關(guān)鍵詞 抗體 嗜酸性粒細(xì)胞 利妥昔單抗 轉(zhuǎn)錄因子?糖蛋白VI 人類呼吸道合胞病毒 單克隆抗體 羅澤利昔珠單抗 斯魯利單抗 基因轉(zhuǎn)移 雙特異性抗體 ?

#今日行業(yè)熱點(diǎn)#

①The Lancet Rheumatology：Autoantibody-negative rheumatoid arthritis: still a challenge for the rheumatologist 綜述：自身抗體陰性的類風(fēng)濕關(guān)節(jié)炎的病理生理機(jī)制和臨床挑戰(zhàn) DOI: 10.1016/S2665-9913(23)00242-4 ②The Lancet Respiratory Medicine：Blood eosinophil-guided oral prednisolone for COPD exacerbations in primary care in the UK (STARR2): a non-inferiority, multicentre, double-blind, placebo-controlled, randomised controlled trial 臨床試驗(yàn)：基于嗜酸性粒細(xì)胞生物標(biāo)志物指導(dǎo)全身性糖皮質(zhì)激素潑尼松龍用于慢性阻塞性肺疾病(COPD)加重的一項(xiàng)非劣效性、多中心、雙盲、安慰劑對照、隨機(jī)對照試驗(yàn) DOI: 10.1016/S2213-2600(23)00298-9 ③Blood：Lenalidomide plus rituximab for the initial treatment of frail older patients with DLBCL: the FIL_ReRi phase 2 study 臨床試驗(yàn)：來那度胺(Lenalidomide)聯(lián)合利妥昔單抗（Rituximab）用于衰弱老年彌漫大B細(xì)胞淋巴瘤(DLBCL)的FIL_ReRi Ⅱ期研究 DOI: 10.1182/blood.2022019173 ④Blood：Genome-wide transcription factor–binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs 全基因組轉(zhuǎn)錄因子結(jié)合圖譜揭示了人類HSPCs調(diào)控結(jié)構(gòu)的細(xì)胞特異性變化 DOI: 10.1182/blood.2023021120 ⑤Blood：A key role for platelet GPVI in neutrophil recruitment, migration, and NETosis in the early stages of acute lung injury 血小板糖蛋白VI（GPVI）通過與癌細(xì)胞Galectin-3互作促進(jìn)轉(zhuǎn)移 DOI: 10.1182/blood.2023019940 ⑥The Journal of Infectious Diseases：Effectiveness of vaccines and monoclonal antibodies against respiratory syncytial virus: Generic protocol for register-based cohort study 針對人類呼吸道合胞病毒(RSV)疫苗和單克隆抗體有效性的隊(duì)列研究通用方案 DOI: 10.1093/infdis/jiad484 ⑦FcRn單抗羅澤利昔珠單抗（Rozanolixizumab）上市申請獲CDE受理，用于全身型重癥肌無力(gMG) ⑧PD-1抑制劑斯魯利單抗聯(lián)合鉑類藥物用于晚期非鱗狀非小細(xì)胞肺癌（NSCLC）的Ⅲ期ASTRUM-002研究達(dá)到主要終點(diǎn) ⑨研究性基因轉(zhuǎn)移療法SRP-9001用于4-7歲杜氏肌營養(yǎng)不良癥（DMD）患兒的III期EMBARK研究失敗，未達(dá)到主要終點(diǎn) ⑩靶向PD-1/TIGIT雙特異性抗體登記啟動(dòng)用于膽道癌術(shù)后輔助治療的III期ARTEMIDE-Bil01（NCT06109779）臨床研究，成為全球首款進(jìn)入III期臨床階段的TIGIT/PD1雙抗 科學(xué)探索的世界充滿挑戰(zhàn)，AtaGenix致敬每一位拓荒者，更致力于成為您信賴的合作伙伴！