【文獻(xiàn)速遞】【Nature】【2022年】【6月】
聲明：本專欄主要對(duì)生命科學(xué)領(lǐng)域的一些期刊文章標(biāo)題進(jìn)行翻譯，所有內(nèi)容均由本人手工整理翻譯。由于本人專業(yè)為生物分析相關(guān)，其他領(lǐng)域如果出現(xiàn)翻譯錯(cuò)誤請(qǐng)諒解。
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未裝箱的谷物
With six sets of chromosomes, the hexaploid cultivated oat (Avena sativa L.) has a complex evolutionary history. In this week’s issue, Nick Sirijovski and his colleagues present a high-quality reference genome for A. sativa alongside those for its close relatives the diploid Avena longiglumis and the tetraploid Avena insularis. By examining the three genomes, the researchers were able to trace genomic reorganizations in the crop’s evolution. They were also able to map the genes for important agronomic traits, highlighting gene families linked to human health and nutrition. With health and sustainability high on global agendas, the team hopes this new resource will bolster genomics-assisted breeding and trait studies to address these challenges and more.
具有六組染色體的六倍體栽培燕麥（Avena sativa L.）具有復(fù)雜的進(jìn)化歷史。在本周的期刊中，Nick Sirijovski和他的同事展示了A. sativa的高質(zhì)量參考基因組及其近親Avena longiglumis和四倍體 Avena insularis的參考基因組。通過檢查這三個(gè)基因組，研究人員能夠追蹤作物進(jìn)化過程中的基因組重組。他們還能夠繪制重要農(nóng)藝性狀的基因圖，突出顯示與人類健康和營(yíng)養(yǎng)相關(guān)的基因家族。隨著健康和可持續(xù)發(fā)展成為全球議程的重中之重，該團(tuán)隊(duì)希望這一新資源能夠加強(qiáng)基因組學(xué)輔助育種和性狀研究，以應(yīng)對(duì)這些挑戰(zhàn)以及更多挑戰(zhàn)。
The Casarabe people lived in southwest Amazonia around AD 500–1400, but understanding of this culture has been limited because the archaeological remains are covered in dense forest. In this week’s issue, Heiko Prümers and his colleagues reveal the discovery of new Casarabe settlements in the Bolivian Amazon. The researchers used lidar to scan the forest, revealing 2 large settlements (each covering more than 100 hectares) and 24 smaller sites, 15 of which had previously been known to exist. The cover image shows Cotoca, one of the two large settlements, in which earthen mounds (one more than 20 metres high) and long causeways can clearly be seen. The team suggests that these results are the first evidence of agrarian-based, low-density urbanism in western Amazonia. They conclude that the region was not as sparsely populated in pre-Hispanic times as was previously thought.
卡薩拉貝人生活在公元500年至1400年左右的亞馬遜流域西南部，但由于考古遺跡被茂密的森林所覆蓋，人們對(duì)這種文化的了解一直很有限。在本周的期刊中，Heiko Prümers和他的同事揭示了在玻利維亞亞馬遜流域發(fā)現(xiàn)新的卡薩拉貝人定居點(diǎn)。研究人員使用激光雷達(dá)掃描森林，發(fā)現(xiàn)了2個(gè)大型定居點(diǎn)（每個(gè)定居點(diǎn)占地超過100 公頃）和24個(gè)較小的地點(diǎn)，其中 15個(gè)以前已知存在。封面圖片展示了兩個(gè)大型聚居地之一的科托卡，其中可以清楚地看到土丘（高20多米）和長(zhǎng)長(zhǎng)的堤道。該團(tuán)隊(duì)表示，這些結(jié)果是亞馬遜西部以農(nóng)業(yè)為基礎(chǔ)的低密度城市化的第一個(gè)證據(jù)。他們得出結(jié)論，該地區(qū)在前西班牙時(shí)期并不像以前想象的那樣人口稀少。
高處的生活
The cover image shows plants growing at altitude on Altar Volcano in Chimborazo, Ecuador. Extreme altitudes pose challenges for most forms of life, and flowering plants are no exception. But flowering plants have been found growing as high as 6,400 metres above sea level. In this week’s issue, Michael Holdsworth and his colleagues reveal a molecular mechanism that helps plants to adapt to the extremes of altitude. The researchers studied a range of plants, representing four diverse clades of flowering plants — thale cress (Arabidopsis thaliana), tomato, poppy and the grass Brachypodium distachyon. They found that plants use genetic adaptations to adjust their sensitivity to atmospheric oxygen, whose partial pressure decreases with altitude. By decoding the ambient oxygen level, the plants are able to sense the altitude at which they grow and optimize internal biochemical processes.
封面圖片展示了在厄瓜多爾欽博拉索的阿爾塔火山高海拔地區(qū)生長(zhǎng)的植物。極端海拔對(duì)大多數(shù)生命形式構(gòu)成挑戰(zhàn)，開花植物也不例外。但已發(fā)現(xiàn)開花植物生長(zhǎng)在海拔6,400米的高處。在本周的期刊中，Michael Holdsworth和他的同事揭示了一種幫助植物適應(yīng)極端海拔高度的分子機(jī)制。研究人員研究了一系列植物，代表開花植物的四種不同進(jìn)化枝——擬南芥（Arabidopsis thaliana）、番茄、罌粟和短柄草（Brachypodium distachyon）。他們發(fā)現(xiàn)植物利用遺傳適應(yīng)來調(diào)整它們對(duì)大氣中氧氣的敏感性，大氣中氧氣的分壓會(huì)隨著高度的增加而降低。通過解碼環(huán)境氧氣水平，植物能夠感知它們生長(zhǎng)的海拔高度并優(yōu)化內(nèi)部生化過程。
不平等的科學(xué)
To study inequality is to confront a world of contrasts: excessive wealth next to palpable poverty; sickness abutting health. The COVID pandemic has exposed and worsened many such disparities. This week, Nature presents a special collection of articles focusing on the researchers trying to quantify and reduce inequality. Whether they are measuring the effects of the pandemic or testing interventions to lift people out of poverty, the message is simple: gathering the right information will help to mitigate the harm caused by inequality.
研究不平等就是要面對(duì)一個(gè)對(duì)比鮮明的世界：過度的財(cái)富與明顯的貧困；疾病和健康。COVID大流行暴露并加劇了許多此類差異。本周，《自然》雜志推出了一系列特別的文章，重點(diǎn)關(guān)注試圖量化和減少不平等的研究人員。無論他們是在衡量大流行病的影響，還是在測(cè)試幫助人們擺脫貧困的干預(yù)措施，信息都很簡(jiǎn)單：收集正確的信息將有助于減輕不平等造成的傷害。
撥亂反正
The cover shows an artistic representation of various cancer cells. The large-scale gains, losses and rearrangements of DNA seen in chromosomal instability are a typical feature of cancer — but there is no comprehensive framework to decode the causes of this genomic variability and their possible links to disease. In this week’s issue, Florian Markowetz, Geoff Macintyre and their colleagues present such a framework with a compendium of 17 signatures of chromosomal instability that can be used to predict how tumours might respond to drugs and that help to identify future therapeutic targets. The team created the compendium by examining 7,880 tumours representing 33 types of cancer. In a separate paper, Nischalan Pillay and colleagues examined 9,873 cancers to generate 21 similar signatures of chromosomal instability.
封面展示了各種癌細(xì)胞的藝術(shù)表現(xiàn)。在染色體不穩(wěn)定性中看到的DNA的大規(guī)模增加、丟失和重排是癌癥的典型特征——但沒有全面的框架來解碼這種基因組變異的原因及其與疾病的可能聯(lián)系。在本周的期刊中，F(xiàn)lorian Markowetz、Geoff Macintyre 和他們的同事提出了這樣一個(gè)框架，其中包含17種染色體不穩(wěn)定性特征的概要，可用于預(yù)測(cè)腫瘤對(duì)藥物的反應(yīng)，并有助于確定未來的治療靶點(diǎn)。該團(tuán)隊(duì)通過檢查代表33種癌癥的7,880個(gè)腫瘤創(chuàng)建了該綱要。在另一篇論文中，Nischalan Pillay及其同事檢查了9,873種癌癥，以產(chǎn)生21種相似的染色體不穩(wěn)定性特征。
1.Loops simplify a set-up to boost quantum computational advantage.
循環(huán)簡(jiǎn)化設(shè)置以提高量子計(jì)算優(yōu)勢(shì)。
2.Nerve regrowth can be painful.
神經(jīng)再生可能很痛苦。
3.The 6G frequency switch that spares scientific services.
節(jié)省科學(xué)服務(wù)的6G頻率開關(guān)。
4.Clues to the identity of the fossil fish Palaeospondylus.
符合化石魚古生物的身份的線索。
5.From the archive: international efforts to curb pollution, and the perils of broadcasting.
從檔案中：國(guó)際遏制污染的努力以及廣播的危險(xiǎn)。
6.Multilayer 2D insulator shows promise for post-silicon electronics.
多層2D絕緣子顯示出對(duì)后硅電子電子產(chǎn)品的希望。
7.An immune molecule segregates memories in time.
免疫分子會(huì)在時(shí)間上分離記憶。
8.The road to fully programmable protein catalysis.
完全可編程的蛋白質(zhì)催化道路。
9.Strongly correlated electron–photon systems.
密切相關(guān)的電子-光子系統(tǒng)。
10.Resolving the H I in damped Lyman α systems that power star formation.
在阻尼的Lymanα系統(tǒng)中解析H I，以驅(qū)動(dòng)星形形成。
11.Probing CP symmetry and weak phases with entangled double-strange baryons.
用糾纏的雙重震撼重子探測(cè)CP對(duì)稱性和弱相。
12.Magneto-optical trapping and sub-Doppler cooling of a polyatomic molecule.
多原子分子的磁光捕獲和子多普勒冷卻。
13.Quantum computational advantage with a programmable photonic processor.
具有可編程光子處理器的量子計(jì)算優(yōu)勢(shì)。
14.Non-Hermitian chiral phononics through optomechanically induced squeezing.
通過光機(jī)械誘導(dǎo)擠壓的非厄米手性聲子學(xué)。
15.Epitaxial single-crystal hexagonal boron nitride multilayers on Ni (111).
Ni（111）上的外延單晶六角硼氮化硼。
16.A tissue-like neurotransmitter sensor for the brain and gut.
大腦和腸道的組織樣神經(jīng)遞質(zhì)傳感器。
17.[18F]Difluorocarbene for positron emission tomography.
[18F]二氟卡賓用于正電子發(fā)射斷層掃描。
18.Morphology of Palaeospondylus shows affinity to tetrapod ancestors.
古質(zhì)體的形態(tài)顯示與四足動(dòng)物祖先的親和力。
19.The mosaic oat genome gives insights into a uniquely healthy cereal crop.
花葉燕麥基因組可深入了解獨(dú)特的健康谷物作物。
20.Single-cell eQTL models reveal dynamic T cell state dependence of disease loci.
單細(xì)胞eQTL模型揭示了疾病基因座的動(dòng)態(tài)T細(xì)胞狀態(tài)依賴性。
21.People construct simplified mental representations to plan.
人們構(gòu)建了簡(jiǎn)化的心理表征來計(jì)劃。
22.Neuropathic pain caused by miswiring and abnormal end organ targeting.
神經(jīng)性疼痛由錯(cuò)誤和異常末端器官靶向引起。
23.CCR5 closes the temporal window for memory linking.
CCR5關(guān)閉時(shí)間窗口以進(jìn)行內(nèi)存鏈接。
24.Gene regulation by gonadal hormone receptors underlies brain sex differences.
性腺激素受體調(diào)控基因是腦性別差異的基礎(chǔ)。
25.Distinct gene clusters drive formation of ferrosome organelles in bacteria.
不同的基因簇驅(qū)動(dòng)細(xì)菌中鐵染色體細(xì)胞器的形成。
26.Developmental dynamics of two bipotent thymic epithelial progenitor types.
兩種二聚體胸腺上皮祖細(xì)胞類型的發(fā)育動(dòng)力學(xué)。
27.Fundamental immune–oncogenicity trade-offs define driver mutation fitness.
基本的免疫-結(jié)合性權(quán)衡定義驅(qū)動(dòng)突變適應(yīng)性。
28.Mitochondrial uncouplers induce proton leak by activating AAC and UCP1.
線粒體解耦合器通過激活A(yù)AC和UCP1誘導(dǎo)質(zhì)子泄漏。
29.Gibbin mesodermal regulation patterns epithelial development.
Gibbin中胚層調(diào)節(jié)模式上皮發(fā)育。
30.MCM complexes are barriers that restrict cohesin-mediated loop extrusion.
MCM復(fù)合物是限制粘蛋白介導(dǎo)的環(huán)擠出的障礙。
31.Fast and efficient DNA replication with purified human proteins.
純化的人蛋白質(zhì)快速有效地復(fù)制DNA。
32.How wingless salamanders fly.
無翅的龜蛙如何飛行。
33.Nanoscale map shows how interfaces impede vibrations.
納米級(jí)圖顯示了界面如何阻礙振動(dòng)。
34.Large-scale early urban settlements in Amazonia.
亞馬遜地區(qū)的大規(guī)模早期城市定居點(diǎn)。
35.Blood’s life history traced through genomic scars.
通過基因組疤痕追溯血液的生命歷史。
36.A chromosome predisposed for sex.
易感性的染色體。
37.Diverse data tighten constraints for neutron stars.
各種數(shù)據(jù)擰緊了中子星的約束。
38.X-ray astronomy comes of age.
X射線天文學(xué)成熟。
39.Binarity of a protostar affects the evolution of the disk and planets.
原恒星的二進(jìn)制會(huì)影響磁盤和行星的演變。
40.Constraining neutron-star matter with microscopic and macroscopic collisions.
與微觀和宏觀碰撞約束中子星體。
41.Observation of ultracold atomic bubbles in orbital microgravity.
在軌道微重力中觀察到超冷原子氣泡。
42.Observation of Cooper pairs in a mesoscopic two-dimensional Fermi gas.
觀察介質(zhì)二維費(fèi)米氣體中的庫(kù)珀對(duì)。
43.Nanoscale imaging of phonon dynamics by electron microscopy.
通過電子顯微鏡對(duì)聲子動(dòng)力學(xué)的納米級(jí)成像。
44.Electrically tunable quantum confinement of neutral excitons.
中性激子的電可調(diào)量子限制。
45.Origin of structural degradation in Li-rich layered oxide cathode.
富含鋰層的氧化物陰極中結(jié)構(gòu)降解的起源。
46.Ni-electrocatalytic Csp3–Csp3 doubly decarboxylative coupling.
Ni電催化Csp3–Csp3雙脫羧耦合。
47.Instantaneous tracking of earthquake growth with elastogravity signals.
用彈性重力信號(hào)瞬時(shí)跟蹤地震的產(chǎn)生。
48.Lidar reveals pre-Hispanic low-density urbanism in the Bolivian Amazon.
激光雷達(dá)揭示了玻利維亞亞馬遜的西班牙裔前低密度城市主義。
49.Island-specific evolution of a sex-primed autosome in a sexual planarian.
在的雙性體中性啟動(dòng)常染色體的島嶼特異性進(jìn)化。
50.The longitudinal dynamics and natural history of clonal haematopoiesis.
克隆造血的縱向動(dòng)力學(xué)和自然歷史。
51.Clonal dynamics of haematopoiesis across the human lifespan.
人類壽命中造血的克隆動(dòng)力學(xué)。
52.Revival of light signalling in the postmortem mouse and human retina.
驗(yàn)尸小鼠和人視網(wǎng)膜中光信號(hào)傳導(dǎo)的復(fù)興。
53.ABO genotype alters the gut microbiota by regulating GalNAc levels in pigs.
ABO基因型通過調(diào)節(jié)豬的GalNAc水平來改變腸道菌群。
54.Prolonged viral suppression with anti-HIV-1 antibody therapy.
抗HIV-1抗體療法長(zhǎng)期抑制病毒。
55.Combination anti-HIV antibodies provide sustained virological suppression.
組合抗HIV抗體可提供持續(xù)的病毒學(xué)抑制。
56.Defining mitochondrial protein functions through deep multiomic profiling.
通過深度多組學(xué)分析來定義線粒體蛋白的功能。
57.Neoantigen quality predicts immunoediting in survivors of pancreatic cancer.
新抗原質(zhì)量可以預(yù)測(cè)胰腺癌幸存者的免疫編輯。
58.Stromal changes in the aged lung induce an emergence from melanoma dormancy.
老年肺的基質(zhì)變化引起了黑色素瘤休眠的出現(xiàn)。
59.Differential cofactor dependencies define distinct types of human enhancers.
差異輔因子依賴性定義了人類增強(qiáng)劑的不同類型。
60.Discovery of non-squalene triterpenes.
非角鯊烯三萜的發(fā)現(xiàn)。
61.Limitations of gamete sequencing for crossover analysis.
配子測(cè)序的局限性用于交叉分析。
62.25 years of valuing ecosystems in decision-making.
在決策中評(píng)估生態(tài)系統(tǒng)的25年。
63.Tiny isotopic difference tests standard model of particle physics.
微小的同位素差異測(cè)試標(biāo)準(zhǔn)粒子物理模型。
64.The first complete human genome.
第一個(gè)完整的人類基因組。
65.Molecular soccer balls connected to make a 2D material.
分子足球連接到制作2D材料。
66.Give physicians’ views to improve COVID vaccine uptake.
給醫(yī)生的觀點(diǎn)以改善COVID疫苗的攝入量。
67.Potato genomes pave the way to crop improvement.
馬鈴薯基因組為作物改善鋪平了道路。
68.A population of ultraviolet-dim protoclusters detected in absorption.
在吸收中檢測(cè)到的紫外暗原星團(tuán)。
69.Measurement of the bound-electron g-factor difference in coupled ions.
耦合離子中邊界電子g因子差的測(cè)量。
70.Realizing the symmetry-protected Haldane phase in Fermi–Hubbard ladders.
意識(shí)到在費(fèi)米-荷蘭階梯中的對(duì)稱性保護(hù)的霍爾丹階段。
71.Superconducting-qubit readout via low-backaction electro-optic transduction.
通過低反作用電光轉(zhuǎn)換的超導(dǎo)量讀數(shù)。
72.Evidence for unconventional superconductivity in twisted trilayer graphene.
扭曲的三層石墨烯中非常規(guī)超導(dǎo)性的證據(jù)。
73.An on-chip photonic deep neural network for image classification.
用于圖像分類的芯片上光子深神經(jīng)網(wǎng)絡(luò)。
74.Synthesis of a monolayer fullerene network.
單層富勒烯網(wǎng)絡(luò)的合成。
75.A solid-state electrolysis process for upcycling aluminium scrap.
用于升級(jí)鋁廢料的固態(tài)電解過程。
76.Topography of mountain belts controlled by rheology and surface processes.
由流變學(xué)和表面過程控制的山帶地形。
77.Fossil biomolecules reveal an avian metabolism in the ancestral dinosaur.
化石生物分子揭示了祖先恐龍中的禽類代謝。
78.Graph pangenome captures missing heritability and empowers tomato breeding.
圖形泛基因組捕獲了缺少的遺傳力并賦予番茄育種的能力。
79.Genome evolution and diversity of wild and cultivated potatoes.
野生和栽培土豆的基因組進(jìn)化和多樣性。
80.Communicating doctors’ consensus persistently increases COVID-19 vaccinations.
傳達(dá)醫(yī)生的共識(shí)持續(xù)增加了COVID-19的疫苗接種。
81.Olfactory sensory experience regulates gliomagenesis via neuronal IGF1.
嗅覺感覺經(jīng)驗(yàn)通過神經(jīng)元IGF1調(diào)節(jié)神經(jīng)膠質(zhì)作用。
82.Divergent transcriptional regulation of astrocyte reactivity across disorders.
跨疾病的星形膠質(zhì)細(xì)胞反應(yīng)性的發(fā)散轉(zhuǎn)錄調(diào)節(jié)。
83.An oxygen-sensing mechanism for angiosperm adaptation to altitude.
氧氣感應(yīng)機(jī)制，用于適應(yīng)高度。
84.Generation of specialized blood vessels via lymphatic transdifferentiation.
通過淋巴轉(zhuǎn)分化生成專門的血管。
85.FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation.
FcγR介導(dǎo)的單核細(xì)胞感染SARS-CoV-2感染會(huì)激活炎癥。
86.Inflammasome activation in infected macrophages drives COVID-19 pathology.
感染巨噬細(xì)胞中的炎性體激活驅(qū)動(dòng)COVID-19病理學(xué)。
87.ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis.
ADAR1掩蓋了ZBP1驅(qū)動(dòng)壞死的癌癥免疫治療諾言。
88.Mechanism of mitoribosomal small subunit biogenesis and preinitiation.
形狀體小亞基生物發(fā)生和預(yù)啟動(dòng)的機(jī)制。
89.Exercise molecule burns away hunger.
運(yùn)動(dòng)分子燒掉饑餓。
90.Collisions hint that four neutrons form a transient isolated entity.
碰撞暗示四個(gè)中子形成了瞬態(tài)孤立實(shí)體。
91.Mutations matter even if proteins stay the same.
即使蛋白質(zhì)保持不變，突變也很重要。
92.From the archive: respect for reptiles, and an astronomical centenary.
來自檔案：尊重爬行動(dòng)物和天文百年紀(jì)念。
93.60 years of chemistry of the noble gases.
貴重氣體化學(xué)60年。
94.Crystalline order offers access to high speeds for organic transistors.
結(jié)晶秩序?yàn)橛袡C(jī)晶體管提供了高速訪問。
95.Two-dimensional materials prospects for non-volatile spintronic memories.
非易失性自旋電子存儲(chǔ)器的二維材料前景。
96.Solar flare accelerates nearly all electrons in a large coronal volume.
太陽(yáng)耀斑在巨大的冠狀體積中幾乎加速了所有電子。
97.Observation of a correlated free four-neutron system.
觀察相關(guān)的自由四間隙系統(tǒng)。
98.Continuous Bose–Einstein condensation.
連續(xù)的Bose–Einstein凝結(jié)。
99.Many-body theory of positron binding to polyatomic molecules.
正電子與多原子分子結(jié)合的多體理論。
100.Engineering topological states in atom-based semiconductor quantum dots.
工程化基于原子的半導(dǎo)體量子點(diǎn)中的拓?fù)錉顟B(tài)。
101.Organic bipolar transistors.
有機(jī)雙極晶體管。
102.Asymmetric pore windows in MOF membranes for natural gas valorization.
MOF膜中的不對(duì)稱孔窗，用于天然氣增值。
103.Hadean isotopic fractionation of xenon retained in deep silicates.
氙的Hadean同位素分餾保留在深硅酸鹽中。
104.The source of the Black Death in fourteenth-century central Eurasia.
14世紀(jì)中部歐亞大陸的黑人死亡的根源。
105.Synonymous mutations in representative yeast genes are mostly strongly non-neutral.
代表性酵母基因中的同義突變大多是非中性的。
106.Spatiotemporal dynamics of noradrenaline during learned behaviour.
在學(xué)習(xí)行為期間去甲腎上腺素的時(shí)空動(dòng)力學(xué)。
107.Molecularly defined circuits for cardiovascular and cardiopulmonary control.
用于心血管和心肺控制的分子定義電路。
108.Lifelong multilineage contribution by embryonic-born blood progenitors.
胚胎出生的血祖細(xì)胞的終身多節(jié)奏貢獻(xiàn)。
109.Discovery of bioactive microbial gene products in inflammatory bowel disease.
在炎癥性腸病中發(fā)現(xiàn)生物活性微生物基因產(chǎn)物。
110.The role of NSP6 in the biogenesis of the SARS-CoV-2 replication organelle.
NSP6在SARS-CoV-2復(fù)制細(xì)胞器的生物發(fā)生中的作用。
111.Pregnancy enables antibody protection against intracellular infection.
妊娠可抗細(xì)胞內(nèi)感染的抗體保護(hù)。
112.Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes.
靶向SLC7A11可改善樹突狀細(xì)胞和糖尿病中傷口愈合的胞吐作用。
113.An exercise-inducible metabolite that suppresses feeding and obesity.
一種可抑制喂養(yǎng)和肥胖癥的運(yùn)動(dòng)誘導(dǎo)代謝產(chǎn)物。
114.Androgen receptor activity in T cells limits checkpoint blockade efficacy.
T細(xì)胞中的雄激素受體活性限制了檢查點(diǎn)阻斷功效。
115.Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy.
雄激素受體阻滯促進(jìn)對(duì)BRAF/MEK靶向治療的反應(yīng)。
116.Mitochondrial base editor induces substantial nuclear off-target mutations.
線粒體基礎(chǔ)編輯器誘導(dǎo)大量的核脫靶突變。
117.Cohesin-mediated loop anchors confine the locations of human replication origins.
粘蛋白介導(dǎo)的環(huán)錨限制了人類復(fù)制起源的位置。
118.Structural basis of GABA reuptake inhibition.
GABA再攝取抑制的結(jié)構(gòu)基礎(chǔ)。
119.Landfalling hurricane track modes and decay.
登陸颶風(fēng)軌道模式和衰減。
120.Reply to: Landfalling hurricane track modes and decay.
回復(fù)：登陸颶風(fēng)軌道模式和衰減。
121.Layered material soaks up molecules to form an electron sieve.
分層材料吸收分子形成電子篩。
122.Bacterial envelope built to a peptidoglycan tune.
細(xì)菌包膜建立在肽聚糖曲調(diào)上。
123.Designer protein circuits enable safe cancer immunotherapy.
蛋白電路設(shè)計(jì)師可實(shí)現(xiàn)安全的癌癥免疫療法。
124.Synthesis reveals unexpected biological targets of a traditional medicine.
合成揭示了傳統(tǒng)醫(yī)學(xué)的意外生物學(xué)靶標(biāo)。
125.Mutation and tissue lineage lead to organ-specific cancer.
突變和組織譜系導(dǎo)致器官特異性癌癥。
126.A repeating fast radio burst associated with a persistent radio source.
與持續(xù)無線電源相關(guān)的重復(fù)快速無線電爆發(fā)。
127.Direct measurement of the 3He+ magnetic moments.
直接測(cè)量3He+磁矩。
128.Fault-tolerant operation of a logical qubit in a diamond quantum processor.
鉆石量子處理器中邏輯量子的耐斷層操作。
129.Ordered and tunable Majorana-zero-mode lattice in naturally strained LiFeAs.
在天然緊致的LiFeAs生命周中有序可調(diào)的Majorana-Zero-Mode晶格。
130.Axial Higgs mode detected by quantum pathway interference in RTe3.
通過RTE3中的量子途徑干擾檢測(cè)到的軸向希格斯模式。
131.Chiral molecular intercalation superlattices.
手性分子插入式晶格。
132.Hypocrystalline ceramic aerogels for thermal insulation at extreme conditions.
在極端條件下用于熱絕緣的低晶陶瓷氣凝膠。
133.Synthesis and target annotation of the alkaloid GB18.
生物堿GB18的合成和目標(biāo)注釋。
134.Intermittent lab earthquakes in dynamically weakening fault gouge.
間歇性實(shí)驗(yàn)室地震動(dòng)態(tài)削弱斷層巖石。
135.Breakage of cytoplasmic chromosomes by pathological DNA base excision repair.
通過病理DNA堿基切除修復(fù)的細(xì)胞質(zhì)染色體破裂。
136.A preoptic neuronal population controls fever and appetite during sickness.
上型神經(jīng)元種群控制疾病期間的發(fā)燒和食欲。
137.Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4.
克隆擴(kuò)展的CD8 T細(xì)胞表征了肌萎縮性側(cè)硬化癥-4。
138.Peptidoglycan maturation controls outer membrane protein assembly.
肽聚糖的成熟控制外膜外蛋白組件。
139.Caspase-7 activates ASM to repair gasdermin and perforin pores.
Caspase-7激活A(yù)SM以修復(fù)脂多糖多肽和穿孔。
140.ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids.
ATGL是一種用于羥基脂肪酸脂肪酸酯的生物合成酶。
141.A pan-cancer compendium of chromosomal instability.
染色體不穩(wěn)定性的泛癌組合。
142.Signatures of copy number alterations in human cancer.
人類癌癥拷貝數(shù)改變的簽名。
143.A vaccine targeting resistant tumours by dual T cell plus NK cell attack.
通過雙T細(xì)胞和NK細(xì)胞攻擊靶向抗性腫瘤的疫苗。
144.The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer.
腎臟譜系因子PAX8控制腎癌中的致癌信號(hào)傳導(dǎo)。
145.Mechanism of replication origin melting nucleated by CMG helicase assembly.
CMG解旋酶組裝復(fù)制起點(diǎn)熔融成核機(jī)理。
146.Structural basis of sodium-dependent bile salt uptake into the liver.
依賴鈉的膽汁鹽吸收肝臟的結(jié)構(gòu)基礎(chǔ)。
147.Structure of the bile acid transporter and HBV receptor NTCP.
膽汁酸轉(zhuǎn)運(yùn)蛋白和HBV受體NTCP的結(jié)構(gòu)。
148.Structural insights into the HBV receptor and bile acid transporter NTCP.
對(duì)HBV受體和膽汁酸轉(zhuǎn)運(yùn)蛋白NTCP的結(jié)構(gòu)見解。
