聲明：本專欄主要對生命科學(xué)領(lǐng)域的一些期刊文章標(biāo)題進(jìn)行翻譯，所有內(nèi)容均由本人手工整理翻譯。由于本人專業(yè)為生物分析相關(guān)，其他領(lǐng)域如果出現(xiàn)翻譯錯誤請諒解。

1.A natural timeless polymorphism allowing circadian clock synchronization in “white nights”.

一種天然的永恒的多態(tài)性允許在 "白夜 "的晝夜時鐘同步。

2.Robust and tunable signal processing in mammalian cells via engineered covalent modification cycles.

哺乳動物細(xì)胞中通過工程化的共價修飾周期進(jìn)行的穩(wěn)健和可調(diào)整的信號處理。

3.Fixational drift is driven by diffusive dynamics in central neural circuitry.

固定性漂移是由中央神經(jīng)回路的擴(kuò)散動力學(xué)驅(qū)動的。

4.Assembly mechanism of the pleomorphic immature poxvirus scaffold.

多形性未成熟痘病毒支架的組裝機(jī)制。

5.A single-cell analysis of breast cancer cell lines to study tumour heterogeneity and drug response.

研究腫瘤異質(zhì)性和藥物反應(yīng)的乳腺癌細(xì)胞系的單細(xì)胞分析。

6.Isolation of infectious Lloviu virus from Schreiber’s bats in Hungary.

從匈牙利的Schreiber's bats中分離出傳染性的Lloviu病毒。

7.cyCombine allows for robust integration of single-cell cytometry datasets within and across technologies.

cyCombine允許在技術(shù)內(nèi)部和跨技術(shù)之間對單細(xì)胞細(xì)胞儀數(shù)據(jù)集進(jìn)行強(qiáng)有力的整合。

8.Human seasonal influenza under COVID-19 and the potential consequences of influenza lineage elimination.

COVID-19下的人類季節(jié)性流感以及流感血統(tǒng)消除的潛在后果。

9.Individual experience as a key to success for the cuckoo catfish brood parasitism.

個體經(jīng)驗是杜鵑貓科魚雛形寄生成功的關(guān)鍵。

10.A probabilistic map of emotional experiences during competitive social interactions.

競爭性社會互動中情緒體驗的概率圖。

11.USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy.

抑制USP8重塑炎癥腫瘤微環(huán)境，增強(qiáng)了免疫療法的效果。

12.Protein-based SARS-CoV-2 spike vaccine booster increases cross-neutralization against SARS-CoV-2 variants of concern in non-human primates.

基于蛋白質(zhì)的SARS-CoV-2尖峰疫苗增強(qiáng)劑提高了對非人靈長類動物所關(guān)注的SARS-CoV-2變種的交叉中和作用。

13.SHAPE-guided RNA structure homology search and motif discovery.

SHAPE引導(dǎo)的RNA結(jié)構(gòu)同源搜索和動機(jī)發(fā)現(xiàn)。

14.Effects of cryo-EM cooling on structural ensembles.

低溫電鏡冷卻對結(jié)構(gòu)集合的影響。

15.Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.

兒童急性淋巴細(xì)胞白血病細(xì)胞系的綜合多組學(xué)和藥物反應(yīng)分析。

16.Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma.

Hand2劃定了間皮細(xì)胞的祖先，并在間皮瘤中重新激活。

17.Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids.

組織細(xì)胞外基質(zhì)水凝膠作為Matrigel的替代品用于培養(yǎng)胃腸道器官。

18.Cyclophilin anaCyp40 regulates photosystem assembly and phycobilisome association in a cyanobacterium.

嗜環(huán)蛋白anaCyp40調(diào)控藍(lán)藻中的光系統(tǒng)組裝和植物蛋白體的結(jié)合。

19.Donut-like organization of inhibition underlies categorical neural responses in the midbrain.

抑制的甜甜圈式組織是中腦分類神經(jīng)反應(yīng)的基礎(chǔ)。

20.Integrating central nervous system metagenomics and host response for diagnosis of tuberculosis meningitis and its mimics.

整合中樞神經(jīng)系統(tǒng)元組學(xué)和宿主反應(yīng)，診斷結(jié)核性腦膜炎及其模擬物。

21.DLMM as a lossless one-shot algorithm for collaborative multi-site distributed linear mixed models.

DLMM作為協(xié)作式多站點分布式線性混合模型的無損單次算法。

22.Reduced neural activity but improved coding in rodent higher-order visual cortex during locomotion.

運(yùn)動過程中嚙齒動物高階視覺皮層的神經(jīng)活動減少但編碼得到改善。

23.Comprehensive generation, visualization, and reporting of quality control metrics for single-cell RNA sequencing data.

單細(xì)胞RNA測序數(shù)據(jù)質(zhì)量控制指標(biāo)的全面生成、可視化和報告。

24.A hydrogen sulphide-responsive and depleting nanoplatform for cancer photodynamic therapy.

用于癌癥光動力治療的硫化氫反應(yīng)性和耗損性納米平臺。

25.Pervasive Transcription-coupled DNA repair in E. coli.

大腸桿菌中普遍存在的轉(zhuǎn)錄偶合DNA修復(fù)。

26.Structure of a tetrameric photosystem I from a glaucophyte alga Cyanophora paradoxa.

來自藍(lán)藻的四聚體光系統(tǒng)I的結(jié)構(gòu)。

27.Cumulative lifetime stressor exposure assessed by the STRAIN predicts economic ambiguity aversion.

STRAIN評估的終身累積壓力源暴露可預(yù)測經(jīng)濟(jì)模糊性厭惡。

28.Knowledge graph-based recommendation framework identifies drivers of resistance in EGFR mutant non-small cell lung cancer.

基于知識圖譜的推薦框架確定了表皮生長因子受體突變的非小細(xì)胞肺癌的抗性驅(qū)動因素。

29.Lung type II alveolar epithelial cells collaborate with CCR2+ inflammatory monocytes in host defense against poxvirus infection.

肺部II型肺泡上皮細(xì)胞與CCR2+炎癥單核細(xì)胞在宿主防御痘病毒感染方面的協(xié)作。

30.A hierarchical transcriptional network activates specific CDK inhibitors that regulate G2 to control cell size and number in Arabidopsis.

分層轉(zhuǎn)錄網(wǎng)絡(luò)激活特定CDK抑制劑，調(diào)節(jié)G2以控制擬南芥的細(xì)胞大小和數(shù)量。

31.Crystal structure and cellular functions of uPAR dimer.

uPAR二聚體的晶體結(jié)構(gòu)和細(xì)胞功能。

32.The phytochrome interacting proteins ERF55 and ERF58 repress light-induced seed germination in Arabidopsis thaliana.

植物色素相互作用蛋白ERF55和ERF58抑制擬南芥中光誘導(dǎo)的種子發(fā)芽。

33.Trade-off between reducing mutational accumulation and increasing commitment to differentiation determines tissue organization.

減少突變積累和增加分化承諾之間的權(quán)衡決定了組織結(jié)構(gòu)。

34.Phage peptides mediate precision base editing with focused targeting window.

噬菌體肽介導(dǎo)的精確堿基編輯具有集中的靶向窗口。

35.Exploring a blue-light-sensing transcription factor to double the peak productivity of oil in Nannochloropsis oceanica.

探索藍(lán)光感應(yīng)轉(zhuǎn)錄因子，使海洋擬南芥的石油峰值生產(chǎn)力翻倍。

36.BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation.

BAF復(fù)合物介導(dǎo)的染色質(zhì)松弛是建立X染色體失活的必要條件。

37.Rho-dependent transcription termination proceeds via three routes.

Rho依賴的轉(zhuǎn)錄終止通過三種途徑進(jìn)行。

38.Neural relational inference to learn long-range allosteric interactions in proteins from molecular dynamics simulations.

從分子動力學(xué)模擬中學(xué)習(xí)蛋白質(zhì)中長程異生相互作用的神經(jīng)關(guān)系推理。

39.Predictive models for the selection of thermally tolerant corals based on offspring survival.

基于子代存活率的耐高溫珊瑚選擇的預(yù)測模型。

40.Highly efficient prime editing by introducing same-sense mutations in pegRNA or stabilizing its structure.

通過在pegRNA中引入同義突變或穩(wěn)定其結(jié)構(gòu)來實現(xiàn)高效的質(zhì)粒編輯。

41.Empirical prediction of variant-activated cryptic splice donors using population-based RNA-Seq data.

利用基于群體的RNA-Seq數(shù)據(jù)對變異激活的隱性剪接供體進(jìn)行經(jīng)驗性預(yù)測。

42.Adipocyte Gq signaling is a regulator of glucose and lipid homeostasis in mice.

脂肪細(xì)胞Gq信號是小鼠葡萄糖和脂質(zhì)平衡的調(diào)節(jié)器。

43.Structural basis of R-loop recognition by the S9.6 monoclonal antibody.

S9.6單克隆抗體識別R環(huán)的結(jié)構(gòu)基礎(chǔ)。

44.Single-cell transcriptomic analysis suggests two molecularly distinct subtypes of intrahepatic cholangiocarcinoma.

單細(xì)胞轉(zhuǎn)錄組分析表明肝內(nèi)膽管癌有兩種分子上不同的亞型。

45.Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617.

對B.1.617保持效力的單特異性和雙特異性單克隆SARS-CoV-2中和抗體。

46.Cell death-induced immunogenicity enhances chemoimmunotherapeutic response by converting immune-excluded into T-cell inflamed bladder tumors.

細(xì)胞死亡誘導(dǎo)的免疫原性通過將免疫排斥轉(zhuǎn)化為T細(xì)胞炎癥的膀胱腫瘤來增強(qiáng)化療免疫治療反應(yīng)。

47.Modeling of waning immunity after SARS-CoV-2 vaccination and influencing factors.

SARS-CoV-2疫苗接種后免疫力減弱的模型分析及影響因素.

48.Genetic variation of macronutrient tolerance in Drosophila melanogaster.

黑腹果蠅對宏量營養(yǎng)素耐受性的遺傳變異.

49.Machine learning reveals cryptic dialects that explain mate choice in a songbird.

機(jī)器學(xué)習(xí)揭示了解釋一種鳴禽的配偶選擇的隱性方言。

50.Flexible auditory training, psychophysics, and enrichment of common marmosets with an automated, touchscreen-based system.

靈活的聽覺訓(xùn)練，心理物理學(xué)，以及用一個自動的、基于觸摸屏的系統(tǒng)來豐富普通狨猴的內(nèi)容。

51.Distinct genomic landscape of Chinese pediatric acute myeloid leukemia impacts clinical risk classification.

中國小兒急性骨髓性白血病的獨特基因組景觀影響臨床風(fēng)險分類。

52.Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci.

芬蘭男性代謝物的全基因組關(guān)聯(lián)研究確定了與疾病相關(guān)的位點。

53.Filopodia rotate and coil by actively generating twist in their actin shaft.

絲狀體通過主動在其肌動蛋白軸上產(chǎn)生扭曲而旋轉(zhuǎn)和盤繞。

54.Correlational networking guides the discovery of unclustered lanthipeptide protease-encoding genes.

相關(guān)網(wǎng)絡(luò)指導(dǎo)發(fā)現(xiàn)未聚類的鑭系肽蛋白酶編碼基因。

55.Nasal airway transcriptome-wide association study of asthma reveals genetically driven mucus pathobiology.

哮喘的鼻腔氣道轉(zhuǎn)錄組關(guān)聯(lián)研究揭示了基因驅(qū)動的粘液病理學(xué)。

56.Programmable design of isothermal nucleic acid diagnostic assays through abstraction-based models.

通過基于抽象的模型對等溫核酸診斷測定進(jìn)行可編程設(shè)計。

57.Windows of developmental sensitivity to social media.

對社交媒體的發(fā)展敏感性的窗口。

58.A computational model of neurodegeneration in Alzheimer’s disease.

阿爾茨海默病的神經(jīng)變性的計算模型.

59.Integrating deep learning and unbiased automated high-content screening to identify complex disease signatures in human fibroblasts.

整合深度學(xué)習(xí)和無偏見的自動高內(nèi)容篩選以識別人類成纖維細(xì)胞中的復(fù)雜疾病特征.

60.Aegilops sharonensis genome-assisted identification of stem rust resistance gene Sr62.

Aegilops sharonensis基因組輔助鑒定抗莖銹病基因Sr62.

61.CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity.

CRISPR激活篩選發(fā)現(xiàn)BCL-2蛋白和B3GNT2是癌癥對T細(xì)胞介導(dǎo)的細(xì)胞毒性產(chǎn)生抗性的驅(qū)動因素。

62.A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens.

一種針對最優(yōu)先的多藥耐藥革蘭氏陰性病原體的合成脂肽。

63.The landscape of receptor-mediated precision cancer combination therapy via a single-cell perspective.

通過單細(xì)胞視角看受體介導(dǎo)的精準(zhǔn)癌癥聯(lián)合治療的前景。

64.Metabolic engineering strategies to produce medium-chain oleochemicals via acyl-ACP:CoA transacylase activity.

通過酰基-ACP:CoA轉(zhuǎn)酰酶活性生產(chǎn)中鏈油類的代謝工程策略。

65.Membrane thickness, lipid phase and sterol type are determining factors in the permeability of membranes to small solutes.

膜厚度、脂相和甾醇類型是膜對小溶質(zhì)滲透性的決定因素。

66.Functional antagonism between ΔNp63α and GCM1 regulates human trophoblast stemness and differentiation.

ΔNp63α和GCM1之間的功能拮抗作用調(diào)節(jié)人類滋養(yǎng)細(xì)胞的干性和分化。

67.Guide RNAs containing universal bases enable Cas9/Cas12a recognition of polymorphic sequences.

含有通用堿基的引導(dǎo)RNA使Cas9/Cas12a能夠識別多態(tài)序列。

68.MERS-CoV ORF4b employs an unusual binding mechanism to target IMPα and block innate immunity.

MERS-CoV ORF4b采用了一種不尋常的結(jié)合機(jī)制，以IMPα為目標(biāo)，阻斷先天免疫。

69.Comparison of clonal architecture between primary and immunodeficient mouse-engrafted acute myeloid leukemia cells.

原發(fā)性和免疫缺陷小鼠移植的急性骨髓性白血病細(xì)胞之間克隆結(jié)構(gòu)的比較。

70.Comprehensive characterization of PTEN mutational profile in a series of 34,129 colorectal cancers.

34,129例結(jié)直腸癌中PTEN突變情況的綜合特征。

71.Ultrastructural insight into SARS-CoV-2 entry and budding in human airway epithelium.

從超微結(jié)構(gòu)上看SARS-CoV-2在人類呼吸道上皮細(xì)胞中的進(jìn)入和出芽情況。

72.Crystal Structures of Wolbachia CidA and CidB Reveal Determinants of Bacteria-induced Cytoplasmic Incompatibility and Rescue.

Wolbachia CidA和CidB的晶體結(jié)構(gòu)揭示了細(xì)菌引起的細(xì)胞質(zhì)不相容和救援的決定因素。

73.Randomized clinical trial to assess the protective efficacy of a Plasmodium vivax CS synthetic vaccine.

隨機(jī)臨床試驗評估間日瘧CS合成疫苗的保護(hù)效力。

74.PUMILIO proteins promote colorectal cancer growth via suppressing p21.

PUMILIO蛋白通過抑制p21促進(jìn)結(jié)直腸癌生長。

75.Clueless/CLUH regulates mitochondrial fission by promoting recruitment of Drp1 to mitochondria.

Clueless/CLUH通過促進(jìn)Drp1招募到線粒體來調(diào)節(jié)線粒體裂變。

76.UBR4/POE facilitates secretory trafficking to maintain circadian clock synchrony.

UBR4/POE促進(jìn)分泌物販運(yùn)以維持晝夜節(jié)律鐘的同步。

77.A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndrome.

一項全基因組元分析確定了與腕管綜合征相關(guān)的50個遺傳位點。

78.Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay.

Pumilio保護(hù)Xbp1 mRNA免受Ire1依賴性衰變的調(diào)節(jié)。

79.BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by H. pylori-driven inflammation.

BMP前饋回路促進(jìn)胃腺末端分化，并被幽門螺桿菌驅(qū)動的炎癥打斷。

80.Integrative network analysis of early-stage lung adenocarcinoma identifies aurora kinase inhibition as interceptor of invasion and progression.

早期肺腺癌的整合網(wǎng)絡(luò)分析確定了極光激酶抑制是入侵和進(jìn)展的攔截器。

81.Acquiring new memories in neocortex of hippocampal-lesioned mice.

在海馬神經(jīng)元缺失的小鼠新皮層中獲得新記憶。

82.Ultrasound-controllable engineered bacteria for cancer immunotherapy.

用于癌癥免疫治療的超聲控制工程細(xì)菌。

83.The architecture of assisted colonisation in sea turtles: building new populations in a biodiversity crisis.

海龜?shù)妮o助殖民結(jié)構(gòu)：在生物多樣性危機(jī)中建立新的種群。

84.Biosynthesizing structurally diverse diols via a general route combining oxidative and reductive formations of OH-groups.

通過氧化和還原形成OH基團(tuán)的一般途徑生物合成結(jié)構(gòu)多樣的二元醇。

85.Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing.

利用DSB修復(fù)來促進(jìn)高效的同源性和非同源性編輯。

86.Genetic regulation of post-translational modification of two distinct proteins.

兩種不同蛋白質(zhì)翻譯后修飾的遺傳調(diào)節(jié)。

87.Targeting myeloid derived suppressor cells reverts immune suppression and sensitizes BRAF-mutant papillary thyroid cancer to MAPK inhibitors.

靶向骨髓源性抑制細(xì)胞可逆轉(zhuǎn)免疫抑制并使BRAF突變的乳頭狀甲狀腺癌對MAPK抑制劑敏感。

88.Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics.

利用綜合單細(xì)胞轉(zhuǎn)錄組學(xué)設(shè)計支持造血干細(xì)胞發(fā)展的生態(tài)位。

89.Stripenn detects architectural stripes from chromatin conformation data using computer vision.

Stripenn利用計算機(jī)視覺從染色質(zhì)構(gòu)象數(shù)據(jù)中檢測建筑條紋。

90.Loss of CLDN5 in podocytes deregulates WIF1 to activate WNT signaling and contributes to kidney disease.

豆莢細(xì)胞中CLDN5的缺失使WIF1失調(diào)以激活WNT信號并導(dǎo)致腎臟疾病。

91.Mechanistic insights into the regulation of plant phosphate homeostasis by the rice SPX2 – PHR2 complex.

對水稻SPX2-PHR2復(fù)合物調(diào)控植物磷酸鹽平衡的機(jī)理的深入研究。

92.A distinct mechanism of C-type inactivation in the Kv-like KcsA mutant E71V.

Kv-like KcsA突變體E71V中C型失活的獨特機(jī)制。

93.Assessment of global health risk of antibiotic resistance genes.

抗生素耐藥基因的全球健康風(fēng)險評估。

94.PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation.

PCBP2通過拮抗cGAS的凝結(jié)調(diào)節(jié)其酶活性來維持抗病毒信號的平衡。

95.Comparative effectiveness and safety of homologous two-dose ChAdOx1 versus heterologous vaccination with ChAdOx1 and BNT162b2.

同源雙劑量ChAdOx1與異源疫苗接種ChAdOx1和BNT162b2的有效性和安全性比較。

96.Expanding biochemical knowledge and illuminating metabolic dark matter with ATLASx.

用ATLASx拓展生化知識，照亮代謝暗物質(zhì)。

97.Design of stable and self-regulated microbial consortia for chemical synthesis.

用于化學(xué)合成的穩(wěn)定和自我調(diào)節(jié)的微生物聯(lián)合體的設(shè)計。

98.Paternal transmission of migration knowledge in a long-distance bird migrant.

長途遷徙鳥類的遷移知識的父系傳播。

99.Measuring protected-area effectiveness using vertebrate distributions from leech iDNA.

利用水蛭iDNA的脊椎動物分布測量保護(hù)區(qū)的有效性。

100.A distinct mechanism of C-type inactivation in the Kv-like KcsA mutant E71V.

Kv-like KcsA突變體E71V中C型失活的獨特機(jī)制。

101.Assessment of global health risk of antibiotic resistance genes.

抗生素耐藥基因的全球健康風(fēng)險評估。

102.PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation.

PCBP2通過拮抗cGAS的凝結(jié)來調(diào)節(jié)cGAS的酶活性，從而維持抗病毒信號的平衡狀態(tài)。

103.Comparative effectiveness and safety of homologous two-dose ChAdOx1 versus heterologous vaccination with ChAdOx1 and BNT162b2.

同源雙劑量ChAdOx1與異源疫苗接種ChAdOx1和BNT162b2的有效性和安全性比較。

104.Expanding biochemical knowledge and illuminating metabolic dark matter with ATLASx.

用ATLASx拓展生化知識，照亮代謝暗物質(zhì)。

105.Design of stable and self-regulated microbial consortia for chemical synthesis.

用于化學(xué)合成的穩(wěn)定和自我調(diào)節(jié)的微生物聯(lián)合體的設(shè)計。

106.Paternal transmission of migration knowledge in a long-distance bird migrant.

長途遷徙鳥類的遷移知識的父系傳播。

107.Measuring protected-area effectiveness using vertebrate distributions from leech iDNA.

利用水蛭iDNA的脊椎動物分布測量保護(hù)區(qū)的有效性。

108.Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary fibrosis.

抑制肺部微生物群衍生的促凋亡肽可改善肺纖維化的急性加重。

109.Lower novelty-related locus coeruleus function is associated with Aβ-related cognitive decline in clinically healthy individuals.

與新奇事物相關(guān)的位置盤功能降低與臨床健康人的Aβ相關(guān)認(rèn)知能力下降有關(guān)。

110.Unveiling RCOR1 as a rheostat at transcriptionally permissive chromatin.

揭開RCOR1作為轉(zhuǎn)錄允許性染色質(zhì)的流變器的面紗。

111.Reconstructing antibody dynamics to estimate the risk of influenza virus infection.

重建抗體動態(tài)以估計流感病毒感染的風(fēng)險。

112.The Chengjiang Biota inhabited a deltaic environment.

澄江生物群棲息在三角洲環(huán)境中。

113.Mechanism of action and therapeutic route for a muscular dystrophy caused by a genetic defect in lipid metabolism.

脂質(zhì)代謝遺傳缺陷導(dǎo)致的肌肉萎縮癥的作用機(jī)制和治療途徑。

114.eIF6 rebinding dynamically couples ribosome maturation and translation.

eIF6再結(jié)合動態(tài)地耦合核糖體成熟和翻譯。

115.Brain-wide projection reconstruction of single functionally defined neurons.

單個功能定義的神經(jīng)元的全腦投影重建。

116.Identification of a protein responsible for the synthesis of archaeal membrane-spanning GDGT lipids.

鑒定一種負(fù)責(zé)合成古細(xì)菌膜跨度GDGT脂質(zhì)的蛋白質(zhì)。

117.Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics.

基于RNA的治療方法的mRNA結(jié)構(gòu)、穩(wěn)定性和翻譯的組合優(yōu)化。

118.Single-cell transcriptomics identifies potential cells of origin of MYC rhabdoid tumors.

單細(xì)胞轉(zhuǎn)錄組學(xué)確定了MYC橫紋肌瘤的潛在起源細(xì)胞。

119.Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors.

中腦投射到基底外側(cè)杏仁核編碼焦慮樣行為，但不是抑郁樣行為。

120.De novo design and directed folding of disulfide-bridged peptide heterodimers.

二硫橋肽異構(gòu)體的從頭設(shè)計和定向折疊。

121.A deep-learning approach for online cell identification and trace extraction in functional two-photon calcium imaging.

功能性雙光子鈣成像中在線細(xì)胞識別和痕跡提取的深度學(xué)習(xí)方法。

122.Decoding internally generated transitions of conscious contents in the prefrontal cortex without subjective reports.

在沒有主觀報告的情況下對前額葉皮層意識內(nèi)容的內(nèi)部產(chǎn)生的轉(zhuǎn)換進(jìn)行解碼。

123.Transcription factors modulate RNA polymerase conformational equilibrium.

轉(zhuǎn)錄因子調(diào)控RNA聚合酶的構(gòu)象平衡。

124.South-to-north migration preceded the advent of intensive farming in the Maya region.

瑪雅地區(qū)集約化耕作出現(xiàn)之前的由南向北的遷移。

125.Deep-learning two-photon fiberscopy for video-rate brain imaging in freely-behaving mice.

深度學(xué)習(xí)的雙光子纖維鏡用于自由行為小鼠的視頻速率大腦成像。

126.Multiplexed action-outcome representation by striatal striosome-matrix compartments detected with a mouse cost-benefit foraging task.

用小鼠成本-收益覓食任務(wù)檢測紋狀體-矩陣區(qū)塊的多重行動-結(jié)果表示。

127.Structures of pseudorabies virus capsids.

偽狂犬病病毒外殼的結(jié)構(gòu)。

128.GIT1 protects against breast cancer growth through negative regulation of Notch.

GIT1通過對Notch的負(fù)向調(diào)節(jié)保護(hù)乳腺癌的生長。

129.Phylotranscriptomic insights into a Mesoproterozoic–Neoproterozoic origin and early radiation of green seaweeds (Ulvophyceae).

系統(tǒng)轉(zhuǎn)錄組對中生代-新生代綠色海藻（Ulvophyceae）的起源和早期輻射的見解。

130.S6K1-mediated phosphorylation of PDK1 impairs AKT kinase activity and oncogenic functions.

S6K1介導(dǎo)的PDK1磷酸化損害AKT激酶活性和致癌功能。

131.Spelling interface using intracortical signals in a completely locked-in patient enabled via auditory neurofeedback training.

通過聽覺神經(jīng)反饋訓(xùn)練，在一個完全鎖定的病人身上利用皮層內(nèi)信號實現(xiàn)拼寫界面。

132.RUFY3 and RUFY4 are ARL8 effectors that promote coupling of endolysosomes to dynein-dynactin.

RUFY3和RUFY4是ARL8效應(yīng)器，促進(jìn)內(nèi)溶酶體與dynein-dynactin的耦合。

133.Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium.

分化細(xì)胞的時空重編程是腸道上皮細(xì)胞再生和腫瘤的基礎(chǔ)。

134.New recognition specificity in a plant immune receptor by molecular engineering of its integrated domain.

通過整合結(jié)構(gòu)域的分子工程在植物免疫受體中的新識別特異性。

135.Massively parallel reporter perturbation assays uncover temporal regulatory architecture during neural differentiation.

大規(guī)模并行報告擾動實驗揭示了神經(jīng)分化過程中的時間調(diào)控架構(gòu)。

136.The induction of natural competence adapts staphylococcal metabolism to infection.

自然能力的誘導(dǎo)使葡萄球菌的代謝適應(yīng)于感染。

137.Atomic resolution dynamics of cohesive interactions in phase-separated Nup98 FG domains.

相分離的Nup98 FG結(jié)構(gòu)域中內(nèi)聚相互作用的原子分辨率動態(tài)。

138.An RNA-binding protein acts as a major post-transcriptional modulator in Bacillus anthracis.

炭疽桿菌中一種RNA結(jié)合蛋白作為主要的轉(zhuǎn)錄后調(diào)節(jié)劑。

139.Asymmetric peptidoglycan editing generates cell curvature in Bdellovibrio predatory bacteria.

不對稱的肽聚糖編輯在捕食性細(xì)菌中產(chǎn)生細(xì)胞曲率。

140.Comparative effectiveness of the BNT162b2 and ChAdOx1 vaccines against Covid-19 in people over 50.

BNT162b2和ChAdOx1疫苗對50歲以上人群Covid-19的有效性比較。

141.cAMP and c-di-GMP synergistically support biofilm maintenance through the direct interaction of their effectors.

cAMP和c-di-GMP通過其效應(yīng)器的直接互動，協(xié)同支持生物膜的維持。

142.Siwi cooperates with Par-1 kinase to resolve the autoinhibitory effect of Papi for Siwi-piRISC biogenesis.

Siwi與Par-1激酶合作，解決Papi對Siwi-piRISC生物生成的自抑制作用。

143.Using CRISPR-Kill for organ specific cell elimination by cleavage of tandem repeats.

利用CRISPR-Kill通過裂解串聯(lián)重復(fù)序列來消除器官特定的細(xì)胞。

144.Rational design of hairpin RNA excited states reveals multi-step transitions.

發(fā)夾式RNA激發(fā)態(tài)的合理設(shè)計揭示了多步驟的轉(zhuǎn)變。

145.ADARs act as potent regulators of circular transcriptome in cancer.

ADARs在癌癥中作為循環(huán)轉(zhuǎn)錄組的有力調(diào)節(jié)者。

146.Progression of type 1 diabetes from latency to symptomatic disease is predicted by distinct autoimmune trajectories.

1型糖尿病從潛伏期到癥狀性疾病的進(jìn)展是由不同的自身免疫軌跡預(yù)測的。

147.A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine.

具有高丙酮酸脫氫酶活性的非分裂細(xì)胞群調(diào)節(jié)著腸道的代謝異質(zhì)性和腫瘤發(fā)生。

148.Transposon insertional mutagenesis of diverse yeast strains suggests coordinated gene essentiality polymorphisms.

不同酵母菌株的轉(zhuǎn)座子插入誘變表明基因本質(zhì)多態(tài)性的協(xié)調(diào)。

149.RUFY3 links Arl8b and JIP4-Dynein complex to regulate lysosome size and positioning.

RUFY3連接Arl8b和JIP4-Dynein復(fù)合物以調(diào)節(jié)溶酶體大小和定位。

150.Zebrafish imaging reveals TP53 mutation switching oncogene-induced senescence from suppressor to driver in primary tumorigenesis.

斑馬魚成像顯示TP53突變在原發(fā)性腫瘤發(fā)生中從抑制者轉(zhuǎn)換為驅(qū)動者。

151.A point mutation in HIV-1 integrase redirects proviral integration into centromeric repeats.

HIV-1整合酶的一個點突變使前病毒整合重定向到中心體重復(fù)區(qū)。

152.S100A9-CXCL12 activation in BRCA1-mutant breast cancer promotes an immunosuppressive microenvironment associated with resistance to immunotherapy.

BRCA1突變型乳腺癌中S100A9-CXCL12的激活促進(jìn)了與免疫療法抗性相關(guān)的免疫抑制微環(huán)境。

153.The interplay of additivity, dominance, and epistasis on fitness in a diploid yeast cross.

二倍體酵母雜交中加性、優(yōu)勢和外顯性的相互作用。

154.Characterization of protein unfolding by fast cross-linking mass spectrometry using di-ortho-phthalaldehyde cross-linkers.

使用二-鄰苯二甲醛交聯(lián)劑的快速交聯(lián)質(zhì)譜法對蛋白質(zhì)展開的特征進(jìn)行分析。

155.CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element.

效應(yīng)器T細(xì)胞中CD4的表達(dá)取決于發(fā)育過程中建立的刺激反應(yīng)元件上的DNA去甲基化。

156.Precise tumor immune rewiring via synthetic CRISPRa circuits gated by concurrent gain/loss of transcription factors.

通過合成的CRISPRa電路對轉(zhuǎn)錄因子的同時增減進(jìn)行精確的腫瘤免疫重構(gòu)。

157.Parallel reduction in flowering time from de novo mutations enable evolutionary rescue in colonizing lineages.

新生突變引起的開花時間的平行減少使殖民系的進(jìn)化得到拯救。

158.Mechanism and biomass association of glucuronoyl esterase: an α/β hydrolase with potential in biomass conversion.

葡醛酸酯酶的機(jī)制和生物質(zhì)關(guān)聯(lián)：一種具有生物質(zhì)轉(zhuǎn)化潛力的α/β水解酶。

159.Large field-of-view non-invasive imaging through scattering layers using fluctuating random illumination.

利用波動隨機(jī)照明通過散射層的大視場非侵入性成像。

160.Evolutionary transition from a single RNA replicator to a multiple replicator network.

從單一RNA復(fù)制器到多復(fù)制器網(wǎng)絡(luò)的進(jìn)化過渡。

161.Structures of a deltacoronavirus spike protein bound to porcine and human receptors.

與豬和人類受體結(jié)合的德爾塔科羅納病毒尖峰蛋白的結(jié)構(gòu)。

162.p16INK4A-deficiency predicts response to combined HER2 and CDK4/6 inhibition in HER2+ breast cancer brain metastases.

p16INK4A缺陷預(yù)測HER2+乳腺癌腦轉(zhuǎn)移患者對聯(lián)合HER2和CDK4/6抑制的反應(yīng)。

163.Thermosensitive hydrogel releasing nitric oxide donor and anti-CTLA-4 micelles for anti-tumor immunotherapy.

釋放一氧化氮供體和抗CTLA-4膠束的熱敏水凝膠用于抗腫瘤免疫治療。

164.The evolution of RET inhibitor resistance in RET-driven lung and thyroid cancers.

RET抑制劑耐藥性在RET驅(qū)動的肺癌和甲狀腺癌中的演變。

165.Extracellular vesiculo-tubular structures associated with suberin deposition in plant cell walls.

與植物細(xì)胞壁中亞精蛋白沉積有關(guān)的細(xì)胞外囊管結(jié)構(gòu)。

166.DNA-based platform for efficient and precisely targeted bioorthogonal catalysis in living systems.

基于DNA的平臺，用于在生命系統(tǒng)中進(jìn)行高效和精確定向的生物正交催化。

167.Genome-wide maps of nucleolus interactions reveal distinct layers of repressive chromatin domains.

全基因組的核仁相互作用圖顯示了壓抑性染色質(zhì)域的不同層次。

168.N7-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis.

N7-甲基鳥苷tRNA修飾通過RPTOR/ULK1/自噬軸促進(jìn)食管鱗狀細(xì)胞癌的腫瘤發(fā)生。

169.Biomimetic hydrogel supports initiation and growth of patient-derived breast tumor organoids.

生物仿生水凝膠支持患者來源的乳腺腫瘤器官的啟動和生長。

170.Identifying regions for enhanced control of gambiense sleeping sickness in the Democratic Republic of Congo.

識別剛果民主共和國加強(qiáng)控制伽馬氏昏睡病的區(qū)域。

171.Extra kinetic dimensions for label discrimination.

標(biāo)簽識別的額外動力學(xué)維度。

172.Structural basis for activation and gating of IP3 receptors.

IP3受體的激活和門控的結(jié)構(gòu)基礎(chǔ)。

173.Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication.

人類鼻病毒促進(jìn)STING販運(yùn)到復(fù)制細(xì)胞器以促進(jìn)病毒復(fù)制。

174.De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report.

在治療免疫力低下的SARS-CoV-2持續(xù)感染期間，重新出現(xiàn)了remdesivir耐藥性突變：一個案例報告。

175.RNA G-quadruplex in TMPRSS2 reduces SARS-CoV-2 infection.

TMPRSS2中的RNA G-四聯(lián)體降低了SARS-CoV-2感染。

176.Oncogenic gene expression and epigenetic remodeling of cis-regulatory elements in ASXL1-mutant chronic myelomonocytic leukemia.

ASXL1突變型慢性粒細(xì)胞白血病的致癌基因表達(dá)和順式調(diào)控元素的表觀遺傳重塑。

177.Single-molecule imaging of microRNA-mediated gene silencing in cells.

細(xì)胞中microRNA介導(dǎo)的基因沉默的單分子成像。

178.Trajectory of immune evasion and cancer progression in hepatocellular carcinoma.

肝細(xì)胞癌免疫規(guī)避和癌癥進(jìn)展的軌跡。

179.Multi-omic cross-sectional cohort study of pre-malignant Barrett’s esophagus reveals early structural variation and retrotransposon activity.

惡性腫瘤前期巴雷特食道的多組學(xué)交叉隊列研究揭示了早期結(jié)構(gòu)變異和逆轉(zhuǎn)錄基因的活性。

180.Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel.

結(jié)構(gòu)指導(dǎo)下的NaX解鎖揭示了一個非選擇性的河豚毒素敏感陽離子通道。

181.Gpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency.

Gpr125是多種乳腺祖細(xì)胞與腫瘤潛伏期相聯(lián)系的統(tǒng)一標(biāo)志。

182.FrCas9 is a CRISPR/Cas9 system with high editing efficiency and fidelity.

FrCas9是一個具有高編輯效率和保真度的CRISPR/Cas9系統(tǒng)。

183.Strain-level characterization of broad host range mobile genetic elements transferring antibiotic resistance from the human microbiome.

從人類微生物組轉(zhuǎn)移抗生素抗性的廣泛宿主范圍移動遺傳元素的菌株水平特征。

184.The Oligodendrocyte Transcription Factor 2 OLIG2 regulates transcriptional repression during myelinogenesis in rodents.

寡頭細(xì)胞轉(zhuǎn)錄因子2 OLIG2在嚙齒動物的髓鞘生成過程中調(diào)節(jié)轉(zhuǎn)錄抑制。

185.Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging.

肌肉干細(xì)胞上的初級纖毛對于維持再生能力至關(guān)重要，并在衰老過程中喪失。

186.Autophagy impairment in liver CD11c+ cells promotes non-alcoholic fatty liver disease through production of IL-23.

肝臟CD11c+細(xì)胞的自噬功能障礙通過產(chǎn)生IL-23促進(jìn)非酒精性脂肪肝的發(fā)生。

187.Flagellin outer domain dimerization modulates motility in pathogenic and soil bacteria from viscous environments.

鞭毛蛋白外域二聚體調(diào)控粘稠環(huán)境中致病菌和土壤細(xì)菌的運(yùn)動能力。

188.Structure and function of the soil microbiome underlying N2O emissions from global wetlands.

全球濕地N2O排放背后的土壤微生物組的結(jié)構(gòu)和功能。

189.Homeostatic serum IgE is secreted by plasma cells in the thymus and enhances mast cell survival.

穩(wěn)態(tài)血清IgE由胸腺中的漿細(xì)胞分泌并增強(qiáng)肥大細(xì)胞的生存能力。

190.Maintenance of mitochondrial integrity in midbrain dopaminergic neurons governed by a conserved developmental transcription factor.

中腦多巴胺能神經(jīng)元線粒體完整性的維持受一個保守的發(fā)育轉(zhuǎn)錄因子的支配。

191.LC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy.

LC3B是一種RNA結(jié)合蛋白，可在自噬過程中引發(fā)mRNA的快速降解。

192.Agent-based modelling of reactive vaccination of workplaces and schools against COVID-19.

基于代理的工作場所和學(xué)校針對COVID-19的反應(yīng)性疫苗接種的模型。

193.All-fiber high-speed image detection enabled by deep learning.

通過深度學(xué)習(xí)實現(xiàn)的全纖維高速圖像檢測。

194.Microalgae-based oral microcarriers for gut microbiota homeostasis and intestinal protection in cancer radiotherapy.

基于微藻的口服微載體用于癌癥放療中的腸道微生物群穩(wěn)態(tài)和腸道保護(hù)。

195.Global profiling of regulatory elements in the histone benzoylation pathway.

組蛋白苯甲?；緩街姓{(diào)控元素的全球剖析。

196.CEP128 is involved in spermatogenesis in humans and mice.

CEP128參與人類和小鼠的精子生成。

197.Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis.

癌癥干細(xì)胞調(diào)控的表型可塑性保護(hù)轉(zhuǎn)移的癌細(xì)胞不受鐵銹病影響。

198.Machine learning discovery of missing links that mediate alternative branches to plant alkaloids.

機(jī)器學(xué)習(xí)發(fā)現(xiàn)介導(dǎo)植物生物堿替代分支的缺失環(huán)節(jié)。

199.Intralocus conflicts associated with a supergene.

與一個超級基因有關(guān)的焦點內(nèi)沖突。

200.Tertiary lymphoid structures critical for prognosis in endometrial cancer patients.

對子宮內(nèi)膜癌患者預(yù)后至關(guān)重要的三級淋巴結(jié)結(jié)構(gòu)。

201.Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab.

炎癥性腸病患者接受英夫利昔單抗和維多利珠單抗治療后的抗體衰減、T細(xì)胞免疫和突破性感染。

202.Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects social cognitive behavior.

中間神經(jīng)元和少突膠質(zhì)細(xì)胞前體細(xì)胞之間的雙向交流受損，影響社會認(rèn)知行為。

203.Indisulam targets RNA splicing and metabolism to serve as a therapeutic strategy for high-risk neuroblastoma.

因迪蘇蘭針對RNA剪接和代謝，作為高危神經(jīng)母細(xì)胞瘤的治療策略。

204.Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase.

Dbf4-Cdc7激酶對MCM雙六聚體激活的結(jié)構(gòu)洞察。

205.Characterisation and induction of tissue-resident gamma delta T-cells to target hepatocellular carcinoma.

針對肝癌的組織駐留伽馬δT細(xì)胞的特征和誘導(dǎo)。

206.Medial prefrontal cortex and anteromedial thalamus interaction regulates goal-directed behavior and dopaminergic neuron activity.

內(nèi)側(cè)前額葉皮層和前內(nèi)側(cè)丘腦的相互作用調(diào)控目標(biāo)導(dǎo)向行為和多巴胺能神經(jīng)元的活動。

207.The aberrant upregulation of exon 10-inclusive SREK1 through SRSF10 acts as an oncogenic driver in human hepatocellular carcinoma.

通過SRSF10對包含10號外顯子的SREK1進(jìn)行異常上調(diào)，成為人類肝細(xì)胞癌的致癌驅(qū)動因素。

208.Dynamics of plasmid-mediated niche invasion, immunity to invasion, and pheromone-inducible conjugation in the murine gastrointestinal tract.

小鼠胃腸道中質(zhì)粒介導(dǎo)的生態(tài)位入侵、入侵免疫和信息素誘導(dǎo)的結(jié)合的動態(tài)變化。

209.Spinal cord injury impairs cardiac function due to impaired bulbospinal sympathetic control.

脊髓損傷因球囊交感神經(jīng)控制受損而損害心臟功能。

210.Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma.

靶向SOX10缺陷細(xì)胞以減少黑色素瘤的休眠侵襲表型狀態(tài)。

211.Myosin VI regulates the spatial organisation of mammalian transcription initiation.

肌球蛋白VI調(diào)控哺乳動物轉(zhuǎn)錄起始的空間組織。

212.Mapping the sequence specificity of heterotypic amyloid interactions enables the identification of aggregation modifiers.

繪制異型淀粉樣物質(zhì)相互作用的序列特異性，能夠識別聚集修飾物。

213.Intrinsically disordered intracellular domains control key features of the mechanically-gated ion channel PIEZO2.

本質(zhì)上無序的細(xì)胞內(nèi)結(jié)構(gòu)域控制著機(jī)械門控離子通道PIEZO2的關(guān)鍵特征。

214.A kinetic model predicts SpCas9 activity, improves off-target classification, and reveals the physical basis of targeting fidelity.

一個動力學(xué)模型預(yù)測了SpCas9的活性，改善了脫靶分類，并揭示了靶向保真度的物理基礎(chǔ)。

215.Electrical modulation of transplanted stem cells improves functional recovery in a rodent model of stroke.

移植干細(xì)胞的電調(diào)控改善了嚙齒類中風(fēng)模型的功能恢復(fù)。

216.A microphysiological model of human trophoblast invasion during implantation.

植入過程中人類滋養(yǎng)細(xì)胞入侵的微觀生理學(xué)模型。

217.A peroxisomal heterodimeric enzyme is involved in benzaldehyde synthesis in plants.

一種過氧化物酶異構(gòu)體參與植物中苯甲醛的合成。

218.Germline mutation landscape of DNA damage repair genes in African Americans with prostate cancer highlights potentially targetable RAD genes.

非裔美國人前列腺癌患者的DNA損傷修復(fù)基因的種系突變情況突出了潛在的可靶向RAD基因。

219.Choice of vector and surgical approach enables efficient cochlear gene transfer in nonhuman primate.

載體和手術(shù)方法的選擇使非人類靈長類動物的耳蝸基因轉(zhuǎn)移變得高效。

220.DIAMetAlyzer allows automated false-discovery rate-controlled analysis for data-independent acquisition in metabolomics.

DIAMetAlyzer允許對代謝組學(xué)中的數(shù)據(jù)獨立采集進(jìn)行自動假發(fā)現(xiàn)率控制的分析。

221.Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors.

伽藍(lán)素受體的異生激動和G蛋白亞型選擇性的分子基礎(chǔ)。

222.Comprehensive evaluation of deconvolution methods for human brain gene expression.

人腦基因表達(dá)的去卷積方法的綜合評價。

223.Numerosity tuning in human association cortices and local image contrast representations in early visual cortex.

人類聯(lián)想皮層的數(shù)字調(diào)諧和早期視覺皮層的局部圖像對比表征。

224.Tau deposition patterns are associated with functional connectivity in primary tauopathies.

Tau沉積模式與原發(fā)性tauopathies的功能連接有關(guān)。

225.Measuring mechanical anisotropy of the cornea with Brillouin microscopy.

用布里淵顯微鏡測量角膜的機(jī)械各向異性。

226.Mixotrophic plankton foraging behaviour linked to carbon export.

混合營養(yǎng)型浮游生物的覓食行為與碳輸出有關(guān)。

227.A specialized bone marrow microenvironment for fetal haematopoiesis.

胎兒造血的專門骨髓微環(huán)境。

228.βIV-spectrin as a stalk cell-intrinsic regulator of VEGF signaling.

βIV-spectrin作為VEGF信號傳導(dǎo)的柄狀細(xì)胞內(nèi)在調(diào)節(jié)器。

229.Phylogenomic analyses highlight innovation and introgression in the continental radiations of Fagaceae across the Northern Hemisphere.

系統(tǒng)基因組分析突出了北半球山羊科植物大陸輻射中的創(chuàng)新和內(nèi)收。

230.Structure-based design of prefusion-stabilized human metapneumovirus fusion proteins.

基于結(jié)構(gòu)的前融合穩(wěn)定的人偏肺病毒融合蛋白的設(shè)計。

231.Benchmarking of SpCas9 variants enables deeper base editor screens of BRCA1 and BCL2.

SpCas9變體的基準(zhǔn)化使BRCA1和BCL2的基礎(chǔ)編輯篩選更加深入。

232.The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.

精氨酸甲基轉(zhuǎn)移酶PRMT7促進(jìn)單核細(xì)胞的外滲，導(dǎo)致COPD的組織損傷。

233.Quantifying and comparing radiation damage in the Protein Data Bank.

量化和比較蛋白質(zhì)數(shù)據(jù)庫中的輻射損傷。

234.Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplastica.

氣道基底干細(xì)胞的功能障礙在氣管支氣管骨質(zhì)增生癥的病理生理學(xué)中起關(guān)鍵作用。

235.Rescuing low frequency variants within intra-host viral populations directly from Oxford Nanopore sequencing data.

直接從牛津納米孔測序數(shù)據(jù)中搶救宿主內(nèi)病毒種群中的低頻變體。

236.DNA methylation-free Arabidopsis reveals crucial roles of DNA methylation in regulating gene expression and development.

無DNA甲基化的擬南芥揭示了DNA甲基化在調(diào)控基因表達(dá)和發(fā)育中的關(guān)鍵作用。

237.Norway spruce postglacial recolonization of Fennoscandia.

挪威云杉冰川期后在芬諾斯卡迪亞的再殖民化。

238.Regulation of protein secretion through chemical regulation of endoplasmic reticulum retention signal cleavage.

通過化學(xué)調(diào)控內(nèi)質(zhì)網(wǎng)保留信號的裂解來調(diào)節(jié)蛋白質(zhì)的分泌。

239.Phase 2 study of pembrolizumab in patients with recurrent and residual high-grade meningiomas.

pembrolizumab在復(fù)發(fā)和殘留的高等級腦膜瘤患者中的2期研究。

240.A systematic review and meta-analysis of gene therapy with hematopoietic stem and progenitor cells for monogenic disorders.

用造血干細(xì)胞和祖細(xì)胞治療單基因疾病的系統(tǒng)回顧和薈萃分析.

241.Texture is encoded in precise temporal spiking patterns in primate somatosensory cortex.

紋理在靈長類動物體感皮層中被編碼為精確的時間性尖峰模式。

242.Apoplastic class III peroxidases PRX62 and PRX69 promote Arabidopsis root hair growth at low temperature.

細(xì)胞膜III類過氧化物酶PRX62和PRX69促進(jìn)擬南芥根毛在低溫下生長。

243.Lysosomal Ca2+-mediated TFEB activation modulates mitophagy and functional adaptation of pancreatic β-cells to metabolic stress.

溶酶體Ca2+介導(dǎo)的TFEB激活調(diào)控有絲分裂和胰島β細(xì)胞對代謝壓力的功能適應(yīng)。

244.Oxidative metabolisms catalyzed Earth’s oxygenation.

氧化代謝催化了地球的氧合作用。

245.Mucospheres produced by a mixotrophic protist impact ocean carbon cycling.

一種混養(yǎng)原生動物產(chǎn)生的粘液球?qū)Ｑ筇佳h(huán)的影響。

246.CrkII/Abl phosphorylation cascade is critical for NLRC4 inflammasome activity and is blocked by Pseudomonas aeruginosa ExoT.

CrkII/Abl磷酸化級聯(lián)對NLRC4炎癥體活動至關(guān)重要，并被銅綠假單胞菌ExoT阻斷。

247.Loss of the Bardet-Biedl protein Bbs1 alters photoreceptor outer segment protein and lipid composition.

Bardet-Biedl蛋白Bbs1的缺失改變了光感受器外節(jié)蛋白和脂質(zhì)的組成。

248.Structural basis for modulation of human NAV1.3 by clinical drug and selective antagonist.

臨床藥物和選擇性拮抗劑調(diào)控人類NAV1.3的結(jié)構(gòu)基礎(chǔ)。

249.Recurring adaptive introgression of a supergene variant that determines social organization.

決定社會組織的超級基因變體的反復(fù)適應(yīng)性引入。

250.Genotyping-by-sequencing-based identification of Arabidopsis pattern recognition receptor RLP32 recognizing proteobacterial translation initiation factor IF1.

基于基因分型-測序的擬南芥模式識別受體RLP32識別蛋白細(xì)菌翻譯起始因子IF1的鑒定。

251.Secondary structure prediction for RNA sequences including N6-methyladenosine.

包括N6-甲基腺苷的RNA序列的二級結(jié)構(gòu)預(yù)測。

252.The methyl phosphate capping enzyme Bmc1/Bin3 is a stable component of the fission yeast telomerase holoenzyme.

磷酸甲酯封蓋酶Bmc1/Bin3是裂殖酵母端粒酶全酶的一個穩(wěn)定組成部分。

253.De novo inter-regional coactivations of preconfigured local ensembles support memory.

預(yù)先配置的局部組合的新的區(qū)域間協(xié)同激活支持記憶。

254.Coincidence of cholinergic pauses, dopaminergic activation and depolarisation of spiny projection neurons drives synaptic plasticity in the striatum.

膽堿能停頓、多巴胺能激活和棘突神經(jīng)元去極化的巧合推動了紋狀體的突觸可塑性。

255.The structural basis for regulation of the glutathione transporter Ycf1 by regulatory domain phosphorylation.

谷胱甘肽轉(zhuǎn)運(yùn)體Ycf1被調(diào)節(jié)域磷酸化調(diào)節(jié)的結(jié)構(gòu)基礎(chǔ)。

256.Functional genomics of RAP proteins and their role in mitoribosome regulation in Plasmodium falciparum.

RAP蛋白的功能基因組學(xué)及其在惡性瘧原蟲中Mitoribosome調(diào)節(jié)中的作用。

257.Structural analysis of 3’UTRs in insect flaviviruses reveals novel determinants of sfRNA biogenesis and provides new insights into flavivirus evolution.

昆蟲黃病毒中3'UTR的結(jié)構(gòu)分析揭示了sfRNA生物生成的新決定因素，并為黃病毒的進(jìn)化提供了新的見解。

258.Gq neuromodulation of BLA parvalbumin interneurons induces burst firing and mediates fear-associated network and behavioral state transition in mice.

BLA副白蛋白中間神經(jīng)元的Gq神經(jīng)調(diào)控誘導(dǎo)突發(fā)射擊并介導(dǎo)小鼠的恐懼相關(guān)網(wǎng)絡(luò)和行為狀態(tài)轉(zhuǎn)換。

259.Inhibition allocates spikes during hippocampal ripples.

抑制在海馬波紋期間分配尖峰。

260.Comprehensive 3D epigenomic maps define limbal stem/progenitor cell function and identity.

全面的三維表觀基因組圖譜定義了肢體干/祖細(xì)胞的功能和身份。

261.In vivo three-dimensional multispectral photoacoustic imaging of dual enzyme-driven cyclic cascade reaction for tumor catalytic therapy.

腫瘤催化治療的雙酶驅(qū)動循環(huán)級聯(lián)反應(yīng)的體內(nèi)三維多譜段光聲成像。

262.Tunable and scalable fabrication of block copolymer-based 3D polymorphic artificial cell membrane array.

基于嵌段共聚物的三維多態(tài)人工細(xì)胞膜陣列的可調(diào)控和可擴(kuò)展的制造。

263.The core and accessory Hfq interactomes across Pseudomonas aeruginosa lineages.

銅綠假單胞菌各系的核心和附屬Hfq交互組。

264.A comprehensive temporal patterning gene network in Drosophila medulla neuroblasts revealed by single-cell RNA sequencing.

通過單細(xì)胞RNA測序揭示果蠅髓質(zhì)神經(jīng)細(xì)胞的綜合時間模式基因網(wǎng)絡(luò)。

265.An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway.

西格瑪-1受體的開放樣構(gòu)象揭示了其配體進(jìn)入途徑。

266.Clinical and genomic features of Chinese lung cancer patients with germline mutations.

中國肺癌患者種系突變的臨床和基因組特征.

267.iRhom pseudoproteases regulate ER stress-induced cell death through IP3 receptors and BCL-2.

iRhom假蛋白酶通過IP3受體和BCL-2調(diào)節(jié)ER應(yīng)激誘導(dǎo)的細(xì)胞死亡。

268.Divergent trajectories of antiviral memory after SARS-CoV-2 infection.

SARS-CoV-2感染后抗病毒記憶的不同軌跡。

269.Fully-automated and ultra-fast cell-type identification using specific marker combinations from single-cell transcriptomic data.

利用單細(xì)胞轉(zhuǎn)錄組數(shù)據(jù)的特定標(biāo)志物組合進(jìn)行全自動和超快速的細(xì)胞類型識別。

270.Improved prediction of protein-protein interactions using AlphaFold2.

使用AlphaFold2改進(jìn)蛋白質(zhì)-蛋白質(zhì)相互作用的預(yù)測。

271.Synthetic glycans control gut microbiome structure and mitigate colitis in mice.

合成糖控制腸道微生物組結(jié)構(gòu)并緩解小鼠結(jié)腸炎。

272.Atomic structure of the predominant GII.4 human norovirus capsid reveals novel stability and plasticity.

主要的GII.4人類諾瓦克病毒外殼的原子結(jié)構(gòu)揭示了新的穩(wěn)定性和可塑性。

273.Fusobacterium nucleatum reduces METTL3-mediated m6A modification and contributes to colorectal cancer metastasis.

核酸鐮刀菌減少了METTL3介導(dǎo)的m6A修飾，有助于結(jié)直腸癌的轉(zhuǎn)移。

274.Bacteria eat nanoprobes for aggregation-enhanced imaging and killing diverse microorganisms.

細(xì)菌食用納米探針進(jìn)行聚集增強(qiáng)成像并殺死不同的微生物。

275.Deep proteomic profiling unveils arylsulfatase A as a non-alcoholic steatohepatitis inducible hepatokine and regulator of glycemic control.

深度蛋白質(zhì)組學(xué)分析揭示了丙烯硫酸酯酶A是一種非酒精性脂肪肝誘導(dǎo)性肝臟因子和血糖控制的調(diào)節(jié)劑。

276.Co-translational assembly orchestrates competing biogenesis pathways.

協(xié)同翻譯組裝協(xié)調(diào)了相互競爭的生物生成途徑。

277.The YΦ motif defines the structure-activity relationships of human 20S proteasome activators.

YΦ motif定義了人類20S蛋白酶體激活劑的結(jié)構(gòu)-活性關(guān)系。

278.Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43.

Sirtuin-1敏感的賴氨酸-136乙?；?qū)動TDP-43的相分離和病理性聚集。

279.Rapid expansion and extinction of antibiotic resistance mutations during treatment of acute bacterial respiratory infections.

急性細(xì)菌性呼吸道感染治療過程中抗生素耐藥性突變的快速擴(kuò)展和消亡。

280.A large and diverse autosomal haplotype is associated with sex-linked colour polymorphism in the guppy.

一個龐大而多樣的常染色體單倍型與石首魚的性聯(lián)顏色多態(tài)性有關(guān)。

281.Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing.

恢復(fù)Sirtuin 2在少突膠質(zhì)細(xì)胞祖細(xì)胞中的核進(jìn)入，促進(jìn)老化過程中的再髓化。

282.The flavonoid corylin exhibits lifespan extension properties in mouse.

黃酮類化合物冠醚在小鼠中表現(xiàn)出延長壽命的特性。

283.An enhancer variant at 16q22.1 predisposes to hepatocellular carcinoma via regulating PRMT7 expression.

16q22.1的一個增強(qiáng)器變體通過調(diào)節(jié)PRMT7的表達(dá)易導(dǎo)致肝細(xì)胞癌。

284.Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity.

靶向GPCRs和RAS相關(guān)分子的自身抗體與COVID-19的嚴(yán)重程度有關(guān)。

285.Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus.

闡明PROCR血管疾病位點的遺傳性交叉疾病關(guān)聯(lián)機(jī)制。

286.First-in-human immunoPET imaging of HIV-1 infection using 89Zr-labeled VRC01 broadly neutralizing antibody.

使用89Zr標(biāo)記的VRC01廣泛中和抗體對HIV-1感染進(jìn)行首次人體免疫PET成像。

287.Mechanosensory trichome cells evoke a mechanical stimuli–induced immune response in Arabidopsis thaliana.

機(jī)械感覺毛細(xì)管細(xì)胞喚起擬南芥的機(jī)械刺激誘導(dǎo)的免疫反應(yīng)。

288.Structural snapshots of V/A-ATPase reveal the rotary catalytic mechanism of rotary ATPases.

V/A-ATP酶的結(jié)構(gòu)快照揭示了旋轉(zhuǎn)ATP酶的旋轉(zhuǎn)催化機(jī)制。

289.Fossil coleoid cephalopod from the Mississippian Bear Gulch Lagerst?tte sheds light on early vampyropod evolution.

來自密西西比熊溝拉格斯塔特的頭足類化石揭示了早期翼足類的進(jìn)化。

290.Arabidopsis RBV is a conserved WD40 repeat protein that promotes microRNA biogenesis and ARGONAUTE1 loading.

擬南芥RBV是一個保守的WD40重復(fù)蛋白，可促進(jìn)microRNA的生物生成和ARGONAUTE1的裝載。

291.Bacterial F-type ATP synthases follow a well-choreographed assembly pathway.

細(xì)菌的F型ATP合成酶遵循一個精心編排的組裝途徑。

292.Ancient genomes from the Himalayas illuminate the genetic history of Tibetans and their Tibeto-Burman speaking neighbors.

來自喜馬拉雅山的古老基因組闡明了藏族和他們的藏緬語鄰居的遺傳歷史。

293.Differential recognition of canonical NF-κB dimers by Importin α3.

進(jìn)口蛋白α3對經(jīng)典NF-κB二聚體的不同識別。

294.MQuad enables clonal substructure discovery using single cell mitochondrial variants.

MQuad利用單細(xì)胞線粒體變體實現(xiàn)了克隆亞結(jié)構(gòu)的發(fā)現(xiàn)。

295.Kinetic model of GPCR-G protein interactions reveals allokairic modulation of signaling.

GPCR-G蛋白相互作用的動力學(xué)模型揭示了Allokairic對信號的調(diào)節(jié)。

296.CMTr cap-adjacent 2′-O-ribose mRNA methyltransferases are required for reward learning and mRNA localization to synapses.

CMTr帽相鄰2′-O-核糖mRNA甲基轉(zhuǎn)移酶是獎勵學(xué)習(xí)和mRNA定位到突觸所需的。

297.Cas9 exo-endonuclease eliminates chromosomal translocations during genome editing.

Cas9外切核酸酶在基因組編輯過程中消除了染色體易位。

298.A bottom-up reward pathway mediated by somatostatin neurons in the medial septum complex underlying appetitive learning.

由內(nèi)側(cè)隔膜復(fù)合體中的體液蛋白神經(jīng)元介導(dǎo)的自下而上的獎勵途徑，是食欲學(xué)習(xí)的基礎(chǔ)。

299.Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer.

共同靶向BAX和BCL-XL蛋白廣泛克服了癌癥中對凋亡的抵抗。

300.Self-attenuating adenovirus enables production of recombinant adeno-associated virus for high manufacturing yield without contamination.

自我減毒的腺病毒使重組腺相關(guān)病毒的生產(chǎn)在無污染的情況下獲得高產(chǎn)。

301.Geographically dispersed zoonotic tuberculosis in pre-contact South American human populations.

接觸前南美人類人口中地理上分散的人畜共患結(jié)核病。

302.Tropical extreme droughts drive long-term increase in atmospheric CO2 growth rate variability.

熱帶極端干旱推動了大氣中二氧化碳增長率變化的長期增加。

303.Breeding future crops to feed the world through de novo domestication.

通過新的馴化培育未來的農(nóng)作物以養(yǎng)活世界。

304.Whole-genome sequencing of 1,171 elderly admixed individuals from Brazil.

巴西1,171名老年混血兒的全基因組測序。

305.Evolution of the SARS-CoV-2 spike protein in the human host.

SARS-CoV-2尖峰蛋白在人類宿主中的進(jìn)化。

306.Oxygen-sensitive methylation of ULK1 is required for hypoxia-induced autophagy.

低氧誘導(dǎo)的自噬需要ULK1的氧敏甲基化。

307.The molecular basis of FimT-mediated DNA uptake during bacterial natural transformation.

細(xì)菌自然轉(zhuǎn)化過程中FimT介導(dǎo)的DNA攝取的分子基礎(chǔ)。

308.Ubiquitin and a charged loop regulate the ubiquitin E3 ligase activity of Ark2C.

泛素和一個帶電環(huán)調(diào)節(jié)Ark2C的泛素E3連接酶活性。

309.Cytonemes coordinate asymmetric signaling and organization in the Drosophila muscle progenitor niche.

細(xì)胞膜協(xié)調(diào)果蠅肌肉原基中的不對稱信號傳遞和組織。

310.The indirect effect of mRNA-based COVID-19 vaccination on healthcare workers’ unvaccinated household members.

基于mRNA的COVID-19疫苗接種對醫(yī)護(hù)人員未接種的家庭成員的間接影響。

311.Waning of SARS-CoV-2 booster viral-load reduction effectiveness.

SARS-CoV-2強(qiáng)化劑降低病毒量的效果減弱。

312.Hysteresis stabilizes dynamic control of self-assembled army ant constructions.

滯后性穩(wěn)定了自組裝軍蟻結(jié)構(gòu)的動態(tài)控制。

313.Neuronal activity in sensory cortex predicts the specificity of learning in mice.

感覺皮層的神經(jīng)元活動預(yù)示著小鼠學(xué)習(xí)的特異性。

314.In vitro maturation of Toxoplasma gondii bradyzoites in human myotubes and their metabolomic characterization.

弓形蟲布拉迪蟲在人類肌管中的體外成熟及其代謝組學(xué)特征。

315.Landscape of adenosine-to-inosine RNA recoding across human tissues.

人體組織中腺苷-肌苷RNA重新編碼的景觀。

316.Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP.

Importin-7對核輸入的機(jī)械控制受其主導(dǎo)貨物YAP的調(diào)節(jié)。

317.Endothelial Unc5B controls blood-brain barrier integrity.

內(nèi)皮細(xì)胞Uc5B控制血腦屏障的完整性。

318.Structural insight into Marburg virus nucleoprotein–RNA complex formation.

對馬爾堡病毒核蛋白-RNA復(fù)合物形成的結(jié)構(gòu)洞察。

319.White matter integrity in mice requires continuous myelin synthesis at the inner tongue.

小鼠的白質(zhì)完整性需要內(nèi)舌的持續(xù)髓鞘合成。

320.The control of transcriptional memory by stable mitotic bookmarking.

穩(wěn)定的有絲分裂書簽對轉(zhuǎn)錄記憶的控制。

321.Associations between alcohol consumption and gray and white matter volumes in the UK Biobank.

英國生物庫中酒精消費(fèi)與灰質(zhì)和白質(zhì)體積之間的關(guān)系。

322.Active label cleaning for improved dataset quality under resource constraints.

在資源限制下主動清理標(biāo)簽以提高數(shù)據(jù)集質(zhì)量。

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