品牌：為華生物

產(chǎn)地：中國(guó)廣州

PEG分子量：2000、3400、5000

外觀：固體粉末或粘稠液體取決于PEG分子量

常用溶劑：DCM，氯仿，熱水

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1,2-dioleoyl-sn-glycero-3-phosphoethanolamine(DOPE)共軛聚乙二醇是磷脂和聚乙二醇結(jié)合，具有親水性和疏水性。聚乙二醇磷脂脂質(zhì)體形成優(yōu)質(zhì)材料,可用于藥物輸送、基因轉(zhuǎn)染和疫苗傳遞。聚乙二醇化磷脂能顯著改善血液循環(huán)時(shí)間和穩(wěn)定封裝藥物。聚乙二醇能增強(qiáng)溶解性和穩(wěn)定性，降低帶電分子表面非特異性結(jié)合，降低多肽的免疫原性。這些材料還可用于靶向給藥通過(guò)修改與目標(biāo)表面配體如抗體、多肽。

1,2-dioleoyl-sn-glycoro-3-phosphoethanolamine (dope) conjugated polyethylene glycol is a combination of phospholipid and polyethylene glycol with hydrophilicity and hydrophobicity. Polyethylene glycol phospholipid liposomes form high-quality materials and can be used for drug delivery, gene transfection and vaccine delivery. Pegylated phospholipids can significantly improve blood circulation time and stably encapsulate drugs. Polyethylene glycol can enhance the solubility and stability, reduce the non-specific binding of charged molecules, and reduce the immunogenicity of peptides. These materials can also be used for targeted drug delivery by modifying ligands with the target surface such as antibodies, polypeptides.

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