關(guān)鍵詞

Spns2 狂犬病單克隆抗體 納武利尤單抗?單克隆抗體 親和力 替雷利珠單抗 奧馬珠單抗 司美格魯肽

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#今日行業(yè)熱點#

①Cell：Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate

磷酸鞘氨醇轉(zhuǎn)運蛋白(Spns2)介導(dǎo)的鞘氨醇-1-磷酸(Sphingosine-1-phosphate, S1P)轉(zhuǎn)運的結(jié)構(gòu)和功能研究

DOI: 10.1016/j.cell.2023.04.028

②International Journal of Infectious Diseases：Classification of breast tumors by using a novel approach based on deep learning methods and feature selection

臨床試驗：比較重組人狂犬病單克隆抗體(Ormutivimab)與人狂犬病免疫球蛋白(HRIG)用于暴露后預(yù)防的效果

DOI: 10.1016/j.ijid.2023.05.017

③Journal of the European Academy of Dermatology and Venereology：Nivolumab for locally advanced and metastatic cutaneous squamous cell carcinoma (NIVOSQUACS study) - phase II data covering impact of concomitant hematological malignancies

臨床試驗：納武利尤單抗用于局部晚期和轉(zhuǎn)移性皮膚鱗狀細(xì)胞癌(NIVOSQUACS研究)——涉及伴隨的血液系統(tǒng)惡性腫瘤影響的II期數(shù)據(jù)

DOI: 10.1111/jdv.19218

④Nucleic Acids Research：SEPPA-mAb: spatial epitope prediction of protein antigens for mAbs

使用SEPPA-mAb進(jìn)行的單克隆抗體的蛋白質(zhì)抗原空間表位預(yù)測

DOI: 10.1093/nar/gkad427

⑤Analytical Chemistry：Rapid Quantitation of Various Therapeutic Monoclonal Antibodies Using Membranes with Fc-Specific Ligands

通過捕獲與片段結(jié)晶(Fc)區(qū)結(jié)合的配體修飾的膜中的單克隆抗體進(jìn)行快速定量

DOI: 10.1021/acs.analchem.3c00531

⑥Immunology：Inhibiting N-glycan processing increases the antibody binding affinity and effector function of human natural killer cells

抑制N-聚糖進(jìn)程可增加人類自然殺傷細(xì)胞的抗體結(jié)合親和力和效應(yīng)功能

DOI: 10.1111/imm.13662

⑦人源化IgG4抗PD-1單克隆抗體替雷利珠單抗獲中國國家藥品監(jiān)督管理局批準(zhǔn)用于食管鱗狀細(xì)胞癌

⑧長效胰高血糖素樣肽-1（GLP-1）類似物司美格魯肽（Semaglutide）的減重IIIa期OASIS 1研究數(shù)據(jù)達(dá)到主要終點

⑨專門針對和阻斷抗免疫球蛋白E（IgE）的抗體藥奧馬珠單抗α（CMAB007）獲中國國家藥品監(jiān)督管理局批準(zhǔn)上市，用于過敏性哮喘

⑩新型泛I類磷脂酰肌醇-3-激酶（PI3K）抑制劑Copanlisib在華申報的首個適應(yīng)癥上市申請已獲得批準(zhǔn)，用于濾泡性淋巴瘤（FL）

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