貨號：DVV02813

產(chǎn)品鏈接：http://www.antibodysystem.com/product/9566.html

寄主物種：Human

物種反應(yīng)性：Human respiratory syncytial virus A (strain A2)

純度：>95% by SDS-PAGE.

應(yīng)用：Research Grade Biosimilar

儲存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.

聯(lián)系方式：027-65279366

參考文獻：

Dissociation of the respiratory syncytial virus F protein-specific human IgG, IgA and IgM response. PMID: 33574352

Cleavage of the respiratory syncytial virus fusion protein is required for its surface expression: role of furin. PMID: 10930660

Prefusion F, Postfusion F, G Antibodies, and Disease Severity in Infants and Young Children With Acute Respiratory Syncytial Virus Infection. PMID: 29029312

Intracellular processing of the human respiratory syncytial virus fusion glycoprotein: amino acid substitutions affecting folding, transport and cleavage. PMID: 1375280

Fusion glycoprotein of human parainfluenza virus type 3: nucleotide sequence of the gene, direct identification of the cleavage-activation site, and comparison with other paramyxoviruses. PMID: 3012869

Membrane-associated respiratory syncytial virus F protein expressed from a human rhinovirus type 14 vector is immunogenic. PMID: 11277694

Alkaline phosphatase fusions to the respiratory syncytial virus F protein as an approach to analyze its membrane topology. PMID: 2558867

呼吸道合胞病毒（respiratory syncytial virus，RSV）為肺炎病毒科正肺病毒屬中一種有包膜的單股負(fù)鏈RNA病毒。RSV是引起全球兒童急性呼吸道感染（acute respiratory tract infection，ARTI）的首要病原體，據(jù)估計，>95%的兒童在2歲之前均感染過RSV。RSV感染的臨床癥狀可為普通上呼吸道感染、毛細(xì)支氣管炎、肺炎，重癥者可引起呼吸衰竭、甚至死亡。2015年，全球由RSV引起的急性下呼吸道感染的5歲以下患兒有3 310萬例，其中住院患兒320萬例，死亡5.96萬例。兒童RSV感染給我國醫(yī)療衛(wèi)生事業(yè)帶來了巨大經(jīng)濟負(fù)擔(dān)，有研究表明我國RSV相關(guān)住院的平均費用達4025元。

目前利巴韋林仍是臨床上治療RSV感染的主要藥物，但療效并不理想。且利巴韋林氣霧劑可致氣管痙攣，對胎兒有致畸可能。而帕利珠單抗作為唯一已上市的RSV預(yù)防及治療藥物，主要用于高危和免疫缺陷兒童，但由于其成本過高，不適于在中低收入國家推廣使用。目前有19種RSV相關(guān)疫苗及單克隆抗體處于臨床試驗階段，RSV疫苗研發(fā)領(lǐng)域的迅速發(fā)展，說明這一全球健康問題的緊迫性。了解一定時期內(nèi)特定區(qū)域RSV流行情況有助于預(yù)防RSV的感染。