聲明：本專欄主要對生命科學(xué)領(lǐng)域的一些期刊文章標(biāo)題進(jìn)行翻譯，所有內(nèi)容均由本人手工整理翻譯。由于本人專業(yè)為生物分析相關(guān)，其他領(lǐng)域如果出現(xiàn)翻譯錯誤請諒解。

1.Splicing is an alternate oncogenic pathway activation mechanism in glioma.

剪接是膠質(zhì)瘤中另一種致癌途徑的激活機制。

2.Duplex DNA and BLM regulate gate opening by the human TopoIIIα-RMI1-RMI2 complex.

雙鏈DNA和BLM調(diào)節(jié)人類TopoIIIα-RMI1-RMI2復(fù)合物的開門。

3.Geminiviruses employ host DNA glycosylases to subvert DNA methylation-mediated defense.

Geminiviruses利用宿主的DNA糖基化酶來顛覆DNA甲基化介導(dǎo)的防御。

4.Removal of lycopene substrate inhibition enables high carotenoid productivity in Yarrowia lipolytica.

去除番茄紅素底物的抑制，使脂溶雅羅菌具有較高的類胡蘿卜素生產(chǎn)率。

5.Cerebellar connectivity maps embody individual adaptive behavior in mice.

小腦連接圖體現(xiàn)了小鼠的個體適應(yīng)性行為。

6.CAR T cells redirected to cell surface GRP78 display robust anti-acute myeloid leukemia activity and do not target hematopoietic progenitor cells.

重定向到細(xì)胞表面GRP78的CAR T細(xì)胞顯示出強大的抗急性骨髓性白血病活性，并且不針對造血祖細(xì)胞。

7.Heterogeneity within and among co-occurring foundation species increases biodiversity.

共同出現(xiàn)的基礎(chǔ)物種內(nèi)部和之間的異質(zhì)性增加了生物多樣性。

8.NAc-VTA circuit underlies emotional stress-induced anxiety-like behavior in the three-chamber vicarious social defeat stress mouse model.

NAc-VTA回路是三室代際社會失敗壓力小鼠模型中情緒壓力誘導(dǎo)的焦慮樣行為的基礎(chǔ)。

9.Rare transmission of commensal and pathogenic bacteria in the gut microbiome of hospitalized adults.

住院成人腸道微生物組中共生菌和致病菌的罕見傳播。

10.Reply to: No specific relationship between hypnotic suggestibility and the rubber hand illusion.

答復(fù)： 催眠暗示性和橡皮手幻覺之間沒有特定的關(guān)系。

11.Mesenchymal stromal cell-derived septoclasts resorb cartilage during developmental ossification and fracture healing.

間質(zhì)基質(zhì)細(xì)胞衍生的隔膜細(xì)胞在發(fā)育期骨化和骨折愈合過程中吸收軟骨。

12.Structure of Vibrio collagenase VhaC provides insight into the mechanism of bacterial collagenolysis.

弧菌膠原酶VhaC的結(jié)構(gòu)提供了對細(xì)菌膠原溶解機制的深入了解。

13.Decisive role of water and protein dynamics in residence time of p38α MAP kinase inhibitors.

水和蛋白質(zhì)動力學(xué)在p38α MAP激酶抑制劑的停留時間中的決定性作用。

14.Host receptor-targeted therapeutic approach to counter pathogenic New World mammarenavirus infections.

宿主受體靶向治療方法對抗新世界乳腺病毒感染的致病性。

15.Transcriptional changes in the mammary gland during lactation revealed by single cell sequencing of cells from human milk.

通過對人乳中的細(xì)胞進(jìn)行單細(xì)胞測序揭示哺乳期乳腺的轉(zhuǎn)錄變化.

16.No specific relationship between hypnotic suggestibility and the rubber hand illusion.

催眠暗示性與橡膠手幻覺之間沒有特定關(guān)系。

17.Phloem iron remodels root development in response to ammonium as the major nitrogen source.

韌皮部鐵重塑根系發(fā)育對作為主要氮源的銨的反應(yīng)。

18.Accumulation of microbial DNAs promotes to islet inflammation and β cell abnormalities in obesity in mice.

微生物DNA的積累促進(jìn)了小鼠肥胖癥中胰腺炎癥和β細(xì)胞的異常。

19.Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease.

線粒體蛋氨酸腺苷轉(zhuǎn)移酶α1的耗竭引發(fā)酒精相關(guān)肝病的線粒體功能紊亂。

20.Divalent metal cations stimulate skeleton interoception for new bone formation in mouse injury models.

二價金屬陽離子刺激小鼠損傷模型中的骨架互換，促進(jìn)新骨形成。

21.Population structure analysis and laboratory monitoring of Shigella by core-genome multilocus sequence typing.

通過核心基因組多焦點序列分型對志賀菌進(jìn)行種群結(jié)構(gòu)分析和實驗室監(jiān)測。

22.A molecular atlas of innate immunity to adjuvanted and live attenuated vaccines, in mice.

小鼠佐劑疫苗和減毒活疫苗先天免疫的分子圖譜。

23.GPCR kinase knockout cells reveal the impact of individual GRKs on arrestin binding and GPCR regulation.

GPCR激酶敲除細(xì)胞揭示了個別GRKs對逮捕素結(jié)合和GPCR調(diào)節(jié)的影響。

24.Structures and function of a tailoring oxidase in complex with a nonribosomal peptide synthetase module.

尾隨氧化酶與非核糖體肽合成酶模塊復(fù)合的結(jié)構(gòu)和功能。

25.Mutations in respiratory complex I promote antibiotic persistence through alterations in intracellular acidity and protein synthesis.

呼吸復(fù)合物I的突變通過改變細(xì)胞內(nèi)酸度和蛋白質(zhì)合成促進(jìn)抗生素的持久性。

26.Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis.

膽堿能信號在造血干細(xì)胞再生過程中保護(hù)造血干細(xì)胞的靜止?fàn)顟B(tài)。

27.Machine learning-informed and synthetic biology-enabled semi-continuous algal cultivation to unleash renewable fuel productivity.

基于機器學(xué)習(xí)和合成生物學(xué)的半連續(xù)海藻培養(yǎng)，釋放出可再生燃料的生產(chǎn)力。

28.Galectin-9 restricts hepatitis B virus replication via p62/SQSTM1-mediated selective autophagy of viral core proteins.

Galectin-9通過p62/SQSTM1介導(dǎo)的病毒核心蛋白的選擇性自噬來限制乙肝病毒的復(fù)制。

29.Carbohydrate-aromatic interface and molecular architecture of lignocellulose.

木質(zhì)纖維素的碳水化合物-芳香劑界面和分子結(jié)構(gòu)。

30.Aberrant upregulation of the glycolytic enzyme PFKFB3 in CLN7 neuronal ceroid lipofuscinosis.

CLN7神經(jīng)元類脂質(zhì)變性癥中糖酵解酶PFKFB3的異常上調(diào)。

31.Multiple conformations of trimeric spikes visualized on a non-enveloped virus.

非包膜病毒上可視化的三聚體尖峰的多種構(gòu)象。

32.Circularly polarised luminescence laser scanning confocal microscopy to study live cell chiral molecular interactions.

圓偏振發(fā)光激光掃描共聚焦顯微鏡研究活細(xì)胞手性分子相互作用。

33.The neglected role of relative humidity in the interannual variability of urban malaria in Indian cities.

相對濕度在印度城市瘧疾年際變化中被忽視的作用。

34.Structural basis for safe and efficient energy conversion in a respiratory supercomplex.

呼吸系統(tǒng)超級復(fù)合體中安全和高效的能量轉(zhuǎn)換的結(jié)構(gòu)基礎(chǔ)。

35.Emerging experience-dependent dynamics in primary somatosensory cortex reflect behavioral adaptation.

初級體感皮層中新出現(xiàn)的經(jīng)驗依賴型動態(tài)反映了行為適應(yīng)性。

36.Non-telecentric two-photon microscopy for 3D random access mesoscale imaging.

用于三維隨機存取中尺度成像的非遠(yuǎn)程中心雙光子顯微鏡。

37.Degradable mesoporous semimetal antimony nanospheres for near-infrared II multimodal theranostics.

可降解介孔半金屬銻納米球用于近紅外II多模式治療學(xué)。

38.Citrus Huanglongbing is a pathogen-triggered immune disease that can be mitigated with antioxidants and gibberellin.

柑橘黃龍冰是一種病原體引發(fā)的免疫性疾病，可以用抗氧化劑和赤霉素緩解。

39.Engineering the stambomycin modular polyketide synthase yields 37-membered mini-stambomycins.

斯坦博霉素模塊化多酮體合成酶的工程化產(chǎn)生了37元的迷你斯坦博霉素。

40.Defective humoral immunity disrupts bile acid homeostasis which promotes inflammatory disease of the small bowel.

體液免疫缺陷破壞了膽汁酸的平衡，促進(jìn)了小腸的炎癥性疾病。

41.Differential roles for DNAJ isoforms in HTT-polyQ and FUS aggregation modulation revealed by chaperone screens.

在HTT-polyQ和FUS聚集調(diào)節(jié)中的DNAJ異構(gòu)體的不同作用被合劑篩選所揭示。

42.The pollen virome of wild plants and its association with variation in floral traits and land use.

野生植物的花粉病毒組及其與花的性狀和土地利用的變化的關(guān)系。

43.Optimising genomic approaches for identifying vancomycin-resistant Enterococcus faecium transmission in healthcare settings.

優(yōu)化基因組學(xué)方法，識別醫(yī)療機構(gòu)中耐萬古霉素的糞腸球菌傳播。

44.Low CCR5 expression protects HIV-specific CD4+ T cells of elite controllers from viral entry.

低CCR5表達(dá)可保護(hù)精英控制者的HIV特異性CD4+T細(xì)胞免受病毒入侵。

45.Targeted activation of midbrain neurons restores locomotor function in mouse models of parkinsonism.

靶向激活中腦神經(jīng)元可恢復(fù)帕金森癥小鼠模型的運動功能。

46.The MuvB complex binds and stabilizes nucleosomes downstream of the transcription start site of cell-cycle dependent genes.

MuvB復(fù)合物結(jié)合并穩(wěn)定細(xì)胞周期依賴基因轉(zhuǎn)錄起始位點下游的核糖體。

47.Hierarchical and nonhierarchical features of the mouse visual cortical network.

小鼠視覺皮層網(wǎng)絡(luò)的層次性和非層次性特征。

48.Mapping molecular subtype specific alterations in breast cancer brain metastases identifies clinically relevant vulnerabilities.

繪制乳腺癌腦轉(zhuǎn)移的分子亞型特異性改變，確定臨床相關(guān)的脆弱性。

49.Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vascular smooth muscle cell mechanosensation via Piezo1.

微觀骨骼硬度通過Piezo1維持病態(tài)血管平滑肌細(xì)胞的機械感覺，促進(jìn)主動脈瘤的發(fā)生。

50.Neutrophil extracellular traps and their histones promote Th17 cell differentiation directly via TLR2.

中性粒細(xì)胞胞外陷阱及其組蛋白通過TLR2直接促進(jìn)Th17細(xì)胞的分化。

51.Mapping brain structural differences and neuroreceptor correlates in Parkinson’s disease visual hallucinations.

繪制帕金森病視覺幻覺的大腦結(jié)構(gòu)差異和神經(jīng)受體的相關(guān)圖。

52.A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host.

一種非催化性的皰疹病毒蛋白通過針對宿主的激酶對接系統(tǒng)重新配置ERK-RSK信號。

53.Heterotrimeric Gq proteins act as a switch for GRK5/6 selectivity underlying β-arrestin transducer bias.

異三聚體Gq蛋白作為GRK5/6選擇性的開關(guān)，是β-arrestin轉(zhuǎn)導(dǎo)器偏向的基礎(chǔ)。

54.Parallel functional assessment of m6A sites in human endodermal differentiation with base editor screens.

用堿基編輯篩選對人類內(nèi)胚層分化中的m6A位點進(jìn)行平行功能評估。

55.USP44 regulates irradiation-induced DNA double-strand break repair and suppresses tumorigenesis in nasopharyngeal carcinoma.

USP44調(diào)控輻照誘導(dǎo)的DNA雙鏈斷裂修復(fù)并抑制鼻咽癌的腫瘤發(fā)生。

56.Improved gRNA secondary structures allow editing of target sites resistant to CRISPR-Cas9 cleavage.

改進(jìn)的gRNA二級結(jié)構(gòu)允許編輯抗CRISPR-Cas9裂解的目標(biāo)位點。

57.Nitrogen nutrition contributes to plant fertility by affecting meiosis initiation.

氮素營養(yǎng)通過影響減數(shù)分裂的啟動對植物的生育能力做出貢獻(xiàn)。

58.Characterization of the COPD alveolar niche using single-cell RNA sequencing.

利用單細(xì)胞RNA測序?qū)OPD肺泡龕的特征進(jìn)行分析。

59.Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding.

對RAS結(jié)合所介導(dǎo)的BRAF單體到二聚體轉(zhuǎn)變的結(jié)構(gòu)見解。

60.A self-supervised domain-general learning framework for human ventral stream representation.

用于人類腹腔流表征的自監(jiān)督領(lǐng)域通用學(xué)習(xí)框架。

61.Ion currents through Kir potassium channels are gated by anionic lipids.

通過Kir鉀通道的離子電流被陰離子脂類所控制。

62.Systematic decomposition of sequence determinants governing CRISPR/Cas9 specificity.

管理CRISPR/Cas9特異性的序列決定因素的系統(tǒng)化分解。

63.A genome-wide association study of serum proteins reveals shared loci with common diseases.

血清蛋白的全基因組關(guān)聯(lián)研究揭示了與常見疾病的共享位點。

64.Focused ultrasound excites cortical neurons via mechanosensitive calcium accumulation and ion channel amplification.

聚焦超聲通過機械敏感的鈣積累和離子通道放大來激發(fā)皮質(zhì)神經(jīng)元。

65.Nodal is a short-range morphogen with activity that spreads through a relay mechanism in human gastruloids.

Nodal是一種短程形態(tài)發(fā)生劑，其活性通過中繼機制在人類胃腸道中傳播。

66.PHOSPHATE STARVATION RESPONSE transcription factors enable arbuscular mycorrhiza symbiosis.

PHOSPHATE STARVATION RESPONSE轉(zhuǎn)錄因子使菌根共生得以進(jìn)行。

67.Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells.

表觀遺傳修飾物的選擇性翻譯影響神經(jīng)干細(xì)胞的時間模式和分化。

68.High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.

嗜熱真核生物80S核糖體的高分辨率結(jié)構(gòu)揭示了轉(zhuǎn)位的原子細(xì)節(jié)。

69.Modular assembly of the principal microtubule nucleator γ-TuRC.

主要微管核子γ-TuRC的模塊化組裝。

70.Coding and regulatory variants are associated with serum protein levels and disease.

編碼和調(diào)節(jié)變體與血清蛋白水平和疾病有關(guān)。

71.The evolution of mechanisms to produce phenotypic heterogeneity in microorganisms.

微生物中產(chǎn)生表型異質(zhì)性的機制的演變。

72.Immunoglobulin signature predicts risk of post-acute COVID-19 syndrome.

免疫球蛋白特征預(yù)測急性COVID-19后綜合征的風(fēng)險。

73.Regional excess mortality during the 2020 COVID-19 pandemic in five European countries.

2020年歐洲五國COVID-19大流行期間的區(qū)域超額死亡率。

74.Rapid metabolism fosters microbial survival in the deep, hot subseafloor biosphere.

快速的新陳代謝促進(jìn)了深層高溫海底生物圈的微生物生存。

75.Misaligned sequencing reads from the GNAQ-pseudogene locus may yield GNAQ artefact variants.

來自GNAQ-假基因位點的錯位測序讀數(shù)可能產(chǎn)生GNAQ假象變體。

76.Breathing coordinates cortico-hippocampal dynamics in mice during offline states.

呼吸協(xié)調(diào)了小鼠離線狀態(tài)下的皮質(zhì)-海馬動態(tài)。

77.Integration of single-cell transcriptomes and chromatin landscapes reveals regulatory programs driving pharyngeal organ development.

單細(xì)胞轉(zhuǎn)錄組和染色質(zhì)地貌的整合揭示了驅(qū)動咽部器官發(fā)育的調(diào)控程序。

78.A pandemic-enabled comparison of discovery platforms demonstrates a na?ve antibody library can match the best immune-sourced antibodies.

一個由大流行促成的發(fā)現(xiàn)平臺的比較表明，一個幼稚的抗體庫可以匹配最好的免疫來源的抗體。

79.Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections.

人類的繁殖受到來自古代智人特異性病毒感染的逆轉(zhuǎn)錄子的調(diào)節(jié)。

80.Hyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer.

超極化13C-MRI確定了中危人類前列腺癌中出現(xiàn)的糖酵解細(xì)胞群。

81.Structural basis of the ligand binding and signaling mechanism of melatonin receptors.

褪黑激素受體配體結(jié)合和信號傳導(dǎo)機制的結(jié)構(gòu)基礎(chǔ)。

82.Significance of gene variants for the functional biogeography of the near-surface Atlantic Ocean microbiome.

基因變異對大西洋近海微生物組功能生物地理學(xué)的意義。

83.Histone demethylase Lsd1 is required for the differentiation of neural cells in Nematostella vectensis.

組蛋白去甲基化酶Lsd1是Nematostella vectensis神經(jīng)細(xì)胞分化的必要條件。

84.Bicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetase.

雙環(huán)唑類藥物通過抑制寄生蟲的苯丙氨酸t(yī)-RNA合成酶而針對弓形蟲的急性和慢性階段。

85.Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant.

由SARS-CoV-2 Delta變體引起的大規(guī)模、有跡可循的爆發(fā)中的病毒感染和傳播。

86.Pandemic preparedness: synthetic biology and publicly funded biofoundries can rapidly accelerate response time.

大流行病的準(zhǔn)備：合成生物學(xué)和公共資助的生物工廠可以迅速加快反應(yīng)時間。

87.Tissue-specific multi-omics analysis of atrial fibrillation.

心房顫動的組織特異性多組學(xué)分析。

88.Activation of the plant mevalonate pathway by extracellular ATP.

細(xì)胞外ATP對植物甲殼素途徑的激活。

89.Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19.

單細(xì)胞多組學(xué)揭示了進(jìn)展期COVID-19中先天和適應(yīng)性免疫系統(tǒng)的不同步。

90.Adenosine receptor 2a agonists target mouse CD11c+T-bet+ B cells in infection and autoimmunity.

腺苷受體2a激動劑在感染和自身免疫中針對小鼠CD11c+T-bet+B細(xì)胞。

91.Genome-wide detection of CRISPR editing in vivo using GUIDE-tag.

使用GUIDE-tag在體內(nèi)檢測CRISPR編輯的全基因組。

92.Massively parallel characterization of engineered transcript isoforms using direct RNA sequencing.

利用直接RNA測序技術(shù)對工程轉(zhuǎn)錄物異構(gòu)體進(jìn)行大規(guī)模平行表征。

93.Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis.

結(jié)核分枝桿菌的ATP結(jié)合盒F蛋白和核糖體之間的相互作用。

94.The combined DNA and RNA synthetic capabilities of archaeal DNA primase facilitate primer hand-off to the replicative DNA polymerase.

弓形蟲DNA引物酶的DNA和RNA合成能力有助于引物移交給復(fù)制型DNA聚合酶。

95.A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling.

一種Klotho衍生的多肽通過靶向TGF-β信號傳導(dǎo)保護(hù)腎臟纖維化。

96.Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids.

轉(zhuǎn)錄因子PU.1的表達(dá)誘導(dǎo)了人類皮質(zhì)器官中小膠質(zhì)細(xì)胞的產(chǎn)生。

97.Shared features and reciprocal complementation of the Chlamydomonas and Arabidopsis microbiota.

衣藻類和擬南芥微生物群的共同特征和互為補充。

98.A structural basis for the diverse linkage specificities within the ZUFSP deubiquitinase family.

ZUFSP去泛素酶家族中不同連接特異性的結(jié)構(gòu)基礎(chǔ)。

99.Resolving the conflict between antibiotic production and rapid growth by recognition of peptidoglycan of susceptible competitors.

通過識別易感競爭者的肽聚糖來解決抗生素生產(chǎn)和快速生長之間的沖突。

100.A bioactivated in vivo assembly nanotechnology fabricated NIR probe for small pancreatic tumor intraoperative imaging.

一種生物激活的體內(nèi)組裝納米技術(shù)制造的近紅外探針用于小胰腺腫瘤術(shù)中成像。

101.Neuroanatomy in a middle Cambrian mollisoniid and the ancestral nervous system organization of chelicerates.

寒武紀(jì)中期軟體動物的神經(jīng)解剖學(xué)和螯足動物的祖先神經(jīng)系統(tǒng)組織。

102.Correction of a Factor VIII genomic inversion with designer-recombinases.

用特制的重組酶糾正因子VIII的基因組倒置。

103.In vivo spatiotemporal control of voltage-gated ion channels by using photoactivatable peptidic toxins.

利用光活化肽類毒素對電壓門離子通道的體內(nèi)時空控制。

104.Multimorbidity and adverse events of special interest associated with Covid-19 vaccines in Hong Kong.

香港的多發(fā)病和與Covid-19疫苗有關(guān)的特別關(guān)注的不良事件。

105.Macrophages in epididymal adipose tissue secrete osteopontin to regulate bone homeostasis.

附睪脂肪組織中的巨噬細(xì)胞分泌骨質(zhì)素以調(diào)節(jié)骨的平衡。

106.Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2.

循環(huán)中表達(dá)ACE2的胞外囊泡阻斷SARS-CoV-2的廣泛菌株。

107.Stereoselective gold(I)-catalyzed approach to the synthesis of complex α-glycosyl phosphosaccharides.

立體選擇性金（I）催化法合成復(fù)雜的α-糖基磷脂糖。

108.Enrichment of the exocytosis protein STX4 in skeletal muscle remediates peripheral insulin resistance and alters mitochondrial dynamics via Drp1.

骨骼肌中分泌蛋白STX4的富集補救了外周胰島素抵抗，并通過Drp1改變了線粒體的動力學(xué)。

109.Advances in mixed cell deconvolution enable quantification of cell types in spatial transcriptomic data.

混合細(xì)胞解卷的進(jìn)展使空間轉(zhuǎn)錄組數(shù)據(jù)中的細(xì)胞類型得到量化。

110.Immune-related adverse events and the balancing act of immunotherapy.

免疫相關(guān)不良事件和免疫療法的平衡行為。

111.Structure of a type IV secretion system core complex encoded by multi-drug resistance F plasmids.

由多藥耐藥性F質(zhì)粒編碼的IV型分泌系統(tǒng)核心復(fù)合物的結(jié)構(gòu)。

112.Crystal structure of the α1B-adrenergic receptor reveals molecular determinants of selective ligand recognition.

α1B-腎上腺素受體的晶體結(jié)構(gòu)揭示了選擇性配體識別的分子決定因素。

113.Quantification of bone marrow interstitial pH and calcium concentration by intravital ratiometric imaging.

用眼內(nèi)比率成像法量化骨髓間的pH值和鈣濃度。

114.The mitochondrial β-oxidation enzyme HADHA restrains hepatic glucagon response by promoting β-hydroxybutyrate production.

線粒體β-氧化酶HADHA通過促進(jìn)β-羥丁酸的產(chǎn)生抑制肝臟的胰高血糖素反應(yīng)。

115.Nuclear and mitochondrial DNA editing in human cells with zinc finger deaminases.

鋅指脫氨酶在人類細(xì)胞中的核和線粒體DNA編輯。

116.Algorithm-aided engineering of aliphatic halogenase WelO5* for the asymmetric late-stage functionalization of soraphens.

脂肪族鹵化酶WelO5*的算法輔助工程，用于山梨醇的不對稱后期功能化。

117.Deciphering the mechanism of processive ssDNA digestion by the Dna2-RPA ensemble.

破譯Dna2-RPA組合對ssDNA的漸進(jìn)式消化機制。

118.Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2.

感染SARS-CoV-2的孕婦的母體-胎兒免疫反應(yīng)。

119.Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae.

預(yù)適應(yīng)性噬菌體療法與抗生素結(jié)合治療耐潘多拉唑肺炎克雷伯菌引起的骨折相關(guān)感染。

120.Resolving the structure of phage–bacteria interactions in the context of natural diversity.

在自然多樣性的背景下解析噬菌體-細(xì)菌相互作用的結(jié)構(gòu)。

121.53BP1 regulates heterochromatin through liquid phase separation.

53BP1通過液相分離調(diào)控異染色質(zhì)。

122.Retinal pigment epithelium-specific CLIC4 mutant is a mouse model of dry age-related macular degeneration.

視網(wǎng)膜色素上皮細(xì)胞特異性CLIC4突變體是干性年齡相關(guān)性黃斑變性的小鼠模型。

123.Microbiome differential abundance methods produce different results across 38 datasets.

微生物組差異豐度方法在38個數(shù)據(jù)集中產(chǎn)生不同的結(jié)果。

124.Identification of a diarylpentanoid-producing polyketide synthase revealing an unusual biosynthetic pathway of 2-(2-phenylethyl)chromones in agarwood.

鑒定一種生產(chǎn)二元戊酸的聚酮體合成酶，揭示了瓊漿玉液中2-(2-苯基乙基)色酮的一種不尋常的生物合成途徑。

125.Synthetic DNA applications in information technology.

合成DNA在信息技術(shù)中的應(yīng)用。

126.Single-molecule analysis of specificity and multivalency in binding of short linear substrate motifs to the APC/C.

短線底物圖案與APC結(jié)合的特異性和多價性的單分子分析。

127.Pantothenate biosynthesis is critical for chronic infection by the neurotropic parasite Toxoplasma gondii.

泛酸生物合成對神經(jīng)性寄生蟲弓形蟲的慢性感染至關(guān)重要。

128.Pre-configuring chromatin architecture with histone modifications guides hematopoietic stem cell formation in mouse embryos.

用組蛋白修飾預(yù)先配置染色質(zhì)結(jié)構(gòu)指導(dǎo)小鼠胚胎中造血干細(xì)胞的形成。

129.Obligate mutualistic cooperation limits evolvability.

義務(wù)性互助合作限制了進(jìn)化性。

130.Epigenetic aging of the demographically non-aging naked mole-rat.

人口學(xué)上不衰老的裸鼴鼠的表觀遺傳學(xué)衰老。

131.Unprotected peptide macrocyclization and stapling via a fluorine-thiol displacement reaction.

通過氟-硫醇置換反應(yīng)實現(xiàn)無保護(hù)肽的大環(huán)化和裝訂。

132.A polytherapy based approach to combat antimicrobial resistance using cubosomes.

利用立方體對抗抗菌素耐藥性的基于多元療法的方法。

133.The three-dimensional structure of Epstein-Barr virus genome varies by latency type and is regulated by PARP1 enzymatic activity.

Epstein-Barr病毒基因組的三維結(jié)構(gòu)因潛伏期類型而異，并受PARP1酶活性調(diào)節(jié)。

134.Distinct kinetics of antibodies to 111 Plasmodium falciparum proteins identifies markers of recent malaria exposure.

對111種惡性瘧原蟲蛋白的抗體的不同動力學(xué)，確定了近期接觸瘧疾的標(biāo)志物。

135.Two opposing hippocampus to prefrontal cortex pathways for the control of approach and avoidance behaviour.

控制接近和回避行為的兩條對立的海馬到前額葉皮層的途徑。

136.Premature commitment to uncertain decisions during human NMDA receptor hypofunction.

人類NMDA受體功能低下時對不確定決定的過早承諾。

137.Contribution of the medial eye field network to the voluntary deployment of visuospatial attention.

內(nèi)側(cè)眼域網(wǎng)絡(luò)對視覺空間注意的自愿部署的貢獻(xiàn)。

138.RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state.

RNF43/ZNRF3的缺失通過損害肝臟再生和改變肝臟脂質(zhì)代謝基態(tài)而容易導(dǎo)致肝細(xì)胞癌。

139.Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants.

調(diào)節(jié)神經(jīng)元分化的轉(zhuǎn)錄程序在DLG2敲除的人類胚胎干細(xì)胞中被破壞，并富集了精神分裂癥和相關(guān)疾病的風(fēng)險變異。

140.Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice.

粘液蛋白3缺陷小鼠的肺氣腫和巨噬細(xì)胞彈性蛋白酶清除功能受損。

141.Minimal genetically encoded tags for fluorescent protein labeling in living neurons.

在活體神經(jīng)元中用于熒光蛋白標(biāo)記的最小基因編碼標(biāo)簽。

142.The genetic architecture underlying prey-dependent performance in a microbial predator.

微生物捕食者的獵物依賴性表現(xiàn)的遺傳結(jié)構(gòu)。

143.Structure and function of a family of tick-derived complement inhibitors targeting properdin.

蜱蟲源性補體抑制劑家族的結(jié)構(gòu)和功能，以profitdin為目標(biāo)。

144.Model-based evaluation of alternative reactive class closure strategies against COVID-19.

基于模型評估針對COVID-19的替代反應(yīng)性類封閉策略。

145.HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia.

HIF-1與TRIM28和DNA-PK相互作用，釋放暫停的RNA聚合酶II并激活目標(biāo)基因轉(zhuǎn)錄以應(yīng)對缺氧。

146.Modeling uniquely human gene regulatory function via targeted humanization of the mouse genome.

通過小鼠基因組的定向人源化建立獨特的人類基因調(diào)控功能模型。

147.Molecular mechanism of agonism and inverse agonism in ghrelin receptor.

胃泌素受體的激動和反激動的分子機制。

148.An intronic transposon insertion associates with a trans-species color polymorphism in Midas cichlid fishes.

一個內(nèi)含轉(zhuǎn)座子的插入與Midas慈鯛魚的跨物種顏色多態(tài)性有關(guān)。

149.Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy.

Tmem120a基因敲除小鼠的基因組位點錯位產(chǎn)生了潛在的脂肪變性。

150.4polar-STORM polarized super-resolution imaging of actin filament organization in cells.

細(xì)胞內(nèi)肌動蛋白絲組織的4polar-STORM極化超分辨率成像。

151.Linking DNA repair and cell cycle progression through serine ADP-ribosylation of histones.

通過組蛋白的絲氨酸ADP-核糖基化將DNA修復(fù)和細(xì)胞周期進(jìn)展聯(lián)系起來。

152.NuA4 and H2A.Z control environmental responses and autotrophic growth in Arabidopsis.

NuA4和H2A.Z控制擬南芥的環(huán)境反應(yīng)和自養(yǎng)生長。

153.Postmortem high-dimensional immune profiling of severe COVID-19 patients reveals distinct patterns of immunosuppression and immunoactivation.

嚴(yán)重的COVID-19患者的死后高維免疫分析揭示了免疫抑制和免疫激活的不同模式。

154.Dynamic targeting enables domain-general inhibitory control over action and thought by the prefrontal cortex.

動態(tài)定位使前額葉皮層對行動和思維進(jìn)行領(lǐng)域性的抑制控制。

155.The formation of avian montane diversity across barriers and along elevational gradients.

跨越障礙和沿著海拔梯度的鳥類山地多樣性的形成。

156.Single particle cryo-EM structure of the outer hair cell motor protein prestin.

外毛細(xì)胞運動蛋白prestin的單顆粒低溫電鏡結(jié)構(gòu)。

157.Genetic diversity in terrestrial subsurface ecosystems impacted by geological degassing.

受地質(zhì)脫氣影響的陸地次表層生態(tài)系統(tǒng)的遺傳多樣性。

158.Mammalian brain glycoproteins exhibit diminished glycan complexity compared to other tissues.

與其他組織相比，哺乳動物的腦糖蛋白表現(xiàn)出較低的糖類復(fù)雜性。

159.Structural basis of prokaryotic ubiquitin-like protein engagement and translocation by the mycobacterial Mpa-proteasome complex.

原核生物泛素樣蛋白被霉菌Mpa-蛋白酶體復(fù)合體參與和轉(zhuǎn)運的結(jié)構(gòu)基礎(chǔ)。

160.Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma.

SUMO異肽酶SENP6的遺傳改變驅(qū)動彌漫性大B細(xì)胞淋巴瘤的淋巴發(fā)生和遺傳不穩(wěn)定性。

161.Tolerogenic nanoparticles mitigate the formation of anti-drug antibodies against pegylated uricase in patients with hyperuricemia.

耐受性納米顆粒緩解了高尿酸血癥患者對聚乙二醇尿酸酶的抗藥性抗體的形成。

162.Reversing insecticide resistance with allelic-drive in Drosophila melanogaster.

用等位基因驅(qū)動逆轉(zhuǎn)黑腹果蠅的殺蟲劑抗性。

163.Coding strategy for surface luminance switches in the primary visual cortex of the awake monkey.

醒著的猴子初級視覺皮層中表面亮度開關(guān)的編碼策略。

164.The rise of grasslands is linked to atmospheric CO2 decline in the late Palaeogene.

草原的興起與古近代晚期大氣中二氧化碳的減少有關(guān)。

165.Biosensor for branched-chain amino acid metabolism in yeast and applications in isobutanol and isopentanol production.

酵母中支鏈氨基酸代謝的生物傳感器及在異丁醇和異戊醇生產(chǎn)中的應(yīng)用。

166.Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors.

通過IRAK1/4抑制劑消除慢性骨髓性白血病干細(xì)胞。

167.Identification of a modular super-enhancer in murine retinal development.

小鼠視網(wǎng)膜發(fā)育中模塊式超級增強器的鑒定。

168.Matrix mechanics regulates epithelial defence against cancer by tuning dynamic localization of filamin.

基質(zhì)力學(xué)通過調(diào)整絲氨酸的動態(tài)定位來調(diào)節(jié)上皮細(xì)胞對癌癥的防御。

169.Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system.

在無細(xì)胞翻譯系統(tǒng)中為治療相關(guān)的多肽和蛋白質(zhì)建立通用的原型方法。

170.Signatures of selection in recently domesticated macadamia.

最近馴化的澳洲堅果中的選擇特征。

171.Neutron crystallography reveals mechanisms used by Pseudomonas aeruginosa for host-cell binding.

中子晶體學(xué)揭示了銅綠假單胞菌用于宿主細(xì)胞結(jié)合的機制。

172.Determinants of synapse diversity revealed by super-resolution quantal transmission and active zone imaging.

超分辨率定量透射和活性區(qū)成像揭示突觸多樣性的決定因素。

173.Design principles for site-selective hydroxylation by a Rieske oxygenase.

Rieske加氧酶的位點選擇性羥基化的設(shè)計原則。

174.Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2.

對SARS-CoV-2宿主內(nèi)多樣性的細(xì)胞類型特異性進(jìn)化的結(jié)構(gòu)見解。

175.The RNA methyltransferase METTL8 installs m3C32 in mitochondrial tRNAsThr/Ser(UCN) to optimise tRNA structure and mitochondrial translation.

RNA甲基轉(zhuǎn)移酶METTL8在線粒體tRNAsThr/Ser(UCN)中安裝m3C32以優(yōu)化tRNA結(jié)構(gòu)和線粒體翻譯。

176.MyoD is a 3D genome structure organizer for muscle cell identity.

MyoD是肌肉細(xì)胞身份的三維基因組結(jié)構(gòu)組織者。

177.BRCA1 deficiency specific base substitution mutagenesis is dependent on translesion synthesis and regulated by 53BP1.

BRCA1缺失特異性堿基替換突變依賴于翻譯合成并受53BP1調(diào)控。

178.Cancer cell-expressed BTNL2 facilitates tumour immune escape via engagement with IL-17A-producing γδ T cells.

癌細(xì)胞表達(dá)的BTNL2通過與產(chǎn)生IL-17A的γδ T細(xì)胞接觸促進(jìn)腫瘤免疫逃逸。

179.Structural basis of BAK activation in mitochondrial apoptosis initiation.

線粒體細(xì)胞凋亡啟動中BAK激活的結(jié)構(gòu)基礎(chǔ)。

180.Transglutaminase 3 crosslinks the secreted gel-forming mucus component Mucin-2 and stabilizes the colonic mucus layer.

轉(zhuǎn)谷氨酰胺酶3交聯(lián)分泌的形成凝膠的粘液成分Mucin-2并穩(wěn)定結(jié)腸粘液層。

181.The transcription factor hepatocyte nuclear factor 4A acts in the intestine to promote white adipose tissue energy storage.

轉(zhuǎn)錄因子肝細(xì)胞核因子4A在腸道內(nèi)作用，促進(jìn)白色脂肪組織能量儲存。

182.molBV reveals immune landscape of bacterial vaginosis and predicts human papillomavirus infection natural history.

molBV揭示了細(xì)菌性陰道病的免疫景觀并預(yù)測了人類乳頭瘤病毒感染的自然歷史。

183.Distinct mechanisms orchestrate the contra-polarity of IRK and KOIN, two LRR-receptor-kinases controlling root cell division.

不同的機制協(xié)調(diào)了IRK和KOIN這兩個控制根細(xì)胞分裂的LRR-受體激酶的反極性。

184.Robust differentiation of human enteroendocrine cells from intestinal stem cells.

從腸道干細(xì)胞分化出的人類腸道內(nèi)分泌細(xì)胞的穩(wěn)健性。

185.MAPK4 promotes triple negative breast cancer growth and reduces tumor sensitivity to PI3K blockade.

MAPK4促進(jìn)三陰性乳腺癌生長并降低腫瘤對PI3K阻斷的敏感性。

186.The CLASSY family controls tissue-specific DNA methylation patterns in Arabidopsis.

CLASSY家族控制擬南芥的組織特異性DNA甲基化模式。

187.Hydrophilic nanoparticles that kill bacteria while sparing mammalian cells reveal the antibiotic role of nanostructures.

殺死細(xì)菌同時放過哺乳動物細(xì)胞的親水納米顆粒揭示了納米結(jié)構(gòu)的抗生素作用。

188.Age influences on the molecular presentation of tumours.

年齡對腫瘤的分子表現(xiàn)的影響。

189.Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes.

與頸部淋巴結(jié)相連的人腦淋巴網(wǎng)絡(luò)的無創(chuàng)MR成像。

190.Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies.

利用納米抗體繪制1918年大流行流感病毒RNA聚合酶上的抑制性位點。

191.MicroRNA-365 regulates human cardiac action potential duration.

MicroRNA-365調(diào)控人類心臟動作電位持續(xù)時間。

192.Zero-preserving imputation of single-cell RNA-seq data.

單細(xì)胞RNA-seq數(shù)據(jù)的保零歸因。

193.A small RNA that cooperatively senses two stacked metabolites in one pocket for gene control.

一種小RNA在一個口袋里合作感知兩種堆積的代謝物，用于基因控制。

194.Gut microbiota promotes cholesterol gallstone formation by modulating bile acid composition and biliary cholesterol secretion.

腸道微生物群通過調(diào)節(jié)膽汁酸成分和膽汁膽固醇分泌促進(jìn)膽固醇膽石的形成。

195.A cortical cell ensemble in the posterior parietal cortex controls past experience-dependent memory updating.

頂葉后皮層的一個皮質(zhì)細(xì)胞組合控制著過去經(jīng)驗依賴的記憶更新。

196.Phosphoglycolate phosphatase homologs act as glycerol-3-phosphate phosphatase to control stress and healthspan in C. elegans.

磷酸甘油酯磷酸酯酶同源物作為甘油-3-磷酸酯磷酸酯酶控制優(yōu)雅動物的壓力和健康范圍。

197.An anionic ligand snap-locks a long-range interaction in a magnesium-folded riboswitch.

陰離子配體鎖住了鎂折疊核糖開關(guān)中的長程相互作用。

198.A BAFF ligand-based CAR-T cell targeting three receptors and multiple B cell cancers.

一種基于BAFF配體的CAR-T細(xì)胞針對三種受體和多種B細(xì)胞癌癥。

199.Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding site.

MYC的典范WNT信號依賴性門控需要遠(yuǎn)端結(jié)合點的非典范CTCF功能。

200.Berberine bridge enzyme-like oxidase-catalysed double bond isomerization acts as the pathway switch in cytochalasin synthesis.

小檗堿橋酶類氧化酶催化的雙鍵異構(gòu)化作為細(xì)胞色素合成的途徑開關(guān)。

201.A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells.

GATA4調(diào)節(jié)的分泌程序通過招募細(xì)胞毒性CD8 T細(xì)胞抑制腫瘤。

202.A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB/CRTC2 transcriptional complex.

一種蜂膠衍生的小分子通過靶向CREB/CRTC2轉(zhuǎn)錄復(fù)合物改善肥胖小鼠的代謝綜合征。

203.Rapid antigen testing as a reactive response to surges in nosocomial SARS-CoV-2 outbreak risk.

快速抗原檢測作為對鼻腔SARS-CoV-2疫情風(fēng)險激增的反應(yīng)性反應(yīng)。

204.DeepNull models non-linear covariate effects to improve phenotypic prediction and association power.

DeepNull建立非線性協(xié)變量效應(yīng)模型，以提高表型預(yù)測和關(guān)聯(lián)能力。

205.C-type lectin receptor CLEC4A2 promotes tissue adaptation of macrophages and protects against atherosclerosis.

C型凝集素受體CLEC4A2促進(jìn)巨噬細(xì)胞的組織適應(yīng)性并保護(hù)其免受動脈硬化的影響。

206.Lifelong single-cell profiling of cranial neural crest diversification in zebrafish.

斑馬魚顱骨神經(jīng)嵴多樣化的終身單細(xì)胞分析.

207.EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation.

EZH2耗竭增強MYC降解抑制神經(jīng)母細(xì)胞瘤和小細(xì)胞癌腫瘤的形成。

208.The catalytic activity of TCPTP is auto-regulated by its intrinsically disordered tail and activated by Integrin alpha-1.

TCPTP的催化活性受其本征無序尾部的自動調(diào)控，并被整合素α-1激活。

209.Integrating gene expression and clinical data to identify drug repurposing candidates for hyperlipidemia and hypertension.

整合基因表達(dá)和臨床數(shù)據(jù)，確定高脂血癥和高血壓的再利用候選藥物。

210.Dynamic transcriptome and chromatin architecture in granulosa cells during chicken folliculogenesis.

雞卵泡生成過程中顆粒細(xì)胞的動態(tài)轉(zhuǎn)錄組和染色質(zhì)結(jié)構(gòu)。

211.Gasdermin D pores are dynamically regulated by local phosphoinositide circuitry.

Gasdermin D孔是由局部磷脂酰亞胺電路動態(tài)調(diào)節(jié)的。

212.The need for improved methodology in protein corona analysis.

蛋白質(zhì)電暈分析中需要改進(jìn)方法。

213.Temperature sensitivity of Notch signaling underlies species-specific developmental plasticity and robustness in amniote brains.

Notch信號的溫度敏感性是羊齒動物大腦中物種特異性發(fā)育可塑性和穩(wěn)健性的基礎(chǔ)。

214.Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps.

基于吡啶哌嗪的RND型多藥排泄泵的異生抑制劑。

215.Cross-reactive memory T cells associate with protection against SARS-CoV-2 infection in COVID-19 contacts.

交叉反應(yīng)性記憶T細(xì)胞與COVID-19接觸者對SARS-CoV-2感染的保護(hù)有關(guān)。

216.Streamlined single-cell proteomics by an integrated microfluidic chip and data-independent acquisition mass spectrometry.

通過集成微流控芯片和數(shù)據(jù)無關(guān)的采集質(zhì)譜技術(shù)簡化單細(xì)胞蛋白質(zhì)組學(xué)。

217.Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation.

細(xì)菌性炎癥期間，氧化脂質(zhì)代謝受線粒體β-氧化控制。

218.A proximity biotinylation-based approach to identify protein-E3 ligase interactions induced by PROTACs and molecular glues.

基于近似生物素化的方法識別PROTACs和分子膠水誘導(dǎo)的蛋白-E3連接酶相互作用。

219.CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells.

CD4和CD8共同受體調(diào)控CD1b限制性T細(xì)胞的功能熱度。

220.Endosomal trafficking defects alter neural progenitor proliferation and cause microcephaly.

內(nèi)體販運缺陷改變神經(jīng)祖細(xì)胞的增殖并導(dǎo)致小頭畸形。

221.Cortical state dynamics and selective attention define the spatial pattern of correlated variability in neocortex.

皮質(zhì)狀態(tài)動態(tài)和選擇性注意確定了新皮層中相關(guān)變異的空間模式。

222.Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression.

Progranulin通過調(diào)節(jié)MHCI的表達(dá)介導(dǎo)了胰腺導(dǎo)管腺癌的免疫規(guī)避。

223.Prediction of biomarkers and therapeutic combinations for anti-PD-1 immunotherapy using the global gene network association.

利用全球基因網(wǎng)絡(luò)關(guān)聯(lián)預(yù)測抗PD-1免疫療法的生物標(biāo)志物和治療組合。

224.Gain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation.

功能增益基因篩選確定了TMEM120A通過STING激活的抗病毒功能。

225.Spatial transcriptomics using combinatorial fluorescence spectral and lifetime encoding, imaging and analysis.

利用組合熒光光譜和壽命編碼、成像和分析的空間轉(zhuǎn)錄組學(xué)。

226.Alteration of ribosome function upon 5-fluorouracil treatment favors cancer cell drug-tolerance.

5-氟尿嘧啶治療時核糖體功能的改變有利于癌細(xì)胞的耐藥性。

227.The transcription factor ZIP-1 promotes resistance to intracellular infection in Caenorhabditis elegans.

轉(zhuǎn)錄因子ZIP-1促進(jìn)優(yōu)雅動物對細(xì)胞內(nèi)感染的抵抗。

228.Maximizing response to intratumoral immunotherapy in mice by tuning local retention.

通過調(diào)整局部滯留，使小鼠對瘤內(nèi)免疫療法的反應(yīng)最大化。

229.Harnessing protein folding neural networks for peptide–protein docking.

利用蛋白質(zhì)折疊神經(jīng)網(wǎng)絡(luò)進(jìn)行肽-蛋白質(zhì)對接。

230.Hypocrates is a genetically encoded fluorescent biosensor for (pseudo)hypohalous acids and their derivatives.

Hypocrates是一種基因編碼的熒光生物傳感器，用于檢測（偽）次鹵酸及其衍生物。

231.Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states.

人類原發(fā)性前列腺癌的單細(xì)胞分析揭示了腫瘤相關(guān)上皮細(xì)胞狀態(tài)的異質(zhì)性。

232.Mini-batch optimization enables training of ODE models on large-scale datasets.

小型批量優(yōu)化使大規(guī)模數(shù)據(jù)集上的ODE模型得到訓(xùn)練。

233.The legacy of the extinct Neotropical megafauna on plants and biomes.

已滅絕的新熱帶巨型動物對植物和生物群落的影響。

234.Helical structure motifs made searchable for functional peptide design.

可用于功能肽設(shè)計的螺旋結(jié)構(gòu)主題的搜索。

235.Cryo-EM demonstrates the in vitro proliferation of an ex vivo amyloid fibril morphology by seeding.

Cryo-EM證明了體外淀粉樣纖維形態(tài)的播種體外增殖。

236.A method to construct the dynamic landscape of a bio-membrane with experiment and simulation.

一種用實驗和模擬構(gòu)建生物膜動態(tài)景觀的方法。

237.Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast.

乳腺轉(zhuǎn)移性浸潤性微乳頭狀癌的基因組改變和細(xì)胞集群的演變。

238.G-quadruplex DNA structures in human stem cells and differentiation.

人類干細(xì)胞和分化中的G-四聯(lián)體DNA結(jié)構(gòu)。

239.A mass spectrometric method for in-depth profiling of phosphoinositide regioisomers and their disease-associated regulation.

一種質(zhì)譜方法，用于深入分析磷脂酰肌醇 regioisomers 及其與疾病相關(guān)的調(diào)節(jié)。

240.Linking post-translational modifications and protein turnover by site-resolved protein turnover profiling.

通過位點分辨蛋白質(zhì)周轉(zhuǎn)率分析將翻譯后修飾和蛋白質(zhì)周轉(zhuǎn)率聯(lián)系起來。

241.Topographic mapping of the glioblastoma proteome reveals a triple-axis model of intra-tumoral heterogeneity.

膠質(zhì)母細(xì)胞瘤蛋白質(zhì)組的地形圖顯示了腫瘤內(nèi)異質(zhì)性的三軸模型。

242.Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and A? pathology.

反應(yīng)性星形膠質(zhì)細(xì)胞在應(yīng)對Tau和A?病理時獲得了神經(jīng)保護(hù)性以及有害性的特征。

243.Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy.

Hcfc1和Ronin的突變導(dǎo)致鈷胺代謝的先天性錯誤和核糖體病。

244.Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states.

Topoisomerase I (TOP1)的動態(tài)：從開放狀態(tài)到封閉狀態(tài)的構(gòu)象轉(zhuǎn)換。

245.Scn1a gene reactivation after symptom onset rescues pathological phenotypes in a mouse model of Dravet syndrome.

癥狀出現(xiàn)后Scn1a基因的重新激活可挽救Dravet綜合征小鼠模型的病理表型。

246.GPR182 limits antitumor immunity via chemokine scavenging in mouse melanoma models.

GPR182在小鼠黑色素瘤模型中通過趨化因子清除作用限制了抗腫瘤免疫力。

247.Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets.

雪貂SARS-CoV-2感染的年齡依賴性致病特征。

248.Crystal structure and functional implication of bacterial STING.

細(xì)菌STING的晶體結(jié)構(gòu)和功能暗示。

249.SYP72 interacts with the mechanosensitive channel MSL8 to protect pollen from hypoosmotic shock during hydration.

SYP72與機械敏感通道MSL8相互作用，保護(hù)花粉在水化過程中免受低滲透性沖擊。

250.Neuronal Yin Yang1 in the prefrontal cortex regulates transcriptional and behavioral responses to chronic stress in mice.

前額葉皮層的神經(jīng)元Yin Yang1調(diào)節(jié)小鼠慢性應(yīng)激的轉(zhuǎn)錄和行為反應(yīng)。

251.C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer.

C/EBPB依賴對棕櫚酸的適應(yīng)性促進(jìn)激素受體陰性乳腺癌的腫瘤形成。

252.Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation.

GLP-1R肽激動劑參與的動態(tài)與G蛋白激活的動力學(xué)相關(guān)。

253.The role of methanotrophy in the microbial carbon metabolism of temperate lakes.

溫帶湖泊微生物碳代謝中甲烷營養(yǎng)的作用。

254.Hyphal compartmentalization and sporulation in Streptomyces require the conserved cell division protein SepX.

鏈霉菌的分層和孢子形成需要保守的細(xì)胞分裂蛋白SepX。

255.Functional dissection of inherited non-coding variation influencing multiple myeloma risk.

影響多發(fā)性骨髓瘤風(fēng)險的遺傳性非編碼變異的功能剖析。

256.Myeloid cell nuclear differentiation antigen controls the pathogen-stimulated type I interferon cascade in human monocytes by transcriptional regulation of IRF7.

骨髓細(xì)胞核分化抗原通過IRF7的轉(zhuǎn)錄調(diào)控人類單核細(xì)胞中病原體刺激的I型干擾素級聯(lián)。

257.Transient neuronal suppression for exploitation of new sensory evidence.

瞬時神經(jīng)元抑制對新感覺證據(jù)的利用。

258.Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia.

孤獨感和社會隔離與精神分裂癥關(guān)系的多基因貢獻(xiàn)。

259.Resonator nanophotonic standing-wave array trap for single-molecule manipulation and measurement.

用于單分子操作和測量的共振器納米光子駐波陣列陷阱.

260.Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors.

公共和私人T細(xì)胞受體識別的HLA-A2限制性SARS-CoV-2尖峰表位的結(jié)構(gòu)評估。

261.TASOR epigenetic repressor cooperates with a CNOT1 RNA degradation pathway to repress HIV.

TASOR表觀遺傳抑制器與CNOT1 RNA降解途徑合作，抑制艾滋病毒。

262.Polyply; a python suite for facilitating simulations of macromolecules and nanomaterials.

Polyply；一個用于促進(jìn)大分子和納米材料模擬的python套件。

263.DNA methylation aging and transcriptomic studies in horses.

馬的DNA甲基化老化和轉(zhuǎn)錄組學(xué)研究。

264.Mechanism for inverted-repeat recombination induced by a replication fork barrier.

復(fù)制叉屏障誘導(dǎo)的倒置重復(fù)重組的機制。

265.A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo.

一種雙特異性單體納米抗體誘導(dǎo)穗狀三聚體二聚體并在體內(nèi)中和SARS-CoV-2。

266.Single cell transcriptomic landscape of diabetic foot ulcers.

糖尿病足潰瘍的單細(xì)胞轉(zhuǎn)錄組景觀。

267.A de novo paradigm for male infertility.

男性不育癥的新模式。

268.Single-cell chromatin accessibility landscape in kidney identifies additional cell-of-origin in heterogenous papillary renal cell carcinoma.

腎臟中的單細(xì)胞染色質(zhì)可及性景觀確定了異源性乳頭狀腎細(xì)胞癌的額外起源細(xì)胞。

269.Association of mutation signature effectuating processes with mutation hotspots in driver genes and non-coding regions.

突變特征效應(yīng)過程與驅(qū)動基因和非編碼區(qū)的突變熱點的關(guān)聯(lián)。

270.Cryo-EM structure of native human thyroglobulin.

原生人甲狀腺球蛋白的低溫電鏡結(jié)構(gòu)。

271.Phylogenetically and functionally diverse microorganisms reside under the Ross Ice Shelf.

羅斯冰架下居住著系統(tǒng)發(fā)育和功能多樣的微生物。

272.Aminoacyl chain translocation catalysed by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase.

一個不尋常的非核糖體多肽合成酶中的II型硫酯酶域催化的氨基鏈轉(zhuǎn)移。

273.An assembly of nuclear bodies associates with the active VSG expression site in African trypanosomes.

在非洲錐蟲中，核體的集合體與活性VSG表達(dá)位點相聯(lián)系。

274.Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells.

克倫特羅通過骨骼肌細(xì)胞的代謝重編程發(fā)揮抗糖尿病活性。

275.Targeting necroptosis in muscle fibers ameliorates inflammatory myopathies.

靶向肌肉纖維的壞死組織可改善炎癥性肌病。

276.Connected function of PRAF/RLD and GNOM in membrane trafficking controls intrinsic cell polarity in plants.

PRAF/RLD和GNOM在膜販運中的連接功能控制了植物的內(nèi)在細(xì)胞極性。

277.Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue.

血管和血腦屏障相關(guān)的變化是雌性小鼠的應(yīng)激反應(yīng)和復(fù)原力以及人類組織的抑郁癥的基礎(chǔ)。

278.Tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis by modulating β-catenin signaling.

抗酒石酸磷酸酶5通過調(diào)控β-catenin信號傳導(dǎo)促進(jìn)肺纖維化。

279.Latency reversal plus natural killer cells diminish HIV reservoir in vivo.

潛伏期逆轉(zhuǎn)加自然殺傷細(xì)胞減少體內(nèi)的HIV儲庫。

280.Overcoming resistance to immune checkpoint therapy in PTEN-null prostate cancer by intermittent anti-PI3Kα/β/δ treatment.

通過間歇性抗PI3Kα/β/δ治療克服PTEN缺失的前列腺癌對免疫檢查點療法的耐藥性。

281.Proximity labeling identifies a repertoire of site-specific R-loop modulators.

近似標(biāo)記確定了一個位點特異性R環(huán)調(diào)節(jié)器的復(fù)制品。

282.Robust and durable serological response following pediatric SARS-CoV-2 infection.

小兒SARS-CoV-2感染后穩(wěn)健而持久的血清學(xué)反應(yīng)。

283.Imagined speech can be decoded from low- and cross-frequency intracranial EEG features.

想象中的語音可以從低頻和跨頻的顱內(nèi)EEG特征中解碼。

284.Context-independent encoding of passive and active self-motion in vestibular afferent fibers during locomotion in primates.

靈長類動物運動過程中前庭傳入纖維的被動和主動自我運動的情境獨立編碼。

285.Nutrient supply controls the linkage between species abundance and ecological interactions in marine bacterial communities.

營養(yǎng)供應(yīng)控制著海洋細(xì)菌群落中物種豐度和生態(tài)相互作用之間的聯(lián)系。

286.The 2018 European heatwave led to stem dehydration but not to consistent growth reductions in forests.

2018年歐洲熱浪導(dǎo)致莖干脫水，但沒有導(dǎo)致森林一致的生長減退。

287.Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan.

Grainyhead 1作為藥物誘導(dǎo)的保守轉(zhuǎn)錄調(diào)節(jié)器與胰島素信號傳導(dǎo)和壽命有關(guān)。

288.Lipidomic profiling of human serum enables detection of pancreatic cancer.

人類血清的脂質(zhì)組學(xué)分析能夠檢測胰腺癌。

289.Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer’s disease.

阿爾茨海默病中線粒體蛋白、APP和tau的琥珀酰化發(fā)生改變。

290.Focal neural perturbations reshape low-dimensional trajectories of brain activity supporting cognitive performance.

局部神經(jīng)擾動重塑了支持認(rèn)知性能的低維大腦活動軌跡。

291.Targeted editing and evolution of engineered ribosomes in vivo by filtered editing.

通過過濾式編輯對體內(nèi)的工程核糖體進(jìn)行定向編輯和進(jìn)化。

292.Dynamics and mechanism of dimer dissociation of photoreceptor UVR8.

光感受器UVR8的二聚體解離的動力學(xué)和機制。

293.Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation.

多巴胺對酪氨酸羥化酶的抑制和Ser40磷酸化的重新激活的結(jié)構(gòu)機制。

294.Molecular insights into the unusually promiscuous and catalytically versatile Fe(II)/α-ketoglutarate-dependent oxygenase SptF.

對異常雜亂和催化多變的Fe(II)/α-酮戊二酸依賴性加氧酶SptF的分子深入研究。

295.The m6A methyltransferase METTL3 regulates muscle maintenance and growth in mice.

m6A甲基轉(zhuǎn)移酶METTL3調(diào)節(jié)小鼠的肌肉維持和生長。

296.Prefrontal cortical plasticity during learning of cognitive tasks.

認(rèn)知任務(wù)學(xué)習(xí)過程中的前額葉皮層可塑性。

297.Smart facemask for wireless CO2 monitoring.

用于無線二氧化碳監(jiān)測的智能面罩。

298.Population homogeneity for the antibody response to COVID-19 BNT162b2/Comirnaty vaccine is only reached after the second dose across all adult age ranges.

在所有成人年齡范圍內(nèi)，對COVID-19 BNT162b2/Comirnaty疫苗的抗體反應(yīng)的群體同質(zhì)性僅在第二劑后達(dá)到。

299.Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction.

抑制骨形態(tài)發(fā)生蛋白1.3可減少疤痕形成，支持心肌梗死后心肌細(xì)胞的存活。

300.Percolation in networks with local homeostatic plasticity.

具有局部穩(wěn)態(tài)可塑性的網(wǎng)絡(luò)中的滲濾作用。

301.Synthetic recovery of impulse propagation in myocardial infarction via silicon carbide semiconductive nanowires.

通過碳化硅半導(dǎo)電納米線合成恢復(fù)心肌梗塞的脈沖傳播.

302.Maternal regulation of biliary disease in neonates via gut microbial metabolites.

母體通過腸道微生物代謝物對新生兒膽道疾病的調(diào)節(jié)。

303.Dynamics of spike-and nucleocapsid specific immunity during long-term follow-up and vaccination of SARS-CoV-2 convalescents.

SARS-CoV-2康復(fù)者長期隨訪和接種疫苗過程中尖峰和核衣殼特異性免疫力的動態(tài)變化。

304.Yeast-derived nanoparticles remodel the immunosuppressive microenvironment in tumor and tumor-draining lymph nodes to suppress tumor growth.

酵母衍生的納米顆粒重塑腫瘤和腫瘤引流淋巴結(jié)的免疫抑制微環(huán)境，抑制腫瘤生長。

305.Chirality transmission in macromolecular domains.

大分子結(jié)構(gòu)域中的手性傳遞。

306.Total energy expenditure is repeatable in adults but not associated with short-term changes in body composition.

成人的總能量消耗是可重復(fù)的，但與身體成分的短期變化無關(guān)。

307.Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract.

微生物酶通過重新激活小鼠胃腸道中的三氯生而誘發(fā)結(jié)腸炎。

308.Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis.

植物甾醇的全基因組元分析揭示了五個新的基因位點和對冠狀動脈硬化的不利影響。

309.Mechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation.

機械力促進(jìn)二甲基精氨酸二甲氨基水解酶1介導(dǎo)的代謝物不對稱二甲基精氨酸的水解以增強骨形成。

310.Guest-host doped strategy for constructing ultralong-lifetime near-infrared organic phosphorescence materials for bioimaging.

構(gòu)建用于生物成像的超長壽命近紅外有機磷光材料的客體摻雜策略。

311.PPARα?ACOT12 axis is responsible for maintaining cartilage homeostasis through modulating de novo lipogenesis.

PPARα-ACOT12軸負(fù)責(zé)通過調(diào)節(jié)新的脂肪生成來維持軟骨的穩(wěn)態(tài)。