聲明：本專欄主要對(duì)生命科學(xué)領(lǐng)域的一些期刊文章標(biāo)題進(jìn)行翻譯，所有內(nèi)容均由本人手工整理翻譯。由于本人專業(yè)為生物分析相關(guān)，其他領(lǐng)域如果出現(xiàn)翻譯錯(cuò)誤請(qǐng)諒解。

1.Functional Amyloid Materials. An oat-globulin amyloid aerogel sits on the awns of oat spikelet. This aerogel was fabricated by plant-based oat-globulin amyloid fibrils, made from oat seeds, as those shown in the photo. As a sustainable material source with diverse functionalities, the ensued amyloids were demonstrated as ideal scaffold for material templates such as aerogels, hydrogels, water purification membranes and bioelectrodes. More details can be found in article number 2104445 by Raffaele Mezzenga and co-workers.

功能性淀粉樣蛋白材料。燕麥球蛋白淀粉樣蛋白氣凝膠位于燕麥小穗的芒上。這種氣凝膠是由植物性燕麥球蛋白淀粉樣原纖維制成的，由燕麥種子制成，如圖所示。作為具有多種功能的可持續(xù)材料來源，所產(chǎn)生的淀粉樣蛋白被證明是氣凝膠、水凝膠、水凈化膜和生物電極等材料模板的理想支架。更多詳細(xì)信息，請(qǐng)參閱 Raffaele Mezzenga 及其同事的文章編號(hào) 2104445。

2.RamA-Dependent Transcription Activation. Transcription activator RamA is linked to multidrug resistance of Klebsiella pneumoniae. In article number 2103669, Xiaodong Zhang, Minggui Wang, and co-workers reveal the molecular basis for how RamA interacts with RNA polymerase (RNAP) and activates transcription that contributes to antibiotic resistance. Both common and distinct features are revealed in activator bindings and uncover distinct roles of the two C-terminal domains of RNAP.

RamA 依賴性轉(zhuǎn)錄激活。轉(zhuǎn)錄激活劑 RamA 與肺炎克雷伯菌的多重耐藥性有關(guān)。在第 2103669 號(hào)文章中，Xiaodong Zhang、Minggui Wang 及其同事揭示了 RamA 如何與 RNA 聚合酶 (RNAP) 相互作用并激活導(dǎo)致抗生素耐藥性的轉(zhuǎn)錄的分子基礎(chǔ)。激活劑結(jié)合揭示了共同和獨(dú)特的特征，并揭示了 RNAP 兩個(gè) C 端結(jié)構(gòu)域的不同作用。

3.Artificial Adaptive and Maladaptive Sensory Receptors. In article number 2103484, Chong-Yun Kang, Jung Ho Yoon, and co-workers implement artificial adaptive and maladaptive sensory receptors using a diffusive memristor as a biological counterpart of the somatosensory system in all vertebrates. A new class of artificial receptor underlying surfacedominated switching dynamics successfully mimics key parameters of the biological receptor, including short-latency, selective response, and tunability.

人工適應(yīng)性和適應(yīng)不良感覺感受器。在第 2103484 號(hào)文章中，Chong-Yun Kang、Jung Ho Yoon 及其同事使用擴(kuò)散憶阻器作為所有脊椎動(dòng)物體感系統(tǒng)的生物對(duì)應(yīng)物，實(shí)現(xiàn)了人工適應(yīng)性和適應(yīng)不良感覺受體。一類新型人工受體基于表面主導(dǎo)的開關(guān)動(dòng)力學(xué)，成功地模擬了生物受體的關(guān)鍵參數(shù)，包括短潛伏期、選擇性響應(yīng)和可調(diào)性。

4.Mesenchymal Stem Cells. Chronic inflammation leads to mitochondrial Ca2+ overload and the inhibition of mitophagy due to activation of Wnt/β-catenin pathway in mesenchymal stem cells (MSCs). As a result, dysfunctional mitochondria impair the differentiation of MSCs. In article number 2103839, Xin Chen, Fang Jin, Yan Jin, Bei Li, and co-workers engineer a novel “nano-repairs”, capturing Ca2+ around mitochondria and eliminating the dysfunctional mitochondria. “Nano-repairs” physiologically restore the function of mitochondria and MSCs, which provide therapy for inflammatory bone diseases.

間充質(zhì)干細(xì)胞。間充質(zhì)干細(xì)胞 (MSC) 中 Wnt/β-catenin 通路的激活導(dǎo)致慢性炎癥導(dǎo)致線粒體 Ca2+ 超載和線粒體自噬抑制。因此，功能失調(diào)的線粒體會(huì)損害 MSC 的分化。在第 2103839 號(hào)文章中，Xin Chen、Fang Jin、Yan Jin、Bei Li 及其同事設(shè)計(jì)了一種新穎的“納米修復(fù)”，捕獲線粒體周圍的 Ca2+ 并消除功能失調(diào)的線粒體。 “納米修復(fù)”可在生理上恢復(fù)線粒體和間充質(zhì)干細(xì)胞的功能，從而為炎癥性骨病提供治療。

5.Colon Mucosa Protecting HA-Enema System. In article number 2103189, Yury Rochev, Abhay Pandit, and co-workers develop a biphasic HMW-hyaluronan (HA) enema suspension that protects the dysregulated colitis colon epithelium. The developed HA-based system modulate the intestinal epithelial junctional proteins and regulatory signalling pathways, resulting in attenuation of inflammation and mucosal protection. Furthermore, the developed system helps restore the dysregulated intestinal barrier functions and helps in distal colitis management.

結(jié)腸粘膜保護(hù) HA 灌腸系統(tǒng)。在第 2103189 號(hào)文章中，Yury Rochev、Abhay Pandit 及其同事開發(fā)了一種雙相 HMW-透明質(zhì)酸 (HA) 灌腸懸浮液，可保護(hù)失調(diào)的結(jié)腸炎結(jié)腸上皮。開發(fā)的基于 HA 的系統(tǒng)可調(diào)節(jié)腸上皮連接蛋白和調(diào)節(jié)信號(hào)通路，從而減輕炎癥和保護(hù)粘膜。此外，開發(fā)的系統(tǒng)有助于恢復(fù)失調(diào)的腸道屏障功能，并有助于遠(yuǎn)端結(jié)腸炎的治療。

6.Advances of Organosulfur Materials for Rechargeable Metal Batteries.

用于可充電金屬電池的有機(jī)硫材料的進(jìn)展。

7.From Mesoscopic Functionalization of Silk Fibroin to Smart Fiber Devices for Textile Electronics and Photonics.

從絲素蛋白的介觀功能化到紡織電子和光子學(xué)的智能纖維器件。

8.“Porous and Yet Dense” Electrodes for High-Volumetric-Performance Electrochemical Capacitors: Principles, Advances, and Challenges.

用于高容量性能電化學(xué)電容器的“多孔而致密”電極：原理、進(jìn)展和挑戰(zhàn)。

9.Lithium–Sulfur Batteries Meet Electrospinning: Recent Advances and the Key Parameters for High Gravimetric and Volume Energy Density.

鋰硫電池遇到靜電紡絲：最新進(jìn)展以及高重量和體積能量密度的關(guān)鍵參數(shù)。

10.2D Material-Based Optical Biosensor: Status and Prospect.

基于二維材料的光學(xué)生物傳感器：現(xiàn)狀與前景。

11.T7 Phage as an Emerging Nanobiomaterial with Genetically Tunable Target Specificity.

T7 噬菌體作為一種新興納米生物材料，具有基因可調(diào)的靶標(biāo)特異性。

12.Oat Plant Amyloids for Sustainable Functional Materials.

用于可持續(xù)功能材料的燕麥植物淀粉樣蛋白。

13.Structures of Class I and Class II Transcription Complexes Reveal the Molecular Basis of RamA-Dependent Transcription Activation.

I 類和 II 類轉(zhuǎn)錄復(fù)合物的結(jié)構(gòu)揭示了 RamA 依賴性轉(zhuǎn)錄激活的分子基礎(chǔ)。

14.Artificial Adaptive and Maladaptive Sensory Receptors Based on a Surface-Dominated Diffusive Memristor.

基于表面主導(dǎo)的擴(kuò)散憶阻器的人工自適應(yīng)和適應(yīng)不良感覺感受器。

15.Nanorepairers Rescue Inflammation-Induced Mitochondrial Dysfunction in Mesenchymal Stem Cells.

納米修復(fù)劑可挽救間充質(zhì)干細(xì)胞中炎癥引起的線粒體功能障礙。

16.Modulation of Gut Barrier Functions in Ulcerative Colitis by Hyaluronic Acid System.

透明質(zhì)酸系統(tǒng)對(duì)潰瘍性結(jié)腸炎腸道屏障功能的調(diào)節(jié)。

17.Swallowing Lithium Dendrites in All-Solid-State Battery by Lithiation with Silicon Nanoparticles.

通過硅納米粒子鋰化吞入全固態(tài)電池中的鋰枝晶。

18.Handheld Device for Selective Benzene Sensing over Toluene and Xylene.

用于對(duì)甲苯和二甲苯進(jìn)行選擇性苯傳感的手持設(shè)備。

19.Boosting Output Performance of Triboelectric Nanogenerator via Mutual Coupling Effects Enabled Photon-Carriers and Plasmon.

通過啟用光子載體和等離子體激元的互耦合效應(yīng)提高摩擦納米發(fā)電機(jī)的輸出性能。

20.Asymmetric Oxo-Bridged ZnPb Bimetallic Electrocatalysis Boosting CO2-to-HCOOH Reduction.

不對(duì)稱氧橋 ZnPb 雙金屬電催化促進(jìn) CO2 還原為 HCOOH。

21.Synergistic Binary Fe–Co Nanocluster Supported on Defective Tungsten Oxide as Efficient Oxygen Reduction Electrocatalyst in Zinc-Air Battery.

缺陷氧化鎢負(fù)載的協(xié)同二元鐵鈷納米團(tuán)簇作為鋅空氣電池中的高效氧還原電催化劑。

22.Reversible Kinetic Trapping of FUS Biomolecular Condensates.

FUS 生物分子凝聚物的可逆動(dòng)力學(xué)捕獲。

23.Elaborately Engineering a Self-Indicating Dual-Drug Nanoassembly for Site-Specific Photothermal-Potentiated Thrombus Penetration and Thrombolysis.

精心設(shè)計(jì)一種自我指示雙藥納米組件，用于特定位點(diǎn)的光熱增強(qiáng)血栓穿透和溶栓。

24.Nanomotor-Derived Porous Biomedical Particles from Droplet Microfluidics.

來自液滴微流體的納米馬達(dá)衍生的多孔生物醫(yī)學(xué)顆粒。

25.Boosting Nitrogen Reduction Reaction via Electronic Coupling of Atomically Dispersed Bismuth with Titanium Nitride Nanorods.

通過原子分散的鉍與氮化鈦納米棒的電子耦合促進(jìn)氮還原反應(yīng)。

26.π-Conjugation Induced Anchoring of Ferrocene on Graphdiyne Enable Shuttle-Free Redox Mediation in Lithium-Oxygen Batteries.

π-共軛誘導(dǎo)二茂鐵在石墨二炔上的錨定可實(shí)現(xiàn)鋰氧電池中的無穿梭氧化還原介導(dǎo)。

27.Defect Sites in Zeolites: Origin and Healing.

沸石中的缺陷位點(diǎn)：起源和修復(fù)。

28.Compact SchCas9 Recognizes the Simple NNGR PAM.

Compact SchCas9 識(shí)別簡(jiǎn)單的 NNGR PAM。

29.Hierarchically Multivalent Peptide–Nanoparticle Architectures: A Systematic Approach to Engineer Surface Adhesion.

分層多價(jià)肽-納米粒子結(jié)構(gòu)：設(shè)計(jì)表面粘附的系統(tǒng)方法。

30.A Survey of Chinese Pig Farms and Human Healthcare Isolates Reveals Separate Human and Animal Methicillin-Resistant Staphylococcus aureus Populations.

對(duì)中國(guó)養(yǎng)豬場(chǎng)和人類醫(yī)療保健菌株的調(diào)查揭示了人類和動(dòng)物的耐甲氧西林金黃色葡萄球菌種群。

31.Self-Enhancing Gel Polymer Electrolyte by In Situ Construction for Enabling Safe Lithium Metal Battery.

通過原位構(gòu)建的自增強(qiáng)凝膠聚合物電解質(zhì)可實(shí)現(xiàn)安全的鋰金屬電池。

32.Coupling Water-Proof Li Anodes with LiOH-Based Cathodes Enables Highly Rechargeable Lithium–Air Batteries Operating in Ambient Air.

將防水鋰陽極與 LiOH 基陰極耦合，可實(shí)現(xiàn)在環(huán)境空氣中運(yùn)行的高度可充電鋰空氣電池。

33.A Self-Degradable Conjugated Polymer for Photodynamic Therapy with Reliable Postoperative Safety.

用于光動(dòng)力治療的自降解共軛聚合物，具有可靠的術(shù)后安全性。

34.A Robust Hierarchical MXene/Ni/Aluminosilicate Glass Composite for High-Performance Microwave Absorption.

用于高性能微波吸收的堅(jiān)固的分層 MXene/Ni/鋁硅酸鹽玻璃復(fù)合材料。

35.In Situ RheoNMR Correlation of Polymer Segmental Mobility with Mechanical Properties during Hydrogel Synthesis.

水凝膠合成過程中聚合物鏈段遷移率與機(jī)械性能的原位流變核磁共振相關(guān)性。

36.CoNiO2/Co4N Heterostructure Nanowires Assisted Polysulfide Reaction Kinetics for Improved Lithium–Sulfur Batteries.

CoNiO2/Co4N 異質(zhì)結(jié)構(gòu)納米線輔助多硫化物反應(yīng)動(dòng)力學(xué)改進(jìn)鋰硫電池。

37.Complex Oxides under Simulated Electric Field: Determinants of Defect Polarization in ABO3 Perovskites.

模擬電場(chǎng)下的復(fù)合氧化物：ABO3 鈣鈦礦中缺陷極化的決定因素。

38.A microRNA Cluster Controls Fat Cell Differentiation and Adipose Tissue Expansion By Regulating SNCG.

microRNA 簇通過調(diào)節(jié) SNCG 來控制脂肪細(xì)胞分化和脂肪組織擴(kuò)張。

39.Together is Better: mRNA Co-Encapsulation in Lipoplexes is Required to Obtain Ratiometric Co-Delivery and Protein Expression on the Single Cell Level.

在一起更好：在單細(xì)胞水平上獲得比例共遞送和蛋白質(zhì)表達(dá)需要將 mRNA 共封裝在脂質(zhì)復(fù)合物中。

40.A Primeval Mechanism of Tolerance to Desiccation Based on Glycolic Acid Saves Neurons in Mammals from Ischemia by Reducing Intracellular Calcium-Mediated Excitotoxicity.

基于乙醇酸的耐干燥的原始機(jī)制通過減少細(xì)胞內(nèi)鈣介導(dǎo)的興奮性毒性來拯救哺乳動(dòng)物神經(jīng)元免受缺血。

41.Achieving Efficient p-Type Organic Thermoelectrics by Modulation of Acceptor Unit in Photovoltaic π-Conjugated Copolymers.

通過調(diào)節(jié)光伏 π 共軛共聚物中的受體單元實(shí)現(xiàn)高效的 p 型有機(jī)熱電材料。

42.Bioinspired Catechol-Grafting PEDOT Cathode for an All-Polymer Aqueous Proton Battery with High Voltage and Outstanding Rate Capacity.

用于具有高電壓和出色倍率容量的全聚合物水性質(zhì)子電池的仿生兒茶酚接枝 PEDOT 陰極。

43.Patient-Derived Upper Tract Urothelial Carcinoma Organoids as a Platform for Drug Screening.

患者來源的上尿路尿路上皮癌類器官作為藥物篩選的平臺(tái)。

44.Discovery of Lead-Free Perovskites for High-Performance Solar Cells via Machine Learning: Ultrabroadband Absorption, Low Radiative Combination, and Enhanced Thermal Conductivities.

通過機(jī)器學(xué)習(xí)發(fā)現(xiàn)用于高性能太陽能電池的無鉛鈣鈦礦：超寬帶吸收、低輻射組合和增強(qiáng)的導(dǎo)熱性。

45.Programmable High-Speed and Hyper-Efficiency DNA Signal Magnifier.

可編程高速、超高效 DNA 信號(hào)放大器。

46.Sulfur Vacancy and Ti3C2Tx Cocatalyst Synergistically Boosting Interfacial Charge Transfer in 2D/2D Ti3C2Tx/ZnIn2S4 Heterostructure for Enhanced Photocatalytic Hydrogen Evolution.

硫空位和 Ti3C2TX 助催化劑協(xié)同促進(jìn) 2D/2D Ti3C2TX/ZnIn2S4 異質(zhì)結(jié)構(gòu)中的界面電荷轉(zhuǎn)移，增強(qiáng)光催化析氫。

47.Wearable Triboelectric Sensors Enabled Gait Analysis and Waist Motion Capture for IoT-Based Smart Healthcare Applications.

可穿戴摩擦電傳感器為基于物聯(lián)網(wǎng)的智能醫(yī)療應(yīng)用提供步態(tài)分析和腰部運(yùn)動(dòng)捕捉。

48.Extracellular DNA. In article number 2103693, Li-na Niu and co-workers discuss a fascinating novel function of extracellular DNA as mineralization initiators in ectopic calcification. Extracellular DNAs regulate matrix calcification outside cells and participate in extracellular mineral nucleation and collagen mineralization. This significant discovery enables facile preparation of biomimetic hybrid materials for tissue engineering and provides a potential solution for treatment of diseases associated with ectopic mineralization.

細(xì)胞外DNA。在第 2103693 號(hào)文章中，Li-na Niu 及其同事討論了細(xì)胞外 DNA 作為異位鈣化礦化引發(fā)劑的一個(gè)令人著迷的新功能。細(xì)胞外 DNA 調(diào)節(jié)細(xì)胞外基質(zhì)鈣化，并參與細(xì)胞外礦物質(zhì)成核和膠原蛋白礦化。這一重大發(fā)現(xiàn)使得能夠輕松制備用于組織工程的仿生混合材料，并為治療與異位礦化相關(guān)的疾病提供了潛在的解決方案。

49.Microengineered Multi-Organoid System. In article number 2103495 by Jianhua Qin and co-workers, a novel microfluidic multi-organoid system derived from hiPSCs is proposed to recapitulate human liver-pancreatic islet axis under both physiological and pathological conditions. It allows to investigate the dynamic interplay between liver and islet in type 2 diabetes, providing a unique platform for the study of complex pathogenesis in metabolic diseases and the development of new therapy.

微工程多器官系統(tǒng)。秦建華及其同事在第 2103495 號(hào)文章中提出了一種源自 hiPSC 的新型微流控多類器官系統(tǒng)，用于在生理和病理?xiàng)l件下重現(xiàn)人類肝胰島軸。它可以研究 2 型糖尿病中肝臟和胰島之間的動(dòng)態(tài)相互作用，為研究代謝疾病的復(fù)雜發(fā)病機(jī)制和開發(fā)新療法提供獨(dú)特的平臺(tái)。

50.Hematopoietic Stem and Progenitor Cells. In article number 2103838, Xiao-Ming Yang, Chang-Yan Li and co-workers identify a critical regulator-HEMGN, that is required for hematopoietic stem and progenitor cells (HSPCs) homing, survival, and reconstitution of blood cells during bone marrow transplantation (BMT). HEMGN acts as a protector which limits interferon-γ (IFN-γ) signaling by suppressing nuclear Stat1 tyrosine phosphorylation and assists HSPCs to combat the transplantation stress. Targeted Hemgn may be used to improve conditioning regimens and engraftment during bone marrow transplantation.

造血干細(xì)胞和祖細(xì)胞。在第 2103838 號(hào)文章中，Xiao-Ming Yang、Chang-Yan Li 及其同事發(fā)現(xiàn)了一個(gè)關(guān)鍵的調(diào)節(jié)因子 - HEMGN，它是骨髓移植過程中造血干細(xì)胞和祖細(xì)胞 (HSPC) 歸巢、存活和血細(xì)胞重建所必需的（骨髓移植）。 HEMGN 作為保護(hù)劑，通過抑制核 Stat1 酪氨酸磷酸化來限制干擾素-γ (IFN-γ) 信號(hào)傳導(dǎo)，并協(xié)助 HSPC 對(duì)抗移植應(yīng)激。靶向 Hemgn 可用于改善骨髓移植期間的預(yù)處理方案和植入。

51.Nanodiamonds. Diamond nanocrystals, namely nanodiamonds, hosting point defects such as nitrogen-vacancy (NV) centers have been emerging as one of the most promising quantum materials. In article number 2103598, Ji Tae Kim, Zhiqin Chu, and co-workers develop a direct printing method for nanodiamonds containing NV centers at the quantum level. The method developed here provides a high-precision, lithography-free route to place diamond defects directly on the universal substrate towards their further developments in many exciting quantum research areas and beyond.

納米金剛石。金剛石納米晶體，即納米金剛石，具有氮空位（NV）中心等點(diǎn)缺陷，已成為最有前途的量子材料之一。在第 2103598 號(hào)文章中，Ji Tae Kim、Zhiqin Chu 及其同事開發(fā)了一種直接打印包含量子水平 NV 中心的納米金剛石的方法。這里開發(fā)的方法提供了一種高精度、無需光刻的途徑，可以將金剛石缺陷直接放置在通用基底上，從而在許多令人興奮的量子研究領(lǐng)域及其他領(lǐng)域進(jìn)一步發(fā)展。

52.Bioinspired Thermal Runaway Retardant Capsules for Improved Safety and Electrochemical Performance in Lithium-Ion Batteries.

仿生熱失控阻燃膠囊可提高鋰離子電池的安全性和電化學(xué)性能。

53.Spider Silk-Inspired Artificial Fibers.

受蜘蛛絲啟發(fā)的人造纖維。

54.Stimuli-Responsive Nanoparticles for Controlled Drug Delivery in Synergistic Cancer Immunotherapy.

用于協(xié)同癌癥免疫治療中受控藥物輸送的刺激響應(yīng)納米顆粒。

55.Biophysical Approaches for Applying and Measuring Biological Forces.

應(yīng)用和測(cè)量生物力的生物物理方法。

56.Therapeutic Potentials of Poly (ADP-Ribose) Polymerase 1 (PARP1) Inhibition in Multiple Sclerosis and Animal Models: Concept Revisiting.

多發(fā)性硬化癥和動(dòng)物模型中多聚（ADP-核糖）聚合酶 1 (PARP1) 抑制的治療潛力：概念重溫。

57.Extracellular DNA: A Missing Link in the Pathogenesis of Ectopic Mineralization.

細(xì)胞外 DNA：異位礦化發(fā)病機(jī)制中缺失的一環(huán)。

58.Microengineered Multi-Organoid System from hiPSCs to Recapitulate Human Liver-Islet Axis in Normal and Type 2 Diabetes.

利用 hiPSC 的微工程多器官系統(tǒng)來重現(xiàn)正常和 2 型糖尿病中的人類肝島軸。

59.Hemgn Protects Hematopoietic Stem and Progenitor Cells Against Transplantation Stress Through Negatively Regulating IFN-γ Signaling.

Hemgn 通過負(fù)向調(diào)節(jié) IFN-γ 信號(hào)傳導(dǎo)來保護(hù)造血干細(xì)胞和祖細(xì)胞免受移植應(yīng)激。

60.On-Demand, Direct Printing of Nanodiamonds at the Quantum Level.

按需直接打印量子級(jí)別的納米金剛石。

61.Pressure-Perceptive Actuators for Tactile Soft Robots and Visual Logic Devices.

用于觸覺軟機(jī)器人和視覺邏輯設(shè)備的壓力感知執(zhí)行器。

62.How Materials and Device Factors Determine the Performance: A Unified Solution for Transistors with Nontrivial Gates and Transistor–Diode Hybrid Integration.

材料和器件因素如何決定性能：具有重要柵極和晶體管-二極管混合集成的晶體管的統(tǒng)一解決方案。

63.Freestanding Graphene Fabric Film for Flexible Infrared Camouflage.

用于靈活紅外偽裝的獨(dú)立式石墨烯織物薄膜。

64.Persistence of Monoclinic Crystal Structure in 3D Second-Order Topological Insulator Candidate 1T′-MoTe2 Thin Flake Without Structural Phase Transition.

無結(jié)構(gòu)相變的 3D 二階拓?fù)浣^緣體候選 1T'-MoTe2 薄片中單斜晶體結(jié)構(gòu)的持久性。

65.Sulfisoxazole Elicits Robust Antitumour Immune Response Along with Immune Checkpoint Therapy by Inhibiting Exosomal PD-L1.

磺胺異惡唑通過抑制外泌體 PD-L1 來引發(fā)強(qiáng)大的抗腫瘤免疫反應(yīng)以及免疫檢查點(diǎn)治療。

66.Multifocal Organoid Capturing of Colon Cancer Reveals Pervasive Intratumoral Heterogenous Drug Responses.

結(jié)腸癌的多灶類器官捕獲揭示了普遍存在的瘤內(nèi)異質(zhì)藥物反應(yīng)。

67.Natural Killer Cell Membrane-Cloaked Virus-Mimicking Nanogenerator with NIR-Triggered Shape Reversal and ?C/?OH Storm for Synergistic Thermodynamic–Chemodynamic Therapy.

具有近紅外觸發(fā)形狀反轉(zhuǎn)和?C/?OH風(fēng)暴的自然殺傷細(xì)胞膜包裹病毒模仿納米發(fā)電機(jī)，用于協(xié)同熱力學(xué)-化學(xué)動(dòng)力學(xué)治療。

68.Ultrabroadband Tellurium Photoelectric Detector from Visible to Millimeter Wave.

從可見光到毫米波的超寬帶碲光電探測(cè)器。

69.Beyond the Phase Segregation: Probing the Irreversible Phase Reconstruction of Mixed-Halide Perovskites.

超越相分離：探索混合鹵化物鈣鈦礦的不可逆相重建。

70.Precise Molecular Engineering of Type I Photosensitizers with Near-Infrared Aggregation-Induced Emission for Image-Guided Photodynamic Killing of Multidrug-Resistant Bacteria.

具有近紅外聚集誘導(dǎo)發(fā)射的 I 型光敏劑的精確分子工程，用于圖像引導(dǎo)光動(dòng)力殺死多重耐藥細(xì)菌。

71.Super-Multiplex Nonlinear Optical Imaging Unscrambles the Statistical Complexity of Cancer Subtypes and Tumor Microenvironment.

超級(jí)多重非線性光學(xué)成像闡明了癌癥亞型和腫瘤微環(huán)境的統(tǒng)計(jì)復(fù)雜性。

72.A General Method to Develop Highly Environmentally Sensitive Fluorescent Probes and AIEgens.

開發(fā)高度環(huán)境敏感的熒光探針和 AIEgens 的通用方法。

73.High-Polarity Fluoroalkyl Ether Electrolyte Enables Solvation-Free Li+ Transfer for High-Rate Lithium Metal Batteries.

高極性氟烷基醚電解質(zhì)可實(shí)現(xiàn)高倍率鋰金屬電池的無溶劑化 Li+ 轉(zhuǎn)移。

74.Respective Roles of Inner and Outer Carbon in Boosting the K+ Storage Performance of Dual-Carbon-Confined ZnSe.

內(nèi)部和外部碳在提高雙碳限制的 ZnSe 的 K+ 存儲(chǔ)性能中的各自作用。

75.Partially Reduced Titanium Niobium Oxide: A High-Performance Lithium-Storage Material in a Broad Temperature Range.

部分還原鈦鈮氧化物：一種寬溫度范圍內(nèi)的高性能儲(chǔ)鋰材料。

76.High-Performance P-Channel Tin Halide Perovskite Thin Film Transistor Utilizing a 2D–3D Core–Shell Structure.

采用 2D-3D 核殼結(jié)構(gòu)的高性能 P 溝道鹵化錫鈣鈦礦薄膜晶體管。

77.Ternary Logic with Stateful Neural Networks Using a Bilayered TaOX-Based Memristor Exhibiting Ternary States.

使用具有三態(tài)狀態(tài)的雙層 TaOX 憶阻器的三態(tài)邏輯和狀態(tài)神經(jīng)網(wǎng)絡(luò)。

78.Anti-MicroRNA-21 Oligonucleotide Loaded Spermine-Modified Acetalated Dextran Nanoparticles for B1 Receptor-Targeted Gene Therapy and Antiangiogenesis Therapy.

用于 B1 受體靶向基因治療和抗血管生成治療的抗 MicroRNA-21 寡核苷酸負(fù)載精胺修飾乙?；暇厶羌{米顆粒。

79.3D-Printed Strong Dental Crown with Multi-Scale Ordered Architecture, High-Precision, and Bioactivity.

3D 打印堅(jiān)固牙冠，具有多尺度有序結(jié)構(gòu)、高精度和生物活性。

80.Efficient Photoinduced Electron Transfer from Pyrene-o-Carborane Heterojunction to Selenoviologen for Enhanced Photocatalytic Hydrogen Evolution and Reduction of Alkynes.

從芘-鄰碳硼烷異質(zhì)結(jié)到硒紫精的高效光誘導(dǎo)電子轉(zhuǎn)移，以增強(qiáng)光催化析氫和炔烴還原。

81.A General Protein Unfolding-Chemical Coupling Strategy for Pure Protein Hydrogels with Mechanically Strong and Multifunctional Properties.

具有機(jī)械強(qiáng)度和多功能特性的純蛋白質(zhì)水凝膠的通用蛋白質(zhì)解折疊化學(xué)偶聯(lián)策略。

82.Dark and Bright Excitons in Halide Perovskite Nanoplatelets.

鹵化物鈣鈦礦納米片中的暗激子和亮激子。

83.Room Temperature Phosphorescent (RTP) Thermoplastic Elastomers with Dual and Variable RTP Emission, Photo-Patterning Memory Effect, and Dynamic Deformation RTP Response.

具有雙重和可變 RTP 發(fā)射、照片圖案記憶效應(yīng)和動(dòng)態(tài)變形 RTP 響應(yīng)的室溫磷光 (RTP) 熱塑性彈性體。

84.Novel Thermal Diffusion Temperature Engineering Leading to High Thermoelectric Performance in Bi2Te3-Based Flexible Thin-Films.

新型熱擴(kuò)散溫度工程可在 Bi2Te3 基柔性薄膜中實(shí)現(xiàn)高熱電性能。

85.Porous PdWM (M = Nb, Mo and Ta) Trimetallene for High C1 Selectivity in Alkaline Ethanol Oxidation Reaction.

多孔 PdWM（M = Nb、Mo 和 Ta）三金屬烯在堿性乙醇氧化反應(yīng)中具有高 C1 選擇性。

86.Highly Emissive Blue Quantum Dots with Superior Thermal Stability via In Situ Surface Reconstruction of Mixed CsPbBr3–Cs4PbBr6 Nanocrystals.

通過混合 CsPbBr3–Cs4PbBr6 納米晶體的原位表面重建獲得具有卓越熱穩(wěn)定性的高發(fā)射藍(lán)色量子點(diǎn)。

87.Atomically Dispersed Cu Nanozyme with Intensive Ascorbate Peroxidase Mimic Activity Capable of Alleviating ROS-Mediated Oxidation Damage.

原子分散的銅納米酶具有強(qiáng)抗壞血酸過氧化物酶模擬活性，能夠減輕 ROS 介導(dǎo)的氧化損傷。

88.FasL+PD-L2+ Identifies a Novel Immunosuppressive Neutrophil Population in Human Gastric Cancer That Promotes Disease Progression.

FasL+PD-L2+ 鑒定出人類胃癌中一種新型免疫抑制性中性粒細(xì)胞群，可促進(jìn)疾病進(jìn)展。

89.White Emissions Containing Room Temperature Phosphorescence from Different Excited States of a D–π–A Molecule Depending on the Aggregate States.

根據(jù)聚集態(tài)，D-π-A 分子的不同激發(fā)態(tài)產(chǎn)生包含室溫磷光的白色發(fā)射。

90.In Situ Fabrication of Cuprous Selenide Electrode via Selenization of Copper Current Collector for High-Efficiency Potassium-Ion and Sodium-Ion Storage.

通過銅集流體的硒化原位制造硒化亞銅電極，用于高效鉀離子和鈉離子存儲(chǔ)。

91.Simple Strategy for Scalable Preparation Carbon Dots: RTP, Time-Dependent Fluorescence, and NIR Behaviors.

可擴(kuò)展制備碳點(diǎn)的簡(jiǎn)單策略：RTP、時(shí)間依賴性熒光和近紅外行為。

92.Ultrasensitive Near-Infrared Circularly Polarized Light Detection Using 3D Perovskite Embedded with Chiral Plasmonic Nanoparticles.

使用嵌入手性等離子體納米顆粒的 3D 鈣鈦礦進(jìn)行超靈敏近紅外圓偏振光檢測(cè)。

93.Magnetophoretic Micro-Distributor. In article number 2103579, Byeonghwa Lim, CheolGi Kim, and co-workers propose a magnetophoretic device which consists of a trampoline micromagnet and active elements which enable the control of individual cell-based on physical variables for the automatic separation or selective clustering for intercellular communications. This technology could be a milestone for a better understanding of the intercellular dynamics between clustered cells at the single-cell level for future cell-on-chip applications.

磁泳微型分配器。在第 2103579 號(hào)文章中，Byinghwa Lim、CheolGi Kim 及其同事提出了一種磁泳裝置，該裝置由蹦床微磁體和有源元件組成，能夠基于物理變量控制單個(gè)細(xì)胞，以實(shí)現(xiàn)細(xì)胞間通信的自動(dòng)分離或選擇性聚類。這項(xiàng)技術(shù)可能是一個(gè)里程碑，有助于更好地理解單細(xì)胞水平上簇狀細(xì)胞之間的細(xì)胞間動(dòng)力學(xué)，以用于未來的片上細(xì)胞應(yīng)用。

94.Plasmonic Optoelectronic Memristors. In article number 2104632, Zhongqiang Wang, Haiyang Xu, Yichun Liu, and co-workers report a new type of plasmonic optoelectronic memristor for neuromorphic vision, in which the fully light-modulated synaptic plasticity is demonstrated using visible and ultraviolet light stimulations. This memristor enables the combination of sensing and image pre-processing functions in a single device, which may promote the future development of efficient neuromorphic vision.

等離激元光電憶阻器。在第 2104632 號(hào)文章中，Zhongqiang Wang、Haiyang Xu、Yicun Liu 及其同事報(bào)告了一種用于神經(jīng)形態(tài)視覺的新型等離子體光電憶阻器，其中使用可見光和紫外光刺激證明了完全光調(diào)制的突觸可塑性。該憶阻器能夠?qū)鞲泻蛨D像預(yù)處理功能組合在單個(gè)設(shè)備中，這可能會(huì)促進(jìn)高效神經(jīng)形態(tài)視覺的未來發(fā)展。

95.Magnetomechanical Stimulation. Magnetomechanical stimulation enables remote and selective control of brain cell activity without any need for genetic modification. Antibody-functionalized magnetic particles are targeted to the mechanosensitive astrocytes and a magnetic field is applied to activate signaling pathways that regulate a wide range of brain functions. More details can be found in article number 2104194 by Yichao Yu, Mark F. Lythgoe, and co-workers.

磁機(jī)械刺激。磁機(jī)械刺激能夠遠(yuǎn)程和選擇性地控制腦細(xì)胞活動(dòng)，而不需要任何基因改造。抗體功能化的磁性顆粒靶向機(jī)械敏感的星形膠質(zhì)細(xì)胞，并應(yīng)用磁場(chǎng)來激活調(diào)節(jié)多種大腦功能的信號(hào)通路。更多詳細(xì)信息，請(qǐng)參閱 Yichao Yu、Mark F. Lythgoe 及其同事撰寫的文章，編號(hào)為 2104194。

96.Vertical Synaptic Devices. In article number 2103808, Jin-Hong Park and co-workers develop a vertical synaptic device featuring remote weight control via e-field-dependent movement of mobile ions in ion-gel layer. This synaptic device successfully demonstrates all essential synaptic characteristics, such as excitatory/inhibitory postsynaptic current, paired-pulse facilitation, and long-term potentiation/depression. Such excellent synaptic properties enable a recognition rate of ≈99% in the training and inference tasks for acoustic and emotional information patterns.

垂直突觸設(shè)備。在文章編號(hào) 2103808 中，Jin-Hong Park 及其同事開發(fā)了一種垂直突觸裝置，其特征是通過離子凝膠層中移動(dòng)離子的電場(chǎng)依賴性運(yùn)動(dòng)來遠(yuǎn)程控制重量。該突觸裝置成功地展示了所有基本的突觸特征，例如興奮性/抑制性突觸后電流、配對(duì)脈沖促進(jìn)和長(zhǎng)期增強(qiáng)/抑制。如此出色的突觸特性使得在聲音和情感信息模式的訓(xùn)練和推理任務(wù)中識(shí)別率達(dá)到約 99%。

97.Electrochemical Computing System. In article number 2104076, Megumi Akai-Kasaya and co-workers develop a simple computing system based on the ionic current of electrochemical solutions at micro-scale electrodes. In this system, even deionized water can show great computational power in solving higher-order nonlinear problems. The addition of polyoxometalate molecules diversifies the Faradic currents, which makes it better at predicting periodic signals.

電化學(xué)計(jì)算系統(tǒng)。在文章編號(hào) 2104076 中，Megumi Akai-Kasaya 和同事開發(fā)了一種基于微型電極電化學(xué)溶液離子電流的簡(jiǎn)單計(jì)算系統(tǒng)。在這個(gè)系統(tǒng)中，即使是去離子水也能在解決高階非線性問題時(shí)表現(xiàn)出強(qiáng)大的計(jì)算能力。多金屬氧酸鹽分子的添加使法拉第電流多樣化，這使得它能夠更好地預(yù)測(cè)周期性信號(hào)。

98.Coordinated Cell Motion. In article number 2104808 by Swetha Raghuraman, Timo Betz, and co-workers, a novel migration phenomenon is presented wherein cancer cells burst out from tumor aggregates as an act of pressure release into the surrounding in-homogeneous soft extra-cellular matrix (ECM) made up of collagen. The pressure within tumor aggregates manifests due to cellular swelling, leading to a super-diffusive coordinated expulsion of cells within 12 hours, directed towards regions providing least mechanical resistance

協(xié)調(diào)細(xì)胞運(yùn)動(dòng)。在 Swetha Raghuraman、Timo Betz 及其同事發(fā)表的第 2104808 篇文章中，提出了一種新的遷移現(xiàn)象，其中癌細(xì)胞通過壓力釋放到周圍不均勻的軟細(xì)胞外基質(zhì) (ECM) 中而從腫瘤聚集體中爆發(fā)出來。由膠原蛋白組成。腫瘤聚集體內(nèi)的壓力因細(xì)胞腫脹而顯現(xiàn)，導(dǎo)致細(xì)胞在 12 小時(shí)內(nèi)超擴(kuò)散協(xié)調(diào)排出，指向機(jī)械阻力最小的區(qū)域

99.Interstitial Fluid Behavior and Diseases.

間質(zhì)液行為和疾病。

100.How to Build a Microplastics-Free Environment: Strategies for Microplastics Degradation and Plastics Recycling.

如何建立無微塑料的環(huán)境：微塑料降解和塑料回收策略。

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