產(chǎn)品名稱(chēng)：

活性氧p16INK4A (C-Term) Rabbit Monoclonal Antibody (Clone RM409)

產(chǎn)地：西安

規(guī)格：1mg 5mg 10mg

純度：99%

用途：僅用于科研

狀態(tài)：固體/粉末

儲(chǔ)藏條件：冷藏-20℃

溫馨提示：僅用于科研，不能用于人體實(shí)驗(yàn)！

說(shuō)明：提供使用說(shuō)明，核磁圖譜，包裝，價(jià)格，產(chǎn)地，制備方法，應(yīng)用，穩(wěn)定性，溶解度，簡(jiǎn)單合成等各種信息　　

p16INK4A is a negative regulator of the cell cycle encoded by the CDKN2A gene in humans that limits cell cycle progression and promotes cellular senescence. It induces cell cycle arrest at the G1 phase by binding to cyclin-dependent kinase 4 (Cdk4) or Cdk6 in the cytoplasm, inhibiting formation of the cyclin D1/Cdk4/6 complex. p16INK4A is expressed at low levels during homeostasis and is increased in response to cellular stressors, including oncogene activation and reactive oxygen species (ROS).It is regulated by a variety of transcriptional, translational, and epigenetic mechanisms, such as chromatin modifications mediated by polycomb repressive complex 1 (PRC1) and PRC2 that inhibit CDKN2A expression. Aberrant CDKN2A mRNA and p16INK4A protein levels have been found in tumor biopsies from patients with a variety of cancers, including colon, breast, gall bladder, or head and neck cancer.CDKN2A SNPs have been found in patients with follicular lymphoma and are associated with reduced overall survival. Cayman's p16INK4A (C-Term) Rabbit Monoclonal Antibody (Clone RM409) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

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編輯：XAQYBIO HAO，2023年4月23日。