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【標(biāo)題速讀】【Science】【2022年】【10月】

2023-05-15 22:20 作者:Rt_Cola  | 我要投稿

聲明:本專欄主要對生命科學(xué)領(lǐng)域的一些期刊文章標(biāo)題進(jìn)行翻譯,所有內(nèi)容均由本人手工整理翻譯。由于本人專業(yè)為生物分析相關(guān),其他領(lǐng)域如果出現(xiàn)翻譯錯誤請諒解。

The skeleton of Hope, a young female blue whale that beached in Ireland in 1891, is suspended from the ceiling of London’s Natural History Museum, pictured here empty of visitors while the museum was closed during the COVID-19 pandemic. Hope’s skull features in new research on mammals that shows how the ecology and life history of species shape the tempo of their evolution. See pages 355 and 377.

1891 年在愛爾蘭擱淺的年輕雌性藍(lán)鯨希望 (Hope) 的骨架懸掛在倫敦自然歷史博物館的天花板上,照片中博物館在COVID-19 大流行期間關(guān)閉時空無一人。 霍普的頭骨出現(xiàn)在對哺乳動物的新研究中,該研究表明物種的生態(tài)學(xué)和生活史如何影響其進(jìn)化速度。 請參見第 355 和 377 頁。
Butterfly wing patterns are mosaics of colored scales, as shown in this high-magnification image of a painted lady (Vanessa cardui) wing. A shared set of deeply conserved gene regulatory sequences are shown to control color pattern formation across species, suggesting that an ancient genetic architecture underlies wing pattern development. See pages 249 and 304.

蝴蝶翅膀圖案是彩色鱗片的馬賽克,如彩繪女士 (Vanessa cardui) 翅膀的高倍放大圖像所示。 一組共享的高度保守的基因調(diào)控序列被證明可以控制跨物種的顏色圖案形成,這表明古老的遺傳結(jié)構(gòu)是翅膀圖案發(fā)育的基礎(chǔ)。 參見第 249 和 304 頁。
Like many viruses, SARS-CoV-2 deploys a molecular arsenal to neutralize the host's immune response. Many of the viral proteins shown here suppress steps in the body’s interferon response, for example (the arrangement and colors of the proteins indicate which genes encode them). An interactive version of the news feature can be found online at https://scim.ag/ViralArsenal. See page 128.

與許多病毒一樣,SARS-CoV-2部署了一個分子武器庫來中和宿主的免疫反應(yīng)。例如,這里顯示的許多病毒蛋白會抑制人體干擾素反應(yīng)的步驟(蛋白質(zhì)的排列和顏色表明哪些基因編碼它們)。 可以在 https://scim.ag/ViralArsenal 在線找到新聞功能的交互式版本。 請參見第 128 頁。
Artist’s impression of the Golgi as it transports newly synthesized lysosomal enzymes toward the lysosome. In the Golgi, LYSET (cyan) retains GlcNAc-1-phosphotransferase (purple) so that it can tag lysosomal enzymes with mannose-6-phosphate (glowing yellow spots), which routes them onward to the lysosome. Two studies identify and characterize LYSET and its role in ensuring the efficient transport and targeting of lysosomal enzymes. See eabn5637 and eabn5648.

藝術(shù)家對高爾基體的印象,因為它將新合成的溶酶體酶輸送到溶酶體。 在高爾基體中,LYSET(青色)保留了 GlcNAc-1-磷酸轉(zhuǎn)移酶(紫色),因此它可以用 6-磷酸甘露糖(發(fā)光的黃色斑點)標(biāo)記溶酶體酶,從而將它們引導(dǎo)至溶酶體。 兩項研究確定并描述了 LYSET 及其在確保溶酶體酶的有效運(yùn)輸和靶向方面的作用。 請參閱eabn5637 和 eabn5648。


1.Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice.

精氨酸激活線粒體三功能蛋白,提高小鼠的抗腫瘤免疫力。

2.Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites.

炎癥性腸病患者的共生微生物群產(chǎn)生基因毒性代謝物。

3.Plastic deformation in silicon nitride ceramics via bond switching at coherent interfaces.

氮化硅陶瓷的塑性變形通過相干界面上的鍵轉(zhuǎn)換.

4.Attenuated evolution of mammals through the Cenozoic.

新生代哺乳動物的衰減性進(jìn)化。

5.Stereochemical editing logic powered by the epimerization of unactivated tertiary stereocenters.

由未激活的三級立體中心的外嵌化驅(qū)動的立體化學(xué)編輯邏輯。

6.Design of fast-onset antidepressant by dissociating SERT from nNOS in the DRN.

通過解離DRN中SERT與nNOS的關(guān)系設(shè)計快速起效的抗抑郁藥.

7.Closed-loop optimization of general reaction conditions for heteroaryl Suzuki-Miyaura coupling.

雜芳基Suzuki-Miyaura偶聯(lián)的一般反應(yīng)條件的閉環(huán)優(yōu)化。

8.Mirror-image T7 transcription of chirally inverted ribosomal and functional RNAs.

鏡像T7轉(zhuǎn)錄奇異反轉(zhuǎn)的核糖體和功能RNA.

9.Largest recent impact craters on Mars: Orbital imaging and surface seismic co-investigation.

火星上最近最大的撞擊坑:?軌道成像和表面地震的共同調(diào)查。

10.Surface waves and crustal structure on Mars.

火星上的表面波和地殼結(jié)構(gòu)。

11.Evolution and antiviral activity of a human protein of retroviral origin.

一種源于逆轉(zhuǎn)錄病毒的人類蛋白的進(jìn)化和抗病毒活性。

12.Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment.

哺乳動物卵母細(xì)胞在線粒體相關(guān)的無膜區(qū)間內(nèi)儲存mRNA。

13.Structure of the hepatitis C virus E1E2 glycoprotein complex.

丙型肝炎病毒E1E2糖蛋白復(fù)合物的結(jié)構(gòu)。

14.Delocalized photonic deep learning on the internet’s edge.

互聯(lián)網(wǎng)邊緣的去中心化光子深度學(xué)習(xí)。

15.Time-restricted feeding mitigates obesity through adipocyte thermogenesis.

時間限制性喂養(yǎng)通過脂肪細(xì)胞生熱作用緩解肥胖癥。

16.Molecular structures reveal synergistic rescue of Δ508 CFTR by Trikafta modulators.

分子結(jié)構(gòu)顯示Trikafta調(diào)節(jié)劑對Δ508 CFTR的協(xié)同救援。

17.An evolutionary trade-off between host immunity and metabolism drives fatty liver in male mice.

宿主免疫力和新陳代謝之間的進(jìn)化權(quán)衡促使雄性小鼠出現(xiàn)脂肪肝。

18.Miniaturized spectrometers with a tunable van der Waals junction.

帶有可調(diào)諧范德瓦爾斯結(jié)的微型光譜儀。

19.Disease outbreaks select for mate choice and coat color in wolves.

疾病爆發(fā)對狼的配偶選擇和毛色的選擇。

20.Deep cis-regulatory homology of the butterfly wing pattern ground plan.

蝴蝶翅膀圖案地平面的深層順式調(diào)控同源性。

21.Highly flexible and superhydrophobic MOF nanosheet membrane for ultrafast alcohol-water separation.

高度靈活和超疏水的MOF納米片膜用于超快的酒精-水分離。

22.Spillover benefits from the world’s largest fully protected MPA.

世界上最大的完全保護(hù)的MPA帶來的溢出效應(yīng)。

23.MTCH2 is a mitochondrial outer membrane protein insertase.

MTCH2是一種線粒體外膜蛋白插入酶。

24.Erratum for the Research Article “Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome,” by P. R. Bhatt et al..

P. R. Bhatt等人的研究文章《SARS-CoV-2 RNA基因組翻譯過程中核糖體移架的結(jié)構(gòu)基礎(chǔ)》的勘誤。

25.A bacterial phospholipid phosphatase inhibits host pyroptosis by hijacking ubiquitin.

一種細(xì)菌磷脂磷酸酶通過劫持泛素來抑制宿主的熱化作用。

26.Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP2.

冷卻激動劑和PIP2對小鼠冷感TRPM8通道的激活機(jī)制。

27.Evolution of increased complexity and specificity at the dawn of form I Rubiscos.

形態(tài)I Rubiscos黎明時增加的復(fù)雜性和特異性的進(jìn)化。

28.In vivo direct imaging of neuronal activity at high temporospatial resolution.

高時間空間分辨率下的神經(jīng)元活動體內(nèi)直接成像。

29.Simultaneous electrical and thermal rectification in a monolayer lateral heterojunction.

單層側(cè)向異質(zhì)結(jié)中的同時電和熱整流。

30.Peptide ligand-mediated trade-off between plant growth and stress response.

肽配體介導(dǎo)的植物生長和壓力反應(yīng)之間的權(quán)衡。

31.Covalent organic framework–based porous ionomers for high-performance fuel cells.

用于高性能燃料電池的共價有機(jī)框架型多孔離子體。

32.Real-time dynamic single-molecule protein sequencing on an integrated semiconductor device.

集成半導(dǎo)體設(shè)備上的實時動態(tài)單分子蛋白質(zhì)測序。

33.Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung.

基底膜上的哨兵p16INK4a+細(xì)胞在肺部形成了一個修復(fù)性龕。

34.Cellular barcoding to decipher clonal dynamics in disease.

解讀疾病中的克隆動態(tài)的細(xì)胞條形碼。

35.Direct identification of the charge state in a single platinum nanoparticle on titanium oxide.

直接識別氧化鈦上單個鉑金納米粒子的電荷狀態(tài)。

36.Mixed plastics waste valorization through tandem chemical oxidation and biological funneling.

通過串聯(lián)化學(xué)氧化和生物漏斗的混合塑料廢物價值化。

37.Polymeric multimaterials by photochemical patterning of crystallinity.

通過光化學(xué)模式化結(jié)晶的聚合物多材料。

38.Lysosomal enzyme trafficking factor LYSET enables nutritional usage of extracellular proteins.

溶酶體酶販運(yùn)因子LYSET使細(xì)胞外蛋白質(zhì)得到營養(yǎng)利用。

39.The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection.

人類疾病基因LYSET對溶酶體酶的運(yùn)輸和病毒感染至關(guān)重要。

40.Translatome and transcriptome co-profiling reveals a role of TPRXs in human zygotic genome activation.

轉(zhuǎn)錄組和轉(zhuǎn)錄組共同分析揭示了TPRXs在人類子代基因組激活中的作用。

41.The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance.

非洲不斷演變的SARS-CoV-2疫情:從迅速擴(kuò)大的基因組監(jiān)測中得到啟示。

42.Electrochemical potential enables dormant spores to integrate environmental signals.

電化學(xué)電位使休眠孢子能夠整合環(huán)境信號。

43.Robust deep learning–based protein sequence design using ProteinMPNN.

使用ProteinMPNN進(jìn)行基于深度學(xué)習(xí)的強(qiáng)大蛋白質(zhì)序列設(shè)計。

44.Hallucinating symmetric protein assemblies.

幻覺對稱蛋白質(zhì)組裝。

45.Structures of +1 nucleosome–bound PIC-Mediator complex.

+1核糖體結(jié)合的PIC-Mediator復(fù)合物的結(jié)構(gòu)。

46.A noncoding single-nucleotide polymorphism at 8q24 drives IDH1-mutant glioma formation.

8q24的非編碼單核苷酸多態(tài)性驅(qū)動IDH1突變的膠質(zhì)瘤形成。

47.Machine learning–enabled high-entropy alloy discovery.

機(jī)器學(xué)習(xí)促成的高熵合金發(fā)現(xiàn)。

48.Emergent phases of ecological diversity and dynamics mapped in microcosms.

生態(tài)多樣性和動態(tài)性的新興階段在微觀世界中的映射。

49.Heavy-tailed sexual contact networks and monkeypox epidemiology in the global outbreak, 2022.

2022年全球爆發(fā)的重尾性接觸網(wǎng)絡(luò)和猴痘流行病學(xué)。

50.Two FTD-ALS genes converge on the endosomal pathway to induce TDP-43 pathology and degeneration.

兩個FTD-ALS基因匯聚于內(nèi)體途徑,誘發(fā)TDP-43病理和變性。

【標(biāo)題速讀】【Science】【2022年】【10月】的評論 (共 條)

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