prolonged extant squamate radiation.

延長(zhǎng)現(xiàn)存魷魚(yú)輻射的進(jìn)化起源。

27.Genetically personalised organ-specific metabolic models in health and disease.

健康和疾病中的基因個(gè)性化器官特定代謝模型。

28.Engineering receptors in the secretory pathway for orthogonal signalling control.

分泌途徑中用于正交信號(hào)控制的工程受體。

29.Shedding light on the base-pair opening dynamics of nucleic acids in living human cells.

揭示活人細(xì)胞中核酸的堿基對(duì)開(kāi)放動(dòng)態(tài)。

30.Chronic stress causes striatal disinhibition mediated by SOM-interneurons in male mice.

慢性壓力導(dǎo)致雄性小鼠SOM-中間神經(jīng)元介導(dǎo)的紋狀體抑制。

31.Acousto-holographic reconstruction of whole-cell stiffness maps.

全細(xì)胞剛度圖的聲學(xué)全息重建。

32.EZH2-H3K27me3 mediated KRT14 upregulation promotes TNBC peritoneal metastasis.

EZH2-H3K27me3介導(dǎo)的KRT14上調(diào)促進(jìn)TNBC腹膜轉(zhuǎn)移。

33.A population-based serological study of post-COVID syndrome prevalence and risk factors in children and adolescents.

基于人群的兒童和青少年COVID后綜合征患病率和風(fēng)險(xiǎn)因素的血清學(xué)研究。

34.Reactive metal boride nanoparticles trap lipopolysaccharide and peptidoglycan for bacteria-infected wound healing.

活性金屬硼化物納米顆粒捕集脂多糖和肽聚糖促進(jìn)細(xì)菌感染的傷口愈合。

35.Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism.

溶酶體損傷驅(qū)動(dòng)線粒體蛋白質(zhì)組重塑并重新規(guī)劃巨噬細(xì)胞的免疫代謝。

36.Breast cancer plasticity is restricted by a LATS1-NCOR1 repressive axis.

乳腺癌的可塑性受到LATS1-NCOR1壓抑軸的限制。

37.Hydrophobicity of arginine leads to reentrant liquid-liquid phase separation behaviors of arginine-rich proteins.

精氨酸的疏水性導(dǎo)致了富含精氨酸的蛋白質(zhì)的返流性液-液相分離行為。

38.Altered tRNA processing is linked to a distinct and unusual La protein in Tetrahymena thermophila.

tRNA加工的改變與嗜熱四膜動(dòng)物中一種獨(dú)特的、不尋常的La蛋白有關(guān)。

39.Genomic basis of the giga-chromosomes and giga-genome of tree peony Paeonia ostii.

樹(shù)狀牡丹Paeonia ostii的千兆染色體和千兆基因組的基因組基礎(chǔ)。

40.DNA methylation-based classification of sinonasal tumors.

基于DNA甲基化的鼻竇腫瘤分類(lèi)。

41.SOTIP is a versatile method for microenvironment modeling with spatial omics data.

SOTIP是一種利用空間全息數(shù)據(jù)進(jìn)行微環(huán)境建模的通用方法。

42.A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiation.

p38α-BLIMP1信號(hào)通路對(duì)漿細(xì)胞分化至關(guān)重要。

43.PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment.

PCGF1-PRC1在造血細(xì)胞系承諾期間將染色質(zhì)壓制與DNA復(fù)制聯(lián)系起來(lái)。

44.Chromatin accessibility dynamics dictate renal tubular epithelial cell response to injury.

染色質(zhì)可及性動(dòng)態(tài)決定了腎小管上皮細(xì)胞對(duì)損傷的反應(yīng)。

45.Gene activation guided by nascent RNA-bound transcription factors.

新生RNA結(jié)合的轉(zhuǎn)錄因子引導(dǎo)基因激活。

46.Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas.

LATS1/2的失活驅(qū)動(dòng)管腔-基底可塑性，啟動(dòng)基底樣乳腺癌。

47.The fate of early perichondrial cells in developing bones.

發(fā)育中的骨骼中早期軟骨周?chē)?xì)胞的命運(yùn)。

48.Low-dose IL-2 reduces IL-21+ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes.

低劑量IL-2降低IL-21+T細(xì)胞頻率并誘導(dǎo)1型糖尿病的抗炎基因表達(dá)。

49.mTORC1 links pathology in experimental models of Still’s disease and macrophage activation syndrome.

mTORC1與斯蒂爾病和巨噬細(xì)胞激活綜合征實(shí)驗(yàn)?zāi)Ｐ偷牟±砺?lián)系。

50.Inflammation promotes resistance to immune checkpoint inhibitors in high microsatellite instability colorectal cancer.

炎癥促進(jìn)高微衛(wèi)星不穩(wěn)定性結(jié)直腸癌對(duì)免疫檢查點(diǎn)抑制劑的抵抗。

51.Extensive germline-somatic interplay contributes to prostate cancer progression through HNF1B co-option of TMPRSS2-ERG.

通過(guò)HNF1B對(duì)TMPRSS2-ERG的共同控制，廣泛的種系-體系相互作用有助于前列腺癌的進(jìn)展。

52.Active DNA damage response signaling initiates and maintains meiotic sex chromosome inactivation.

活躍的DNA損傷反應(yīng)信號(hào)啟動(dòng)并維持減數(shù)分裂性染色體失活。

53.Secreted EMC10 is upregulated in human obesity and its neutralizing antibody prevents diet-induced obesity in mice.

分泌的EMC10在人類(lèi)肥胖癥中上調(diào)，其中和抗體可防止飲食誘導(dǎo)的小鼠肥胖癥。

54.Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae.

大腦Aβ沉積和神經(jīng)退行性后遺癥的時(shí)間性不耦合的實(shí)驗(yàn)證據(jù)。

55.Plant genetic diversity affects multiple trophic levels and trophic interactions.

植物遺傳多樣性影響多種營(yíng)養(yǎng)水平和營(yíng)養(yǎng)相互作用。

56.Kinetochore- and chromosome-driven transition of microtubules into bundles promotes spindle assembly.

基因核和染色體驅(qū)動(dòng)的微管成束的轉(zhuǎn)變促進(jìn)了紡錘體的組裝。

57.Modular stimuli-responsive hydrogel sealants for early gastrointestinal leak detection and containment.

模塊化刺激反應(yīng)水凝膠密封劑用于早期胃腸道泄漏檢測(cè)和遏制。

58.Predicting protein function and orientation on a gold nanoparticle surface using a residue-based affinity scale.

利用基于殘基的親和力尺度預(yù)測(cè)金納米粒子表面的蛋白質(zhì)功能和取向。

59.Greater genetic diversity is needed in human pluripotent stem cell models.

人類(lèi)多能干細(xì)胞模型需要更大的遺傳多樣性。

60.CryoEM structure and assembly mechanism of a bacterial virus genome gatekeeper.

細(xì)菌病毒基因組守門(mén)員的低溫EM結(jié)構(gòu)和組裝機(jī)制。

61.Structural basis for lipid and copper regulation of the ABC transporter MsbA.

脂質(zhì)和銅對(duì)ABC轉(zhuǎn)運(yùn)體MsbA調(diào)節(jié)的結(jié)構(gòu)基礎(chǔ)。

62.Orthogonal glycolytic pathway enables directed evolution of noncanonical cofactor oxidase.

正交的糖酵解途徑使非經(jīng)典輔助因子氧化酶的定向進(jìn)化。

63.Decoding molecular programs in melanoma brain metastases.

解碼黑色素瘤腦轉(zhuǎn)移的分子程序。

64.Creb5 coordinates synovial joint formation with the genesis of articular cartilage.

Creb5協(xié)調(diào)滑膜關(guān)節(jié)的形成與關(guān)節(jié)軟骨的生成。

65.Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase.

真核生物低聚糖轉(zhuǎn)移酶的糖類(lèi)識(shí)別和反應(yīng)引物的分子基礎(chǔ)。

66.Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1.

RNA聚合酶II在含有連接物組蛋白H1的染色體上轉(zhuǎn)錄的結(jié)構(gòu)基礎(chǔ)。

67.Structural characterization of protective non-neutralizing antibodies targeting Crimean-Congo hemorrhagic fever virus.

針對(duì)克里米亞-剛果出血熱病毒的保護(hù)性非中和抗體的結(jié)構(gòu)特征。

68.ARID1A loss induces polymorphonuclear myeloid-derived suppressor cell chemotaxis and promotes prostate cancer progression.

ARID1A缺失誘導(dǎo)多形核髓源性抑制細(xì)胞趨化并促進(jìn)前列腺癌的進(jìn)展。

69.Characterisation of SARS-CoV-2 genomic variation in response to molnupiravir treatment in the AGILE Phase IIa clinical trial.

AGILE IIa期臨床試驗(yàn)中SARS-CoV-2基因組變異對(duì)莫尼帕韋治療反應(yīng)的特征。

70.Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1.

母體先鋒轉(zhuǎn)錄因子FoxH1的DNA識(shí)別的分子基礎(chǔ)。

71.Rad52’s DNA annealing activity drives template switching associated with restarted DNA replication.

Rad52的DNA退火活性驅(qū)動(dòng)與重新啟動(dòng)的DNA復(fù)制有關(guān)的模板切換。

72.Seroepidemiology of enterovirus A71 infection in prospective cohort studies of children in southern China, 2013-2018.

2013-2018年中國(guó)南方兒童前瞻性隊(duì)列研究中的腸道病毒A71感染血清流行病學(xué)。

73.Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins.

核糖體結(jié)合的HMGN蛋白對(duì)白色脂肪組織可塑性和能量代謝的表觀遺傳調(diào)節(jié)。

74.Increased fire activity under high atmospheric oxygen concentrations is compatible with the presence of forests.

高大氣氧濃度下火災(zāi)活動(dòng)的增加與森林的存在相適應(yīng)。

75.Varying strength of selection contributes to the intragenomic diversity of rRNA genes.

不同強(qiáng)度的選擇有助于rRNA基因的基因組內(nèi)多樣性。

76.Immune phenotypes that are associated with subsequent COVID-19 severity inferred from post-recovery samples.

從恢復(fù)后的樣本中推斷出與隨后的COVID-19嚴(yán)重程度有關(guān)的免疫表型。

77.Gating and ion selectivity of Channelrhodopsins are critical for photo-activated orientation of Chlamydomonas as shown by in vivo point mutation.

通過(guò)體內(nèi)點(diǎn)突變顯示Channelrhodopsins的門(mén)控和離子選擇性對(duì)衣藻的光活化定向至關(guān)重要。

78.Alveolar macrophage metabolic programming via a C-type lectin receptor protects against lipo-toxicity and cell death.

肺泡巨噬細(xì)胞通過(guò)C型凝集素受體進(jìn)行代謝編程，可防止脂質(zhì)毒性和細(xì)胞死亡。

79.mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity.

mTORC1信號(hào)傳導(dǎo)促進(jìn)不同干細(xì)胞分化以塑造發(fā)育中的小鼠肺部，并與線粒體能力有關(guān)。

80.Insights into protein post-translational modification landscapes of individual human cells by trapped ion mobility time-of-flight mass spectrometry.

通過(guò)捕獲的離子移動(dòng)性飛行時(shí)間質(zhì)譜對(duì)單個(gè)人類(lèi)細(xì)胞的蛋白質(zhì)翻譯后修飾景觀的深入了解。

81.A marine sponge-derived lectin reveals hidden pathway for thrombopoietin receptor activation.

一種源自海洋海綿的凝集素揭示了血小板生成素受體激活的隱藏途徑。

82.PICH acts as a force-dependent nucleosome remodeler.

PICH作為力依賴(lài)的核糖體重塑者。

83.Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity.

I型干擾素免疫的激活和調(diào)節(jié)缺陷與COVID-19嚴(yán)重程度的增加有關(guān)。

84.Reduced secretion of neuronal growth regulator 1 contributes to impaired adipose-neuronal crosstalk in obesity.

神經(jīng)元生長(zhǎng)調(diào)節(jié)劑1的分泌減少有助于肥胖癥中脂肪-神經(jīng)元串?dāng)_的受損。

85.Induction of cross-neutralizing antibodies by a permuted hepatitis C virus glycoprotein nanoparticle vaccine candidate.

一種經(jīng)過(guò)處理的丙型肝炎病毒糖蛋白納米顆粒候選疫苗誘導(dǎo)的交叉中和抗體。

86.A single-cell analysis reveals tumor heterogeneity and immune environment of acral melanoma.

單細(xì)胞分析顯示尖銳黑色素瘤的腫瘤異質(zhì)性和免疫環(huán)境。

87.circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment.

肉瘤中circCsnk1g3和circAnkib1調(diào)控的干擾素反應(yīng)通過(guò)塑造免疫微環(huán)境促進(jìn)腫瘤的發(fā)生。

88.Amyloid fibril structure from the vascular variant of systemic AA amyloidosis.

來(lái)自系統(tǒng)性AA淀粉樣變的血管變體的淀粉樣纖維結(jié)構(gòu)。

89.A soft and ultrasensitive force sensing diaphragm for probing cardiac organoids instantaneously and wirelessly.

用于即時(shí)和無(wú)線探測(cè)心臟器官的柔軟和超敏銳的力感應(yīng)膜片。

90.GPSM1 impairs metabolic homeostasis by controlling a pro-inflammatory pathway in macrophages.

GPSM1通過(guò)控制巨噬細(xì)胞的促炎癥途徑損害代謝平衡。

91.Low-dose AAV-CRISPR-mediated liver-specific knock-in restored hemostasis in neonatal hemophilia B mice with subtle antibody response.

低劑量AAV-CRISPR介導(dǎo)的肝臟特異性基因敲入恢復(fù)了新生兒血友病B型小鼠的止血功能，并有細(xì)微的抗體反應(yīng)。

92.The molecular organization of differentially curved caveolae indicates bendable structural units at the plasma membrane.

不同彎曲度的洞石的分子組織表明質(zhì)膜上的可彎曲結(jié)構(gòu)單元。

93.Evaluating cancer etiology and risk with a mathematical model of tumor evolution.

用腫瘤演變的數(shù)學(xué)模型評(píng)估癌癥病因和風(fēng)險(xiǎn)。

94.AlphaPeptDeep: a modular deep learning framework to predict peptide properties for proteomics.

AlphaPeptDeep：一個(gè)模塊化的深度學(xué)習(xí)框架，用于預(yù)測(cè)蛋白質(zhì)組學(xué)的肽屬性。

95.Resource sharing is sufficient for the emergence of division of labour.

資源共享對(duì)分工的出現(xiàn)是充分的。

96.Postnatal expansion of mesenteric lymph node stromal cells towards reticular and CD34+ stromal cell subsets.

產(chǎn)后腸系膜淋巴結(jié)基質(zhì)細(xì)胞向網(wǎng)狀和CD34+基質(zhì)細(xì)胞亞群的擴(kuò)展。

97.Integration of single-cell transcriptomes and biological function reveals distinct behavioral patterns in bone marrow endothelium.

單細(xì)胞轉(zhuǎn)錄組和生物功能的整合揭示了骨髓內(nèi)皮細(xì)胞的不同行為模式。

98.High-resolution reconstruction of a Jumbo-bacteriophage infecting capsulated bacteria using hyperbranched tail fibers.

利用超分支的尾部纖維高分辨率重建感染膠囊細(xì)菌的巨型噬菌體。

99.Genomic disparities between cancers in adolescent and young adults and in older adults.

青少年和年輕人以及老年人的癌癥之間的基因組差異。

100.Enhanced access to the human phosphoproteome with genetically encoded phosphothreonine.

用基因編碼的磷酸蘇氨酸加強(qiáng)對(duì)人類(lèi)磷蛋白組的訪問(wèn)。

101.High-throughput screening of caterpillars as a platform to study host–microbe interactions and enteric immunity.

以毛蟲(chóng)的高通量篩選作為研究宿主-微生物相互作用和腸道免疫的平臺(tái)。

102.Global landscape of replicative DNA polymerase usage in the human genome.

人類(lèi)基因組中復(fù)制性DNA聚合酶使用的全球情況。

103.Critical Offset Magnetic PArticle SpectroScopy for rapid and highly sensitive medical point-of-care diagnostics.

用于快速和高度敏感的醫(yī)療點(diǎn)診斷的臨界偏移磁懸浮粒子光譜儀。

104.CXCL13 is a predictive biomarker in idiopathic multicentric Castleman disease.

CXCL13是特發(fā)性多中心卡斯?fàn)柭〉念A(yù)測(cè)性生物標(biāo)志物。

105.AMPK induces degradation of the transcriptional repressor PROX1 impairing branched amino acid metabolism and tumourigenesis.

AMPK誘導(dǎo)轉(zhuǎn)錄抑制器PROX1的降解，損害支鏈氨基酸的代謝和腫瘤的發(fā)生。

106.Hybrid chalcogen bonds in prodrug nanoassemblies provides dual redox-responsivity in the tumor microenvironment.

原藥納米組合中的混合黃銅鍵在腫瘤微環(huán)境中提供雙重氧化還原反應(yīng)。

107.Uptake mechanism of iron-phytosiderophore from the soil based on the structure of yellow stripe transporter.

基于黃色條紋轉(zhuǎn)運(yùn)體結(jié)構(gòu)的土壤中鐵-植物苷脂的吸收機(jī)制。

108.Primate-specific transposable elements shape transcriptional networks during human development.

靈長(zhǎng)類(lèi)特異性可轉(zhuǎn)錄元素在人類(lèi)發(fā)育過(guò)程中塑造轉(zhuǎn)錄網(wǎng)絡(luò)。

109.Spatially aware dimension reduction for spatial transcriptomics.

用于空間轉(zhuǎn)錄組學(xué)的空間感知降維。

110.A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometry.

一個(gè)類(lèi)錯(cuò)配的TCR通過(guò)一個(gè)非正統(tǒng)但功能齊全的結(jié)合幾何學(xué)繞過(guò)了MHC的限制。

111.Phase separation modulates the assembly and dynamics of a polarity-related scaffold-signaling hub.

相分離調(diào)控極性相關(guān)支架-信號(hào)樞紐的組裝和動(dòng)態(tài)。

112.Reversion mutations in germline BRCA1/2-mutant tumors reveal a BRCA-mediated phenotype in non-canonical histologies.

種系BRCA1/2突變腫瘤的逆轉(zhuǎn)突變揭示了非經(jīng)典組織學(xué)中BRCA介導(dǎo)的表型。

113.Comparison of antibody responses to SARS-CoV-2 variants in Australian children.

澳大利亞兒童對(duì)SARS-CoV-2變種的抗體反應(yīng)比較。

114.Kinetics of mRNA nuclear export regulate innate immune response gene expression.

mRNA核出口的動(dòng)力學(xué)調(diào)節(jié)先天免疫反應(yīng)基因的表達(dá)。

115.Construction of a synthetic methodology-based library and its application in identifying a GIT/PIX protein–protein interaction inhibitor.

基于合成方法的庫(kù)的構(gòu)建及其在鑒定GIT/PIX蛋白-蛋白相互作用抑制劑中的應(yīng)用。

116.Smc5/6’s multifaceted DNA binding capacities stabilize branched DNA structures.

Smc5/6的多方面DNA結(jié)合能力穩(wěn)定了支鏈DNA結(jié)構(gòu)。

117.Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis.

成骨細(xì)胞/造血干細(xì)胞衍生的白細(xì)胞介素-11調(diào)控成骨和系統(tǒng)性脂肪生成。

118.Compact zinc finger base editors that edit mitochondrial or nuclear DNA in vitro and in vivo.

在體外和體內(nèi)編輯線粒體或核DNA的緊湊型鋅指基編輯。

119.RNA-controlled nucleocytoplasmic shuttling of mRNA decay factors regulates mRNA synthesis and a novel mRNA decay pathway.

RNA控制的mRNA衰變因子的核細(xì)胞質(zhì)穿梭調(diào)節(jié)mRNA的合成和一種新的mRNA衰變途徑。

120.Differential compartmentalization of myeloid cell phenotypes and responses towards the CNS in Alzheimer’s disease.

阿爾茨海默病中骨髓細(xì)胞表型和對(duì)中樞神經(jīng)系統(tǒng)反應(yīng)的差異區(qū)劃。

121.Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model.

阿爾茨海默病相關(guān)的蛋白激酶Cα變體的活性增強(qiáng)促使小鼠模型的認(rèn)知能力下降。

122.Structure- and computational-aided engineering of an oxidase to produce isoeugenol from a lignin-derived compound.

一個(gè)氧化酶的結(jié)構(gòu)和計(jì)算輔助工程，從木質(zhì)素衍生的化合物中產(chǎn)生異丁香酚。

123.GhostKnockoff inference empowers identification of putative causal variants in genome-wide association studies.

GhostKnockoff推斷增強(qiáng)了全基因組關(guān)聯(lián)研究中推定因果變體的識(shí)別能力。

124.Multi-omics analysis identifies osteosarcoma subtypes with distinct prognosis indicating stratified treatment.

多組學(xué)分析確定了具有不同預(yù)后的骨肉瘤亞型，表明分層治療。

125.Polymeric micelles effectively reprogram the tumor microenvironment to potentiate nano-immunotherapy in mouse breast cancer models.

聚合物膠束有效地重塑了腫瘤微環(huán)境，增強(qiáng)了小鼠乳腺癌模型的納米免疫療法。

126.Genomic signatures of recent convergent transitions to social life in spiders.

蜘蛛近期向社會(huì)生活的趨同過(guò)渡的基因組特征。

127.High-precision estimation of emitter positions using Bayesian grouping of localizations.

利用貝葉斯定位分組對(duì)發(fā)射器位置進(jìn)行高精度估計(jì)。

128.Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature.

基于顯微鏡的金黃色葡萄球菌臨床分離物感染的表型分析揭示了細(xì)胞內(nèi)生活方式是一個(gè)普遍的特征。

129.Sampling of structure and sequence space of small protein folds.

小型蛋白質(zhì)褶皺的結(jié)構(gòu)和序列空間的取樣。

130.Polyploidy, regular patterning of genome copies, and unusual control of DNA partitioning in the Lyme disease spirochete.

萊姆病螺旋體的多倍體、基因組拷貝的規(guī)則模式化和DNA分區(qū)的異?？刂?。

131.A non-coding GWAS variant impacts anthracycline-induced cardiotoxic phenotypes in human iPSC-derived cardiomyocytes.

一個(gè)非編碼的GWAS變體影響了人類(lèi)iPSC衍生的心肌細(xì)胞中蒽環(huán)類(lèi)藥物誘導(dǎo)的心臟毒性表型。

132.CRISPR-Cas12a induced DNA double-strand breaks are repaired by multiple pathways with different mutation profiles in Magnaporthe oryzae.

CRISPR-Cas12a誘導(dǎo)的DNA雙鏈斷裂在木蘭花菌中通過(guò)多種途徑修復(fù)，其突變情況不同。

133.Functionally integrating nanoparticles alleviate deep vein thrombosis in pregnancy and rescue intrauterine growth restriction.

功能整合型納米顆粒緩解妊娠期深靜脈血栓并挽救宮內(nèi)生長(zhǎng)受限。

134.Biomimetic electrodynamic nanoparticles comprising ginger-derived extracellular vesicles for synergistic anti-infective therapy.

由生姜衍生的細(xì)胞外囊泡組成的生物仿生電動(dòng)納米顆粒用于協(xié)同抗感染治療。

135.Gut to lung translocation and antibiotic mediated selection shape the dynamics of Pseudomonas aeruginosa in an ICU patient.

腸道到肺部的轉(zhuǎn)位和抗生素介導(dǎo)的選擇塑造了ICU病人中銅綠假單胞菌的動(dòng)態(tài)。

136.Long noncoding RNA DIO3OS induces glycolytic-dominant metabolic reprogramming to promote aromatase inhibitor resistance in breast cancer.

長(zhǎng)非編碼RNA DIO3OS誘導(dǎo)糖酵解主導(dǎo)的代謝重編程，促進(jìn)乳腺癌中芳香化酶抑制劑的抗性。

137.Sphingosine 1-phosphate mediates adiponectin receptor signaling essential for lipid homeostasis and embryogenesis.

鞘氨醇1-磷酸介導(dǎo)對(duì)脂質(zhì)平衡和胚胎發(fā)育至關(guān)重要的脂肪素受體信號(hào)傳遞。

138.SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation.

SENP1通過(guò)抑制RIPK1驅(qū)動(dòng)的細(xì)胞凋亡和炎癥來(lái)預(yù)防脂肪性肝炎。

139.Ancient oral microbiomes support gradual Neolithic dietary shifts towards agriculture.

古代口腔微生物組支持新石器時(shí)代的飲食逐漸向農(nóng)業(yè)轉(zhuǎn)變。

140.Prematurely terminated intron-retaining mRNAs invade axons in SFPQ null-driven neurodegeneration and are a hallmark of ALS.

過(guò)早終止的保留內(nèi)含子的mRNA在SFPQ無(wú)效驅(qū)動(dòng)的神經(jīng)變性中侵入軸突，是ALS的一個(gè)標(biāo)志。

141.Mapping the effects of pregnancy on resting state brain activity, white matter microstructure, neural metabolite concentrations and grey matter architecture.

繪制懷孕對(duì)靜止?fàn)顟B(tài)大腦活動(dòng)、白質(zhì)微結(jié)構(gòu)、神經(jīng)代謝物濃度和灰質(zhì)結(jié)構(gòu)的影響。

142.Expanding cross-presenting dendritic cells enhances oncolytic virotherapy and is critical for long-term anti-tumor immunity.

擴(kuò)大交叉呈遞的樹(shù)突狀細(xì)胞可增強(qiáng)溶瘤病毒治療，對(duì)長(zhǎng)期抗腫瘤免疫至關(guān)重要。

143.Wildflower phenological escape differs by continent and spring temperature.

野花的物候逃逸因大陸和春季溫度而不同。

144.DeepPROTACs is a deep learning-based targeted degradation predictor for PROTACs.

DeepPROTACs是一個(gè)基于深度學(xué)習(xí)的PROTACs定向降解預(yù)測(cè)器。

145.Leveraging data-driven self-consistency for high-fidelity gene expression recovery.

利用數(shù)據(jù)驅(qū)動(dòng)的自洽性進(jìn)行高保真基因表達(dá)恢復(fù)。

146.Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB.

核受體REV-ERB的合成激動(dòng)劑激活的結(jié)構(gòu)基礎(chǔ)。

147.Alveolar cell fate selection and lifelong maintenance of AT2 cells by FGF signaling.

肺泡細(xì)胞的命運(yùn)選擇和FGF信號(hào)對(duì)AT2細(xì)胞的終身維護(hù)。

148.Renewal of planktonic foraminifera diversity after the Cretaceous Paleogene mass extinction by benthic colonizers.

白堊紀(jì)古生物大滅絕后底棲殖民者對(duì)浮游有孔蟲(chóng)多樣性的更新。

149.Activated astrocytes attenuate neocortical seizures in rodent models through driving Na+-K+-ATPase.

激活的星形膠質(zhì)細(xì)胞通過(guò)驅(qū)動(dòng)Na+-K+-ATP酶減弱嚙齒動(dòng)物模型中的新皮質(zhì)發(fā)作。

150.Regulome analysis in B-acute lymphoblastic leukemia exposes Core Binding Factor addiction as a therapeutic vulnerability.

B型急性淋巴細(xì)胞白血病的調(diào)控組分析暴露了核心結(jié)合因子成癮的治療弱點(diǎn)。

151.Biodegradation of highly crystallized poly(ethylene terephthalate) through cell surface codisplay of bacterial PETase and hydrophobin.

高度結(jié)晶的聚對(duì)苯二甲酸乙二醇酯的生物降解通過(guò)細(xì)菌PET酶和疏水性蛋白的細(xì)胞表面共同顯示。

152.Structural basis for activation of DNMT1.

激活DNMT1的結(jié)構(gòu)基礎(chǔ)。

153.A CRISPR endonuclease gene drive reveals distinct mechanisms of inheritance bias.

一種CRISPR內(nèi)切酶基因驅(qū)動(dòng)揭示了不同的遺傳偏向機(jī)制。

154.Chromosome segregation fidelity requires microtubule polyglutamylation by the cancer downregulated enzyme TTLL11.

染色體分離的保真度需要癌癥下調(diào)酶TTLL11的微管聚谷氨酸化。

155.Biotechnologically produced chitosans with nonrandom acetylation patterns differ from conventional chitosans in properties and activities.

具有非隨機(jī)乙?；Ｊ降纳锛夹g(shù)生產(chǎn)的殼聚糖在特性和活性上與傳統(tǒng)殼聚糖不同。

156.Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration.

CD206+M2類(lèi)巨噬細(xì)胞的耗竭誘導(dǎo)纖維脂肪生成祖細(xì)胞的激活和肌肉再生。

157.Cholesterol-induced LRP3 downregulation promotes cartilage degeneration in osteoarthritis by targeting Syndecan-4.

膽固醇誘導(dǎo)的LRP3下調(diào)通過(guò)靶向Syndecan-4促進(jìn)骨關(guān)節(jié)炎的軟骨變性。

158.Multi-omics signatures of the human early life exposome.

人類(lèi)生命早期暴露組的多組學(xué)特征。

159.Antigenic sin of wild-type SARS-CoV-2 vaccine shapes poor cross-neutralization of BA.4/5/2.75 subvariants in BA.2 breakthrough infections.

野生型SARS-CoV-2疫苗的抗原罪在BA.2突破性感染中對(duì)BA.4/5/2.75亞變體的交叉中和作用不佳。

160.Feedback between mechanosensitive signaling and active forces governs endothelial junction integrity.

機(jī)械敏感信號(hào)和主動(dòng)力量之間的反饋制約著內(nèi)皮細(xì)胞連接的完整性。

161.PPARγ lipodystrophy mutants reveal intermolecular interactions required for enhancer activation.

PPARγ脂肪變異體揭示了增強(qiáng)子激活所需的分子間相互作用。

162.Structure of the human heparan sulfate polymerase complex EXT1-EXT2.

人類(lèi)肝素硫酸鹽聚合酶復(fù)合物EXT1-EXT2的結(jié)構(gòu)。

163.How people wake up is associated with previous night’s sleep together with physical activity and food intake.

人們?nèi)绾涡褋?lái)與前一晚的睡眠連同身體活動(dòng)和食物攝入有關(guān)。

164.Mutant RIG-I enhances cancer-related inflammation through activation of circRIG-I signaling.

突變的RIG-I通過(guò)激活circRIG-I信號(hào)增強(qiáng)了癌癥相關(guān)的炎癥。

165.Structural and functional asymmetry of RING trimerization controls priming and extension events in TRIM5α autoubiquitylation.

RING三聚體的結(jié)構(gòu)和功能不對(duì)稱(chēng)性控制了TRIM5α自泛素化的引申和延伸事件。

166.How Carvedilol activates β2-adrenoceptors.

卡維地洛如何激活β2-腎上腺素受體.

167.Integrating transcription factor occupancy with transcriptome-wide association analysis identifies susceptibility genes in human cancers.

整合轉(zhuǎn)錄因子占用與全轉(zhuǎn)錄組關(guān)聯(lián)分析，確定人類(lèi)癌癥的易感基因。

168.Transposable element-mediated rearrangements are prevalent in human genomes.

可轉(zhuǎn)座元素介導(dǎo)的重排在人類(lèi)基因組中普遍存在。

169.Deep learning to decompose macromolecules into independent Markovian domains.

深度學(xué)習(xí)將大分子分解為獨(dú)立的馬爾科夫域。

170.Consistent diel activity patterns of forest mammals among tropical regions.

熱帶地區(qū)森林哺乳動(dòng)物一致的晝夜活動(dòng)模式。

171.DNA mechanical flexibility controls DNA potential to activate cGAS-mediated immune surveillance.

DNA的機(jī)械靈活性控制著激活cGAS介導(dǎo)的免疫監(jiān)視的DNA潛能。

172.PEAR1 regulates expansion of activated fibroblasts and deposition of extracellular matrix in pulmonary fibrosis.

PEAR1調(diào)控肺纖維化中活化成纖維細(xì)胞的擴(kuò)張和細(xì)胞外基質(zhì)的沉積。

173.The non-catalytic role of DNA polymerase epsilon in replication initiation in human cells.

DNA聚合酶epsilon在人類(lèi)細(xì)胞復(fù)制啟動(dòng)中的非催化作用。

174.Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downregulating TGF-β via Smad3 acetylation.

藥物抑制HDAC6可通過(guò)Smad3乙?；抡{(diào)TGF-β，改善肌營(yíng)養(yǎng)不良小鼠的肌肉表型。

175.BRAF activation by metabolic stress promotes glycolysis sensitizing NRASQ61-mutated melanomas to targeted therapy.

新陳代謝壓力激活BRAF促進(jìn)糖酵解使NRASQ61突變的黑色素瘤對(duì)靶向治療敏感。

176.Metabolic and proteomic signatures of type 2 diabetes subtypes in an Arab population.

阿拉伯人口中2型糖尿病亞型的代謝和蛋白質(zhì)組學(xué)特征。

177.Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state.

與DNA寡核苷酸抑制劑結(jié)合的具有催化活性的APOBEC3G的結(jié)構(gòu)顯示了過(guò)渡態(tài)的四面體幾何結(jié)構(gòu)。

178.Phosphorylation disrupts long-distance electron transport in cytochrome c.

磷酸化破壞了細(xì)胞色素c的長(zhǎng)距離電子運(yùn)輸。

179.A Myb enhancer-guided analysis of basophil and mast cell differentiation.

嗜堿細(xì)胞和肥大細(xì)胞分化的MYB增強(qiáng)器引導(dǎo)的分析。

180.A glutamine-based single α-helix scaffold to target globular proteins.

以谷氨酸為基礎(chǔ)的單α螺旋支架瞄準(zhǔn)球狀蛋白。

181.Prioritizing autoimmunity risk variants for functional analyses by fine-mapping mutations under natural selection.

通過(guò)自然選擇下的精細(xì)映射突變，優(yōu)先考慮自身免疫風(fēng)險(xiǎn)變體的功能分析。

182.An atlas of amyloid aggregation: the impact of substitutions, insertions, deletions and truncations on amyloid beta fibril nucleation.

淀粉樣蛋白聚集圖譜：替代、插入、缺失和截?cái)鄬?duì)淀粉樣蛋白β纖維核的影響。

183.A comprehensive update to the Mycobacterium tuberculosis H37Rv reference genome.

結(jié)核分枝桿菌H37Rv參考基因組的全面更新。

184.A widespread group of large plasmids in methanotrophic Methanoperedens archaea.

嗜甲烷的Methanoperedens古菌中廣泛存在的一組大型質(zhì)粒。

185.Unscheduled DNA replication in G1 causes genome instability and damage signatures indicative of replication collisions.

G1中不定期的DNA復(fù)制導(dǎo)致了基因組的不穩(wěn)定和表明復(fù)制碰撞的損傷特征。

186.Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus.

疫苗病毒對(duì)細(xì)胞膜DNA感應(yīng)失活的結(jié)構(gòu)基礎(chǔ)。

187.The Heterochromatin protein 1 is a regulator in RNA splicing precision deficient in ulcerative colitis.

異染色質(zhì)蛋白1是潰瘍性結(jié)腸炎中RNA剪接精確性缺乏的調(diào)節(jié)器。

188.Cancer cell survival depends on collagen uptake into tumor-associated stroma.

癌細(xì)胞的生存取決于對(duì)腫瘤相關(guān)基質(zhì)的膠原蛋白攝取。

189.Biological effects of the loss of homochirality in a multicellular organism.

多細(xì)胞生物體中同源性喪失的生物學(xué)效應(yīng)。

190.A redox switch regulates the assembly and anti-CRISPR activity of AcrIIC1.

一個(gè)氧化還原開(kāi)關(guān)調(diào)控AcrIIC1的組裝和抗CRISPR活性。

191.Pre-equilibrium biosensors as an approach towards rapid and continuous molecular measurements.

預(yù)平衡生物傳感器是實(shí)現(xiàn)快速和連續(xù)分子測(cè)量的一種方法。

192.Donor-strand exchange drives assembly of the TasA scaffold in Bacillus subtilis biofilms.

供體鏈交換驅(qū)動(dòng)TasA支架在枯草芽孢桿菌生物膜中的組裝。

193.Structural basis for recognition of transcriptional terminator structures by ProQ/FinO domain RNA chaperones.

ProQ/FinO域RNA伴侶識(shí)別轉(zhuǎn)錄終止器結(jié)構(gòu)的結(jié)構(gòu)基礎(chǔ)。

194.Heme-deficient metabolism and impaired cellular differentiation as an evolutionary trade-off for human infectivity in Trypanosoma brucei gambiense.

血液缺乏的新陳代謝和細(xì)胞分化受損，作為人類(lèi)感染性的一種進(jìn)化權(quán)衡，氏甘比亞錐蟲(chóng)。

195.Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis.

系統(tǒng)性硬化癥中的中心粒缺陷、染色體不穩(wěn)定和cGAS-STING激活。

196.Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration.

偏重ELMO2的構(gòu)象，揭示了可以利用肌細(xì)胞融合來(lái)改善肌肉再生。

197.Impact of pulmonary African trypanosomes on the immunology and function of the lung.

肺部非洲錐蟲(chóng)對(duì)肺部免疫學(xué)和功能的影響。

198.Developing medical imaging AI for emerging infectious diseases.

為新出現(xiàn)的傳染病開(kāi)發(fā)醫(yī)學(xué)成像AI。

199.Global crop yields can be lifted by timely adaptation of growing periods to climate change.

通過(guò)及時(shí)調(diào)整生長(zhǎng)期以適應(yīng)氣候變化，全球作物產(chǎn)量可得到提升。

200.Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia models.

去甲腎上腺素轉(zhuǎn)運(yùn)體缺陷導(dǎo)致家族性自閉癥模型中交感神經(jīng)過(guò)度活躍。

201.Transposable elements maintain genome-wide heterozygosity in inbred populations.

可轉(zhuǎn)座元素維持近交系種群的全基因組雜合性。

202.Single cell characterization of myeloma and its precursor conditions reveals transcriptional signatures of early tumorigenesis.

骨髓瘤及其前體條件的單細(xì)胞特征顯示了早期腫瘤發(fā)生的轉(zhuǎn)錄特征。

203.Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

腫瘤隊(duì)列中的體細(xì)胞突變分布為癌癥的正向選擇提供了信號(hào)。

204.TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks.

TOPOVIBL-REC114相互作用調(diào)控減數(shù)分裂期DNA雙鏈斷裂。

205.CRY2 interacts with CIS1 to regulate thermosensory flowering via FLM alternative splicing.

CRY2與CIS1相互作用，通過(guò)FLM替代剪接調(diào)節(jié)熱敏花。

206.Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity.

T細(xì)胞受體和CD4與肽-MHC的合作性結(jié)合增強(qiáng)了抗原敏感性。

207.CHD7 regulates otic lineage specification and hair cell differentiation in human inner ear organoids.

CHD7調(diào)控人類(lèi)內(nèi)耳器官中的聽(tīng)覺(jué)譜系規(guī)范和毛細(xì)胞分化。

208.Activation and signaling mechanism revealed by GPR119-Gs complex structures.

GPR119-Gs復(fù)合物結(jié)構(gòu)所揭示的激活和信號(hào)傳導(dǎo)機(jī)制。

209.Identification of purine biosynthesis as an NADH-sensing pathway to mediate energy stress.

鑒定嘌呤生物合成為NADH感應(yīng)途徑以介導(dǎo)能量壓力。

210.mTOR inhibition attenuates chemosensitivity through the induction of chemotherapy resistant persisters.

mTOR抑制通過(guò)誘導(dǎo)化療耐藥性持久性減弱化療敏感性。

211.Patterned mechanical feedback establishes a global myosin gradient.

模式化的機(jī)械反饋建立了一個(gè)全球性的肌球蛋白梯度。

212.Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A.

中性粒細(xì)胞在透析過(guò)程中對(duì)血管周細(xì)胞層的突破需要肥大細(xì)胞派生的IL-17A。

213.Ciliary neurotrophic factor-mediated neuroprotection involves enhanced glycolysis and anabolism in degenerating mouse retinas.

睫狀神經(jīng)營(yíng)養(yǎng)因子介導(dǎo)的神經(jīng)保護(hù)涉及變性小鼠視網(wǎng)膜的糖酵解和新陳代謝增強(qiáng)。

214.A Glb1-2A-mCherry reporter monitors systemic aging and predicts lifespan in middle-aged mice.

Glb1-2A-mCherry報(bào)告器監(jiān)測(cè)系統(tǒng)老化并預(yù)測(cè)中年小鼠的壽命。

215.The evolution of reproductive modes and life cycles in amphibians.

兩棲動(dòng)物的繁殖模式和生命周期的進(jìn)化。

216.Host biology, ecology and the environment influence microbial biomass and diversity in 101 marine fish species.

宿主生物學(xué)、生態(tài)學(xué)和環(huán)境影響101種海洋魚(yú)類(lèi)的微生物生物量和多樣性。

217.Cryo-EM structure of ex vivo fibrils associated with extreme AA amyloidosis prevalence in a cat shelter.

與貓咪收容所中極端AA淀粉樣變流行相關(guān)的體外纖維的低溫電鏡結(jié)構(gòu)。

218.Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism.

從胚胎干細(xì)胞中產(chǎn)生的可移植的人類(lèi)甲狀腺器官以拯救甲狀腺功能減退癥。

219.Feedforward growth rate control mitigates gene activation burden.

前饋生長(zhǎng)速率控制減輕了基因激活負(fù)擔(dān)。

220.H2A.Z deposition by SWR1C involves multiple ATP-dependent steps.

SWR1C的H2A.Z沉積涉及多個(gè)ATP依賴(lài)性的步驟。

221.Evaluation of cutaneous immune response in a controlled human in vivo model of mosquito bites.

蚊子叮咬人體模型中皮膚免疫反應(yīng)的評(píng)價(jià)。

222.N6-methyladenosine modification governs liver glycogenesis by stabilizing the glycogen synthase 2 mRNA.

N6-甲基腺苷修飾通過(guò)穩(wěn)定糖原合成酶2 mRNA來(lái)調(diào)控肝臟糖的生成。

223.Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation.

五聚體配體門(mén)控離子通道的開(kāi)放通道結(jié)構(gòu)揭示了小葉特異性磷脂調(diào)節(jié)的機(jī)制。

224.A multicentre single arm phase 2 trial of neoadjuvant pyrotinib and letrozole plus dalpiciclib for triple-positive breast cancer.

新輔助Pyrotinib和letrozole加dalpiciclib治療三陽(yáng)性乳腺癌的多中心單臂2期試驗(yàn)。

225.The endocannabinoid anandamide is an airway relaxant in health and disease.

健康和疾病中的內(nèi)源性安非他命是一種氣道松弛劑。

226.XNAzymes targeting the SARS-CoV-2 genome inhibit viral infection.

靶向SARS-CoV-2基因組的XNA酶可抑制病毒感染。

227.YAP promotes cell-autonomous immune responses to tackle intracellular Staphylococcus aureus in vitro.

YAP促進(jìn)細(xì)胞自主免疫反應(yīng)，以應(yīng)對(duì)體外的細(xì)胞內(nèi)金黃色葡萄球菌。

228.Compensatory epistasis maintains ACE2 affinity in SARS-CoV-2 Omicron BA.1.

在SARS-CoV-2 Omicron BA.1中，補(bǔ)償性外顯作用維持ACE2的親和力。

229.CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder.

CBP-HSF2在Rubinstein-Taybi神經(jīng)發(fā)育障礙中的結(jié)構(gòu)和功能相互作用。

230.Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex.

激動(dòng)劑結(jié)合的Hsp90-XAP2-AHR細(xì)胞膜復(fù)合物的低溫EM結(jié)構(gòu)。

231.Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission.

對(duì)瘧原蟲(chóng)傳播至關(guān)重要的驅(qū)動(dòng)蛋白馬達(dá)的機(jī)械化學(xué)調(diào)控。

232.RasGRP1 promotes the acute inflammatory response and restricts inflammation-associated cancer cell growth.

RasGRP1促進(jìn)急性炎癥反應(yīng)并限制炎癥相關(guān)的癌細(xì)胞生長(zhǎng)。

233.Understanding VPAC receptor family peptide binding and selectivity.

了解VPAC受體家族的肽結(jié)合和選擇性。

234.Increased slow dynamics defines ligandability of BTB domains.

增加的慢速動(dòng)力學(xué)定義了BTB結(jié)構(gòu)域的配位性。

235.F-actin architecture determines constraints on myosin thick filament motion.

F-actin結(jié)構(gòu)決定了對(duì)肌球蛋白粗絲運(yùn)動(dòng)的限制。

236.Global disparities in SARS-CoV-2 genomic surveillance.

SARS-CoV-2基因組監(jiān)測(cè)的全球差異。

237.Ascertaining cells’ synaptic connections and RNA expression simultaneously with barcoded rabies virus libraries.

用條形碼狂犬病毒庫(kù)同時(shí)確定細(xì)胞的突觸連接和RNA表達(dá)。

238.Interferon-λ treatment accelerates SARS-CoV-2 clearance despite age-related delays in the induction of T cell immunity.

干擾素-λ治療加速了SARS-CoV-2的清除，盡管與年齡有關(guān)的T細(xì)胞免疫的誘導(dǎo)延遲了。

239.Structure of the reduced microsporidian proteasome bound by PI31-like peptides in dormant spores.

休眠孢子中由PI31樣肽結(jié)合的還原小孢子蟲(chóng)蛋白體的結(jié)構(gòu)。

240.Interruption of post-Golgi STING trafficking activates tonic interferon signaling.

高爾基體后STING販運(yùn)的中斷激活了強(qiáng)直性干擾素信號(hào)。

241.Muscle5: High-accuracy alignment ensembles enable unbiased assessments of sequence homology and phylogeny.

肌肉5：高精度的排列組合能夠?qū)π蛄型葱院拖到y(tǒng)發(fā)育進(jìn)行無(wú)偏見(jiàn)的評(píng)估。

242.Ordovician opabiniid-like animals and the role of the proboscis in euarthropod head evolution.

奧陶紀(jì)類(lèi)鴉片動(dòng)物和長(zhǎng)鼻器在歐亞大陸動(dòng)物頭部進(jìn)化中的作用。

243.Two simple movement mechanisms for spatial division of labour in social insects.

社會(huì)性昆蟲(chóng)空間分工的兩種簡(jiǎn)單運(yùn)動(dòng)機(jī)制。

244.Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in mice.

基于粘膜TLR2激活蛋白的疫苗接種誘導(dǎo)了小鼠強(qiáng)大的肺部免疫力和對(duì)SARS-CoV-2的保護(hù)。

245.Human multilineage pro-epicardium/foregut organoids support the development of an epicardium/myocardium organoid.

人類(lèi)多系原心包/心肌器官支持心包/心肌器官的發(fā)展。

246.Metagenomics of Parkinson’s disease implicates the gut microbiome in multiple disease mechanisms.

帕金森病的元基因組學(xué)表明腸道微生物組與多種疾病機(jī)制有關(guān)。

247.Selective retention of virus-specific tissue-resident T cells in healed skin after recovery from herpes zoster.

帶狀皰疹痊愈后皮膚中病毒特異性組織駐留T細(xì)胞的選擇性保留。

248.Mode of delivery modulates the intestinal microbiota and impacts the response to vaccination.

輸送方式調(diào)節(jié)腸道微生物群并影響對(duì)疫苗接種的反應(yīng)。

249.Specification of female germline by microRNA orchestrated auxin signaling in Arabidopsis.

擬南芥中通過(guò)microRNA協(xié)調(diào)的輔助信號(hào)對(duì)雌性生殖系統(tǒng)的規(guī)范。

250.Effectiveness of a third BNT162b2 mRNA COVID-19 vaccination during pregnancy: a national observational study in Israel.

懷孕期間第三次BNT162b2 mRNA COVID-19疫苗接種的有效性：以色列的一項(xiàng)國(guó)家觀察研究。

251.Prediction of inter-chain distance maps of protein complexes with 2D attention-based deep neural networks.

用基于二維注意力的深度神經(jīng)網(wǎng)絡(luò)預(yù)測(cè)蛋白質(zhì)復(fù)合體的鏈間距離圖。

252.Mechanistic investigation of human maturation of Okazaki fragments reveals slow kinetics.

對(duì)人類(lèi)岡崎片段成熟的機(jī)制調(diào)查顯示了緩慢的動(dòng)力學(xué)。

308.IL-33 induces thymic involution-associated naive T cell aging and impairs host control of severe infection.

IL-33誘導(dǎo)胸腺內(nèi)陷相關(guān)的幼稚T細(xì)胞老化并損害宿主對(duì)嚴(yán)重感染的控制。

309.Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food.

壓力驅(qū)動(dòng)的下丘腦外側(cè)突觸對(duì)腹側(cè)被蓋區(qū)多巴胺神經(jīng)元的增效作用導(dǎo)致對(duì)適口食物的消費(fèi)增加。

310.Prognostic and predictive value of a pathomics signature in gastric cancer.

胃癌病理組學(xué)特征的預(yù)后和預(yù)測(cè)價(jià)值。

311.The prognostic and diagnostic value of intraleukocytic malaria pigment in patients with severe falciparum malaria.

嚴(yán)重惡性瘧疾患者的白細(xì)胞內(nèi)瘧原蟲(chóng)的預(yù)后和診斷價(jià)值。

312.The SOD1-mediated ALS phenotype shows a decoupling between age of symptom onset and disease duration.

SOD1介導(dǎo)的ALS表型顯示出癥狀發(fā)生的年齡與疾病持續(xù)時(shí)間之間的脫鉤關(guān)系。

313.A flexible cross-platform single-cell data processing pipeline.

一個(gè)靈活的跨平臺(tái)的單細(xì)胞數(shù)據(jù)處理管道。

314.Computationally designed GPCR quaternary structures bias signaling pathway activation.

計(jì)算設(shè)計(jì)的GPCR四元結(jié)構(gòu)偏重于信號(hào)通路的激活。

315.Sexually dimorphic architecture and function of a mechanosensory circuit in C. elegans.

秀麗亞人機(jī)械感覺(jué)回路的性別二形結(jié)構(gòu)和功能。

316.Glycolytic flux control by drugging phosphoglycolate phosphatase.

通過(guò)藥物治療磷酸甘油酯磷酸酶來(lái)控制糖酵解通量。

317.dcHiC detects differential compartments across multiple Hi-C datasets.

dcHiC檢測(cè)跨多個(gè)Hi-C數(shù)據(jù)集的差異區(qū)間.

318.Developmental disruption and restoration of brain synaptome architecture in the murine Pax6 neurodevelopmental disease model.

小鼠Pax6神經(jīng)發(fā)育疾病模型中大腦突觸組結(jié)構(gòu)的發(fā)育破壞和恢復(fù)。

319.A fourth dose of the inactivated SARS-CoV-2 vaccine redistributes humoral immunity to the N-terminal domain.

第四劑SARS-CoV-2滅活疫苗將體液免疫力重新分配到N端域。

320.Programmable integrin and N-cadherin adhesive interactions modulate mechanosensing of mesenchymal stem cells by cofilin phosphorylation.

可編程的整合素和N-cadherin粘附作用通過(guò)cofilin磷酸化調(diào)節(jié)間充質(zhì)干細(xì)胞的機(jī)械感應(yīng)。

321.Differential impact of ubiquitous and muscle dynamin 2 isoforms in muscle physiology and centronuclear myopathy.

無(wú)處不在的和肌肉的Dynamin 2異構(gòu)體在肌肉生理學(xué)和核心肌病中的不同影響。

322.Dominant ARF3 variants disrupt Golgi integrity and cause a neurodevelopmental disorder recapitulated in zebrafish.

顯性ARF3變體破壞了高爾基體的完整性，并導(dǎo)致了在斑馬魚(yú)中再現(xiàn)的神經(jīng)發(fā)育障礙。

323.An opioid-gated thalamoaccumbal circuit for the suppression of reward seeking in mice.

抑制小鼠獎(jiǎng)勵(lì)尋求的阿片門(mén)控丘腦回路。

324.Collective genomic segments with differential pleiotropic patterns between cognitive dimensions and psychopathology.

認(rèn)知維度和精神病理學(xué)之間的集體基因組段具有不同的多態(tài)性。

325.pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation.

pTINCR微蛋白通過(guò)CDC42 SUMOylation和激活促進(jìn)上皮細(xì)胞分化并抑制腫瘤生長(zhǎng)。

326.Influenza A virus reassortment in mammals gives rise to genetically distinct within-host subpopulations.

哺乳動(dòng)物中的甲型流感病毒重配產(chǎn)生了遺傳上不同的宿主亞群。

327.Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits.

血清IgA水平的遺傳調(diào)控和對(duì)常見(jiàn)的免疫、感染、腎臟和心腦代謝特征的易感性。

328.Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations.

幽門(mén)螺旋桿菌在有害突變的替代作用下反復(fù)向非洲以外的地區(qū)擴(kuò)展。

329.PD-L1 negatively regulates antifungal immunity by inhibiting neutrophil release from bone marrow.

PD-L1通過(guò)抑制中性粒細(xì)胞從骨髓中釋放來(lái)負(fù)向調(diào)節(jié)抗真菌免疫力。

330.Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration.

骨骼祖細(xì)胞的線粒體氧化代謝受損導(dǎo)致肌肉骨骼解體。

331.SuperFi-Cas9 exhibits remarkable fidelity but severely reduced activity yet works effectively with ABE8e.

SuperFi-Cas9表現(xiàn)出顯著的保真度，但活性嚴(yán)重降低，卻能與ABE8e有效配合。

332.A nascent peptide code for translational control of mRNA stability in human cells.

人類(lèi)細(xì)胞中mRNA穩(wěn)定性的翻譯控制的新生肽代碼。

333.A click chemistry amplified nanopore assay for ultrasensitive quantification of HIV-1 p24 antigen in clinical samples.

用于臨床樣本中HIV-1 p24抗原超靈敏定量的點(diǎn)擊化學(xué)擴(kuò)增納米孔檢測(cè)法。

334.Molecular identity of proprioceptor subtypes innervating different muscle groups in mice.

支配小鼠不同肌肉群的本體感受器亞型的分子特征。

335.Structural basis of human SNAPc recognizing proximal sequence element of snRNA promoter.

人類(lèi)SNAPc識(shí)別snRNA啟動(dòng)子近端序列元素的結(jié)構(gòu)基礎(chǔ)。

336.Variant-specific symptoms of COVID-19 in a study of 1,542,510 adults in England.

英國(guó)1,542,510名成人研究中COVID-19的變體特異癥狀。

337.Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice.

深度表型和終身軌跡顯示長(zhǎng)壽調(diào)節(jié)劑對(duì)C57BL/6J小鼠衰老過(guò)程的影響有限。

338.Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders.

六種神經(jīng)發(fā)育和精神疾病的協(xié)調(diào)性皮質(zhì)厚度改變。

339.Design and directed evolution of noncanonical β-stereoselective metalloglycosidases.

非經(jīng)典的β-立體選擇性金屬糖苷酶的設(shè)計(jì)和定向進(jìn)化。

340.Disulfiram ameliorates nonalcoholic steatohepatitis by modulating the gut microbiota and bile acid metabolism.

雙硫侖通過(guò)調(diào)節(jié)腸道微生物群和膽汁酸代謝改善非酒精性脂肪性肝炎。

341.Protein control of photochemistry and transient intermediates in phytochromes.

植物色素中光化學(xué)和瞬時(shí)中間產(chǎn)物的蛋白質(zhì)控制。

342.Neural implementation of computational mechanisms underlying the continuous trade-off between cooperation and competition.

合作與競(jìng)爭(zhēng)之間持續(xù)權(quán)衡的計(jì)算機(jī)制的神經(jīng)實(shí)現(xiàn)。

343.Near infrared-activatable biomimetic nanogels enabling deep tumor drug penetration inhibit orthotopic glioblastoma.

使腫瘤藥物深入滲透的近紅外可激活生物仿生納米凝膠對(duì)正位膠質(zhì)母細(xì)胞瘤的抑制。

344.Optical cavity-mediated exciton dynamics in photosynthetic light harvesting 2 complexes.

光合采光2復(fù)合物中光腔介導(dǎo)的激子動(dòng)力學(xué)。

345.Stromal FOXF2 suppresses prostate cancer progression and metastasis by enhancing antitumor immunity.

基質(zhì)FOXF2通過(guò)增強(qiáng)抗腫瘤免疫力抑制前列腺癌的進(jìn)展和轉(zhuǎn)移。

346.The 3D structure of lipidic fibrils of α-synuclein.

α-synuclein的脂質(zhì)纖維的三維結(jié)構(gòu)。

347.Integrase-mediated differentiation circuits improve evolutionary stability of burdensome and toxic functions in E. coli.

完整性介導(dǎo)的分化回路提高了大腸桿菌中負(fù)擔(dān)性和毒性功能的進(jìn)化穩(wěn)定性。

348.Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations.

具有不同外顯子19突變的EGFR的不同抑制劑敏感性的生物化學(xué)和結(jié)構(gòu)基礎(chǔ)。

349.Systematic characterization of cancer transcriptome at transcript resolution.

癌癥轉(zhuǎn)錄組在轉(zhuǎn)錄本分辨率下的系統(tǒng)性特征。

350.Formation of synthetic RNA protein granules using engineered phage-coat-protein -RNA complexes.

利用工程化的噬菌體-衣殼-蛋白質(zhì)-RNA復(fù)合物形成合成的RNA蛋白顆粒。

351.The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma.

去泛素酶OTUD1調(diào)控多發(fā)性骨髓瘤中免疫球蛋白的產(chǎn)生和蛋白酶體抑制劑的敏感性。

352.Ferritin triggers neutrophil extracellular trap-mediated cytokine storm through Msr1 contributing to adult-onset Still’s disease pathogenesis.

鐵蛋白通過(guò)Msr1引發(fā)中性粒細(xì)胞胞外捕集器介導(dǎo)的細(xì)胞因子風(fēng)暴，有助于成年發(fā)病的斯蒂爾病的發(fā)病機(jī)制。

353.An mTORC1-mediated negative feedback loop constrains amino acid-induced FLCN-Rag activation in renal cells with TSC2 loss.

mTORC1介導(dǎo)的負(fù)反饋回路制約了TSC2缺失的腎細(xì)胞中氨基酸誘導(dǎo)的FLCN-Rag激活。

354.Magic-angle-spinning NMR structure of the kinesin-1 motor domain assembled with microtubules reveals the elusive neck linker orientation.

與微管組裝在一起的驅(qū)動(dòng)蛋白-1運(yùn)動(dòng)域的魔角旋轉(zhuǎn)核磁共振結(jié)構(gòu)揭示了難以捉摸的頸部連接體方向。

355.A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience.

一個(gè)保守的基于巨蛋白的分子橋?qū)χ|(zhì)販運(yùn)和抗寒能力至關(guān)重要。

356.Intranasal delivery of a rationally attenuated SARS-CoV-2 is immunogenic and protective in Syrian hamsters.

合理減弱的SARS-CoV-2的鼻內(nèi)遞送對(duì)敘利亞倉(cāng)鼠具有免疫原性和保護(hù)作用。

357.Fertilization mode differentially impacts the evolution of vertebrate sperm components.

受精模式對(duì)脊椎動(dòng)物精子成分進(jìn)化的影響不同。

358.Vascular endothelium deploys caveolin-1 to regulate oligodendrogenesis after chronic cerebral ischemia in mice.

小鼠慢性腦缺血后血管內(nèi)皮部署Caveolin-1以調(diào)節(jié)少突變。

359.De novo identification of microbial contaminants in low microbial biomass microbiomes with Squeegee.

用Squeegee對(duì)低微生物生物量微生物組中的微生物污染物進(jìn)行從頭識(shí)別。

360.Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers.

選擇性的PROTAC介導(dǎo)的SMARCA2降解對(duì)SMARCA4突變的癌癥有效果。

361.An alternative splicing modulator decreases mutant HTT and improves the molecular fingerprint in Huntington’s disease patient neurons.

一種替代剪接調(diào)節(jié)劑減少了突變體HTT，改善了亨廷頓病患者神經(jīng)元的分子指紋。

==========================================

由于字?jǐn)?shù)限制，關(guān)注我的個(gè)人公眾號(hào)“遠(yuǎn)夢(mèng)研”查看更多