聲明：本專欄主要對生命科學(xué)領(lǐng)域的一些期刊文章標(biāo)題進(jìn)行翻譯，所有內(nèi)容均由本人手工整理翻譯。由于本人專業(yè)為生物分析相關(guān)，其他領(lǐng)域如果出現(xiàn)翻譯錯(cuò)誤請諒解。

1.Dynamic chirality control. Stereogenic sp 3-hybridized carbon centres are the principal building blocks of chiral organic molecules. Usually, these centres are configurationally fixed. Now, a team led by Paul R. McGonigal has taken advantage of low-energy pericyclic rearrangements to create rigid cage molecules with fluxional sp 3 stereochemistry, influencing chiral information transfer. The sp 3-carbon stereochemistry of the cages is inverted through strain-assisted Cope rearrangements. The cover shows the fluxional carbon cage structure.

動態(tài)手性控制。立體異構(gòu)sp 3 雜化碳中心是手性有機(jī)分子的主要構(gòu)建模塊。通常，這些中心的配置是固定的?，F(xiàn)在，Paul R. McGonigal 領(lǐng)導(dǎo)的團(tuán)隊(duì)利用低能周環(huán)重排創(chuàng)造了具有流動 sp 3 立體化學(xué)的剛性籠分子，影響手性信息傳遞?；\的 sp 3-碳立體化學(xué)通過應(yīng)變輔助 Cope 重排被反轉(zhuǎn)。封面展示了流動的碳籠結(jié)構(gòu)。

2.Control of dynamic sp3-C stereochemistry.

動態(tài) sp3-C 立體化學(xué)的控制。

3.A columnar liquid quasicrystal with a honeycomb structure that consists of triangular, square and trapezoidal cells.

具有蜂窩結(jié)構(gòu)的柱狀液體準(zhǔn)晶體，由三角形、正方形和梯形細(xì)胞組成。

4.Isolation, bonding and reactivity of a monomeric stibine oxide.

單體氧化銻的分離、鍵合和反應(yīng)性。

5.Aromatic hexazine [N6]4? anion featured in the complex structure of the high-pressure potassium nitrogen compound K9N56.

高壓鉀氮化合物 K9N56 復(fù)雜結(jié)構(gòu)中具有芳香族六嗪 [N6]4? 陰離子。

6.Modular enantioselective access to β-amino amides by Br?nsted acid-catalysed multicomponent reactions.

通過布朗斯臺德酸催化多組分反應(yīng)模塊化對映選擇性獲得 β-氨基酰胺。

7.Connecting the geometric and electronic structures of the nitrogenase iron–molybdenum cofactor through site-selective 57Fe labelling.

通過位點(diǎn)選擇性 57Fe 標(biāo)記連接固氮酶鐵鉬輔因子的幾何結(jié)構(gòu)和電子結(jié)構(gòu)。

8.Stepwise on-demand functionalization of multihydrosilanes enabled by a hydrogen-atom-transfer photocatalyst based on eosin Y.

基于曙紅 Y 的氫原子轉(zhuǎn)移光催化劑實(shí)現(xiàn)多氫硅烷的逐步按需官能化。

9.Autonomous and directional flow of water and transport of particles across a subliming dynamic crystal surface.

水的自主定向流動和顆粒在升華動態(tài)晶體表面的傳輸。

10.Catalytic undirected borylation of tertiary C–H bonds in bicyclo[1.1.1]pentanes and bicyclo[2.1.1]hexanes.

雙環(huán)[1.1.1]戊烷和雙環(huán)[2.1.1]己烷中叔C-H鍵的催化無向硼基化。

11.Spatiotemporal functional assembly of split protein pairs through a light-activated SpyLigation.

通過光激活 SpyLigation 進(jìn)行分裂蛋白對的時(shí)空功能組裝。

12.Electrochemical synthesis of propylene from carbon dioxide on copper nanocrystals.

銅納米晶體上二氧化碳電化學(xué)合成丙烯。

13.Catalytic enantioselective nucleophilic desymmetrization of phosphonate esters.

膦酸酯的催化對映選擇性親核去對稱化。

14.Isolation of a californium(II) crown–ether complex.

锎(II)冠醚絡(luò)合物的分離。

15.OregonFluor enables quantitative intracellular paired agent imaging to assess drug target availability in live cells and tissues.

OregonFluor 能夠進(jìn)行定量細(xì)胞內(nèi)配對試劑成像，以評估活細(xì)胞和組織中藥物靶標(biāo)的可用性。

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1.Arene addition. 1,3-Dipolar cycloadditions are well known transformations in organic synthesis, however, the reactivity of benzene rings in these processes is underexplored. Now, a team led by Valery V. Fokin has shown that diazoalkenes — generated in situ from lithium acetylides and N-sulfonyl azides — can undergo intramolecular 1,3-dipolar cycloaddition with aromatic rings. The process provides a route for the synthesis of medicinally relevant heterocycles. The cover shows an artistic representation of an aromatic ring reacting with a diazoalkene.

添加芳烴。?1,3-偶極環(huán)加成是有機(jī)合成中眾所周知的轉(zhuǎn)化，然而，這些過程中苯環(huán)的反應(yīng)性尚未得到充分研究。現(xiàn)在，由 Valery V. Fokin 領(lǐng)導(dǎo)的團(tuán)隊(duì)證明，由乙炔鋰和 N-磺酰疊氮化物原位生成的重氮烯烴可以與芳香環(huán)進(jìn)行分子內(nèi) 1,3-偶極環(huán)加成。該方法為合成醫(yī)學(xué)相關(guān)雜環(huán)化合物提供了一條途徑。封面展示了芳環(huán)與重氮烯反應(yīng)的藝術(shù)表現(xiàn)。

2.Not all catenanes with oriented rings are topologically chiral.

并非所有具有定向環(huán)的索烯都是拓?fù)涫中缘摹?/p>

3.Arenes participate in 1,3-dipolar cycloaddition with in situ-generated diazoalkenes.

芳烴參與與原位生成的重氮烯烴的 1,3-偶極環(huán)加成反應(yīng)。

4.A high-dimensional microfluidic approach for selection of aptamers with programmable binding affinities.

用于選擇具有可編程結(jié)合親和力的適體的高維微流體方法。

5.A catenane that is topologically achiral despite being composed of oriented rings.

盡管由定向環(huán)組成，但在拓?fù)渖鲜欠鞘中缘乃飨?/p>

6.Indole-5,6-quinones display hallmark properties of eumelanin.

5,6-吲哚醌顯示出真黑素的標(biāo)志性特性。

7.Metal-free reduction of CO2 to formate using a photochemical organohydride-catalyst recycling strategy.

使用光化學(xué)有機(jī)氫化物催化劑回收策略將二氧化碳無金屬還原為甲酸鹽。

8.Spatiotemporal and global profiling of DNA–protein interactions enables discovery of low-affinity transcription factors.

DNA-蛋白質(zhì)相互作用的時(shí)空和全局分析能夠發(fā)現(xiàn)低親和力轉(zhuǎn)錄因子。

9.Synthesis of planar chiral ferrocenes via enantioselective remote C–H activation.

通過對映選擇性遠(yuǎn)程 C-H 活化合成平面手性二茂鐵。

10.Uniform segmented platelet micelles with compositionally distinct and selectively degradable cores.

均勻分段的血小板膠束，具有成分不同且可選擇性降解的核心。

11.Emulsion-oriented assembly for Janus double-spherical mesoporous nanoparticles as biological logic gates.

作為生物邏輯門的 Janus 雙球形介孔納米粒子的乳液導(dǎo)向組裝。

12.Growth of single-crystal imine-linked covalent organic frameworks using amphiphilic amino-acid derivatives in water.

使用兩親性氨基酸衍生物在水中生長單晶亞胺連接的共價(jià)有機(jī)框架。

13.Accurate structure models and absolute configuration determination using dynamical effects in continuous-rotation 3D electron diffraction data.

利用連續(xù)旋轉(zhuǎn) 3D 電子衍射數(shù)據(jù)中的動力學(xué)效應(yīng)進(jìn)行精確的結(jié)構(gòu)模型和絕對構(gòu)型確定。

14.Nature-inspired methylated polyhydroxybutyrates from C1 and C4 feedstocks.

來自 C1 和 C4 原料的受自然啟發(fā)的甲基化聚羥基丁酸酯。

15.Regio- and enantioselective remote dioxygenation of internal alkenes.

內(nèi)部烯烴的區(qū)域選擇性和對映選擇性遠(yuǎn)程雙氧化。

16.A C–H activation-based enantioselective synthesis of lower carbo[n]helicenes.

基于 AC-H 活化的低碳[n]螺烯的對映選擇性合成。

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1.Complex colloidal clathrate crystals. Clathrates, which consist of host molecules arranged in a hierarchy of polyhedral cages around guest species that they encapsulate, have attracted much attention for their host–guest chemistry. Now, using simulations, Sharon Glotzer and co-workers have shown that hard, otherwise non-interacting particles with truncated triangular bipyramid shapes self-assemble into open colloidal crystals isostructural to clathrates using only entropy. The resulting structures (depicted on the cover) consist of freely rotating guests within a rigid host network.

復(fù)雜的膠體包合物晶體。包合物由排列在其封裝的客體物種周圍的多面體籠層次結(jié)構(gòu)中的主體分子組成，其主客體化學(xué)引起了廣泛關(guān)注。現(xiàn)在，Sharon Glotzer 和同事通過模擬表明，具有截?cái)嗳请p錐形狀的堅(jiān)硬的、非相互作用的粒子僅使用熵就可以自組裝成與包合物同構(gòu)的開放膠體晶體。由此產(chǎn)生的結(jié)構(gòu)（如封面所示）由嚴(yán)格的主題網(wǎng)絡(luò)內(nèi)自由輪換的客體組成。

2.Route to complex colloidal crystals through entropy compartmentalization.

通過熵區(qū)室化形成復(fù)雜的膠體晶體。

3.Five mutually orthogonal aaRS–tRNA pairs for genetic code expansion.

用于遺傳密碼擴(kuò)展的五個(gè)相互正交的 aaRS-tRNA 對。

4.Entropy compartmentalization stabilizes open host–guest colloidal clathrates.

熵區(qū)室化穩(wěn)定了開放的主客體膠體包合物。

5.Atomistic simulations of the Escherichia coli ribosome provide selection criteria for translationally active substrates.

大腸桿菌核糖體的原子模擬為翻譯活性底物提供了選擇標(biāo)準(zhǔn)。

6.Multistep, site-selective noncovalent synthesis of two-dimensional block supramolecular polymers.

二維嵌段超分子聚合物的多步、位點(diǎn)選擇性非共價(jià)合成。

7.Near-infrared-activated anticancer platinum(IV) complexes directly photooxidize biomolecules in an oxygen-independent manner.

近紅外激活的抗癌鉑（IV）絡(luò)合物以不依賴于氧的方式直接光氧化生物分子。

8.Surface-exposed silver nanoclusters inside molecular metal oxide cavities.

分子金屬氧化物空腔內(nèi)表面暴露的銀納米簇。

9.Quintuply orthogonal pyrrolysyl-tRNA synthetase/tRNAPyl pairs.

五重正交吡咯賴氨酰-tRNA 合成酶/tRNAPyl 對。

10.Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase enzymes to include non-α-amino acids in vitro and in vivo.

擴(kuò)大吡咯賴氨酰轉(zhuǎn)移 RNA 合成酶的底物范圍，包括體外和體內(nèi)的非 α-氨基酸。

11.Real-time monitoring of reaction stereochemistry through single-molecule observations of chirality-induced spin selectivity.

通過手性誘導(dǎo)的自旋選擇性的單分子觀察實(shí)時(shí)監(jiān)測反應(yīng)立體化學(xué)。

12.In vivo metallophilic self-assembly of a light-activated anticancer drug.

光激活抗癌藥物的體內(nèi)親金屬自組裝。

13.Multi-site programmable functionalization of alkenes via controllable alkene isomerization.

通過可控烯烴異構(gòu)化對烯烴進(jìn)行多位點(diǎn)可編程官能化。

14.In vitro selection of macrocyclic peptide inhibitors containing cyclic γ2,4-amino acids targeting the SARS-CoV-2 main protease.

體外選擇含有針對 SARS-CoV-2 主要蛋白酶的環(huán)狀 γ2,4-氨基酸的大環(huán)肽抑制劑。

15.Spin-dependent reactivity and spin-flipping dynamics in oxygen atom scattering from graphite.

石墨散射氧原子的自旋相關(guān)反應(yīng)性和自旋翻轉(zhuǎn)動力學(xué)。

16.Transient water wires mediate selective proton transport in designed channel proteins.

瞬態(tài)水線介導(dǎo)設(shè)計(jì)的通道蛋白中的選擇性質(zhì)子傳輸。

17.Why charging Li–air batteries with current low-voltage mediators is slow and singlet oxygen does not explain degradation.

為什么用當(dāng)前的低壓介體對鋰空氣電池充電速度很慢，并且單線態(tài)氧并不能解釋降解。

18.Activity-based directed evolution of a membrane editor in mammalian cells.

哺乳動物細(xì)胞膜編輯器基于活動的定向進(jìn)化。

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1.Copper-catalysed carbene chemistry. While the use of metal catalysts to control the reactivity of carbenes has long offered a powerful approach to organic synthesis, copper difluorocarbene chemistry has so far been elusive. Now, Xiao-Song Xue, Xingang Zhang and co-workers have synthesized and isolated copper(I) difluorocarbene complexes, which have enabled the development of a copper-catalysed difluorocarbene transfer reaction. The cover depicts an artistic representation of the copper(I) complex reacting with free difluorocarbene compounds.

銅催化卡賓化學(xué)。雖然使用金屬催化劑來控制卡賓的反應(yīng)性長期以來為有機(jī)合成提供了一種強(qiáng)大的方法，但二氟卡賓銅的化學(xué)迄今為止仍難以實(shí)現(xiàn)?，F(xiàn)在，薛曉松、張新剛及其同事合成并分離了二氟卡賓銅(I)絡(luò)合物，這使得銅催化的二氟卡賓轉(zhuǎn)移反應(yīng)得以發(fā)展。封面描繪了銅（I）配合物與游離二氟卡賓化合物反應(yīng)的藝術(shù)表現(xiàn)。

2.A near-linear lanthanide complex that displays magnet-like behaviour.

一種近線性鑭系元素絡(luò)合物，表現(xiàn)出類似磁鐵的行為。

3.Synthesis of oligosaccharide libraries for systematic explorations of heparan sulfate sequence space.

合成寡糖文庫以系統(tǒng)探索硫酸乙酰肝素序列空間。

4.Copper-catalysed difluorocarbene transfer enables modular synthesis.

銅催化的二氟卡賓轉(zhuǎn)移可實(shí)現(xiàn)模塊化合成。

5.A bridged backbone strategy enables collective synthesis of strychnan alkaloids.

橋接骨架策略能夠集體合成馬錢子生物堿。

6.Tandem intermolecular [4?+?2] cycloadditions are catalysed by glycosylated enzymes for natural product biosynthesis.

串聯(lián)分子間[4 + 2]環(huán)加成由糖基化酶催化，用于天然產(chǎn)物生物合成。

7.Energy-transfer-induced [3+2] cycloadditions of N–N pyridinium ylides.

N-N吡啶鎓葉立德的能量轉(zhuǎn)移誘導(dǎo)的[3+2]環(huán)加成。

8.A trivalent 4f complex with two bis-silylamide ligands displaying slow magnetic relaxation.

具有兩個(gè)雙甲硅烷基酰胺配體的三價(jià) 4f 絡(luò)合物，表現(xiàn)出緩慢的磁弛豫。

9.Efficient platform for synthesizing comprehensive heparan sulfate oligosaccharide libraries for decoding glycosaminoglycan–protein interactions.

用于合成綜合硫酸乙酰肝素寡糖文庫以解碼糖胺聚糖-蛋白質(zhì)相互作用的高效平臺。

10.Exciton annihilation in molecular aggregates suppressed through quantum interference.

通過量子干涉抑制分子聚集體中的激子湮滅。

11.The dynamics of agonist-β2-adrenergic receptor activation induced by binding of GDP-bound Gs protein.

GDP 結(jié)合 Gs 蛋白結(jié)合誘導(dǎo)激動劑-β2-腎上腺素能受體激活的動力學(xué)。

12.Bismuth radical catalysis in the activation and coupling of redox-active electrophiles.

氧化還原活性親電子試劑的活化和偶聯(lián)中的鉍自由基催化。

13.Fibril formation and ordering of disordered FUS LC driven by hydrophobic interactions.

由疏水相互作用驅(qū)動的無序 FUS LC 的原纖維形成和排序。

14.2-Oxabicyclo[2.1.1]hexanes as saturated bioisosteres of the ortho-substituted phenyl ring.

2-氧雜雙環(huán)[2.1.1]己烷作為鄰位取代苯環(huán)的飽和生物等排體。

15.Fragmentation and [4?+?3] cycloaddition in sodorifen biosynthesis.

sodorifen 生物合成中的斷裂和 [4 + 3] 環(huán)加成。

16.Efficient photon upconversion enabled by strong coupling between silicon quantum dots and anthracene.

通過硅量子點(diǎn)和蒽之間的強(qiáng)耦合實(shí)現(xiàn)高效的光子上轉(zhuǎn)換。

17.Tubulin engineering by semi-synthesis reveals that polyglutamylation directs detyrosination.

半合成微管蛋白工程揭示多聚谷氨酰化指導(dǎo)去酪氨酸化。

18.Metal-dependent enzyme symmetry guides the biosynthetic flux of terpene precursors.

金屬依賴性酶對稱性指導(dǎo)萜烯前體的生物合成通量。