PEG磷脂發(fā)揮怎樣的作用？

磷脂用作藥用輔料具有乳化、藥物增溶的作用，是脂質(zhì)體、脂肪乳、納米粒等緩控釋藥物制劑重要的材料。對(duì)磷脂分子進(jìn)行修飾，可以使這些制劑具備特定條件釋放、靶向定位的能力。常用的修飾方法包括：引入聚合物改善制劑的血循環(huán)時(shí)間、崩解時(shí)間；引入免疫因子增強(qiáng)靶向性；引入標(biāo)記物用以診斷和追蹤等。功能化PEG磷脂，是聚乙二醇(PEG)的末端可以進(jìn)一步的修飾用以連接多肽、核酸等配體，是常用的一種改善磷脂性能的聚合物；PEG磷脂載體具有免疫靶向性，具有營(yíng)養(yǎng)、治療作用的磷脂用作藥用輔料。

現(xiàn)在已經(jīng)有多種PEG磷脂作為抗腫瘤藥物制劑進(jìn)入臨床試驗(yàn)階段。為華生物給大家介紹其中的幾款:SH、Biotin、Mal、COOH、

DSPE-PEG2000-SH，巰基封端

DSPE-PEG2000-Biotin，生物素封端

DSPE-PEG2000-Mal，馬來(lái)酰亞胺封端

DSPE-PEG2000-COOH，羧酸封端

除此之外為華生物還帶來(lái)一些熒光分子，例如FITC、Rhodamine、CY3、CY5等等

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Phospholipids as pharmaceutical excipients have the functions of emulsification and drug solubilization, and are important materials for liposomes, fat emulsions, nanoparticles and other slow-release and controlled-release drug preparations. The modification of phospholipid molecules can make these preparations have the ability of specific release and targeting. Common modification methods include: introducing polymer to improve the blood circulation time and disintegration time of the preparation; Introducing immune factors to enhance targeting; Introducing markers for diagnosis and tracking. Functionalized peg phospholipids, which can be further modified at the end of polyethylene glycol (PEG) to connect polypeptides, nucleic acids and other ligands, are commonly used polymers to improve the performance of phospholipids; Peg phospholipid carrier has immune targeting, and phospholipids with nutritional and therapeutic effects are used as pharmaceutical excipients.