國際獸醫(yī)癲癇工作組共識建議：歐洲犬癲癇的藥物治療

Sofie F.M. Bhatti1*, Luisa De Risio2 , Karen Mu?ana3 , Jacques Penderis4 , Veronika M. Stein5 , Andrea Tipold5 , Mette Berendt6 , Robyn G. Farquhar7 , Andrea Fischer8 , Sam Long9 , Wolfgang L?scher10, Paul J.J. Mandigers11, Kaspar Matiasek12, Akos Pakozdy13, Edward E. Patterson14, Simon Platt15, Michael Podell16, Heidrun Potschka17, Clare Rusbridge18,19 and Holger A. Volk20?

Aims of AED treatment

抗癲癇藥物治療的目的

The ideal goal of AED therapy is to balance the ability to eliminate epileptic seizures with the quality of life of the patient. Seizure eradication is often not likely in dogs. More realistic goals are to decrease seizure frequency, duration, severity and the total number of epileptic seizures that occur over a short time span, with no or limited and acceptable AED adverse effects to maximize the dog’s and owner’s quality of life. Clinicians should approach treatment using the following paradigm [23, 76, 91, 92, 120]:

– Decide when to start AED treatment?

– Choose the most appropriate AED and dosage?

– Know if and when to monitor serum AED concentrations and adjust treatment accordingly?

– Know when to add or change to a different AED?

– Promote pet owner compliance

抗癲癇藥物治療的理想目標(biāo)是在控制癲癇性抽搐發(fā)作和維持病患的生活質(zhì)量之間取得平衡。

在犬，根除抽搐發(fā)作（Seizure eradication）通常是不可能的。

更現(xiàn)實(shí)的目標(biāo)是減少抽搐發(fā)作的頻率、持續(xù)時(shí)間、嚴(yán)重程度和在短時(shí)間內(nèi)發(fā)生的癲癇性抽搐發(fā)作的總數(shù)，沒有或很少的以及可接受的抗癲癇藥物的相關(guān)副作用，以最大限度地提高犬和寵主的生活質(zhì)量。

臨床醫(yī)生應(yīng)采用以下治療模式[23,76,91,92,120]:

-決定什么時(shí)候開始抗癲癇藥物治療?

-選擇最合適的抗癲癇藥物及劑量?

-知道是否以及什么時(shí)候監(jiān)測血清抗癲癇藥物濃度并相應(yīng)調(diào)整治療?

-知道什么時(shí)候添加或更換另一種的抗癲癇藥物?

-督促寵物主人遵醫(yī)囑