聲明：本專欄主要對生命科學(xué)領(lǐng)域的一些期刊文章標(biāo)題進(jìn)行翻譯，所有內(nèi)容均由本人手工整理翻譯。由于本人專業(yè)為生物分析相關(guān)，其他領(lǐng)域如果出現(xiàn)翻譯錯(cuò)誤請諒解。

1.Root and branch. Trees in dryland ecosystems play an important part in carbon cycling, but extensive data on their number and distribution have been lacking. In this week’s issue, Compton Tucker and his colleagues present an inventory of nearly 10 billion trees in sub-Saharan Africa. The researchers used machine learning to scan high-resolution satellite images to cover an area of nearly 10 million square kilometres. This allowed them to map individual trees and estimate the amount of carbon stored in the foliage, wood and roots of each tree. They divided the drylands into four zones, depending on the annual rainfall, and found that individual trees stored 51 kilograms of carbon in the driest regions, rising to 98 kilograms where the rainfall was greatest. The team has made a database of wood mass, foliage mass, root mass and carbon stock for each tree freely available (see go.nature.com/3ys6nhu).

根與枝。旱地生態(tài)系統(tǒng)中的樹木在碳循環(huán)中發(fā)揮著重要作用，但缺乏關(guān)于其數(shù)量和分布的廣泛數(shù)據(jù)。在本周的期刊中，康普頓·塔克 (Compton Tucker) 和他的同事介紹了撒哈拉以南非洲地區(qū)近 100 億棵樹木的清單。研究人員利用機(jī)器學(xué)習(xí)掃描高分辨率衛(wèi)星圖像，覆蓋了近1000萬平方公里的區(qū)域。這使得他們能夠繪制每棵樹的地圖，并估計(jì)每棵樹的葉子、木材和根部儲存的碳量。他們根據(jù)年降雨量將旱地分為四個(gè)區(qū)域，發(fā)現(xiàn)在最干旱的地區(qū)，每棵樹儲存的碳量為 51 公斤，在降雨量最大的地區(qū)，每棵樹的碳儲存量為 98 公斤。該團(tuán)隊(duì)免費(fèi)提供了每棵樹的木材質(zhì)量、葉子質(zhì)量、根質(zhì)量和碳儲量的數(shù)據(jù)庫（參見 go.nature.com/3ys6nhu）。

2.Murky waters. The cover image shows an algal bloom off the coast of Alaska in 2017. Phytoplankton blooms are accumulations of microscopic algae in the surface layer of water systems. Although they can provide food and nutrients for other organisms, they can also cause serious environmental problems. In this week’s issue, Lian Feng and colleagues present a comprehensive map of bloom distribution and trends in coastal waters. The researchers assessed 760,000 images captured by NASA’s Aqua satellite between 2003 and 2020, and identified blooms on the coast of 126 of the 153 ocean-bordering countries they examined. They found that the area of water affected by blooms expanded by 13.6% between 2003 and 2020, and that this increased bloom frequency correlated with changing ocean circulations and rising sea-surface temperatures.

渾濁的水域。封面圖片顯示了 2017 年阿拉斯加海岸的藻華。浮游植物華是水系統(tǒng)表層微觀藻類的積累。盡管它們可以為其他生物提供食物和營養(yǎng)，但它們也會造成嚴(yán)重的環(huán)境問題。在本周的期刊中，連峰和同事展示了沿海水域水華分布和趨勢的綜合地圖。研究人員評估了 NASA Aqua 衛(wèi)星在 2003 年至 2020 年間拍攝的 76 萬張圖像，并在他們檢查的 153 個(gè)臨海國家中的 126 個(gè)國家的海岸發(fā)現(xiàn)了水華。他們發(fā)現(xiàn)，2003年至2020年間，受水華影響的水域面積擴(kuò)大了13.6%，這種水華頻率的增加與海洋環(huán)流的變化和海面溫度的上升有關(guān)。

3.Twist factor. Chiral molecules are structures that have the same composition but are mirror images of each other. In this week’s issue, Nicholas Kotov and his colleagues use self-assembling nanosheets that form bow-tie-like microparticles to examine whether it is practical to use geometrical measures of chirality for chemical structures. The nanosheets hierarchically assemble into nanoribbons that stack together and twist to look like bow ties (as pictured on the cover), with the direction of twist depending on the chirality of the molecules used to form the nanosheets. Crucially, the twist angle of the bow ties is highly controllable. The team found that the various bow-tie particles interacted differently with circularly polarized light depending on their chirality measure. The researchers also printed their bow-tie particles onto fabric, creating photonically active metasurfaces that they suggest could form the basis for fiducial markers for lidars.

扭轉(zhuǎn)系數(shù)。手性分子是具有相同組成但互為鏡像的結(jié)構(gòu)。在本周的期刊中，尼古拉斯·科托夫（Nicholas Kotov）和他的同事使用自組裝納米片來形成領(lǐng)結(jié)狀微粒，以檢查使用手性幾何測量來測量化學(xué)結(jié)構(gòu)是否實(shí)用。納米片分層組裝成納米帶，納米帶堆疊在一起并扭曲，看起來像領(lǐng)結(jié)（如封面所示），扭曲的方向取決于用于形成納米片的分子的手性。至關(guān)重要的是，領(lǐng)結(jié)的扭轉(zhuǎn)角度是高度可控的。研究小組發(fā)現(xiàn)，各種領(lǐng)結(jié)粒子與圓偏振光的相互作用不同，具體取決于其手性測量。研究人員還將他們的領(lǐng)結(jié)顆粒打印到織物上，創(chuàng)建光子活性超表面，他們認(rèn)為這可以構(gòu)成激光雷達(dá)基準(zhǔn)標(biāo)記的基礎(chǔ)。

4.Driving test. One of the main hurdles to putting autonomous cars on the road is how to ensure the reliability of the artificial intelligence that replaces the human driver. Evaluating the safety of an AI driver to the level of a human in a naturalistic environment would require testing across hundreds of millions of miles — something that is clearly impractical. In this week’s issue, Henry Liu and his colleagues tackle this problem by training an AI to help test the AI in the driving seat. The researchers used dense deep reinforcement learning to train the AI tester, which allowed the tester to ignore safe scenarios and instead build a testing environment that focused on potentially dangerous situations. The team then successfully tested a real car using augmented reality — while the autonomous vehicle drove round a track it had to cope with virtual dangers set by the tester. The researchers say the system can speed up safety evaluations by several orders of magnitude.

駕駛測試。自動駕駛汽車上路的主要障礙之一是如何確保取代人類駕駛員的人工智能的可靠性。在自然環(huán)境中將人工智能駕駛員的安全性評估為人類水平需要進(jìn)行數(shù)億英里的測試——這顯然是不切實(shí)際的。在本周的期刊中，Henry Liu 和他的同事通過訓(xùn)練人工智能來幫助測試駕駛座上的人工智能來解決這個(gè)問題。研究人員使用密集的深度強(qiáng)化學(xué)習(xí)來訓(xùn)練人工智能測試人員，這使得測試人員可以忽略安全場景，而是構(gòu)建一個(gè)專注于潛在危險(xiǎn)情況的測試環(huán)境。然后，該團(tuán)隊(duì)成功地使用增強(qiáng)現(xiàn)實(shí)技術(shù)測試了一輛真實(shí)的汽車——自動駕駛汽車在賽道上行駛時(shí)，它必須應(yīng)對測試人員設(shè)置的虛擬危險(xiǎn)。研究人員表示，該系統(tǒng)可以將安全評估速度提高幾個(gè)數(shù)量級。

5.Swahili ancestry. Medieval people on the Swahili coast of East Africa were among the first sub-Saharan people to practise Islam. David Reich, Chapurukha Kusimba and colleagues sequenced DNA from 80 individuals buried in six medieval and early modern coastal Swahili stone towns, dating between 1250 and 1800. Their analysis shows that African women and Asian men began mixing along the East African coast before the year 1000, and that the earliest Asian migrants were of largely Persian origin. These findings match the Kilwa Chronicle, the oldest story told by the people of the Swahili coast. About one-tenth of the ancestry of the earliest Asian migrants came from India. The cover image is adapted from a photograph of a Swahili woman in Zanzibar taken in 1896. The textile patterns of the garment have been redrawn to reflect themes in the paper, including DNA, medieval dhows to signify trade, and symbols from Islam to represent cultural influence.

斯瓦希里血統(tǒng)。東非斯瓦希里海岸的中世紀(jì)人民是撒哈拉以南地區(qū)最早信奉伊斯蘭教的人民之一。 David Reich、Chapurukha Kusimba 及其同事對 80 個(gè)人的 DNA 進(jìn)行了測序，這些人埋藏在 6 個(gè)中世紀(jì)和早期現(xiàn)代沿海斯瓦希里石頭城鎮(zhèn)中，年代可追溯至 1250 年至 1800 年。他們的分析表明，非洲女性和亞洲男性在 1000 年之前就開始在東非海岸混合生活，最早的亞洲移民主要是波斯裔。這些發(fā)現(xiàn)與斯瓦希里海岸人民講述的最古老的故事《基爾瓦編年史》相符。最早的亞洲移民的祖先中約有十分之一來自印度。封面圖片改編自 1896 年在桑給巴爾拍攝的斯瓦希里婦女的照片。服裝的紡織圖案經(jīng)過重新繪制，以反映報(bào)紙中的主題，包括 DNA、代表貿(mào)易的中世紀(jì)單桅帆船以及代表文化的伊斯蘭教符號影響。

6.Carbon stocks of billions of individual African dryland trees estimated.

估算了數(shù)十億非洲旱地樹木的碳儲量。

7.A gut reaction can tune tumour fate during chemotherapy.

腸道反應(yīng)可以在化療期間調(diào)節(jié)腫瘤的命運(yùn)。

8.Black holes and neutron stars beat alike when bright.

黑洞和中子星在明亮?xí)r的跳動是相似的。

9.Rainfall affects interactions between plant neighbours.

降雨影響植物鄰居之間的相互作用。

10.The genomic history of ice-age Europeans.

冰河時(shí)代歐洲人的基因組歷史。

11.Drug trial for Alzheimer’s disease is a game changer.

阿爾茨海默病的藥物試驗(yàn)改變了游戲規(guī)則。

12.A shared accretion instability for black holes and neutron stars.

黑洞和中子星共有的吸積不穩(wěn)定性。

13.Critical role of hydrogen for superconductivity in nickelates.

氫對于鎳酸鹽超導(dǎo)性的關(guān)鍵作用。

14.Disorder-tuned conductivity in amorphous monolayer carbon.

無定形單層碳的無序調(diào)節(jié)電導(dǎo)率。

15.Ladderphane copolymers for high-temperature capacitive energy storage.

用于高溫電容儲能的梯烷共聚物。

16.Electrochemical reactor dictates site selectivity in N-heteroarene carboxylations.

電化學(xué)反應(yīng)器決定了 N-雜芳烴羧化的位點(diǎn)選擇性。

17.Optimal nitrogen rate strategy for sustainable rice production in China.

中國水稻可持續(xù)生產(chǎn)的最優(yōu)施氮策略

18.Sub-continental-scale carbon stocks of individual trees in African drylands.

非洲旱地次大陸范圍內(nèi)個(gè)別樹木的碳儲量。

19.Oceanic climate changes threaten the sustainability of Asia’s water tower.

海洋氣候變化威脅著亞洲水塔的可持續(xù)性。

20.Primary N2–He gas field formation in intracratonic sedimentary basins.

克拉通內(nèi)沉積盆地原生 N2-He 氣田的形成。

21.Effects of moisture and density-dependent interactions on tropical tree diversity.

水分和密度依賴性相互作用對熱帶樹木多樣性的影響。

22.Annelid functional genomics reveal the origins of bilaterian life cycles.

環(huán)節(jié)動物功能基因組學(xué)揭示了兩側(cè)對稱動物生命周期的起源。

23.Essential elements of radical pair magnetosensitivity in Drosophila.

果蠅自由基對磁敏感性的基本要素。

24.Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers.

舊石器時(shí)代晚期到新石器時(shí)代歐洲狩獵采集者的古基因組學(xué)。

25.Chemically defined cytokine-free expansion of human haematopoietic stem cells.

化學(xué)定義的人類造血干細(xì)胞的無細(xì)胞因子擴(kuò)增。

26.FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2.

FXR 抑制可通過減少 ACE2 來防止 SARS-CoV-2 感染。

27.Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA.1 attenuation.

Spike 和 nsp6 是 SARS-CoV-2 Omicron BA.1 衰減的關(guān)鍵決定因素。

28.Active eosinophils regulate host defence and immune responses in colitis.

活躍的嗜酸性粒細(xì)胞調(diào)節(jié)結(jié)腸炎中的宿主防御和免疫反應(yīng)。

29.Targeting TBK1 to overcome resistance to cancer immunotherapy.

靶向 TBK1 克服癌癥免疫療法的耐藥性。

30.Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer.

微生物群衍生的 3-IAA 影響胰腺癌的化療效果。

31.Chemistry governs water organization at a graphene electrode.

化學(xué)控制著石墨烯電極上的水組織。

32.How an anxious heart talks to the brain.

焦慮的心如何與大腦對話。

33.MicroRNA uses a gym to get fit for cuts by Dicer enzyme.

MicroRNA 使用健身房來通過 Dicer 酶進(jìn)行切割。

34.How wildfires deplete ozone in the stratosphere.

野火如何消耗平流層中的臭氧。

35.Hopes raised for room-temperature superconductivity, but doubts remain.

人們對室溫超導(dǎo)性抱有希望，但疑慮依然存在。

36.Path unveiled for protein entry into chloroplasts.

蛋白質(zhì)進(jìn)入葉綠體的路徑揭曉。

37.Fatty acids prime the lung as a site for tumour spread.

脂肪酸使肺部成為腫瘤擴(kuò)散的場所。

38.Deuterium-enriched water ties planet-forming disks to comets and protostars.

富含氘的水將行星形成盤與彗星和原恒星聯(lián)系在一起。

39.Atomic Bose–Einstein condensate in twisted-bilayer optical lattices.

扭曲雙層光學(xué)晶格中的原子玻色-愛因斯坦凝聚態(tài)。

40.Geometric frustration of Jahn–Teller order in the infinite-layer lattice.

無限層晶格中 Jahn-Teller 序的幾何挫敗。

41.Evidence of near-ambient superconductivity in a N-doped lutetium hydride.

N 摻雜氫化镥具有近環(huán)境超導(dǎo)性的證據(jù)。

42.Population-based heteropolymer design to mimic protein mixtures.

基于群體的雜聚物設(shè)計(jì)來模擬蛋白質(zhì)混合物。

43.Chlorine activation and enhanced ozone depletion induced by wildfire aerosol.

野火氣溶膠引起的氯活化和臭氧消耗加劇。

44.The evolution of the marine carbonate factory.

海洋碳酸鹽工廠的演變。

45.Tropical deforestation causes large reductions in observed precipitation.

熱帶森林砍伐導(dǎo)致觀測到的降水量大幅減少。

46.Valley formation aridifies East Africa and elevates Congo Basin rainfall.

山谷的形成使東非干旱并增加了剛果盆地的降雨量。

47.Coastal phytoplankton blooms expand and intensify in the 21st century.

21 世紀(jì)沿海浮游植物大量繁殖并加劇。

48.Evolution of the germline mutation rate across vertebrates.

脊椎動物種系突變率的演變。

49.Cardiogenic control of affective behavioural state.

情感行為狀態(tài)的心源性控制。

50.Coordination of bacterial cell wall and outer membrane biosynthesis.

細(xì)菌細(xì)胞壁和外膜生物合成的協(xié)調(diào)。

51.Autoimmunity in Down’s syndrome via cytokines, CD4 T cells and CD11c+ B cells.

唐氏綜合癥中通過細(xì)胞因子、CD4 T 細(xì)胞和 CD11c+ B 細(xì)胞產(chǎn)生的自身免疫。

52.TET2 guards against unchecked BATF3-induced CAR T cell expansion.

TET2 可防止不受控制的 BATF3 誘導(dǎo)的 CAR T 細(xì)胞擴(kuò)增。

53.Sequence determinant of small RNA production by DICER.

DICER 產(chǎn)生小 RNA 的序列決定因素。

54.Structure of the human DICER–pre-miRNA complex in a dicing state.

處于切割狀態(tài)的人類 DICER-pre-miRNA 復(fù)合物的結(jié)構(gòu)。

55.H3K4me3 regulates RNA polymerase II promoter-proximal pause-release.

H3K4me3 調(diào)節(jié) RNA 聚合酶 II 啟動子近端暫停釋放。

56.Architecture of chloroplast TOC–TIC translocon supercomplex.

葉綠體 TOC-TIC 易位子超級復(fù)合體的結(jié)構(gòu)。

57.Multivariate BWAS can be replicable with moderate sample sizes.

多變量 BWAS 可以通過適度的樣本量進(jìn)行復(fù)制。

58.Reply to: Multivariate BWAS can be replicable with moderate sample sizes.

回復(fù)：多元 BWAS 可以通過中等樣本量進(jìn)行復(fù)制。

59.Bow-tie particles boast a tunable twist.

領(lǐng)結(jié)粒子擁有可調(diào)節(jié)的扭曲。

60.Bacterial meningitis hits an immunosuppressive nerve.

細(xì)菌性腦膜炎攻擊免疫抑制神經(jīng)。

61.Regrowing tropical forests absorb megatonnes of carbon.

重新生長的熱帶森林吸收了數(shù)百萬噸的碳。

62.How loss of social status affects the brain.

社會地位的喪失如何影響大腦。

63.From the archive: Saturn, and Charles Darwin shares animal stories.

來自檔案館：土星和查爾斯·達(dá)爾文分享動物故事。

64.Mitochondrial molecule controls inflammation.

線粒體分子控制炎癥。

65.Bleb protrusions help cancer cells to cheat death.

泡狀突起有助于癌細(xì)胞逃避死亡。

66.Topological spin texture in the pseudogap phase of a high-Tc superconductor.

高溫超導(dǎo)體贗能隙相中的拓?fù)渥孕棙?gòu)。

67.Ultrafast tunable lasers using lithium niobate integrated photonics.

使用鈮酸鋰集成光子學(xué)的超快可調(diào)諧激光器。

68.Photonically active bowtie nanoassemblies with chirality continuum.

具有手性連續(xù)體的光子活性領(lǐng)結(jié)納米組件。

69.Tunnelling measured in a very slow ion–molecule reaction.

在非常慢的離子-分子反應(yīng)中測量隧道效應(yīng)。

70.Control of stereogenic oxygen in a helically chiral oxonium ion.

螺旋手性氧鎓離子中立體氧的控制。

71.The carbon sink of secondary and degraded humid tropical forests.

次生和退化濕潤熱帶森林的碳匯。

72.Regime shift in Arctic Ocean sea ice thickness.

北冰洋海冰厚度的變化。

73.Deep, ultra-hot-melting residues as cradles of mantle diamond.

深層超熱熔殘?jiān)堑蒯＝饎偸膿u籃。

74.Weak upper-mantle base revealed by postseismic deformation of a deep earthquake.

深部地震的震后變形揭示了薄弱的上地?；?。

75.Future temperature extremes threaten land vertebrates.

未來的極端溫度將威脅陸地脊椎動物。

76.Protomelission is an early dasyclad alga and not a Cambrian bryozoan.

Protomelission 是一種早期的藻類，而不是寒武紀(jì)苔蘚蟲。

77.Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion.

細(xì)菌劫持腦膜神經(jīng)免疫軸以促進(jìn)大腦入侵。

78.Molecular fate-mapping of serum antibody responses to repeat immunization.

重復(fù)免疫的血清抗體反應(yīng)的分子命運(yùn)圖譜。

79.Macrophage fumarate hydratase restrains mtRNA-mediated interferon production.

巨噬細(xì)胞富馬酸水合酶抑制 mtRNA 介導(dǎo)的干擾素產(chǎn)生。

80.Fumarate induces vesicular release of mtDNA to drive innate immunity.

富馬酸鹽誘導(dǎo)線粒體 DNA 的囊泡釋放，以驅(qū)動先天免疫。

81.Co-opting signalling molecules enables logic-gated control of CAR T cells.

增選信號分子可實(shí)現(xiàn) CAR T 細(xì)胞的邏輯門控控制。

82.Blebs promote cell survival by assembling oncogenic signalling hubs.

氣泡通過組裝致癌信號中樞來促進(jìn)細(xì)胞存活。

83.Nucleolar URB1 ensures 3′ ETS rRNA removal to prevent exosome surveillance.

核仁 URB1 確保 3' ETS rRNA 去除，以防止外泌體監(jiān)視。

84.Phototrophy by antenna-containing rhodopsin pumps in aquatic environments.

水生環(huán)境中含有天線的視紫紅質(zhì)泵的光養(yǎng)作用。

85.Structural basis for bacterial energy extraction from atmospheric hydrogen.

從大氣氫中提取細(xì)菌能量的結(jié)構(gòu)基礎(chǔ)。

86.Common orthopaedic trauma may explain 31,000-year-old remains.

常見的骨科創(chuàng)傷可以解釋 31,000 年前的遺骸。

87.Reply to: Common orthopaedic trauma may explain 31,000-year-old remains.

回復(fù)：常見的骨科創(chuàng)傷可以解釋31000年前的遺骸。

88.Huge broad-bean genome could improve yields of an underused crop.

巨大的蠶豆基因組可以提高未充分利用的作物的產(chǎn)量。

89.Activated immune cells drive neurodegeneration in an Alzheimer’s model.

激活的免疫細(xì)胞會導(dǎo)致阿爾茨海默病模型中的神經(jīng)退行性變。

90.Political endorsements can affect scientific credibility.

政治認(rèn)可會影響科學(xué)可信度。

91.A compelling explanation for the enigmatic small object ‘Oumuamua.

對神秘小物體“Oumuamua”的令人信服的解釋。

92.Synthetic bacterial genome upgraded for viral defence and biocontainment.

合成細(xì)菌基因組升級用于病毒防御和生物遏制。

93.From the archive: the cell cycle and Antarctic exploration.

來自檔案：細(xì)胞周期和南極探險(xiǎn)。

94.Hazards help autonomous cars to drive safely.

危險(xiǎn)有助于自動駕駛汽車安全駕駛。

95.Black holes up close.

近距離觀察黑洞。

96.A helium-burning white dwarf binary as a supersoft X-ray source.

作為超軟 X 射線源的氦燃燒白矮星雙星。

97.Acceleration of 1I/‘Oumuamua from radiolytically produced H2 in H2O ice.

H2O 冰中輻射分解產(chǎn)生的 H2 對 1I/'Oumuamua 的加速。

98.Quantum-enabled millimetre wave to optical transduction using neutral atoms.

使用中性原子實(shí)現(xiàn)量子毫米波到光轉(zhuǎn)換。

99.Dense reinforcement learning for safety validation of autonomous vehicles.

用于自動駕駛車輛安全驗(yàn)證的密集強(qiáng)化學(xué)習(xí)。

100.Diode effect in Josephson junctions with a single magnetic atom.

具有單個(gè)磁性原子的約瑟夫森結(jié)中的二極管效應(yīng)。

101.Catalytic asymmetric synthesis of cannabinoids and menthol from neral.

從橙花醛催化不對稱合成大麻素和薄荷醇。

102.Basin-scale reconstruction of euxinia and Late Devonian mass extinctions.

盆地尺度重建euxinia和晚泥盆世大規(guī)模滅絕。

103.Core origin of seismic velocity anomalies at Earth’s core–mantle boundary.

地球核心-地幔邊界地震速度異常的核心起源。

104.The giant diploid faba genome unlocks variation in a global protein crop.

巨大的二倍體蠶豆基因組解鎖了全球蛋白質(zhì)作物的變異。

105.An airway-to-brain sensory pathway mediates influenza-induced sickness.

氣道到大腦的感覺通路介導(dǎo)流感引起的疾病。

106.Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy.

小膠質(zhì)細(xì)胞介導(dǎo)的 T 細(xì)胞浸潤會導(dǎo)致 tau 蛋白病的神經(jīng)變性。

107.Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates.

阻斷 NS3-NS4B 相互作用可抑制非人類靈長類動物中的登革熱病毒。

108.Non-viral precision T?cell receptor replacement for personalized cell therapy.

用于個(gè)性化細(xì)胞治療的非病毒精準(zhǔn) T 細(xì)胞受體替代。

109.Neoantigen-targeted CD8+ T cell responses with PD-1 blockade therapy.

PD-1 阻斷療法的新抗原靶向 CD8+ T 細(xì)胞反應(yīng)。

110.The dietary sweetener sucralose is a negative modulator of T cell-mediated responses.

膳食甜味劑三氯蔗糖是 T 細(xì)胞介導(dǎo)反應(yīng)的負(fù)調(diào)節(jié)劑。

111.Spatial mapping of mitochondrial networks and bioenergetics in lung cancer.

肺癌線粒體網(wǎng)絡(luò)和生物能學(xué)的空間繪圖。

112.A swapped genetic code prevents viral infections and gene transfer.

交換的遺傳密碼可以防止病毒感染和基因轉(zhuǎn)移。

113.The structural basis for HIV-1 Vif antagonism of human APOBEC3G.

HIV-1 Vif 拮抗人類 APOBEC3G 的結(jié)構(gòu)基礎(chǔ)。

114.Autoregulation of GPCR signalling through the third intracellular loop.

通過第三個(gè)細(xì)胞內(nèi)環(huán)路自動調(diào)節(jié) GPCR 信號傳導(dǎo)。

115.Structural basis of odorant recognition by a human odorant receptor.

人類氣味受體識別氣味的結(jié)構(gòu)基礎(chǔ)。

116.Southern Ocean heat sink hindered by melting ice.

南大洋散熱器因冰融化而受阻。

117.Inheritance of epigenetic DNA marks studied in new mouse model.

在新的小鼠模型中研究表觀遺傳 DNA 標(biāo)記的遺傳。

118.Earliest molecular events of vision revealed.

揭示了最早的視覺分子事件。

119.Eggs made from male mouse stem cells using error-prone culture.

使用易錯(cuò)培養(yǎng)法由雄性小鼠干細(xì)胞制成的卵子。

120.A glimpse at the inner structure of the proton.

質(zhì)子內(nèi)部結(jié)構(gòu)一瞥。

121.Fastest-ever calcium sensors broaden the potential of neuronal imaging.

有史以來最快的鈣傳感器拓寬了神經(jīng)元成像的潛力。

122.Forming intracluster gas in a galaxy protocluster at a redshift of 2.16.

在紅移為 2.16 的星系原星系團(tuán)中形成星系團(tuán)內(nèi)氣體。

123.Determining the gluonic gravitational form factors of the proton.

確定質(zhì)子的膠子引力形狀因子。

124.Universal logic with encoded spin qubits in silicon.

硅中具有編碼自旋量子位的通用邏輯。

125.Thousands of conductance levels in memristors integrated on CMOS.

CMOS 上集成的憶阻器具有數(shù)千個(gè)電導(dǎo)級別。

126.Bright and stable perovskite light-emitting diodes in the near-infrared range.

在近紅外范圍內(nèi)明亮且穩(wěn)定的鈣鈦礦發(fā)光二極管。

127.Photosynthesis re-wired on the pico-second timescale.

光合作用在皮秒時(shí)間尺度上重新布線。

128.Abyssal ocean overturning slowdown and warming driven by Antarctic meltwater.

南極融水驅(qū)動的深海海洋速度減慢和變暖。

129.Diagnosing destabilization risk in global land carbon sinks.

診斷全球陸地碳匯的不穩(wěn)定風(fēng)險(xiǎn)。

130.Degassing of early-formed planetesimals restricted water delivery to Earth.

早期形成的星子的脫氣限制了向地球輸送水。

131.Continent-wide declines in shallow reef life over a decade of ocean warming.

十年來海洋變暖導(dǎo)致整個(gè)大陸淺層珊瑚礁生命減少。

132.Entwined African and Asian genetic roots of medieval peoples of the Swahili coast.

斯瓦希里海岸中世紀(jì)民族的非洲和亞洲遺傳根源交織在一起。

133.Diminishing benefits of urban living for children and adolescents’ growth and development.

城市生活對兒童和青少年成長和發(fā)展的好處正在減少。

134.Fast and sensitive GCaMP calcium indicators for imaging neural populations.

用于神經(jīng)群體成像的快速、靈敏的 GCaMP 鈣指示劑。

135.Population dynamics of head-direction neurons during drift and reorientation.

漂移和重新定向過程中頭部方向神經(jīng)元的群體動態(tài)。

136.Generation of functional oocytes from male mice in vitro.

體外雄性小鼠功能性卵母細(xì)胞的產(chǎn)生。

137.Immunoglobulin M perception by FcμR.

FcμR 感知免疫球蛋白 M。

138.MEN1 mutations mediate clinical resistance to menin inhibition.

MEN1 突變介導(dǎo)對 menin 抑制的臨床抵抗。

139.The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia.

menin 抑制劑 revumenib 用于治療 KMT2A 重排或 NPM1 突變白血病。

140.Whole-genome doubling drives oncogenic loss of chromatin segregation.

全基因組加倍導(dǎo)致染色質(zhì)分離的致癌損失。

141.Structural basis of mitochondrial membrane bending by the I–II–III2–IV2 supercomplex.

I–II–III2–IV2 超復(fù)合物導(dǎo)致線粒體膜彎曲的結(jié)構(gòu)基礎(chǔ)。

142.Ultrafast structural changes direct the first molecular events of vision.

超快的結(jié)構(gòu)變化指導(dǎo)了視覺的第一個(gè)分子事件。

143.Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation.

機(jī)械力和配體依賴性粘附 GPCR 解離的分子傳感。