聲明：本專(zhuān)欄主要對(duì)生命科學(xué)領(lǐng)域的一些期刊文章標(biāo)題進(jìn)行翻譯，所有內(nèi)容均由本人手工整理翻譯。由于本人專(zhuān)業(yè)為生物分析相關(guān)，其他領(lǐng)域如果出現(xiàn)翻譯錯(cuò)誤請(qǐng)諒解。

1.Tailored properties through controlled polymerization. Stereochemistry is a crucial yet hard to control parameter that influences the physical properties of polymers. Now, Quentin Michaudel and co-workers disclose a stereocontrolled acyclic diene metathesis (ADMET) polymerization that leverages the high stereoselectivity of a dithiolate Ru catalyst and uses specifically designed diene monomers to afford polymers with predictable compositions of cis and trans alkenes. This strategy enables the thermal properties and crystallinity of various polymers to be modulated through modification of their cis:trans alkene content. The cover shows an artistic representation of diene monomers and oligomers undergoing stereocontrolled ADMET through reaction with the Ru catalyst to form cis alkenes.

通過(guò)受控聚合定制性能。立體化學(xué)是影響聚合物物理性質(zhì)的關(guān)鍵但難以控制的參數(shù)?，F(xiàn)在，Quentin Michaudel 及其同事公開(kāi)了一種立體控制的無(wú)環(huán)二烯復(fù)分解 (ADMET) 聚合，該聚合利用二硫醇釕催化劑的高立體選擇性，并使用專(zhuān)門(mén)設(shè)計(jì)的二烯單體來(lái)提供具有可預(yù)測(cè)的順式和反式烯烴組成的聚合物。這種策略使得各種聚合物的熱性能和結(jié)晶度能夠通過(guò)改變其順式：反式烯烴含量來(lái)調(diào)節(jié)。封面展示了二烯單體和低聚物通過(guò)與 Ru 催化劑反應(yīng)形成順式烯烴進(jìn)行立體控制 ADMET 的藝術(shù)表現(xiàn)。

2.Stereocontrolled acyclic diene metathesis polymerization.

立體控制的無(wú)環(huán)二烯復(fù)分解聚合。

3.Genetically encoded chemical crosslinking of RNA in vivo.

體內(nèi) RNA 的基因編碼化學(xué)交聯(lián)。

4.Genetically encoded chemical crosslinking of carbohydrate.

碳水化合物的基因編碼化學(xué)交聯(lián)。

5.A general arene C–H functionalization strategy via electron donor–acceptor complex photoactivation.

通過(guò)電子供體-受體復(fù)合物光活化的通用芳烴 C-H 功能化策略。

6.Quantum nanomagnets in on-surface metal-free porphyrin chains.

表面無(wú)金屬卟啉鏈中的量子納米磁體。

7.Genetically programmed cell-based synthesis of non-natural peptide and depsipeptide macrocycles.

非天然肽和縮酚肽大環(huán)化合物的基因編程細(xì)胞合成。

8.Non-complementary strand commutation as a fundamental alternative for information processing by DNA and gene regulation.

非互補(bǔ)鏈交換作為 DNA 和基因調(diào)控信息處理的基本替代方案。

9.Efficient room-temperature phosphorescence of covalent organic frameworks through covalent halogen doping.

通過(guò)共價(jià)鹵素?fù)诫s實(shí)現(xiàn)共價(jià)有機(jī)框架的高效室溫磷光。

10.A two-residue nascent-strand steric gate controls synthesis of 2′-O-methyl- and 2′-O-(2-methoxyethyl)-RNA.

兩個(gè)殘基的新生鏈空間門(mén)控制 2'-O-甲基-和 2'-O-(2-甲氧基乙基)-RNA 的合成。

11.Targeted activation in localized protein environments via deep red photoredox catalysis.

通過(guò)深紅色光氧化還原催化在局部蛋白質(zhì)環(huán)境中進(jìn)行靶向激活。

12.Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors.

化學(xué)連通聚合物納米反應(yīng)器中非平衡酶反饋的光開(kāi)關(guān)門(mén)控。

13.A soil-inspired dynamically responsive chemical system for microbial modulation.

一種受土壤啟發(fā)的動(dòng)態(tài)響應(yīng)化學(xué)系統(tǒng)，用于微生物調(diào)節(jié)。

14.The gas-phase formation mechanism of iodic acid as an atmospheric aerosol source.

碘酸作為大氣氣溶膠源的氣相形成機(jī)制。

15.On-surface synthesis of disilabenzene-bridged covalent organic frameworks.

二硅苯橋聯(lián)共價(jià)有機(jī)骨架的表面合成。

16.Insights into the ribosome function from the structures of non-arrested ribosome–nascent chain complexes.

從非停滯核糖體-新生鏈復(fù)合物的結(jié)構(gòu)洞察核糖體功能。

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1.Carbon nanohoops through and through. Interlocked nanocarbons have been attracting attention on account of both their intriguing structures and potential utility, but their synthesis is challenging. Now, a team led by Ramesh Jasti has used an active-template approach to efficiently prepare such threaded compounds. A metal ion held in the central cavity of a macrocyclic precursor catalyses cross-coupling reactions to form a series of mechanically interlocked intermediates. These are then converted into fully π-conjugated species, such as the catenanes and rotaxane depicted on the cover.

碳納米圈徹頭徹尾?；ユi納米碳因其有趣的結(jié)構(gòu)和潛在的實(shí)用性而引起人們的關(guān)注，但它們的合成具有挑戰(zhàn)性?，F(xiàn)在，由 Ramesh Jasti 領(lǐng)導(dǎo)的團(tuán)隊(duì)已經(jīng)使用活性模板方法來(lái)有效地制備此類(lèi)螺紋化合物。保持在大環(huán)前體中心空腔中的金屬離子催化交叉偶聯(lián)反應(yīng)，形成一系列機(jī)械聯(lián)鎖的中間體。然后將它們轉(zhuǎn)化為完全 π 共軛的物質(zhì)，例如封面上描繪的索烷和輪烷。

2.Active template strategy for the preparation of π-conjugated interlocked nanocarbons.

用于制備π共軛聯(lián)鎖納米碳的活性模板策略。

3.A cyclase that catalyses competing 2 + 2 and 4 + 2 cycloadditions.

一種催化競(jìng)爭(zhēng)性 2 + 2 和 4 + 2 環(huán)加成反應(yīng)的環(huán)化酶。

4.Organocatalytic asymmetric deoxygenation of sulfones to access chiral sulfinyl compounds.

砜的有機(jī)催化不對(duì)稱(chēng)脫氧以獲得手性亞磺酰基化合物。

5.Observation of resonances in the transition state region of the F?+?NH3 reaction using anion photoelectron spectroscopy.

使用陰離子光電子能譜觀察 F + NH3 反應(yīng)過(guò)渡態(tài)區(qū)域的共振。

6.An isolable germylyne radical with a one-coordinate germanium atom.

具有單配位鍺原子的可分離甲炔自由基。

7.Using enzymes to tame nitrogen-centred radicals for enantioselective hydroamination.

使用酶馴服以氮為中心的自由基以進(jìn)行對(duì)映選擇性氫胺化。

8.Using supramolecular machinery to engineer directional charge propagation in photoelectrochemical devices.

使用超分子機(jī)械設(shè)計(jì)光電化學(xué)器件中的定向電荷傳播。

9.Using waste poly(vinyl chloride) to synthesize chloroarenes by plasticizer-mediated electro(de)chlorination.

利用廢聚氯乙烯通過(guò)增塑劑介導(dǎo)的電（脫）氯化合成氯芳烴。

10.Supercrystal engineering of atomically precise gold nanoparticles promoted by surface dynamics.

表面動(dòng)力學(xué)促進(jìn)原子級(jí)精確金納米粒子的超晶工程。

11.Adaptive insertion of a hydrophobic anchor into a poly(ethylene glycol) host for programmable surface functionalization.

將疏水錨自適應(yīng)插入聚乙二醇主體中，以實(shí)現(xiàn)可編程表面功能化。

12.Iterative synthesis of 1,3-polyboronic esters with high stereocontrol and application to the synthesis of bahamaolide A.

高立體控制1,3-聚硼酸酯的迭代合成及其在巴哈莫內(nèi)酯A合成中的應(yīng)用

13.Digital micelles of encoded polymeric amphiphiles for direct sequence reading and ex vivo label-free quantification.

編碼聚合兩親物的數(shù)字膠束，用于直接序列讀取和離體無(wú)標(biāo)記定量。

14.Inverse kinetic isotope effects in the oxygen reduction reaction at platinum single crystals.

鉑單晶氧還原反應(yīng)中的逆動(dòng)力學(xué)同位素效應(yīng)。

15.A circular polyester platform based on simple gem-disubstituted valerolactones.

基于簡(jiǎn)單寶石二取代戊內(nèi)酯的圓形聚酯平臺(tái)。

16.Photocatalytic nitrogen fixation under an ambient atmosphere using a porous coordination polymer with bridging dinitrogen anions.

使用具有橋聯(lián)二氮陰離子的多孔配位聚合物在環(huán)境大氣下進(jìn)行光催化固氮。

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1.Effects of enzyme entanglement. Enzymes with identical sequences of amino acids can display different levels of activity when they are encoded with different messenger RNA (mRNA) sequences; however, the reason for this has not been clear. Now, a team led by Edward P. O’Brien has shown that synonymous mutations in mRNA can alter the partitioning of proteins into long-lived soluble misfolded states, and that these different states can possess different levels of activity. The cover depicts an enzyme adopting a misfolded structure during the folding process.

酶纏結(jié)的影響。具有相同氨基酸序列的酶，當(dāng)由不同的信使RNA (mRNA)序列編碼時(shí)，可以表現(xiàn)出不同水平的活性；然而，其原因尚不清楚?，F(xiàn)在，Edward P. O'Brien 領(lǐng)導(dǎo)的團(tuán)隊(duì)表明，mRNA 中的同義突變可以改變蛋白質(zhì)的分配，形成長(zhǎng)期可溶的錯(cuò)誤折疊狀態(tài)，并且這些不同的狀態(tài)可以具有不同水平的活性。封面描繪了一種在折疊過(guò)程中采用錯(cuò)誤折疊結(jié)構(gòu)的酶。

2.How synonymous mutations alter enzyme structure and function over long timescales.

同義突變?nèi)绾卧谳^長(zhǎng)時(shí)間內(nèi)改變酶的結(jié)構(gòu)和功能。

3.Organogel delivery vehicles for the stabilization of organolithium reagents.

用于穩(wěn)定有機(jī)鋰試劑的有機(jī)凝膠遞送載體。

4.Hydrogen atom collisions with a semiconductor efficiently promote electrons to the conduction band.

氫原子與半導(dǎo)體的碰撞有效地將電子提升到導(dǎo)帶。

5.Mechanically gated formation of donor–acceptor Stenhouse adducts enabling mechanochemical multicolour soft lithography.

供體-受體斯滕豪斯加合物的機(jī)械門(mén)控形成，實(shí)現(xiàn)機(jī)械化學(xué)多色軟光刻。

6.Quantum interference effects elucidate triplet-pair formation dynamics in intramolecular singlet-fission molecules.

量子干涉效應(yīng)闡明了分子內(nèi)單線(xiàn)裂變分子中三重線(xiàn)對(duì)形成動(dòng)力學(xué)。

7.φ-Aromaticity in prismatic {Bi6}-based clusters.

φ-基于棱柱 {Bi6} 的團(tuán)簇中的芳香性。

8.Enantioselective synthesis of atropisomeric indoles via iron-catalysed oxidative cross-coupling.

通過(guò)鐵催化的氧化交叉偶聯(lián)對(duì)映選擇性合成阻轉(zhuǎn)異構(gòu)吲哚。

9.Recyclable cyclic bio-based acrylic polymer via pairwise monomer enchainment by a trifunctional Lewis pair.

可回收的環(huán)狀生物基丙烯酸聚合物，通過(guò)三官能路易斯對(duì)成對(duì)單體連接。

10.Photoswitching neutral homoaromatic hydrocarbons.

光開(kāi)關(guān)中性同芳烴。

11.meta-Selective C–H arylation of phenols via regiodiversion of electrophilic aromatic substitution.

通過(guò)親電芳香取代的區(qū)域轉(zhuǎn)移對(duì)苯酚進(jìn)行元選擇性 C-H 芳基化。

12.Cu-catalysed enantioselective radical heteroatomic S–O cross-coupling.

Cu催化的對(duì)映選擇性自由基雜原子S-O交叉偶聯(lián)。

13.Enantioselective fullerene functionalization through stereochemical information transfer from a self-assembled cage.

通過(guò)自組裝籠的立體化學(xué)信息轉(zhuǎn)移進(jìn)行對(duì)映選擇性富勒烯功能化。

14.Dimeric and trimeric catenation of giant chiral [8?+?12] imine cubes driven by weak supramolecular interactions.

由弱超分子相互作用驅(qū)動(dòng)的巨型手性[8 + 12]亞胺立方體的二聚和三聚連接。

15.A synergistic Rh(I)/organoboron-catalysed site-selective carbohydrate functionalization that involves multiple stereocontrol.

協(xié)同 Rh(I)/有機(jī)硼催化的位點(diǎn)選擇性碳水化合物功能化，涉及多重立體控制。

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1.Cooperative components. Many biological nanomachines are assembled from multiple components, but the functional advantages of nanosystems composed of multiple self-assembling molecules compared with those formed from just one component are not well understood. Now, Dominic Lauzon and Alexis Vallée-Bélisle use a DNA-based model system to provide insight into the functionalities that emerge when a nanostructure assembles from multiple components. The cover depicts the programmable assembly of trimeric nanosystems in an anti-cooperative and cooperative manner, and with control over the time-dependence of formation.

合作組件。許多生物納米機(jī)器由多個(gè)組件組裝而成，但與僅由一個(gè)組件形成的納米系統(tǒng)相比，由多個(gè)自組裝分子組成的納米系統(tǒng)的功能優(yōu)勢(shì)尚不清楚?，F(xiàn)在，Dominic Lauzon 和 Alexis Vallée-Bélisle 使用基于 DNA 的模型系統(tǒng)來(lái)深入了解納米結(jié)構(gòu)由多個(gè)組件組裝而成時(shí)出現(xiàn)的功能。封面描繪了三聚體納米系統(tǒng)以反合作和合作方式的可編程組裝，并控制形成的時(shí)間依賴(lài)性。

2.Nanomachines built from multiple components can have functional advantages.

由多個(gè)組件構(gòu)建的納米機(jī)器具有功能優(yōu)勢(shì)。

3.Serial rotation electron diffraction for rapid phase analysis to accelerate materials development.

串行旋轉(zhuǎn)電子衍射用于快速相分析，以加速材料開(kāi)發(fā)。

4.Functional advantages of building nanosystems using multiple molecular components.

使用多個(gè)分子成分構(gòu)建納米系統(tǒng)的功能優(yōu)勢(shì)。

5.Janus-type emission from a cyclometalated iron(III) complex.

來(lái)自環(huán)金屬化鐵 (III) 配合物的 Janus 型發(fā)射。

6.Plasmonic visible–near infrared photothermal activation of olefin metathesis enabling photoresponsive materials.

烯烴復(fù)分解的等離子體可見(jiàn)光-近紅外光熱活化可實(shí)現(xiàn)光響應(yīng)材料。

7.High-throughput phase elucidation of polycrystalline materials using serial rotation electron diffraction.

使用串行旋轉(zhuǎn)電子衍射對(duì)多晶材料進(jìn)行高通量相解析。

8.Structural resolution of a small organic molecule by serial X-ray free-electron laser and electron crystallography.

通過(guò)串行 X 射線(xiàn)自由電子激光和電子晶體學(xué)對(duì)有機(jī)小分子進(jìn)行結(jié)構(gòu)分辨率。

9.Metalloradical approach for concurrent control in intermolecular radical allylic C?H amination.

用于同時(shí)控制分子間自由基烯丙基 C?H 胺化的金屬自由基方法。

10.Nanoparticle stereochemistry-dependent endocytic processing improves in vivo mRNA delivery.

納米顆粒立體化學(xué)依賴(lài)性?xún)?nèi)吞加工可改善體內(nèi) mRNA 遞送。

11.Rupturing aromaticity by periphery overcrowding.

外圍過(guò)度擁擠破壞了芳香性。

12.An NmrA-like enzyme-catalysed redox-mediated Diels–Alder cycloaddition with anti-selectivity.

一種類(lèi)似 NmrA 的酶催化氧化還原介導(dǎo)的具有反選擇性的 Diels-Alder 環(huán)加成反應(yīng)。

13.A catalytic alkene insertion approach to bicyclo[2.1.1]hexane bioisosteres.

雙環(huán)[2.1.1]己烷生物等排體的催化烯烴插入方法。

14.Reversible transformations between the non-porous phases of a flexible coordination network enabled by transient porosity.

由瞬態(tài)孔隙率實(shí)現(xiàn)的靈活配位網(wǎng)絡(luò)的無(wú)孔相之間的可逆轉(zhuǎn)變。

15.Alkyl sulfinates as cross-coupling partners for programmable and stereospecific installation of C(sp3) bioisosteres.

烷基亞磺酸鹽作為 C(sp3) 生物等排體的可編程和立體定向安裝的交叉偶聯(lián)伙伴。

16.Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis.

不尋常的肽結(jié)合蛋白指導(dǎo)鱷魚(yú)素生物合成中吡咯并吲哚啉生物堿的形成。

17.End-of-life upcycling of polyurethanes using a room temperature, mechanism-based degradation.

使用室溫、基于機(jī)制的降解對(duì)聚氨酯進(jìn)行報(bào)廢升級(jí)回收。

18.Protein nanopore reveals the renin–angiotensin system crosstalk with single-amino-acid resolution.

蛋白質(zhì)納米孔以單氨基酸分辨率揭示腎素-血管緊張素系統(tǒng)串?dāng)_。