產(chǎn)品名稱：

活性氧Cu/Zn SOD Monoclonal Antibody，Cu/Zn Superoxide Dismutase

產(chǎn)地：西安

規(guī)格：1mg 5mg 10mg

純度：99%

用途：僅用于科研

狀態(tài)：固體/粉末

儲藏條件：冷藏-20℃

溫馨提示：僅用于科研，不能用于人體實(shí)驗！

說明：提供使用說明，核磁圖譜，包裝，價格，產(chǎn)地，制備方法，應(yīng)用，穩(wěn)定性，溶解度，簡單合成等各種信息　　

Cu/Zn Superoxide dismutase (Cu/Zn SOD) is an antioxidant enzyme that protects cells from oxidative stress by scavenging superoxide anions.1 It exists as a homodimer that is stabilized by a disulfide bond between the subunits. Each monomer is composed of a Greek key β-barrel and an active site channel made up of a β4/β5 loop, which interacts with the dimer interface and active site zinc, and an electrostatic loop, which facilitates superoxide entry into the copper-containing active site.2 Cu/Zn SOD is ubiquitously expressed and primarily localizes to the cytosol but has also been found in the nucleus, peroxisomes, lysosomes, and the intermembrane space of mitochondria.3,4 It catalyzes the dismutation of superoxide to hydrogen peroxide and oxygen by alternating reduction and reoxidation of copper at the enzyme active site.1 Overexpression of SOD1 protects against increases in reactive oxygen species (ROS) and apoptosis in an in vitro model of renal ischemia induced by ATP depletion.5 In vivo, transgenic mice expressing the destabilized Cu/Zn SODG93A mutation exhibit impaired spinal cord mitochondrial respiration.6,7 Mutations in SOD1 are associated with amyotrophic lateral sclerosis (ALS).8 Cayman’s Cu/Zn SOD Monoclonal Antibody can be used for flow cytometry (FC), immunoprecipitation (IP), and Western blot (WB) applications.

Cu/Zn超氧化物歧化酶（Cu/Zn SOD）是一種抗氧化酶，通過清除超氧化物陰離子來保護(hù)細(xì)胞免受氧化應(yīng)激。1它以同源二聚體的形式存在，通過亞基之間的二硫鍵穩(wěn)定。每個單體由希臘鍵β-桶和活性位點(diǎn)通道組成，活性位點(diǎn)通道由β4/β5環(huán)和靜電環(huán)組成，β4/β5-環(huán)與二聚體界面和活性位點(diǎn)鋅相互作用，靜電環(huán)促進(jìn)超氧化物進(jìn)入含銅活性位點(diǎn)。2 Cu/Zn SOD普遍表達(dá)，主要定位于胞質(zhì)溶膠，但也存在于細(xì)胞核、過氧化物酶體，溶酶體和線粒體的膜間空間。3，4它通過在酶活性位點(diǎn)交替還原和再氧化銅，催化超氧化物歧化為過氧化氫和氧氣。1在ATP耗竭誘導(dǎo)的腎缺血體外模型中，SOD1的過度表達(dá)可防止活性氧（ROS）的增加和細(xì)胞凋亡。5在體內(nèi)，表達(dá)不穩(wěn)定的Cu/Zn SODG93A突變的轉(zhuǎn)基因小鼠表現(xiàn)出脊髓線粒體呼吸受損。6,7 SOD1突變與肌萎縮側(cè)索硬化癥（ALS）有關(guān)。8開曼群島的Cu/Zn-SOD單克隆抗體可用于流式細(xì)胞術(shù)（FC）、免疫沉淀（IP）和蛋白質(zhì)印跡（WB）應(yīng)用。

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編輯：XAQYBIO HAO，2023年4月10日。