產(chǎn)品名稱：

活性氧MCB-613，296792-62-6，4-ethyl-2,6-bis(3-pyridinylmethylene)-cyclohexanone

產(chǎn)地：西安

規(guī)格：1mg 5mg 10mg

純度：99%

用途：僅用于科研

狀態(tài)：固體/粉末

儲藏條件：冷藏-20℃

溫馨提示：僅用于科研，不能用于人體實驗！

說明：提供使用說明，核磁圖譜，包裝，價格，產(chǎn)地，制備方法，應(yīng)用，穩(wěn)定性，溶解度，簡單合成等各種信息　　

The p160 steroid receptor coactivator (SRC) family, SRC-1/NCOA1, SRC-2/NCOA2/TIF2/GRIP1, and SRC-3/NCOA3/AIB1/RAC3/ACTR/pCIP, interact with nuclear receptors and other transcription factors to drive target gene expression and integrate growth signaling pathways on which cancer cells rely. MCB-613 is a small molecule stimulator of SRC-1, SRC-2, and SRC-3 that has been used to disrupt cancer cell homeostatic dependence on SRCs.1 MCB-613 can increase the interaction of SRCs with the coactivators CBP and CARM1 and can induce ER stress coupled to the generation of reactive oxygen species.1 Overactivation of SRCs by 1-7 μM MCB-613 was shown to selectively and dose dependently induce paraptosis in a variety of cancer cells in vitro but not in normal cells.1 At 20 mg/kg, MCB-613 was also shown to inhibit tumor growth in an MCF-7 breast cancer xenograft model in mice.1

p160類固醇受體輔激活子（SRC）家族、SRC-1/NCOA1、SRC-2/NCOA2/TIF2/GRIP1和SRC-3/NCOA3/AIB1/RAC3/ACTR/pCIP與核受體和其他轉(zhuǎn)錄因子相互作用，以驅(qū)動靶基因表達(dá)并整合癌癥細(xì)胞所依賴的生長信號通路。MCB-613是SRC-1、SRC-2和SRC-3的小分子刺激物，以及用于破壞癌癥細(xì)胞對SRC的穩(wěn)態(tài)依賴性的SRC-3。1 MCB-613可以增加SRC與輔活化劑CBP和CARM1的相互作用，并可以誘導(dǎo)內(nèi)質(zhì)網(wǎng)應(yīng)激與活性氧物種的生成相耦合。1 1-7μM MCB-612過度激活SRC，在體外可選擇性地和劑量依賴性地誘導(dǎo)多種癌癥細(xì)胞的截癱，但不是在正常細(xì)胞中。1在20 mg/kg的MCF-7乳腺癌小鼠異種移植瘤模型中，MCB-613也顯示出抑制腫瘤生長。

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編輯：XAQYBIO HAO，2023年4月10日。