簡(jiǎn)介

????Cannabidiol (CBD) has been shown to inhibit pain in various rodent models, but the mechanism of this effect is unknown.?We describe the ability of CBD to inhibit repetitive action potential firing in primary nociceptive neurons from mouse dorsal?root ganglia and analyze the effects on voltage-dependent sodium channels.?We find that CBD interacts with TTX-resistant sodium?channels in a state-dependent manner suggesting particularly tight binding to slow inactivated states of NAV1.8?channels,?which dominate the overall inactivation of NAV1.8 channels for small maintained depolarizations from the resting potential.?The results suggest that CBD can exert analgesic effects in part by directly inhibiting repetitive firing?of primary nociceptors?and suggest a strategy of identifying compounds that bind selectively to slow inactivated states of NAV1.8 channels for developing?effective analgesics.

????大麻二酚（Cannabidiol，CBD）是一種從工業(yè)大麻中提取的化合物，已在多種嚙齒動(dòng)物模型中被證明具有抑制疼痛的作用，但這種作用的機(jī)制尚不清楚。近期，來(lái)自哈佛醫(yī)學(xué)院Bruce Bean課題組的張涵雄（Han-Xiong Bear Zhang）的工作表明，CBD可以通過(guò)直接抑制初級(jí)痛覺(jué)感受體的重復(fù)放電來(lái)部分發(fā)揮鎮(zhèn)痛作用。與此同時(shí)，他們提出，通過(guò)篩選選擇性結(jié)合相關(guān)NAV1.8離子通道慢失活狀態(tài)（slow inactivated state）的化合物，有望開(kāi)發(fā)有效的鎮(zhèn)痛藥物。

會(huì)議信息

主題：云端論腦32期-張涵雄博士生

時(shí)間：

北京7月4日，周日，9: 00AM

美西7月3日，周六，18: 00PM

美東7月3日，周六，21: 00PM

柏林7月4日，周日，3: 00AM

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https://ucsf.zoom.us/j/4229780613

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會(huì)議ID: 4229780613

密碼：13579