【標(biāo)題速讀】【Ncomm】【biological-sciences】【2022年】【8月】
聲明：本專欄主要對生命科學(xué)領(lǐng)域的一些期刊文章標(biāo)題進(jìn)行翻譯，所有內(nèi)容均由本人手工整理翻譯。由于本人專業(yè)為生物分析相關(guān)，其他領(lǐng)域如果出現(xiàn)翻譯錯(cuò)誤請諒解。
1.Structural and mechanistic basis for recognition of alternative tRNA precursor substrates by bacterial ribonuclease P.
細(xì)菌核糖核酸酶P識別替代tRNA前體底物的結(jié)構(gòu)和機(jī)制基礎(chǔ)。
2.Structural basis of ion uptake in copper-transporting P1B-type ATPases.
銅轉(zhuǎn)運(yùn)的P1B型ATP酶的離子吸收的結(jié)構(gòu)基礎(chǔ)。
3.PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability.
PD-L2通過維持代謝活性和Foxp3穩(wěn)定性控制外周誘導(dǎo)的調(diào)節(jié)性T細(xì)胞。
4.OXTRHigh stroma fibroblasts control the invasion pattern of oral squamous cell carcinoma via ERK5 signaling.
OXTR高基質(zhì)成纖維細(xì)胞通過ERK5信號控制口腔鱗狀細(xì)胞癌的侵襲模式。
5.Noninvasive imaging of the tumor immune microenvironment correlates with response to immunotherapy in gastric cancer.
腫瘤免疫微環(huán)境的無創(chuàng)成像與胃癌免疫療法的反應(yīng)相關(guān)。
6.Single-cell transcriptome and translatome dual-omics reveals potential mechanisms of human oocyte maturation.
單細(xì)胞轉(zhuǎn)錄組和翻譯組雙組學(xué)揭示了人類卵細(xì)胞成熟的潛在機(jī)制。
7.Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA.
形狀選擇性識別和氨基酰化的結(jié)構(gòu)基礎(chǔ)，一種D-armless人類線粒體tRNA。
8.Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti.
蚊子Aedes aegypti中Toll免疫受體激活的結(jié)構(gòu)和動態(tài)。
9.Structural bases for aspartate recognition and polymerization efficiency of cyanobacterial cyanophycin synthetase.
天門冬氨酸識別的結(jié)構(gòu)基礎(chǔ)和藍(lán)細(xì)菌藍(lán)藻素合成酶的聚合效率。
10.Early macrophage response to obesity encompasses Interferon Regulatory Factor 5 regulated mitochondrial architecture remodelling.
巨噬細(xì)胞對肥胖癥的早期反應(yīng)包含了干擾素調(diào)節(jié)因子5調(diào)節(jié)的線粒體結(jié)構(gòu)重塑。
11.Controlling gene expression with deep generative design of regulatory DNA.
用調(diào)控DNA的深度生成設(shè)計(jì)控制基因表達(dá)。
12.Tackling recalcitrant Pseudomonas aeruginosa infections in critical illness via anti-virulence monotherapy.
通過抗病毒單體療法解決危重病中頑固的銅綠假單胞菌感染問題。
13.Antiviral efficacy of favipiravir against Zika and SARS-CoV-2 viruses in non-human primates.
法匹拉韋對非人靈長類動物的寨卡和SARS-CoV-2病毒的抗病毒效果。
14.Organic phosphorescent nanoscintillator for low-dose X-ray-induced photodynamic therapy.
用于低劑量X射線誘導(dǎo)的光動力療法的有機(jī)磷光納米閃爍器。
15.Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia.
多組學(xué)分析定義了高度難治性RAS負(fù)擔(dān)的嬰兒急性淋巴細(xì)胞白血病未成熟亞組。
16.Transcontinental spread and evolution of Mycobacterium tuberculosis W148 European/Russian clade toward extensively drug resistant tuberculosis.
結(jié)核分枝桿菌W148歐洲/俄羅斯支系的跨洲傳播和向廣泛耐藥結(jié)核的進(jìn)化。
17.Dynamic mechanisms of CRISPR interference by Escherichia coli CRISPR-Cas3.
大腸桿菌CRISPR-Cas3干擾的動態(tài)機(jī)制。
18.Integrated relationship of nasopharyngeal airway host response and microbiome associates with bronchiolitis severity.
鼻咽部氣道宿主反應(yīng)和微生物組與支氣管炎嚴(yán)重程度的綜合關(guān)系。
19.Deconvoluting complex correlates of COVID-19 severity with a multi-omic pandemic tracking strategy.
用多組學(xué)大流行追蹤策略解構(gòu)COVID-19嚴(yán)重性的復(fù)雜相關(guān)因素。
20.A multi-functional role for the MCM8/9 helicase complex in maintaining fork integrity during replication stress.
MCM8/9螺旋酶復(fù)合物在復(fù)制壓力下維持叉子完整性的多功能作用。
21.Comprehensive structural assignment of glycosaminoglycan oligo- and polysaccharides by protein nanopore.
通過蛋白質(zhì)納米孔對糖胺聚糖的寡糖和多糖進(jìn)行綜合結(jié)構(gòu)分配。
22.Endophenotype effect sizes support variant pathogenicity in monogenic disease susceptibility genes.
內(nèi)生型效應(yīng)大小支持單基因疾病易感基因的變體致病性。
23.Biliary NIK promotes ductular reaction and liver injury and fibrosis in mice.
膽汁NIK促進(jìn)小鼠的導(dǎo)管反應(yīng)和肝臟損傷及纖維化。
24.Synthesizing theories of human language with Bayesian program induction.
用貝葉斯程序歸納法合成人類語言理論。
25.Adipocytes control food intake and weight regain via Vacuolar-type H+ ATPase.
脂肪細(xì)胞通過空泡型H+ATP酶控制食物攝入和體重恢復(fù)。
26.A Pilot randomized trial to examine effects of a hybrid closed-loop insulin delivery system on neurodevelopmental and cognitive outcomes in adolescents with type 1 diabetes.
一項(xiàng)試點(diǎn)隨機(jī)試驗(yàn)，檢查混合閉環(huán)胰島素輸送系統(tǒng)對1型糖尿病青少年的神經(jīng)發(fā)育和認(rèn)知結(jié)果的影響。
27.The automated Galaxy-SynBioCAD pipeline for synthetic biology design and engineering.
用于合成生物學(xué)設(shè)計(jì)和工程的自動化Galaxy-SynBioCAD管道。
28.Deep learning image segmentation reveals patterns of UV reflectance evolution in passerine birds.
深度學(xué)習(xí)圖像分割揭示了鳥類紫外線反射率的演變模式。
29.Proteolytic processing induces a conformational switch required for antibacterial toxin delivery.
蛋白水解加工誘導(dǎo)抗菌毒素遞送所需的構(gòu)象轉(zhuǎn)換。
30.Cytoplasmic forces functionally reorganize nuclear condensates in oocytes.
細(xì)胞質(zhì)力在功能上重組了卵母細(xì)胞中的核凝集物
31.PIF7 is a master regulator of thermomorphogenesis in shade.
PIF7是陰影下熱形態(tài)發(fā)生的主調(diào)控器。
32.Degenerate boundaries for multiple-alternative decisions.
多重選擇決策的退行性界線。
33.Structure of a nucleosome-bound MuvB transcription factor complex reveals DNA remodelling.
核糖體結(jié)合的MuvB轉(zhuǎn)錄因子復(fù)合物的結(jié)構(gòu)顯示了DNA重塑。
34.Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor.
布氏錐蟲的不變表面糖蛋白65是一種補(bǔ)體C3受體。
35.A brainstem monosynaptic excitatory pathway that drives locomotor activities and sympathetic cardiovascular responses.
驅(qū)動運(yùn)動活動和交感神經(jīng)心血管反應(yīng)的腦干單突觸興奮性通路。
36.HnRNPK maintains single strand RNA through controlling double-strand RNA in mammalian cells.
HnRNPK通過控制哺乳動物細(xì)胞中的雙鏈RNA維持單鏈RNA。
37.Subcortical-cortical dynamical states of the human brain and their breakdown in stroke.
人腦的皮層下-皮層動態(tài)狀態(tài)及其在中風(fēng)中的分解。
38.Divergent changes in particulate and mineral-associated organic carbon upon permafrost thaw.
凍土融化時(shí)顆粒和礦物相關(guān)有機(jī)碳的差異性變化.
39.NODULIN HOMEOBOX is required for heterochromatin homeostasis in Arabidopsis.
NODULIN HOMEOBOX是擬南芥異染色質(zhì)平衡的必要條件。
40.Limited impact of fingolimod treatment during the initial weeks of ART in SIV-infected rhesus macaques.
芬戈莫德治療在SIV感染獼猴ART最初幾周的有限影響。
41.Repurposing the mitotic machinery to drive cellular elongation and chromatin reorganisation in Plasmodium falciparum gametocytes.
重新利用有絲分裂機(jī)制來驅(qū)動惡性瘧原蟲配子細(xì)胞的細(xì)胞伸長和染色質(zhì)重組。
42.Organization of the gravity-sensing system in zebrafish.
斑馬魚重力感應(yīng)系統(tǒng)的組織。
43.The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and EXO1.
KU-PARP14軸不同程度地調(diào)節(jié)MRE11和EXO1對停滯復(fù)制叉的DNA切除。
44.Retromer deficiency in Tauopathy models enhances the truncation and toxicity of Tau.
Tauopathy模型中Retromer的缺乏增強(qiáng)了Tau的截?cái)嗪投拘浴?/p>
45.Early postnatal serotonin modulation prevents adult-stage deficits in Arid1b-deficient mice through synaptic transcriptional reprogramming.
產(chǎn)后早期5-羥色胺調(diào)控通過突觸轉(zhuǎn)錄重編程防止Arid1b缺陷小鼠成年階段的缺陷。
46.Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression.
通過靶向持續(xù)的腎小管p21表達(dá)逆轉(zhuǎn)糖尿病腎病中的腎臟高血糖記憶。
47.Fast DNA-PAINT imaging using a deep neural network.
使用深度神經(jīng)網(wǎng)絡(luò)的快速DNA-PAINT成像。
48.Paving the way to improve therapy for Myeloproliferative Neoplasms.
為改善骨髓增生性腫瘤的治療鋪平道路。
49.Call for a unified approach to Monkeypox infection in pregnancy: Lessons from the COVID-19 pandemic.
呼吁對懷孕期間的猴痘感染采取統(tǒng)一的方法：來自COVID-19大流行的教訓(xùn)。
50.Structure of the human NK cell NKR-P1:LLT1 receptor:ligand complex reveals clustering in the immune synapse.
人類NK細(xì)胞NKR-P1:LLT1受體：配體復(fù)合物的結(jié)構(gòu)揭示了免疫突觸中的集群。
51.Perforin-2 clockwise hand-over-hand pre-pore to pore transition mechanism.
穿孔蛋白-2順時(shí)針手拉手前孔到孔的過渡機(jī)制。
52.The protein arginine methyltransferase PRMT9 attenuates MAVS activation through arginine methylation.
蛋白精氨酸甲基轉(zhuǎn)移酶PRMT9通過精氨酸甲基化減弱了MAVS的激活。
53.Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment.
干性腫瘤細(xì)胞的Midkine表達(dá)推動了對mTOR抑制和免疫抑制微環(huán)境的持久性。
54.Spatially patterned hydrogen peroxide orchestrates stomatal development in Arabidopsis.
空間模式的過氧化氫協(xié)調(diào)了擬南芥的氣孔發(fā)育。
55.Specificity of the Hox member Deformed is determined by transcription factor levels and binding site affinities.
Hox成員Deformed的特異性由轉(zhuǎn)錄因子水平和結(jié)合點(diǎn)親和力決定。
56.Directed evolution of phosphite dehydrogenase to cycle noncanonical redox cofactors via universal growth selection platform.
亞磷酸酯脫氫酶的定向進(jìn)化，通過通用生長選擇平臺循環(huán)非經(jīng)典的氧化還原輔助因子。
57.Efficient DNA fluorescence labeling via base excision trapping.
通過堿基切除誘捕實(shí)現(xiàn)高效的DNA熒光標(biāo)記。
a 在 DNA 合成過程中摻入脫氨基堿基，然后進(jìn)行 DNA 修復(fù)和 UBER 標(biāo)記。 b 堿基切除捕獲機(jī)制 (BETr)。 c 在 dsDNA (DNA_dU/DNA, 400nM) 和 DNA/RNA 雜交體 (DNA_dU/RNA, 400nM) 中，BETr 標(biāo)記后熒光強(qiáng)度發(fā)生變化。 d 使用 2 U/mL Klenow (exo-) 原位 DNA 合成和 BETr 過程的熒光強(qiáng)度變化。 e 使用 2 U/μL Revert Aid H 減去 RT 的原位逆轉(zhuǎn)錄和 BETr 標(biāo)記的熒光強(qiáng)度變化。 f 通過缺口平移對 gDNA 進(jìn)行原位 BETr 標(biāo)記的圖示。 g 切口平移和原位 BETr 標(biāo)記期間的熒光增強(qiáng)取決于 dUTP 相對于 dTTP 的相對濃度。 h 熒光強(qiáng)度比較取決于原位標(biāo)記 100 分鐘后 dUTP 的相對濃度。 [CCVJ-1] = 20 μM，[UDG] = 10U/mL (c–e)，20U/mL（g，h），[目標(biāo) ODN] = 1 μM (9dA)，0.5 μM（RNA）， [gDNA]?= 40 μg/mL，[引物] = 5 μM（引物），1 μM（RT 引物），[dNTP（A、C、G）]?= 50 μM，[dUTP] =?100 μM（c–e ). [dUTP+dTTP] = 100μM (g, h)。 在 c、d、g、h Fluoroskan Ascent 酶標(biāo)儀（485nm/538nm）或 e Bio-Tek Synergy HT 酶標(biāo)儀上在 37°C 下測量熒光強(qiáng)度。
58.DAXX-ATRX regulation of p53 chromatin binding and DNA damage response.
DAXX-ATRX對p53染色質(zhì)結(jié)合和DNA損傷反應(yīng)的調(diào)節(jié)。
59.BRAT1 links Integrator and defective RNA processing with neurodegeneration.
BRAT1將整合器和RNA處理缺陷與神經(jīng)退行性聯(lián)系起來。
60.Decomposing virulence to understand bacterial clearance in persistent infections.
分解毒力以了解持久性感染中的細(xì)菌清除。
61.The CCTG PA.7 phase II trial of gemcitabine and nab-paclitaxel with or without durvalumab and tremelimumab as initial therapy in metastatic pancreatic ductal adenocarcinoma.
CCTG PA.7二期試驗(yàn)，吉西他濱和納布-紫杉醇聯(lián)合或不聯(lián)合Durvalumab和Tremelimumab作為轉(zhuǎn)移性胰腺導(dǎo)管腺癌的初始治療。
62.Water-organizing motif continuity is critical for potent ice nucleation protein activity.
水組織圖案的連續(xù)性對強(qiáng)效冰核蛋白的活性至關(guān)重要。
63.Multivalent interactions between molecular components involved in fast endophilin mediated endocytosis drive protein phase separation.
參與快速內(nèi)啡肽介導(dǎo)的內(nèi)吞作用的分子成分之間的多價(jià)相互作用驅(qū)動蛋白質(zhì)相分離。
64.Liquid-infused microstructured bioadhesives halt non-compressible hemorrhage.
液體注入的微結(jié)構(gòu)生物粘合劑阻止了不可壓縮的出血。
65.AMPK deficiency in smooth muscles causes persistent pulmonary hypertension of the new-born and premature death.
平滑肌中AMPK的缺失導(dǎo)致新生兒持續(xù)肺動脈高壓和過早死亡。
66.Inducible expression of large gRNA arrays for multiplexed CRISPRai applications.
用于多重CRISPRai應(yīng)用的大型gRNA陣列的誘導(dǎo)性表達(dá)。
67.Nanoscale segregation of channel and barrier claudins enables paracellular ion flux.
通道和屏障Claudins的納米級隔離使細(xì)胞旁的離子通暢。
68.Single residue modulators of amyloid formation in the N-terminal P1-region of α-synuclein.
α-synuclein的N端P1區(qū)淀粉樣蛋白形成的單殘基調(diào)節(jié)器。
69.Microengineered devices enable long-term imaging of the ventral nerve cord in behaving adult Drosophila.
微型工程設(shè)備使行為的成年果蠅的腹側(cè)神經(jīng)索的長期成像成為可能。
70.An interplay between cellular growth and atypical fusion defines morphogenesis of a modular glial niche in Drosophila.
細(xì)胞生長和非典型融合之間的相互作用確定了果蠅模塊化膠質(zhì)壁龕的形態(tài)發(fā)生。
71.Designed peptides as nanomolar cross-amyloid inhibitors acting via supramolecular nanofiber co-assembly.
設(shè)計(jì)的肽作為納摩爾交叉淀粉樣蛋白抑制劑，通過超分子納米纖維共同組裝發(fā)揮作用。
72.Cellular taxonomy of Hic1+ mesenchymal progenitor derivatives in the limb: from embryo to adult.
肢體中Hic1+間質(zhì)祖先衍生物的細(xì)胞分類：從胚胎到成人。
73.Discrete subicular circuits control generalization of hippocampal seizures.
分離的亞細(xì)胞回路控制海馬發(fā)作的泛化。
74.Oligodendrocyte differentiation alters tRNA modifications and codon optimality-mediated mRNA decay.
少突膠質(zhì)細(xì)胞分化改變了tRNA修飾和密碼子優(yōu)化介導(dǎo)的mRNA衰減。
75.Tripterygium wilfordii cytochrome P450s catalyze the methyl shift and epoxidations in the biosynthesis of triptonide.
Tripterygium wilfordii細(xì)胞色素P450s在三苯氧胺的生物合成中催化甲基轉(zhuǎn)移和環(huán)氧化作用。
76.Specificity of TGF-β1 signal designated by LRRC33 and integrin αVβ8.
由LRRC33和整合素αVβ8指定的TGF-β1信號的特異性。
77.CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis.
CK2誘導(dǎo)的HHEX與YAP-TEAD4復(fù)合物的合作促進(jìn)結(jié)直腸腫瘤的發(fā)生。
78.Regulation of neuroendocrine plasticity by the RNA-binding protein ZFP36L1.
RNA結(jié)合蛋白ZFP36L1對神經(jīng)內(nèi)分泌可塑性的調(diào)節(jié)。
79.Cholinergic basal forebrain nucleus of Meynert regulates chronic pain-like behavior via modulation of the prelimbic cortex.
膽堿能的前腦基底核Meynert通過調(diào)控前腦皮層調(diào)節(jié)慢性疼痛樣行為。
80.Single-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroids.
肝母細(xì)胞瘤的單細(xì)胞分析確定了使用患者特異性腫瘤球狀體預(yù)測化療敏感性的腫瘤特征。
81.Control cell migration by engineering integrin ligand assembly.
通過工程整合素配體組裝控制細(xì)胞遷移。
82.Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence.
上皮-間質(zhì)可塑性決定了雌激素受體陽性乳腺癌的休眠期，而上皮的重新轉(zhuǎn)換則促使復(fù)發(fā)。
83.Selective suppression of melanoma lacking IFN-γ pathway by JAK inhibition depends on T cells and host TNF signaling.
JAK抑制對缺乏IFN-γ途徑的黑色素瘤的選擇性抑制取決于T細(xì)胞和宿主TNF信號。
84.Catalytic innovation underlies independent recruitment of polyketide synthases in cocaine and hyoscyamine biosynthesis.
催化創(chuàng)新是可卡因和透明胺生物合成中多酮體合成酶獨(dú)立招募的基礎(chǔ)。
85.Consistent predator-prey biomass scaling in complex food webs.
復(fù)雜食物網(wǎng)中一致的捕食者-獵物生物量比例。
86.Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance.
闡明克服鹵蟲酮抗性的瘧原蟲脯氨酰-tRNA合成酶抑制劑的途徑。
87.A neural correlate of perceptual segmentation in macaque middle temporal cortical area.
獼猴中顳皮層區(qū)域感知分割的神經(jīng)關(guān)聯(lián)。
88.Splicing QTL analysis focusing on coding sequences reveals mechanisms for disease susceptibility loci.
關(guān)注編碼序列的剪接QTL分析揭示了疾病易感位點(diǎn)的機(jī)制。
89.Rational design of a sensitivity-enhanced tracer for discovering efficient APC–Asef inhibitors.
合理設(shè)計(jì)敏感性增強(qiáng)的示蹤劑，發(fā)現(xiàn)高效的APC-Asef抑制劑。
90.Striatal dopamine dissociates methylphenidate effects on value-based versus surprise-based reversal learning.
紋狀體多巴胺使哌醋甲酯對基于價(jià)值和基于驚奇的逆轉(zhuǎn)學(xué)習(xí)的影響不一致。
91.Structural analysis of Red1 as a conserved scaffold of the RNA-targeting MTREC/PAXT complex.
Red1作為RNA靶向MTREC/PAXT復(fù)合物的保守支架的結(jié)構(gòu)分析。
92.Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape.
Omicron SARS-CoV-2突變穩(wěn)定了尖峰向上的RBD構(gòu)象并導(dǎo)致非RBM結(jié)合的單克隆抗體逃逸。
93.Genome-wide mutational signatures in low-coverage whole genome sequencing of cell-free DNA.
無細(xì)胞DNA的低覆蓋率全基因組測序中的全基因組突變特征。
94.Covalent TCR-peptide-MHC interactions induce T cell activation and redirect T cell fate in the thymus.
共價(jià)TCR-肽-MHC相互作用誘導(dǎo)T細(xì)胞激活并重定向胸腺中的T細(xì)胞命運(yùn)。
95.scRNA-seq of gastric tumor shows complex intercellular interaction with an alternative T cell exhaustion trajectory.
胃腫瘤的scRNA-seq顯示復(fù)雜的細(xì)胞間相互作用與另一種T細(xì)胞衰竭軌跡。
96.Raptors avoid the confusion effect by targeting fixed points in dense aerial prey aggregations.
猛禽通過瞄準(zhǔn)密集的空中獵物聚集區(qū)的固定點(diǎn)來避免混亂效應(yīng)。
97.Nucleosome-directed replication origin licensing independent of a consensus DNA sequence.
獨(dú)立于共識DNA序列的核糖體指導(dǎo)的復(fù)制起源許可。
98.Delineating Mycobacterium abscessus population structure and transmission employing high-resolution core genome multilocus sequence typing.
采用高分辨率核心基因組多焦點(diǎn)序列分型來描述膿腫分枝桿菌的種群結(jié)構(gòu)和傳播。
99.De novo protein design of photochemical reaction centers.
光化學(xué)反應(yīng)中心的新蛋白質(zhì)設(shè)計(jì)。
100.Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes.
多門類外顯子測序顯示INHBE突變與有利的脂肪分布和保護(hù)糖尿病有關(guān)。
101.Linear and nonlinear correlation estimators unveil undescribed taxa interactions in microbiome data.
線性和非線性相關(guān)估計(jì)器揭示了微生物組數(shù)據(jù)中未描述的類群相互作用。
102.KLF4 recruits SWI/SNF to increase chromatin accessibility and reprogram the endothelial enhancer landscape under laminar shear stress.
KLF4招募SWI/SNF以增加染色質(zhì)的可及性，并在層狀剪切應(yīng)力下重新規(guī)劃內(nèi)皮細(xì)胞增強(qiáng)器景觀。
103.Duplicated ribosomal protein paralogs promote alternative translation and drug resistance.
重復(fù)的核糖體蛋白旁系物促進(jìn)替代翻譯和耐藥性。
104.Estimating effects of parents’ cognitive and non-cognitive skills on offspring education using polygenic scores.
利用多基因評分估計(jì)父母的認(rèn)知和非認(rèn)知技能對后代教育的影響。
105.Rhythmic transcription of Bmal1 stabilizes the circadian timekeeping system in mammals.
Bmal1的節(jié)律性轉(zhuǎn)錄穩(wěn)定了哺乳動物的晝夜守時(shí)系統(tǒng)。
106.Multifunctional nanoparticle potentiates the in situ vaccination effect of radiation therapy and enhances response to immune checkpoint blockade.
多功能納米粒子增強(qiáng)了放療的原位接種效果并提高了對免疫檢查點(diǎn)阻斷的反應(yīng)。
107.Rainfall and sea level drove the expansion of seasonally flooded habitats and associated bird populations across Amazonia.
降雨和海平面推動了整個(gè)亞馬遜地區(qū)季節(jié)性洪水棲息地和相關(guān)鳥類種群的擴(kuò)張。
108.A single WNT enhancer drives specification and regeneration of the Drosophila wing.
一個(gè)單一的WNT增強(qiáng)器驅(qū)動果蠅翅膀的規(guī)范和再生。
109.Muconic acid production from glucose and xylose in Pseudomonas putida via evolution and metabolic engineering.
普氏假單胞菌通過進(jìn)化和代謝工程從葡萄糖和木糖中生產(chǎn)粘液酸。
110.Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals.
血漿代謝組的全基因組關(guān)聯(lián)研究確定了與黑人心臟代謝疾病有關(guān)的代謝物。
111.The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force.
日本COVID-19工作組465份COVID-19感染樣本的全血轉(zhuǎn)錄調(diào)控圖譜。
112.Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models.
溶酶體外分泌會從神經(jīng)元中釋放出致病的α-突觸核苷酸物種，在突觸核苷酸病模型中。
113.Single cell transcriptomic analysis of the immune cell compartment in the human small intestine and in Celiac disease.
人類小腸和乳糜瀉中免疫細(xì)胞區(qū)的單細(xì)胞轉(zhuǎn)錄組分析。
114.Evolution of longitudinal division in multicellular bacteria of the Neisseriaceae family.
奈瑟爾科多細(xì)胞細(xì)菌的縱向分裂進(jìn)化。
115.Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology.
人類額葉皮層的全基因組關(guān)聯(lián)研究確定了路易體病理學(xué)中不同的甲基化。
116.Immunogenicity to COVID-19 mRNA vaccine third dose in people living with HIV.
COVID-19 mRNA疫苗第三劑對HIV感染者的免疫原性。
117.Global systematic review with meta-analysis reveals yield advantage of legume-based rotations and its drivers.
全球性的系統(tǒng)回顧與薈萃分析揭示了以豆科植物為基礎(chǔ)的輪作的產(chǎn)量優(yōu)勢及其驅(qū)動因素。
118.Human acute inflammatory recovery is defined by co-regulatory dynamics of white blood cell and platelet populations.
人類急性炎癥的恢復(fù)是由白細(xì)胞和血小板群體的共同調(diào)控動態(tài)定義的。
119.Comparison of the 2021 COVID-19 roadmap projections against public health data in England.
2021年COVID-19路線圖預(yù)測與英格蘭公共衛(wèi)生數(shù)據(jù)的比較。
120.Population-based tract-to-region connectome of the human brain and its hierarchical topology.
基于人群的人腦道-區(qū)域連接組及其分層拓?fù)浣Y(jié)構(gòu)。
121.Antiviral and clinical activity of bamlanivimab in a randomized trial of non-hospitalized adults with COVID-19.
Bamlanivimab在非住院成人COVID-19的隨機(jī)試驗(yàn)中的抗病毒和臨床活性。
122.A nanopore interface for higher bandwidth DNA computing.
用于更高帶寬DNA計(jì)算的納米孔接口。
123.Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.
用光活化依賴性接近標(biāo)記進(jìn)行時(shí)空分辨的蛋白質(zhì)網(wǎng)絡(luò)分析。
124.Integrated multi-omics reveals cellular and molecular interactions governing the invasive niche of basal cell carcinoma.
綜合多組學(xué)揭示了支配基底細(xì)胞癌侵襲龕的細(xì)胞和分子相互作用。
125.Mapping effective connectivity of human amygdala subdivisions with intracranial stimulation.
利用顱內(nèi)刺激繪制人類杏仁核分區(qū)的有效連接圖。
126.Global systematic review with meta-analysis shows that warming effects on terrestrial plant biomass allocation are influenced by precipitation and mycorrhizal association.
全球系統(tǒng)回顧與薈萃分析表明，氣候變暖對陸地植物生物量分配的影響受到降水和菌根聯(lián)合的影響。
127.Flavin-enabled reductive and oxidative epoxide ring opening reactions.
黃素促成的還原性和氧化性環(huán)氧化物開環(huán)反應(yīng)。
128.Earlier Alzheimer’s disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading.
阿爾茨海默病發(fā)病較早，與大腦樞紐區(qū)域的tau病理有關(guān)，并促進(jìn)了tau的擴(kuò)散。
129.Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis.
轉(zhuǎn)座子激活的POU5F1B促進(jìn)結(jié)直腸癌生長和轉(zhuǎn)移。
130.Designing isolation guidelines for COVID-19 patients with rapid antigen tests.
用快速抗原檢測為COVID-19患者設(shè)計(jì)隔離指南。
131.Temporally restricted activation of IFNβ signaling underlies response to immune checkpoint therapy in mice.
IFNβ信號的時(shí)間限制性激活是小鼠對免疫檢查點(diǎn)療法反應(yīng)的基礎(chǔ)。
132.Modelling the medium-term dynamics of SARS-CoV-2 transmission in England in the Omicron era.
模擬Omicron時(shí)代SARS-CoV-2在英國傳播的中期動態(tài)。
133.Permian hypercarnivore suggests dental complexity among early amniotes.
二疊紀(jì)超大型食肉動物表明早期羊齒動物中牙齒的復(fù)雜性。
134.Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6.
晶體結(jié)構(gòu)揭示了雙特異性泛素/FAT10 E1酶Uba6的催化和調(diào)節(jié)機(jī)制。
135.In situ structure and dynamics of an alphacoronavirus spike protein by cryo-ET and cryo-EM.
通過低溫ET和低溫EM研究嗜血桿菌穗狀蛋白的原位結(jié)構(gòu)和動力學(xué)。
136.SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8+ T-cells.
SARS CoV-2 mRNA疫苗使?jié)摲腍IV暴露于Nef特異性CD8+T細(xì)胞。
137.Increasing sensitivity of dryland vegetation greenness to precipitation due to rising atmospheric CO2.
大氣中二氧化碳含量上升導(dǎo)致旱地植被綠度對降水的敏感性增加。
138.Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition.
免疫介導(dǎo)的腎小管萎縮促進(jìn)急性腎臟損傷向慢性腎臟疾病過渡。
139.Ferritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons.
鐵蛋白介導(dǎo)的鐵解毒作用促進(jìn)優(yōu)雅動物和小鼠神經(jīng)元的低溫生存。
140.Socially meaningful visual context either enhances or inhibits vocalisation processing in the macaque brain.
有社會意義的視覺背景增強(qiáng)或抑制獼猴大腦的發(fā)聲處理。
141.Phylogenetically and catabolically diverse diazotrophs reside in deep-sea cold seep sediments.
深海冷泉沉積物中居住著系統(tǒng)發(fā)育和分解代謝不同的重氮生物。
142.Multiscale light-sheet organoid imaging framework.
多尺度光片類器官成像框架。
143.Heterogenous humoral and cellular immune responses with distinct trajectories post-SARS-CoV-2 infection in a population-based cohort.
基于人群的SARS-CoV-2感染后具有不同軌跡的體液和細(xì)胞免疫反應(yīng)。
144.Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs.
大麻素誘導(dǎo)脂質(zhì)納米盤中α1-甘氨酸受體增效的結(jié)構(gòu)基礎(chǔ)。
145.On maternity and the stronger immune response in women.
關(guān)于產(chǎn)婦和婦女更強(qiáng)的免疫反應(yīng)。
146.Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota.
口服Blautia wexlerae通過腸道微生物群的代謝重塑改善肥胖癥和2型糖尿病。
147.Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex.
設(shè)計(jì)一個(gè)自主的VH結(jié)構(gòu)域來調(diào)控細(xì)胞內(nèi)的通路并審視eIF4F復(fù)合物。
148.BNT162b2-boosted immune responses six months after heterologous or homologous ChAdOx1nCoV-19/BNT162b2 vaccination against COVID-19.
BNT162b2在異源或同源的ChAdOx1nCoV-19/BNT162b2疫苗接種COVID-19六個(gè)月后增強(qiáng)了免疫反應(yīng)。
149.Inorganic nanosheets facilitate humoral immunity against medical implant infections by modulating immune co-stimulatory pathways.
無機(jī)納米片通過調(diào)節(jié)免疫共刺激途徑促進(jìn)對醫(yī)療植入物感染的體液免疫。
150.Rubisco forms a lattice inside alpha-carboxysomes.
Rubisco在alpha-carboxysomes內(nèi)形成一個(gè)晶格。
151.Predicting response to immunotherapy in gastric cancer via multi-dimensional analyses of the tumour immune microenvironment.
通過腫瘤免疫微環(huán)境的多維分析預(yù)測胃癌免疫療法的反應(yīng)。
152.SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization.
值得關(guān)注的SARS-CoV-2變體：尖峰蛋白突變分析和廣泛中和的表位。
153.SARS-CoV-2 antibodies and breakthrough infections in the Virus Watch cohort.
病毒觀察隊(duì)列中的SARS-CoV-2抗體和突破性感染。
154.Cross-tissue analysis of blood and brain epigenome-wide association studies in Alzheimer’s disease.
阿爾茨海默病的血液和大腦表觀基因組關(guān)聯(lián)研究的跨組織分析。
155.Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly.
mTORC1通過調(diào)節(jié)V-ATP酶的組裝直接控制溶酶體的分解代謝活動。
156.Promotion of neutralizing antibody-independent immunity to wild-type and SARS-CoV-2 variants of concern using an RBD-Nucleocapsid fusion protein.
利用RBD-核殼融合蛋白促進(jìn)對野生型和SARS-CoV-2變體的中和抗體依賴性免疫力。
157.Experimental exploration of a ribozyme neutral network using evolutionary algorithm and deep learning.
使用進(jìn)化算法和深度學(xué)習(xí)對核酸酶中性網(wǎng)絡(luò)的實(shí)驗(yàn)探索。
158.Intrinsic cell rheology drives junction maturation.
細(xì)胞內(nèi)在流變學(xué)驅(qū)動結(jié)點(diǎn)成熟。
159.AAA?+?ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1.
AAA + ATPase Thorase通過mTOR復(fù)合物1的拆解抑制mTOR信號傳導(dǎo)。
160.MARTX toxin of Vibrio vulnificus induces RBC phosphatidylserine exposure that can contribute to thrombosis.
弧菌的MARTX毒素誘導(dǎo)紅細(xì)胞磷脂酰絲氨酸暴露，可促使血栓形成。
161.Halogenation of tyrosine perturbs large-scale protein self-organization.
酪氨酸的鹵化擾亂了大規(guī)模的蛋白質(zhì)自組織。
162.High impact of bacterial predation on cyanobacteria in soil biocrusts.
細(xì)菌捕食對土壤生物殼中藍(lán)藻的高度影響。
163.Structural basis for proton coupled cystine transport by cystinosin.
胱氨酸酶質(zhì)子耦合胱氨酸轉(zhuǎn)運(yùn)的結(jié)構(gòu)基礎(chǔ)。
164.GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements.
妊娠期肝內(nèi)膽汁淤積癥的GWAS元分析牽涉到多個(gè)肝臟基因和調(diào)節(jié)元件。
165.Cryo-EM structures of the channelrhodopsin ChRmine in lipid nanodiscs.
脂質(zhì)納米盤中的通道色素ChRmine的低溫EM結(jié)構(gòu)。
166.The origin and evolution of open habitats in North America inferred by Bayesian deep learning models.
貝葉斯深度學(xué)習(xí)模型推斷的北美開放棲息地的起源和演變。
167.Terrigenous dissolved organic matter persists in the energy-limited deep groundwaters of the Fennoscandian Shield.
芬諾斯坦地盾能量有限的深層地下水中持續(xù)存在土生的溶解性有機(jī)物。
168.A nanoengineered topical transmucosal cisplatin delivery system induces anti-tumor response in animal models and patients with oral cancer.
一種納米工程局部經(jīng)粘膜的順鉑輸送系統(tǒng)在動物模型和口腔癌患者中誘發(fā)抗腫瘤反應(yīng)。
169.A lymphatic-absorbed multi-targeted kinase inhibitor for myelofibrosis therapy.
一種淋巴吸收的多靶點(diǎn)激酶抑制劑用于骨髓纖維化治療。
170.Trends in COVID-19 hospital outcomes in England before and after vaccine introduction, a cohort study.
疫苗引入前后英格蘭COVID-19醫(yī)院結(jié)果的趨勢，一項(xiàng)隊(duì)列研究。
171.Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis.
時(shí)空單細(xì)胞調(diào)控圖譜揭示了牙齒形態(tài)發(fā)生過程中神經(jīng)嵴系的多樣化和細(xì)胞功能。
172.A direct excitatory projection from entorhinal layer 6b neurons to the hippocampus contributes to spatial coding and memory.
內(nèi)丘6b層神經(jīng)元對海馬的直接興奮性投射有助于空間編碼和記憶。
173.Copper starvation induces antimicrobial isocyanide integrated into two distinct biosynthetic pathways in fungi.
銅饑餓誘導(dǎo)抗菌劑異氰酸酯集成到真菌的兩個(gè)不同的生物合成途徑中。
174.Transcription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes.
IRF8對單核細(xì)胞中STING激活和先天免疫反應(yīng)的轉(zhuǎn)錄非依賴性調(diào)節(jié)。
175.ABCA1 is an extracellular phospholipid translocase.
ABCA1是一種細(xì)胞外磷脂轉(zhuǎn)運(yùn)酶。
176.Dynamic cybergenetic control of bacterial co-culture composition via optogenetic feedback.
通過光遺傳學(xué)反饋對細(xì)菌共培養(yǎng)物組成的動態(tài)網(wǎng)絡(luò)遺傳控制。
177.The combination of genomic offset and niche modelling provides insights into climate change-driven vulnerability.
基因組偏移和生態(tài)位模型的結(jié)合提供了對氣候變化驅(qū)動的脆弱性的見解。
178.Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma.
單細(xì)胞空間分析揭示了膠質(zhì)母細(xì)胞瘤中免疫調(diào)節(jié)性嘌呤信號的拓?fù)浣Y(jié)構(gòu)。
179.Neural circuit for social authentication in song learning.
歌曲學(xué)習(xí)中社會認(rèn)證的神經(jīng)回路。
180.A functional role of meningeal lymphatics in sex difference of stress susceptibility in mice.
腦膜淋巴管在小鼠壓力易感性的性別差異中的功能作用。
181.Early treatment regimens achieve sustained virologic remission in infant macaques infected with SIV at birth.
早期治療方案實(shí)現(xiàn)了出生時(shí)感染SIV的嬰兒獼猴的持續(xù)病毒學(xué)緩解。
182.Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease.
人類和小鼠帕金森病模型中的初級纖毛和SHH信號傳導(dǎo)障礙。
183.A TrkB agonist prodrug prevents bone loss via inhibiting asparagine endopeptidase and increasing osteoprotegerin.
一種TrkB激動劑原藥通過抑制天冬酰胺內(nèi)肽酶和增加骨保護(hù)素來防止骨質(zhì)流失。
184.A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues.
一個(gè)新的基因組可以識別衰老細(xì)胞，并預(yù)測各組織中與衰老相關(guān)的途徑。
185.Mannose ameliorates experimental colitis by protecting intestinal barrier integrity.
甘露糖通過保護(hù)腸道屏障的完整性改善了實(shí)驗(yàn)性結(jié)腸炎。
186.Visualization of conformational changes and membrane remodeling leading to genome delivery by viral class-II fusion machinery.
病毒二類融合機(jī)制導(dǎo)致基因組傳遞的構(gòu)象變化和膜重塑的可視化。
187.Structural basis of transcriptional regulation by a nascent RNA element, HK022 putRNA.
新生?RNA?元素?HK022 putRNA?轉(zhuǎn)錄調(diào)控的結(jié)構(gòu)基礎(chǔ)。
188.Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors.
對異檸檬酸脫氫酶1突變體抑制劑ivosidenib的耐藥性可以通過替代的二聚體-界面結(jié)合抑制劑來克服。
189.Strigolactones are chemoattractants for host tropism in Orobanchaceae parasitic plants.
Strigolactones是Orobanchaceae寄生植物的宿主趨向性的化學(xué)吸引劑。
190.Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo.
哌嗪衍生的脂質(zhì)納米粒子在體內(nèi)向免疫細(xì)胞傳遞mRNA。
191.Chimeric GPCRs mimic distinct signaling pathways and modulate microglia responses.
嵌合GPCRs模擬不同的信號通路并調(diào)節(jié)小膠質(zhì)細(xì)胞反應(yīng)。
192.Social incentivization of instrumental choice in mice requires amygdala-prelimbic cortex-nucleus accumbens connectivity.
小鼠工具性選擇的社會激勵需要杏仁核-前腦皮層-阿肯色的連接。
193.SH3 domain regulation of RhoGAP activity: Crosstalk between p120RasGAP and DLC1 RhoGAP.
SH3結(jié)構(gòu)域?qū)hoGAP活性的調(diào)節(jié)：?p120RasGAP和DLC1 RhoGAP之間的相互作用。
194.Expression plasticity regulates intraspecific variation in the acclimatization potential of a reef-building coral.
表達(dá)可塑性調(diào)控造礁珊瑚適應(yīng)性潛力的種內(nèi)變化。
195.A slow-cycling/quiescent cells subpopulation is involved in glioma invasiveness.
緩慢循環(huán)/靜止細(xì)胞亞群參與膠質(zhì)瘤的侵襲性
196.Circular EZH2-encoded EZH2-92aa mediates immune evasion in glioblastoma via inhibition of surface NKG2D ligands.
環(huán)形EZH2編碼的EZH2-92aa通過抑制表面NKG2D配體介導(dǎo)膠質(zhì)母細(xì)胞瘤的免疫規(guī)避。
197.Structures of UBA6 explain its dual specificity for ubiquitin and FAT10.
UBA6的結(jié)構(gòu)解釋了其對泛素和FAT10的雙重特異性。
198.Spidroin N-terminal domain forms amyloid-like fibril based hydrogels and provides a protein immobilization platform.
Spidroin的N端結(jié)構(gòu)域形成了基于淀粉樣纖維的水凝膠，并提供了一個(gè)蛋白質(zhì)固定化的平臺。
199.Visualizing molecular interactions that determine assembly of a bullet-shaped vesicular stomatitis virus particle.
可視化決定子彈型水泡口炎病毒顆粒組裝的分子相互作用。
200.Precision dynamical mapping using topological data analysis reveals a hub-like transition state at rest.
利用拓?fù)鋵W(xué)數(shù)據(jù)分析的精確動態(tài)圖譜揭示了靜止時(shí)的樞紐狀過渡狀態(tài)。
201.Sirt2 promotes white matter oligodendrogenesis during development and in models of neonatal hypoxia.
Sirt2在發(fā)育過程中和新生兒缺氧模型中促進(jìn)白質(zhì)少突起。
202.Second-dose ChAdOx1 and BNT162b2 COVID-19 vaccines and thrombocytopenic, thromboembolic and hemorrhagic events in Scotland.
蘇格蘭第二劑量ChAdOx1和BNT162b2 COVID-19疫苗與血小板減少、血栓栓塞和出血性事件。
203.Distractibility and impulsivity neural states are distinct from selective attention and modulate the implementation of spatial attention.
分心性和沖動性神經(jīng)狀態(tài)與選擇性注意不同，并能調(diào)節(jié)空間注意的實(shí)施。
204.Structural basis for Sarbecovirus ORF6 mediated blockage of nucleocytoplasmic transport.
Sarbecovirus ORF6介導(dǎo)的核細(xì)胞質(zhì)運(yùn)輸受阻的結(jié)構(gòu)基礎(chǔ)。
205.ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19.
ELF5是嚴(yán)重COVID-19的潛在呼吸道上皮細(xì)胞特異性風(fēng)險(xiǎn)基因。
206.Regional connectivity drove bidirectional transmission of SARS-CoV-2 in the Middle East during travel restrictions.
區(qū)域連通性推動了SARS-CoV-2在中東地區(qū)旅行限制期間的雙向傳播。
207.PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression.
PKD1和PKD2 mRNA順式抑制驅(qū)動多囊腎病的進(jìn)展。
208.Rapid evolution of mutation rate and spectrum in response to environmental and population-genetic challenges.
應(yīng)對環(huán)境和群體遺傳挑戰(zhàn)的突變率和光譜的快速演變。
209.Adaptation to novel spatially-structured environments is driven by the capsule and alters virulence-associated traits.
對新的空間結(jié)構(gòu)環(huán)境的適應(yīng)是由膠囊驅(qū)動的，并改變了毒力相關(guān)的性狀。
210.A method for Boolean analysis of protein interactions at a molecular level.
一種在分子水平上對蛋白質(zhì)相互作用進(jìn)行布爾分析的方法。
211.Vaccine effectiveness of CoronaVac against COVID-19 among children in Brazil during the Omicron period.
在Omicron時(shí)期，CoronaVac對巴西兒童的COVID-19的疫苗有效性。
212.Anionic nanoplastic exposure induces endothelial leakiness.
陰離子納米塑料暴露誘導(dǎo)內(nèi)皮滲漏。
213.XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair.
XPC-PARP復(fù)合物參與染色質(zhì)重塑器ALC1以催化全球基因組DNA損傷修復(fù)。
214.Reformation of the chondroitin sulfate glycocalyx enables progression of AR-independent prostate cancer.
硫酸軟骨素糖復(fù)合物的改造使不依賴AR的前列腺癌的進(jìn)展。
215.Visual evoked feedforward–feedback traveling waves organize neural activity across the cortical hierarchy in mice.
視覺誘發(fā)的前饋行波組織了小鼠整個(gè)皮層的神經(jīng)活動。
216.Extraction of accurate cytoskeletal actin velocity distributions from noisy measurements.
從噪聲測量中提取準(zhǔn)確的細(xì)胞骨架肌動蛋白速度分布。
217.Individuals with ventromedial frontal damage display unstable but transitive preferences during decision making.
額葉內(nèi)側(cè)損傷的個(gè)體在決策過程中顯示出不穩(wěn)定的但具有轉(zhuǎn)折性的偏好。
218.Empirical evidence on the efficiency of backward contact tracing in COVID-19.
關(guān)于COVID-19中后向接觸追蹤效率的經(jīng)驗(yàn)性證據(jù)。
219.Control of non-REM sleep by ventrolateral medulla glutamatergic neurons projecting to the preoptic area.
外側(cè)延髓谷氨酸神經(jīng)元對非快速眼動睡眠的控制，投射到視前區(qū)的谷氨酸神經(jīng)元。
220.Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance.
一種CRISPR激活小鼠的產(chǎn)生，能夠?qū)η忠u性淋巴瘤進(jìn)行建模并對venetoclax的耐藥性進(jìn)行詢問。
221.Mycobacterial resistance to zinc poisoning requires assembly of P-ATPase-containing membrane metal efflux platforms.
霉菌對鋅中毒的抗性需要裝配含P-ATP酶的膜金屬流出平臺。
222.Protection of COVID-19 vaccination and previous infection against Omicron BA.1, BA.2 and Delta SARS-CoV-2 infections.
COVID-19疫苗接種和先前感染對Omicron BA.1、BA.2和Delta SARS-CoV-2感染的保護(hù)。
223.Structural basis for receptor selectivity and inverse agonism in S1P5 receptors.
S1P5受體中受體選擇性和反激動性的結(jié)構(gòu)基礎(chǔ)。
224.Single-atom nanozymes catalytically surpassing naturally occurring enzymes as sustained stitching for brain trauma.
單原子納米酶的催化作用超過了自然發(fā)生的酶，作為腦創(chuàng)傷的持續(xù)縫合。
225.Accurate population proxies do not exist between 11.7 and 15 ka in North America.
北美洲11.7-15ka之間不存在準(zhǔn)確的人口代用指標(biāo)。
226.Reply to: Accurate population proxies do not exist between 11.7 and 15 ka in North America.
回復(fù)：?準(zhǔn)確的人口代用指標(biāo)在北美11.7和15 ka之間不存在。
227.Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2.
對人類興奮性氨基酸轉(zhuǎn)運(yùn)體EAAT2的抑制機(jī)制的結(jié)構(gòu)見解。
228.Biocatalytic routes to stereo-divergent iridoids.
生物催化的立體異構(gòu)虹膜路線。
229.Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription.
環(huán)狀RNA circTmem241通過啟動Elk3轉(zhuǎn)錄驅(qū)動第三組先天淋巴細(xì)胞分化。
230.Clonal diversification and histogenesis of malignant germ cell tumours.
惡性生殖細(xì)胞腫瘤的克隆多樣化和組織發(fā)生。
231.Ultra-deep sequencing validates safety of CRISPR/Cas9 genome editing in human hematopoietic stem and progenitor cells.
超深度測序驗(yàn)證了CRISPR/Cas9基因組編輯在人類造血干細(xì)胞和祖細(xì)胞中的安全性。
232.Restructured membrane contacts rewire organelles for human cytomegalovirus infection.
重組的膜接觸為人類巨細(xì)胞病毒感染的細(xì)胞器重新布線。
233.SARS-CoV-2 and other respiratory pathogens are detected in continuous air samples from congregate settings.
SARS-CoV-2和其他呼吸道病原體在聚集場所的連續(xù)空氣樣本中被檢測出來。
234.PTEN inhibits AMPK to control collective migration.
PTEN抑制AMPK以控制集體遷移。
235.The causes and consequences of Alzheimer’s disease: phenome-wide evidence from Mendelian randomization.
阿爾茨海默病的原因和后果：來自孟德爾隨機(jī)化的全表型證據(jù)。
236.Thermal adaptation best explains Bergmann’s and Allen’s Rules across ecologically diverse shorebirds.
熱適應(yīng)能最好地解釋伯格曼規(guī)則和艾倫規(guī)則在不同生態(tài)環(huán)境下的海岸鳥。
237.Transcription-coupled and epigenome-encoded mechanisms direct H3K4 methylation.
轉(zhuǎn)錄耦合和表觀基因組編碼機(jī)制指導(dǎo)H3K4甲基化。
238.CHIKV infection reprograms codon optimality to favor viral RNA translation by altering the tRNA epitranscriptome.
CHIKV感染通過改變tRNA表觀轉(zhuǎn)錄組來重新規(guī)劃密碼子的優(yōu)化以利于病毒RNA的翻譯。
239.Comparative immunogenicity and reactogenicity of heterologous ChAdOx1-nCoV-19-priming and BNT162b2 or mRNA-1273-boosting with homologous COVID-19 vaccine regimens.
異源ChAdOx1-nCoV-19-priming和BNT162b2或mRNA-1273-boosting與同源COVID-19疫苗方案的免疫原性和反應(yīng)原性的比較。
240.Adenosine triphosphate-activated prodrug system for on-demand bacterial inactivation and wound disinfection.
三磷酸腺苷激活的原藥系統(tǒng)用于按需滅活細(xì)菌和傷口消毒。
241.TET enzymes regulate skeletal development through increasing chromatin accessibility of RUNX2 target genes.
TET酶通過增加RUNX2靶基因的染色質(zhì)可及性調(diào)節(jié)骨骼發(fā)育。
242.Megahertz pulse trains enable multi-hit serial femtosecond crystallography experiments at X-ray free electron lasers.
兆赫茲脈沖序列使X射線自由電子激光器的多擊串聯(lián)飛秒晶體學(xué)實(shí)驗(yàn)得以進(jìn)行。
243.Science in the time of COVID-19: Reflections on the UK Events Research Programme.
COVID-19時(shí)代的科學(xué)：?對英國事件研究計(jì)劃的反思。
244.mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1.
mTORC1通過SCYL1的磷酸化控制高爾基結(jié)構(gòu)和囊泡的分泌。
245.Targeting the Retinoblastoma/E2F repressive complex by CDK4/6 inhibitors amplifies oncolytic potency of an oncolytic adenovirus.
CDK4/6抑制劑靶向視網(wǎng)膜母細(xì)胞瘤/E2F抑制復(fù)合物，放大了腫瘤腺病毒的殺傷力。
246.PRC1-mediated epigenetic programming is required to generate the ovarian reserve.
PRC1介導(dǎo)的表觀遺傳編程是產(chǎn)生卵巢儲備的必要條件。
247.Molecular basis of MHC I quality control in the peptide loading complex.
MHC I質(zhì)量控制的分子基礎(chǔ)在多肽裝載復(fù)合物中的應(yīng)用。
248.Identification of a HTT-specific binding motif in DNAJB1 essential for suppression and disaggregation of HTT.
DNAJB1中HTT特異性結(jié)合圖案的鑒定，對HTT的抑制和分解至關(guān)重要。
249.Evidence for a HURP/EB free mixed-nucleotide zone in kinetochore-microtubules.
證據(jù)表明，在動點(diǎn)-微管中存在一個(gè)HURP/EB自由混合核苷酸區(qū)。
250.Molecular characterization of the missing electron pathways for butanol synthesis in Clostridium acetobutylicum.
乙酰丁酸梭菌中合成丁醇的缺失電子途徑的分子特征。
251.Neuronal congruency effects in macaque prefrontal cortex.
獼猴前額葉皮層的神經(jīng)元一致性效應(yīng)。
252.Conserved subcortical processing in visuo-vestibular gaze control.
視覺-前庭凝視控制中保守的皮層下處理。
253.Omicron BA.4/BA.5 escape neutralizing immunity elicited by BA.1 infection.
Omicron BA.4/BA.5逃避由BA.1感染引起的中和免疫力。
254.Local molecular and global connectomic contributions to cross-disorder cortical abnormalities.
局部分子和全球連接組對跨障礙性皮質(zhì)異常的貢獻(xiàn)。
255.Microbe capture by splenic macrophages triggers sepsis via T cell-death-dependent neutrophil lifespan shortening.
脾臟巨噬細(xì)胞捕獲的微生物通過T細(xì)胞死亡依賴的中性粒細(xì)胞壽命縮短引發(fā)敗血癥。
256.Repeated genetic adaptation to altitude in two tropical butterflies.
兩種熱帶蝴蝶對海拔高度的重復(fù)遺傳適應(yīng)。
257.Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains.
綠色植物OTUB亞家族中保守的Met1特異性圖案使水稻OTUB1能夠水解Met1泛素鏈。
258.Structural and biochemical basis for DNA and RNA catalysis by human Topoisomerase 3β.
人類拓?fù)洚悩?gòu)酶3β的DNA和RNA催化作用的結(jié)構(gòu)和生化基礎(chǔ)。
259.Connecting omics signatures and revealing biological mechanisms with iLINCS.
用iLINCS連接omics特征并揭示生物機(jī)制。
260.MYC sensitises cells to apoptosis by driving energetic demand.
MYC通過驅(qū)動能量需求使細(xì)胞對凋亡敏感。
261.Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice.
Kiss1神經(jīng)元中的Dicer消融會優(yōu)先損害雌性小鼠的青春期和生育能力。
262.The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis of ccRCC by modulating TGF-β signaling.
SWI/SNF染色質(zhì)重塑因子DPF3通過調(diào)控TGF-β信號調(diào)節(jié)ccRCC的轉(zhuǎn)移。
263.Integrated methylome and phenome study of the circulating proteome reveals markers pertinent to brain health.
循環(huán)蛋白質(zhì)組的綜合甲基組和表型組研究揭示了與大腦健康有關(guān)的標(biāo)志物。
264.A CRISPR-based ultrasensitive assay detects attomolar concentrations of SARS-CoV-2 antibodies in clinical samples.
基于CRISPR的超靈敏檢測法可檢測臨床樣本中的阿托摩爾濃度的SARS-CoV-2抗體。
a UCAD 分析工作流程的示意圖。 b 用于觸發(fā) CRISPR-Cas12a 側(cè)鏈切割活性的 dsDNA 模板序列設(shè)計(jì)，以及將 dsDNA 模板拆分為用于 UCAD 的 TS 和 NTS 探針的策略。 c 兩個(gè) UCAD 探針通過親和基序與同一抗 RBD 抗體的接近結(jié)合將雙鏈結(jié)構(gòu)域的 Tm 從 10 提高到 46°C，從而實(shí)現(xiàn) TS 和 NTS 探針之間的穩(wěn)定結(jié)合。 d, e 使用 UCAD 檢測商業(yè)購買的認(rèn)證抗 SARS-CoV-2 IgG/IgM 陽性和陰性血清樣品中抗 RBD IgG (d) 和 IgM (e) 的動力學(xué)曲線。 f 通過繪制 CRISPR-Cas12a 反應(yīng)第 40 分鐘的熒光強(qiáng)度，建立了用于檢測濃度范圍為 1aM 至 1pM 的抗 SARS-CoV-2 刺突蛋白 RBD 人單克隆抗體（克?。篛TIH401）的校準(zhǔn)曲線目標(biāo)濃度的函數(shù)，還與沒有 RPA 放大的 UCAD 進(jìn)行了比較。每個(gè)濃度都有重復(fù)測量 (n = 2)。 g, h 使用 UCAD 和商用 ELISA 試劑盒檢測經(jīng)認(rèn)證的抗 SARS-CoV-2 IgG/IgM 陽性血清中的抗 RBD IgG (g) 和 IgM (h)，該血清稀釋于陰性人血清中，稀釋倍數(shù)為 1 至 100,000 . 每個(gè)濃度都有重復(fù)測量 (n = 2)。
265.Raptor downregulation rescues neuronal phenotypes in mouse models of Tuberous Sclerosis Complex.
Raptor下調(diào)可拯救結(jié)節(jié)性硬化綜合癥小鼠模型的神經(jīng)元表型。
266.Development of a pentavalent broadly protective nucleoside-modified mRNA vaccine against influenza B viruses.
針對乙型流感病毒的五價(jià)廣泛保護(hù)性核苷修飾的mRNA疫苗的開發(fā)。
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