聲明：本專欄主要對生命科學(xué)領(lǐng)域的一些期刊文章標(biāo)題進(jìn)行翻譯，所有內(nèi)容均由本人手工整理翻譯。由于本人專業(yè)為生物分析相關(guān)，其他領(lǐng)域如果出現(xiàn)翻譯錯誤請諒解。

1.Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy.

孕期和嬰兒期mRNA疫苗產(chǎn)品和功能性抗體經(jīng)胎盤轉(zhuǎn)移的評估。

2.Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex.

IGF/IGFBP/ALS三元復(fù)合物的組裝和拆卸的結(jié)構(gòu)基礎(chǔ)。

3.Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure.

ChREBPβ的不適應(yīng)性正反饋生產(chǎn)是糖毒性β細(xì)胞衰竭的基礎(chǔ)。

4.Knowledge-graph-based cell-cell communication inference for spatially resolved transcriptomic data with SpaTalk.

基于知識圖譜的細(xì)胞-細(xì)胞通訊推斷，用于空間分辨率的轉(zhuǎn)錄組數(shù)據(jù)與SpaTalk。

5.Structure-guided and phage-assisted evolution of a therapeutic anti-EGFR antibody to reverse acquired resistance.

結(jié)構(gòu)指導(dǎo)和噬菌體輔助下的抗EGFR抗體的進(jìn)化，以逆轉(zhuǎn)獲得性抗性。

6.RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation and inflammation partially through CysLT1R.

RNA結(jié)合蛋白RBM3部分通過CysLT1R內(nèi)在地抑制了肺部先天淋巴細(xì)胞的激活和炎癥。

7.Evidence accumulation occurs locally in the parietal cortex.

證據(jù)顯示積累發(fā)生在頂葉皮層局部。

8.CDC-like kinase 4 deficiency contributes to pathological cardiac hypertrophy by modulating NEXN phosphorylation.

CDC樣激酶4的缺失通過調(diào)節(jié)NEXN的磷酸化促進(jìn)了病理性心臟肥大的發(fā)生。

9.Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells.

硫酸膽固醇通過促進(jìn)結(jié)腸上皮細(xì)胞的膽固醇生物合成而緩解潰瘍性結(jié)腸炎。

10.Balanced gene dosage control rather than parental origin underpins genomic imprinting.

平衡的基因劑量控制而不是父母的來源是基因組印記的基礎(chǔ)。

11.Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling.

鳥苷酸結(jié)合蛋白對病原體的選擇性殺傷是導(dǎo)致炎癥體信號的分子機(jī)制。

12.Functional neuronal circuitry and oscillatory dynamics in human brain organoids.

人腦器官中的神經(jīng)元功能回路和震蕩動力學(xué)。

13.TRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway.

TRIM28依賴的SUMOylation保護(hù)成年卵巢免受睪丸途徑的激活。

14.SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model.

SARS-CoV-2 VOC類型和生物性別影響莫爾納比韋在嚴(yán)重COVID-19矮倉鼠模型中的療效。

15.Neprilysins regulate muscle contraction and heart function via cleavage of SERCA-inhibitory micropeptides.

尼普利酶通過裂解SERCA抑制性微肽調(diào)節(jié)肌肉收縮和心臟功能。

16.FLASHIda enables intelligent data acquisition for top–down proteomics to boost proteoform identification counts.

FLASHIda實(shí)現(xiàn)了自上而下蛋白質(zhì)組學(xué)的智能數(shù)據(jù)采集，以提高蛋白質(zhì)形態(tài)鑒定的數(shù)量。

17.Defunctionalizing intracellular organelles such as mitochondria and peroxisomes with engineered phospholipase A/acyltransferases.

用工程化的磷脂酶/脂肪轉(zhuǎn)移酶使線粒體和過氧化物酶等細(xì)胞內(nèi)細(xì)胞器去功能化。

18.Proteotoxicity caused by perturbed protein complexes underlies hybrid incompatibility in yeast.

由擾亂的蛋白質(zhì)復(fù)合體引起的蛋白質(zhì)毒性是酵母中雜交不相容的基礎(chǔ)。

19.CDK9 activity switch associated with AFF1 and HEXIM1 controls differentiation initiation from epidermal progenitors.

與AFF1和HEXIM1相關(guān)的CDK9活性開關(guān)控制表皮祖細(xì)胞的分化啟動。

20.Mouse fetal growth restriction through parental and fetal immune gene variation and intercellular communications cascade.

通過父母和胎兒免疫基因變異和細(xì)胞間通訊級聯(lián)的小鼠胎兒生長受限。

21.Cross-validation of distance measurements in proteins by PELDOR/DEER and single-molecule FRET.

通過PELDOR/DEER和單分子FRET對蛋白質(zhì)的距離測量進(jìn)行交叉驗(yàn)證。

22.Cloning southern corn rust resistant gene RppK and its cognate gene AvrRppK from Puccinia polysora.

克隆南方玉米銹病抗性基因RppK及其來自Puccinia polysora的同源基因AvrRppK。

23.Gata6+ resident peritoneal macrophages promote the growth of liver metastasis.

Gata6+常駐腹腔巨噬細(xì)胞促進(jìn)肝臟轉(zhuǎn)移的生長。

24.Transcription factor network analysis identifies REST/NRSF as an intrinsic regulator of CNS regeneration in mice.

轉(zhuǎn)錄因子網(wǎng)絡(luò)分析確定REST/NRSF是小鼠中樞神經(jīng)系統(tǒng)再生的內(nèi)在調(diào)節(jié)因子。

25.An acquired phosphatidylinositol 4-phosphate transport initiates T-cell deterioration and leukemogenesis.

一種獲得性磷脂酰肌醇-4-磷酸的運(yùn)輸啟動了T細(xì)胞的惡化和白血病的發(fā)生。

26.Tryptophan C-mannosylation is critical for Plasmodium falciparum transmission.

色氨酸C-甘露糖基化對惡性瘧原蟲的傳播至關(guān)重要。

27.Orbitofrontal cortex contributes to the comparison of values underlying economic choices.

眶額皮層有助于經(jīng)濟(jì)選擇的基礎(chǔ)價值比較。

28.Fatigue-free artificial ionic skin toughened by self-healable elastic nanomesh.

由自愈性彈性納米網(wǎng)加固的無疲勞人工離子皮膚。

29.Cascaded dissipative DNAzyme-driven layered networks guide transient replication of coded-strands as gene models.

級聯(lián)耗散DNA酶驅(qū)動的分層網(wǎng)絡(luò)引導(dǎo)編碼條帶的瞬時復(fù)制作為基因模型。

30.A multimodal iPSC platform for cystic fibrosis drug testing.

用于囊性纖維化藥物測試的多模態(tài)iPSC平臺。

31.HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis.

HSF1的磷酸化通過TRRAP-TIP60復(fù)合物建立活躍的染色質(zhì)狀態(tài)，并促進(jìn)腫瘤的發(fā)生。

32.Dynamics of competing SARS-CoV-2 variants during the Omicron epidemic in England.

英國Omicron疫情期間競爭性SARS-CoV-2變體的動態(tài)變化。

33.Fire activity as measured by burned area reveals weak effects of ENSO in?C.

由燒毀面積衡量的火災(zāi)活動揭示了C ENSO的微弱影響。

34.TidyMass an object-oriented reproducible analysis framework for LC–MS data.

TidyMass一個面向?qū)ο蟮腖C-MS數(shù)據(jù)可重復(fù)分析框架。

35.Protein shape sampled by ion mobility mass spectrometry consistently improves protein structure prediction.

離子移動質(zhì)譜采樣的蛋白質(zhì)形狀持續(xù)改善蛋白質(zhì)結(jié)構(gòu)預(yù)測。

36.Reply to: Fire activity as measured by burned area reveals weak effects of ENSO in C.

Reply to：?以燒毀面積衡量的火災(zāi)活動揭示了C ENSO的微弱影響。

37.A unique class of Zn2+-binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile.

一類獨(dú)特的Zn2+結(jié)合的絲氨酸基PBPs是艱難梭菌的頭孢菌素抗性和孢子生成的基礎(chǔ)。

38.Single-droplet surface-enhanced Raman scattering decodes the molecular determinants of liquid-liquid phase separation.

單滴表面增強(qiáng)拉曼散射破解了液-液相分離的分子決定因素。

39.A modular spring-loaded actuator for mechanical activation of membrane proteins.

用于機(jī)械激活膜蛋白的模塊化彈簧推桿。

40.A density-based enrichment measure for assessing colocalization in single-molecule localization microscopy data.

用于評估單分子定位顯微鏡數(shù)據(jù)中的共聚焦的基于密度的富集措施。

41.Aberrant androgen action in prostatic progenitor cells induces oncogenesis and tumor development through IGF1 and Wnt axes.

前列腺祖細(xì)胞中的雄性激素作用異常，通過IGF1和Wnt軸誘導(dǎo)致癌和腫瘤發(fā)展。

42.Fusion protein strategies for cryo-EM study of G protein-coupled receptors.

用于G蛋白偶聯(lián)受體的低溫電鏡研究的融合蛋白策略。

43.Phosphatidylinositol-4-phosphate controls autophagosome formation in Arabidopsis thaliana.

磷脂酰肌醇-4-磷酸控制擬南芥中自噬體的形成。

44.De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals.

從自然發(fā)生的納米晶體中重新確定殺蚊子的Cry11Aa和Cry11Ba結(jié)構(gòu)。

45.PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus.

PACAP-PAC1R通過下丘腦外側(cè)調(diào)控恐懼的消除。

46.Confinement anisotropy drives polar organization of two DNA molecules interacting in a nanoscale cavity.

封閉各向異性驅(qū)動兩個DNA分子在納米級腔體中相互作用的極性組織。

47.Sustainable environmental remediation via biomimetic multifunctional lignocellulosic nano-framework.

通過仿生多功能木質(zhì)纖維素納米框架的可持續(xù)環(huán)境修復(fù)。

48.Topological digestion drives time-varying rheology of entangled DNA fluids.

拓?fù)湎?qū)動糾纏的DNA流體的時間變化流變學(xué)。

49.Notch, RORC and IL-23 signals cooperate to promote multi-lineage human innate lymphoid cell differentiation.

Notch、RORC和IL-23信號合作促進(jìn)多線人類先天淋巴細(xì)胞分化。

50.Structures of Atm1 provide insight into [2Fe-2S] cluster export from mitochondria.

Atm1的結(jié)構(gòu)提供了關(guān)于[2F-2S]簇從線粒體輸出的見解。

51.Dietary protein increases T-cell-independent sIgA production through changes in gut microbiota-derived extracellular vesicles.

膳食蛋白通過改變腸道微生物群衍生的胞外囊泡增加T細(xì)胞無關(guān)的sIgA產(chǎn)生。

52.Actin nano-architecture of phagocytic podosomes.

吞噬細(xì)胞莢膜的肌動蛋白納米結(jié)構(gòu)。

53.The Cryo-EM structures of two amphibian antimicrobial cross-β amyloid fibrils.

兩種兩棲動物抗菌性交叉β淀粉樣纖維的低溫電鏡結(jié)構(gòu)。

54.Targeting transcription in heart failure via CDK7/12/13 inhibition.

通過CDK7/12/13抑制針對心力衰竭的轉(zhuǎn)錄。

55.A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions.

一種具有附屬蛋白缺失的SARS-CoV-2活體減毒疫苗候選者。

56.Body size, shape and ecology in tetrapods.

四足動物的體型、形狀和生態(tài)學(xué)。

57.Genome-wide association study identifies Sj?gren’s risk loci with functional implications in immune and glandular cells.

全基因組關(guān)聯(lián)研究確定了具有免疫和腺體細(xì)胞功能影響的斯約克氏癥風(fēng)險位點(diǎn)。

58.Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines.

COVID-19 mRNA疫苗激發(fā)的抗體對SARS-CoV-2變體的不同中和與抑制作用。

59.Decoding kinase-adverse event associations for small molecule kinase inhibitors.

解碼小分子激酶抑制劑的激酶-不良事件關(guān)聯(lián)。

60.Rare loss of function variants in the hepatokine gene INHBE protect from abdominal obesity.

肝素基因INHBE的罕見功能缺失變體對腹型肥胖的保護(hù)。

61.Cohesin couples transcriptional bursting probabilities of inducible enhancers and promoters.

Cohesin耦合了誘導(dǎo)性增強(qiáng)子和啟動子的轉(zhuǎn)錄爆發(fā)概率。

62.Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice.

Triclosan的哺乳期傳遞促進(jìn)了新生小鼠的非酒精性脂肪肝。

63.Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression.

全球ENIGMA研究中評估的局灶性和全身性癲癇的結(jié)構(gòu)網(wǎng)絡(luò)改變遵循癲癇風(fēng)險基因表達(dá)的軸。

64.Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life.

母體和圍產(chǎn)期肥胖通過IL-6-FoxO1軸誘導(dǎo)后天的支氣管阻塞和肺部高血壓。

65.ProtGPT2 is a deep unsupervised language model for protein design.

ProtGPT2是一個用于蛋白質(zhì)設(shè)計(jì)的深度無監(jiān)督語言模型。

66.UV photonic integrated circuits for far-field structured illumination autofluorescence microscopy.

用于遠(yuǎn)場結(jié)構(gòu)化照明自發(fā)熒光顯微鏡的紫外光子集成電路.

67.Molecular mechanism of toxin neutralization in the HipBST toxin-antitoxin system of Legionella pneumophila.

嗜肺軍團(tuán)菌HipBST毒素-抗毒素系統(tǒng)中毒素中和的分子機(jī)制。

68.Paeniclostridium sordellii hemorrhagic toxin targets TMPRSS2 to induce colonic epithelial lesions.

梭菌出血性毒素靶向TMPRSS2，誘發(fā)結(jié)腸上皮病變。

69.Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut.

人類腸道粘液酶對含O-聚糖斑塊的糖蛋白的裂解的結(jié)構(gòu)和機(jī)理的見解。

70.T cell receptor β-chain-targeting chimeric antigen receptor T cells against T cell malignancies.

T細(xì)胞受體β鏈靶向嵌合抗原受體T細(xì)胞對抗T細(xì)胞惡性腫瘤。

71.Cryo-EM structures of Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae.

霍亂弧菌的Na+泵送NADH-泛醌氧化還原酶的低溫EM結(jié)構(gòu)。

72.Global genomic analyses of wheat powdery mildew reveal association of pathogen spread with historical human migration and trade.

小麥白粉病的全球基因組分析揭示了病原體傳播與歷史上人類移民和貿(mào)易的關(guān)系。

73.Aggregative trans-eQTL analysis detects trait-specific target gene sets in whole blood.

聚合反式QTL分析檢測全血中特異性狀的目標(biāo)基因集。

74.Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer.

靶向新生脂肪生成和Lands循環(huán)誘導(dǎo)KRAS突變型肺癌的鐵中毒。

75.Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration.

老年性黃斑變性的轉(zhuǎn)錄組和蛋白質(zhì)組特征。

76.An automated 13.5?hour system for scalable diagnosis and acute management guidance for genetic diseases.

用于遺傳性疾病的可擴(kuò)展診斷和急性管理指導(dǎo)的13.5小時自動化系統(tǒng)。

77.Win-win opportunities combining high yields with high multi-taxa biodiversity in tropical agroforestry.

熱帶農(nóng)林業(yè)中高產(chǎn)量與高多塔生物多樣性相結(jié)合的雙贏機(jī)會。

78.Plastic pollution fosters more microbial growth in lakes than natural organic matter.

塑料污染比天然有機(jī)物更能促進(jìn)湖泊中的微生物生長。

79.Engineered bioorthogonal POLY-PROTAC nanoparticles for tumour-specific protein degradation and precise cancer therapy.

用于腫瘤特異性蛋白質(zhì)降解和精確癌癥治療的工程化生物正交POLY-PROTAC納米粒子。

80.Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ.

苯丙氨酸通過修飾IRβ?lián)p害胰島素信號并抑制葡萄糖攝取。

81.KSTAR: An algorithm to predict patient-specific kinase activities from phosphoproteomic data.

KSTAR：一種從磷蛋白組數(shù)據(jù)中預(yù)測患者特定激酶活性的算法。

82.Lymphatic-preserving treatment sequencing with immune checkpoint inhibition unleashes cDC1-dependent antitumor immunity in HNSCC.

保留淋巴的治療順序與免疫檢查點(diǎn)的抑制釋放了HNSCC的CDC1依賴性抗腫瘤免疫力。

83.Postmitotic differentiation of human monocytes requires cohesin-structured chromatin.

人類單核細(xì)胞的有絲分裂后的分化需要粘連蛋白結(jié)構(gòu)的染色質(zhì)。

84.Cell landscape of larval and adult Xenopus laevis at single-cell resolution.

單細(xì)胞分辨率下的幼蟲和成蟲的細(xì)胞景觀。

85.Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain.

HMG CoA還原酶的調(diào)節(jié)性降解需要甾醇感應(yīng)結(jié)構(gòu)域的構(gòu)象變化。

86.Light-activated mitochondrial fission through optogenetic control of mitochondria-lysosome contacts.

通過光遺傳學(xué)控制線粒體-lysosome接觸的光激活線粒體裂變。

87.Structure and assembly of cargo Rubisco in two native α-carboxysomes.

兩個本地α-羧基體中貨物Rubisco的結(jié)構(gòu)和組裝。

88.Extreme purifying selection against point mutations in the human genome.

人類基因組中針對點(diǎn)突變的極端純化選擇。

89.Maternal SMCHD1 regulates Hox gene expression and patterning in the mouse embryo.

母體SMCHD1調(diào)控小鼠胚胎中Hox基因的表達(dá)和模式化.

90.The architecture of kinesin-3 KLP-6 reveals a multilevel-lockdown mechanism for autoinhibition.

kinesin-3 KLP-6的結(jié)構(gòu)揭示了一種多級鎖定的自我抑制機(jī)制.

91.Frequency spectra and the color of cellular noise.

頻譜和細(xì)胞噪聲的顏色。

92.Length-dependent motions of SARS-CoV-2 frameshifting RNA pseudoknot and alternative conformations suggest avenues for frameshifting suppression.

SARS-CoV-2移幀RNA假結(jié)的長度依賴性運(yùn)動和替代構(gòu)象表明移幀抑制的途徑。

93.Noise correlations in neural ensemble activity limit the accuracy of hippocampal spatial representations.

神經(jīng)集合活動中的噪聲相關(guān)性限制了海馬空間表征的準(zhǔn)確性。

94.Therapeutic targeting of ATR in alveolar rhabdomyosarcoma.

ATR在肺泡橫紋肌肉瘤中的治療目標(biāo)。

95.The RalGAPα1–RalA signal module protects cardiac function through regulating calcium homeostasis.

RalGAPα1-RalA信號模塊通過調(diào)節(jié)鈣平衡保護(hù)心臟功能。

96.Single-cell transcriptome atlas of the human corpus cavernosum.

人類海綿體的單細(xì)胞轉(zhuǎn)錄組圖譜。

97.Multi-step screening of DNA/lipid nanoparticles and co-delivery with siRNA to enhance and prolong gene expression.

多步驟篩選DNA/脂質(zhì)納米顆粒并與siRNA共同傳遞以增強(qiáng)和延長基因表達(dá)。

98.Structural basis of human TREX1 DNA degradation and autoimmune disease.

人類TREX1 DNA降解和自身免疫性疾病的結(jié)構(gòu)基礎(chǔ)。

99.An analysis of 45 large-scale wastewater sites in England to estimate SARS-CoV-2 community prevalence.

對英格蘭45個大規(guī)模廢水點(diǎn)的分析，以估計(jì)SARS-CoV-2的社區(qū)流行率。

100.Warming and redistribution of nitrogen inputs drive an increase in terrestrial nitrous oxide emission factor.

氣候變暖和氮素輸入的重新分布推動了陸地氧化亞氮排放因子的增加。

101.Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis.

ERG信號傳導(dǎo)功能失調(diào)驅(qū)動肺血管老化和持續(xù)纖維化。

102.Pancreatic tumor eradication via selective Pin1 inhibition in cancer-associated fibroblasts and T lymphocytes engagement.

通過選擇性抑制癌癥相關(guān)成纖維細(xì)胞和T淋巴細(xì)胞的Pin1根除胰腺腫瘤的作用。

103.DNA nicks induce mutational signatures associated with BRCA1 deficiency.

DNA釘子誘發(fā)與BRCA1缺陷相關(guān)的突變特征。

104.Integrin α3β1 promotes vessel formation of glioblastoma-associated endothelial cells through calcium-mediated macropinocytosis and lysosomal exocytosis.

整合素α3β1通過鈣介導(dǎo)的巨噬細(xì)胞和溶酶體外滲作用促進(jìn)膠質(zhì)母細(xì)胞相關(guān)內(nèi)皮細(xì)胞的血管形成。

105.A phylogenetically-restricted essential cell cycle progression factor in the human pathogen Candida albicans.

人類病原體白色念珠菌中一個系統(tǒng)發(fā)育受限的基本細(xì)胞周期進(jìn)展因子。

106.Discovering the drivers of clonal hematopoiesis.

發(fā)現(xiàn)克隆性造血的驅(qū)動因素。

107.Extensive co-binding and rapid redistribution of NANOG and GATA6 during emergence of divergent lineages.

NANOG和GATA6在分歧系出現(xiàn)過程中的廣泛共同結(jié)合和快速重新分布。

108.Development of a nanoparticle-based immunotherapy targeting PD-L1 and PLK1 for lung cancer treatment.

基于納米顆粒的免疫療法的發(fā)展，以PD-L1和PLK1為目標(biāo)，用于肺癌治療。

109.Natural variation of DROT1 confers drought adaptation in upland rice.

DROT1的自然變異賦予高地水稻的干旱適應(yīng)性。

110.A proteolytically activated antimicrobial toxin encoded on a mobile plasmid of Bacteroidales induces a protective response.

菌類的移動質(zhì)粒上編碼的蛋白溶解活性抗菌毒素誘導(dǎo)保護(hù)性反應(yīng)。

111.Rep15 interacts with several Rab GTPases and has a distinct fold for a Rab effector.

Rep15與幾個Rab GTP酶相互作用，并具有Rab效應(yīng)器的獨(dú)特折疊。

112.Landscape of somatic alterations in large-scale solid tumors from an Asian population.

來自亞洲人群的大規(guī)模實(shí)體腫瘤中體細(xì)胞改變的景觀。

113.Multiple anthropogenic pressures eliminate the effects of soil microbial diversity on ecosystem functions in experimental microcosms.

多種人為壓力消除了實(shí)驗(yàn)性微生態(tài)環(huán)境中土壤微生物多樣性對生態(tài)系統(tǒng)功能的影響。

114.Construction of the axolotl cell landscape using combinatorial hybridization sequencing at single-cell resolution.

利用組合雜交測序在單細(xì)胞分辨率下構(gòu)建斧頭魚的細(xì)胞景觀。

115.A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer.

卵巢癌中超級增強(qiáng)子驅(qū)動的致癌基因表達(dá)程序的多組學(xué)剖析。

116.Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology.

肝素誘導(dǎo)α-synuclein形成新的纖維多態(tài)性，減輕神經(jīng)病理學(xué)的影響。

117.Modulating co-translational protein folding by rational design and ribosome engineering.

通過合理設(shè)計(jì)和核糖體工程調(diào)控共翻譯蛋白折疊。

118.Accurate somatic variant detection using weakly supervised deep learning.

使用弱監(jiān)督的深度學(xué)習(xí)進(jìn)行準(zhǔn)確的體細(xì)胞變異檢測。

119.Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma.

胸腺瘤中髓質(zhì)胸腺上皮細(xì)胞異常神經(jīng)肌肉基因的表達(dá)。

120.Calcium/calmodulin-dependent protein kinase IV promotes imiquimod-induced psoriatic inflammation via macrophages and keratinocytes in mice.

鈣/鈣調(diào)蛋白依賴性蛋白激酶IV通過小鼠的巨噬細(xì)胞和角質(zhì)細(xì)胞促進(jìn)咪喹莫特誘導(dǎo)的銀屑病炎癥。

121.Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations.

DNMT3B同源多聚體的結(jié)構(gòu)顯示出易受ICF突變的損害。

122.A temperature-regulated circuit for feeding behavior.

攝食行為的溫度調(diào)節(jié)回路。

123.Targeting loop3 of sclerostin preserves its cardiovascular protective action and promotes bone formation.

靶向sclerostin的loop3可保留其心血管保護(hù)作用并促進(jìn)骨形成。

124.Development of a novel core genome MLST scheme for tracing multidrug resistant Staphylococcus capitis.

用于追蹤多藥耐藥葡萄球菌的新型核心基因組MLST方案的開發(fā)。

125.Predicting memory from the network structure of naturalistic events.

從自然事件的網(wǎng)絡(luò)結(jié)構(gòu)中預(yù)測記憶。

126.Personalized bacteriophage therapy to treat pandrug-resistant spinal Pseudomonas aeruginosa infection.

個性化的噬菌體療法治療耐藥性脊柱銅綠假單胞菌感染。

127.A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells.

機(jī)械傳感器PIEZO1在葡萄糖誘導(dǎo)的胰島素分泌中的關(guān)鍵作用。

128.Neurocomputational mechanisms of confidence in self and others.

對自己和他人的信心的神經(jīng)計(jì)算機(jī)制。

129.Nanoscale regulation of Ca2+ dependent phase transitions and real-time dynamics of SAP97/hDLG.

Ca2+依賴性相變的納米級調(diào)節(jié)和SAP97/hDLG的實(shí)時動態(tài)。

130.TDP1-independent pathways in the process and repair of TOP1-induced DNA damage.

TOP1誘導(dǎo)的DNA損傷的過程和修復(fù)中不依賴TDP1的途徑。

131.Differential analysis of RNA structure probing experiments at nucleotide resolution: uncovering regulatory functions of RNA structure.

核苷酸分辨率下的RNA結(jié)構(gòu)探測實(shí)驗(yàn)的差異分析：揭示RNA結(jié)構(gòu)的調(diào)控功能。

132.A macroscopic link between interhemispheric tract myelination and cortico-cortical interactions during action reprogramming.

行動重編程過程中半球間束髓化和皮質(zhì)-皮質(zhì)相互作用之間的宏觀聯(lián)系。

133.Altered tRNA dynamics during translocation on slippery mRNA as determinant of spontaneous ribosome frameshifting.

滑溜溜的mRNA上易位時改變的tRNA動態(tài)是自發(fā)核糖體移架的決定因素。

134.Emergency triage of brain computed tomography via anomaly detection with a deep generative model.

通過深度生成模型的異常檢測對大腦計(jì)算機(jī)斷層成像進(jìn)行緊急分流。

135.Detection of neutralizing antibodies against multiple SARS-CoV-2 strains in dried blood spots using cell-free PCR.

利用無細(xì)胞PCR檢測干血斑中針對多種SARS-CoV-2毒株的中和抗體.

136.Etv2 regulates enhancer chromatin status to initiate Shh expression in the limb bud.

Etv2調(diào)控增強(qiáng)子染色質(zhì)狀態(tài)以啟動肢芽中的Shh表達(dá)。

137.Population genomics of Group B Streptococcus reveals the genetics of neonatal disease onset and meningeal invasion.

B組鏈球菌的群體基因組學(xué)揭示了新生兒疾病發(fā)病和腦膜侵入的遺傳學(xué)。

138.Water as the often neglected medium at the interface between materials and biology.

水是材料和生物學(xué)界面上經(jīng)常被忽視的介質(zhì)。

139.Post-translational amino acid conversion in photosystem II as a possible origin of photosynthetic oxygen evolution.

光系統(tǒng)II的翻譯后氨基酸轉(zhuǎn)換是光合氧進(jìn)化的可能起源。

140.Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex.

異質(zhì)核糖核酸蛋白U（HNRNPU）保障了發(fā)育中的小鼠皮層。

141.Biallelic and gene-wide genomic substitution for endogenous intron and retroelement mutagenesis in human cells.

人類細(xì)胞中內(nèi)源性內(nèi)含子和逆轉(zhuǎn)錄元素突變的雙片和全基因組替代。

142.Lateral habenula glutamatergic neurons projecting to the dorsal raphe nucleus promote aggressive arousal in mice.

投射到背脊核的外側(cè)哈維納谷氨酸神經(jīng)元促進(jìn)小鼠的攻擊性喚醒。

143.Engineered biomimetic nanoparticles achieve targeted delivery and efficient metabolism-based synergistic therapy against glioblastoma.

工程化仿生納米粒子實(shí)現(xiàn)了對膠質(zhì)母細(xì)胞瘤的靶向輸送和基于代謝的高效協(xié)同治療。

144.Dynamic influences on static measures of metacognition.

對元認(rèn)知的靜態(tài)措施的動態(tài)影響。

145.A metagenomic DNA sequencing assay that is robust against environmental DNA contamination.

一種對環(huán)境DNA污染具有魯棒性的元基因組DNA測序方法。

146.Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration.

靶向視黃酸受體α-核抑制器的相互作用激活伴侶素介導(dǎo)的自噬并保護(hù)視網(wǎng)膜變性。

147.A nationwide questionnaire study of post-acute symptoms and health problems after SARS-CoV-2 infection in Denmark.

丹麥SARS-CoV-2感染后急性癥狀和健康問題的全國性問卷研究。

148.Mechanism of threonine ADP-ribosylation of F-actin by a Tc toxin.

Tc毒素對F-actin的蘇氨酸ADP-核苷酸化的機(jī)制。

149.A Bayesian approach to infer recombination patterns in coronaviruses.

用貝葉斯方法推斷冠狀病毒的重組模式.

150.Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape.

Kinesin-8特異性環(huán)路-2根據(jù)管蛋白原絲形狀控制運(yùn)動域的雙重活動.

151.Pseudomonas aeruginosa SutA wedges RNAP lobe domain open to facilitate promoter DNA unwinding.

銅綠假單胞菌SutA楔入RNAP葉狀結(jié)構(gòu)域以促進(jìn)啟動子DNA解開。

152.Model-guided engineering of DNA sequences with predictable site-specific recombination rates.

模型指導(dǎo)下的DNA序列工程，具有可預(yù)測的特定位點(diǎn)重組率。

153.An epigenome atlas of neural progenitors within the embryonic mouse forebrain.

胚胎期小鼠前腦內(nèi)神經(jīng)祖先的表觀基因組圖譜。

154.Neuropilin 1 and its inhibitory ligand mini-tryptophanyl-tRNA synthetase inversely regulate VE-cadherin turnover and vascular permeability.

Neuropilin 1及其抑制性配體mini-tryptophanyl-tRNA synthetase反向調(diào)節(jié)VE-cadherin周轉(zhuǎn)和血管通透性。

155.Drivers and trends of global soil microbial carbon over two decades.

二十年來全球土壤微生物碳的驅(qū)動力和趨勢.

156.Polycomb-lamina antagonism partitions heterochromatin at the nuclear periphery.

Polycomb-lamina的拮抗作用將異染色質(zhì)分割在核周邊。

157.Disruption of tubulin-alpha4a polyglutamylation prevents aggregation of hyper-phosphorylated tau and microglia activation in mice.

破壞管蛋白-α4a的聚谷氨酸化可防止小鼠高磷酸化tau的聚集和小膠質(zhì)細(xì)胞的激活。

158.Inactivation of Sirt6 ameliorates muscular dystrophy in mdx mice by releasing suppression of utrophin expression.

Sirt6的失活通過釋放對utrophin表達(dá)的抑制改善了mdx小鼠的肌肉萎縮。

159.Thalamo-hippocampal pathway regulates incidental memory capacity in mice.

Thalamo-hippocampal通路調(diào)節(jié)小鼠的附帶記憶能力。

160.The mechanism of replication stalling and recovery within repetitive DNA.

重復(fù)性DNA內(nèi)復(fù)制停頓和恢復(fù)的機(jī)制。

161.Stomatin modulates adipogenesis through the ERK pathway and regulates fatty acid uptake and lipid droplet growth.

Stomatin通過ERK途徑調(diào)節(jié)脂肪生成，并調(diào)節(jié)脂肪酸的攝取和脂滴的生長。

162.Genomic insights into the secondary aquatic transition of penguins.

對企鵝二級水生過渡的基因組學(xué)見解。

163.α-Synuclein fibril-specific nanobody reduces prion-like α-synuclein spreading in mice.

α-Synuclein纖維特異性納米抗體減少小鼠中類似朊病毒的α-synuclein擴(kuò)散。

164.A brain precursor atlas reveals the acquisition of developmental-like states in adult cerebral tumours.

大腦前體圖譜揭示了成人腦腫瘤中類似發(fā)育狀態(tài)的獲得。

165.Increased neutralization and IgG epitope identification after MVA-MERS-S booster vaccination against Middle East respiratory syndrome.

針對中東呼吸綜合征的MVA-MERS-S加強(qiáng)型疫苗接種后，中和作用和IgG表位鑒定增加。

166.Drought-Induced Civil Conflict Among the Ancient Maya.

古代瑪雅人中干旱引起的內(nèi)部沖突.

167.Reactivity-dependent profiling of RNA 5-methylcytidine dioxygenases.

RNA 5-甲基胞苷二氧化酶的反應(yīng)性依賴分析。

168.N6-methyladenosine modification-mediated mRNA metabolism is essential for human pancreatic lineage specification and islet organogenesis.

N6-甲基腺苷修飾介導(dǎo)的mRNA代謝對人類胰腺線型規(guī)范和胰島器官生成至關(guān)重要。

169.Periosteal stem cells control growth plate stem cells during postnatal skeletal growth.

骨膜干細(xì)胞在產(chǎn)后骨骼生長過程中控制生長板干細(xì)胞。

170.Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression.

腺苷A1受體激動劑對Gαob的選擇性激活引起鎮(zhèn)痛而無心肺功能抑制。

171.Duration of protection of CoronaVac plus heterologous BNT162b2 booster in the Omicron period in Brazil.

巴西Omicron時期CoronaVac加異源BNT162b2助推器的保護(hù)時間。

172.Immune responses in Omicron SARS-CoV-2 breakthrough infection in vaccinated adults.

接種疫苗的成年人在Omicron SARS-CoV-2突破性感染中的免疫反應(yīng)。

173.People infer communicative action through an expectation for efficient communication.

人們通過對高效溝通的期望來推斷溝通行動。

174.Structural basis for the activation and ligand recognition of the human oxytocin receptor.

人類催產(chǎn)素受體的激活和配體識別的結(jié)構(gòu)基礎(chǔ)。

175.Orexin neurons inhibit sleep to promote arousal.

Orexin神經(jīng)元抑制睡眠以促進(jìn)喚醒。

176.Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues.

蛋白質(zhì)組學(xué)分析揭示了鱗狀細(xì)胞癌和腺癌在多種組織中的關(guān)鍵差異。

177.Hepatocyte growth factor derived from senescent cells attenuates cell competition-induced apical elimination of oncogenic cells.

來自衰老細(xì)胞的肝細(xì)胞生長因子減弱了細(xì)胞競爭引起的致癌細(xì)胞的頂端消除。

178.Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children.

循環(huán)Tfh細(xì)胞的年齡依賴性變化影響兒童功能性瘧疾抗體的發(fā)展。

179.Efficient spatially targeted gene editing using a near-infrared activatable protein-conjugated nanoparticle for brain applications.

利用近紅外可激活蛋白結(jié)合的納米粒子進(jìn)行高效的空間定向基因編輯，用于腦部應(yīng)用。

180.ZnT8 loss-of-function accelerates functional maturation of hESC-derived β cells and resists metabolic stress in diabetes.

ZnT8功能缺失加速了hESC衍生的β細(xì)胞的功能成熟并抵抗糖尿病的代謝壓力。

181.The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis.

CIP2A-TOPBP1復(fù)合物在有絲分裂過程中保障了染色體的穩(wěn)定性。

182.Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation.

溶酶體蛋白跨膜5通過調(diào)節(jié)BMPR1A溶酶體降解促進(jìn)肺部特定轉(zhuǎn)移。

183.Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance.

激活VCP D1 ATP酶的化合物同時增強(qiáng)了自噬和蛋白體神經(jīng)毒性蛋白的清除。

184.Loss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity.

免疫相關(guān)GTP酶GM4951的缺失導(dǎo)致非酒精性脂肪肝而無肥胖癥。

185.Timing is everything: structural insights into the disease-linked Kv3 channels controlling fast action-potential firing in the brain.

時間就是一切：對控制大腦快速動作電位發(fā)射的與疾病相關(guān)的Kv3通道的結(jié)構(gòu)見解。

186.MRTF specifies a muscle-like contractile module in Porifera.

MRTF在多孔類動物中指定了一個類似肌肉的收縮模塊。

187.A synaptic signal for novelty processing in the hippocampus.

海馬體中新奇事物處理的突觸信號。

188.The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance.

多發(fā)性骨髓瘤細(xì)胞的表面組提示潛在的免疫治療策略和耐藥性的蛋白質(zhì)標(biāo)記。

189.Somatic cell fate maintenance in mouse fetal testes via autocrine/paracrine action of AMH and activin B.

通過AMH和激活素B的自分泌/旁分泌作用維持小鼠胎兒睪丸中的體細(xì)胞命運(yùn)。

190.Cutaneous and acral melanoma cross-OMICs reveals prognostic cancer drivers associated with pathobiology and ultraviolet exposure.

皮膚和尖銳黑色素瘤交叉OMIC揭示了與病理生物學(xué)和紫外線暴露有關(guān)的預(yù)后癌癥驅(qū)動因素。

191.Recovery of Lutacidiplasmatales archaeal order genomes suggests convergent evolution in Thermoplasmatota.

恢復(fù)Lutacidiplasmatales古生物秩序基因組表明Thermoplasmatota的趨同進(jìn)化。

192.Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis.

腫瘤性BRAF通過抑制細(xì)胞分裂誘導(dǎo)全基因組加倍。

193.Inhibition of NMDA receptors through a membrane-to-channel path.

通過膜到通道的途徑抑制NMDA受體。

194.Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain.

人類Kv3.1通道的冷凍電鏡結(jié)構(gòu)顯示了細(xì)胞質(zhì)T1結(jié)構(gòu)域的門控。

195.Hepatic non-parenchymal S100A9-TLR4-mTORC1 axis normalizes diabetic ketogenesis.

肝臟非血小板S100A9-TLR4-mTORC1軸使糖尿病生酮作用正常化。

196.SLITRK2 variants associated with neurodevelopmental disorders impair excitatory synaptic function and cognition in mice.

與神經(jīng)發(fā)育障礙相關(guān)的SLITRK2變體損害了小鼠的興奮性突觸功能和認(rèn)知能力。

197.Hypoxia induces HIF1α-dependent epigenetic vulnerability in triple negative breast cancer to confer immune effector dysfunction and resistance to anti-PD-1 immunotherapy.

低氧誘導(dǎo)三陰性乳腺癌的HIF1α依賴性表觀遺傳脆弱性，賦予免疫效應(yīng)器功能障礙和對抗PD-1免疫療法的抗性。

198.Trigger factor both holds and folds its client proteins.

觸發(fā)因子既保持又折疊其客戶蛋白。

199.Building programmable multicompartment artificial cells incorporating remotely activated protein channels using microfluidics and acoustic levitation.

利用微流控技術(shù)和聲學(xué)懸浮技術(shù)建立可編程的多室人工細(xì)胞，其中包括遠(yuǎn)程激活的蛋白質(zhì)通道。

200.Humanized mice for investigating sustained Plasmodium vivax blood-stage infections and transmission.

用于研究持續(xù)間日瘧血液階段感染和傳播的人性化小鼠。

201.Differences in barriers for controlled learning about safety between biotechnology and chemistry.

生物技術(shù)和化學(xué)之間的安全控制學(xué)習(xí)障礙的差異。

202.Identifying multicellular spatiotemporal organization of cells with SpaceFlow.

用SpaceFlow識別細(xì)胞的多細(xì)胞時空組織。

203.Cell-autonomous Hedgehog signaling controls Th17 polarization and pathogenicity.

細(xì)胞自主的Hedgehog信號控制Th17的極化和致病性。

204.Natural Killer cells demonstrate distinct eQTL and transcriptome-wide disease associations, highlighting their role in autoimmunity.

自然殺傷細(xì)胞表現(xiàn)出獨(dú)特的eQTL和全轉(zhuǎn)錄組疾病關(guān)聯(lián)，突出了其在自身免疫中的作用。

205.A monomeric mycobacteriophage immunity repressor utilizes two domains to recognize an asymmetric DNA sequence.

一個單體的噬菌體免疫抑制器利用兩個結(jié)構(gòu)域來識別不對稱的DNA序列。

206.HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8+ T-cell infiltration into tumors.

HRS磷酸化驅(qū)動免疫抑制性外泌體的分泌，并限制CD8+T細(xì)胞對腫瘤的浸潤。

207.Inhibition of myeloid-derived suppressor cell arginase-1 production enhances T-cell-based immunotherapy against Cryptococcus neoformans infection.

抑制骨髓源性抑制細(xì)胞精氨酸酶-1的產(chǎn)生增強(qiáng)了基于T細(xì)胞的免疫療法對抗新隱球菌感染。

208.Breaking photoswitch activation depth limit using ionising radiation stimuli adapted to clinical application.

利用適應(yīng)臨床應(yīng)用的電離輻射刺激打破光開關(guān)的激活深度限制。

209.A time-resolved multi-omics atlas of Acanthamoeba castellanii encystment.

蓖麻桿菌囊腫的時間分辨多組學(xué)圖譜.

210.Structures of β1-adrenergic receptor in complex with Gs and ligands of different efficacies.

β1-腎上腺素能受體與Gs和不同功效配體的復(fù)合體結(jié)構(gòu).

211.Auxotrophic and prototrophic conditional genetic networks reveal the rewiring of transcription factors in Escherichia coli.

輔助型和原型型條件遺傳網(wǎng)絡(luò)揭示了大腸桿菌中轉(zhuǎn)錄因子的重構(gòu)。

212.Microglia coordinate cellular interactions during spinal cord repair in mice.

小膠質(zhì)細(xì)胞協(xié)調(diào)小鼠脊髓修復(fù)過程中的細(xì)胞相互作用。

213.Controlled activation of cortical astrocytes modulates neuropathic pain-like behaviour.

皮質(zhì)星形膠質(zhì)細(xì)胞的控制性激活可調(diào)節(jié)神經(jīng)性疼痛樣行為。

214.Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension.

加速賴氨酸代謝傳達(dá)鹽敏感性高血壓的腎臟保護(hù)。

215.Equilibrated evolution of the mixed auto-/allopolyploid haplotype-resolved genome of the invasive hexaploid Prussian carp.

侵入性六倍體普魯士鯉魚的混合自體/全多倍體單倍型解析基因組的平衡進(jìn)化。

216.Adipocyte lysoplasmalogenase TMEM86A regulates plasmalogen homeostasis and protein kinase A-dependent energy metabolism.

脂肪細(xì)胞溶血素酶TMEM86A調(diào)控溶血素平衡和蛋白激酶A依賴的能量代謝。

217.Phagocytosis of Plasmodium falciparum ring-stage parasites predicts protection against malaria.

惡性瘧原蟲環(huán)狀階段寄生蟲的吞噬作用預(yù)測了對瘧疾的保護(hù)。

218.The shape of things to come: structural insights into how prion proteins encipher heritable information.

未來事物的形態(tài)：對朊病毒蛋白如何加密遺傳信息的結(jié)構(gòu)見解。

219.Cryo-EM structure of anchorless RML prion reveals variations in shared motifs between distinct strains.

無錨的RML朊病毒的低溫電鏡結(jié)構(gòu)揭示了不同菌株之間共享圖案的變化。

220.The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment.

弓形蟲的內(nèi)在無序蛋白TgIST通過阻斷輔助因子的招募來抑制STAT1的信號傳導(dǎo)。

221.2.7?? cryo-EM structure of ex vivo RML prion fibrils.

體外RML朊病毒纖維的2.7埃低溫電鏡結(jié)構(gòu)。

222.Bromodomain factor 5 is an essential regulator of transcription in Leishmania.

溴域因子5是利什曼病毒轉(zhuǎn)錄的一個重要調(diào)節(jié)器。

223.A reference single-cell regulomic and transcriptomic map of cynomolgus monkeys.

犬牙交錯的單細(xì)胞調(diào)控和轉(zhuǎn)錄組參考圖。

224.Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.

用于加速蛋白質(zhì)相互作用組發(fā)現(xiàn)的可擴(kuò)展的多重聯(lián)合分餾/質(zhì)譜分析平臺。

225.Integration of tumor extrinsic and intrinsic features associates with immunotherapy response in non-small cell lung cancer.

腫瘤外在和內(nèi)在特征的整合與非小細(xì)胞肺癌的免疫治療反應(yīng)有關(guān)。

226.Model building of protein complexes from intermediate-resolution cryo-EM maps with deep learning-guided automatic assembly.

利用深度學(xué)習(xí)引導(dǎo)的自動裝配，從中分辨率低溫電鏡圖中建立蛋白質(zhì)復(fù)合體模型。

227.Massively targeted evaluation of therapeutic CRISPR off-targets in cells.

細(xì)胞中治療性CRISPR脫靶的大規(guī)模定向評估。

228.De-etiolation-induced protein 1 (DEIP1) mediates assembly of the cytochrome b6f complex in Arabidopsis.

脫葉誘導(dǎo)蛋白1（DEIP1）介導(dǎo)了擬南芥中細(xì)胞色素b6f復(fù)合物的組裝。

229.A SOX17-PDGFB signaling axis regulates aortic root development.

SOX17-PDGFB信號軸調(diào)控主動脈根的發(fā)育。

230.Monomeric prefusion structure of an extremophile gamete fusogen and stepwise formation of the postfusion trimeric state.

一個極端親緣配子體融合前的單體結(jié)構(gòu)和融合后三聚體狀態(tài)的逐步形成。

231.Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer.

與疾病相關(guān)的MEK突變體的質(zhì)量差異揭示了癌癥的分子特征和異常信號傳導(dǎo)-串?dāng)_。

232.Single cell sequencing identifies clonally expanded synovial CD4+ TPH cells expressing GPR56 in rheumatoid arthritis.

單細(xì)胞測序確定了類風(fēng)濕關(guān)節(jié)炎中表達(dá)GPR56的滑膜CD4+TPH細(xì)胞的克隆擴(kuò)展。

233.Human-type sialic acid receptors contribute to avian influenza A virus binding and entry by hetero-multivalent interactions.

人型唾液酸受體通過異質(zhì)多價的相互作用對禽類甲型流感病毒的結(jié)合和進(jìn)入做出貢獻(xiàn)。

234.Selective expression of variant surface antigens enables Plasmodium falciparum to evade immune clearance in vivo.

變體表面抗原的選擇性表達(dá)使惡性瘧原蟲在體內(nèi)逃避免疫清除。

235.The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors.

HHIP-AS1 lncRNA通過穩(wěn)定人類SHH驅(qū)動的腫瘤中的dynein complex 1來促進(jìn)腫瘤的發(fā)生。

236.Community voices: policy proposals to promote inclusion in academia through the lens of women in science.

社區(qū)的聲音：通過科學(xué)界女性的視角促進(jìn)學(xué)術(shù)界的包容性的政策建議。

237.Loop-extrusion and polymer phase-separation can co-exist at the single-molecule level to shape chromatin folding.

Loop-extrusion和聚合物相分離可以在單分子水平上共存以塑造染色質(zhì)的折疊。

238.CD8 lymphocytes mitigate HIV-1 persistence in lymph node follicular helper T cells during hyperacute-treated infection.

CD8淋巴細(xì)胞緩解了超急性感染期間HIV-1在淋巴結(jié)濾泡輔助T細(xì)胞中的持續(xù)存在。

239.Deciphering polymorphism in 61,157 Escherichia coli genomes via epistatic sequence landscapes.

通過外顯序列景觀破譯61157個大腸桿菌基因組的多態(tài)性。

240.Genome-wide signatures of synergistic epistasis during parallel adaptation in a Baltic Sea copepod.

波羅的海橈足動物平行適應(yīng)過程中的全基因組協(xié)同外顯性特征。

241.Ultra-sensitive monitoring of leukemia patients using superRCA mutation detection assays.

使用superRCA突變檢測法對白血病患者進(jìn)行超靈敏的監(jiān)測。

242.Genomic epidemiology of Delta SARS-CoV-2 during transition from elimination to suppression in Aotearoa New Zealand.

新西蘭Aotearoa地區(qū)SARS-CoV-2病毒從消除到抑制過渡期間的基因組流行病學(xué)。

243.An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides.

一種LNA-酰胺修飾，增強(qiáng)了細(xì)胞對硫代磷酸酯外顯子跳過寡核苷酸的吸收和活性。

244.Precision cancer sono-immunotherapy using deep-tissue activatable semiconducting polymer immunomodulatory nanoparticles.

利用深層組織可激活的半導(dǎo)體聚合物免疫調(diào)節(jié)納米顆粒進(jìn)行精確的癌癥聲學(xué)免疫治療。

245.Malaria parasite heme biosynthesis promotes and griseofulvin protects against cerebral malaria in mice.

瘧原蟲血紅素生物合成對小鼠腦性瘧疾的促進(jìn)和格列本脲的保護(hù)作用。

246.Base editing in human cells with monomeric DddA-TALE fusion deaminases.

單體DddA-TALE融合脫氨酶在人類細(xì)胞中的堿基編輯。

247.A randomized phase 3 trial of Gemcitabine or Nab-paclitaxel combined with cisPlatin as first-line treatment in patients with metastatic triple-negative breast cancer.

吉西他濱或納布-紫杉醇聯(lián)合順鉑作為轉(zhuǎn)移性三陰性乳腺癌患者的一線治療的隨機(jī)3期試驗(yàn)。

248.Trypsin is a coordinate regulator of N and P nutrients in marine phytoplankton.

胰蛋白酶是海洋浮游植物中N和P營養(yǎng)成分的協(xié)調(diào)調(diào)節(jié)劑。

249.Self-assembly of tessellated tissue sheets by expansion and collision.

通過擴(kuò)張和碰撞實(shí)現(xiàn)方塊組織片的自組裝。

250.Cumulative cultural evolution and mechanisms for cultural selection in wild bird songs.

野生鳥類歌曲的累積性文化演化和文化選擇機(jī)制.

251.Single-cell analysis highlights differences in druggable pathways underlying adaptive or fibrotic kidney regeneration.

單細(xì)胞分析突出了適應(yīng)性或纖維化腎臟再生的可藥性途徑的差異。

252.Nestin-dependent mitochondria-ER contacts define stem Leydig cell differentiation to attenuate male reproductive ageing.

Nestin依賴的線粒體-ER接觸定義了干系的Leydig細(xì)胞分化以減弱男性生殖衰老。

253.Spatially resolved proteomic map shows that extracellular matrix regulates epidermal growth.

空間分辨率的蛋白質(zhì)組圖顯示細(xì)胞外基質(zhì)調(diào)控表皮生長。

254.Reply to: Questioning whether the IgM Fc receptor (FcμR) is expressed by innate immune cells.

回復(fù)：：?質(zhì)疑IgM Fc受體（FcμR）是否由先天免疫細(xì)胞表達(dá)。

255.Questioning whether IgM Fc receptor (FcμR) is expressed by innate immune cells.

質(zhì)疑IgM Fc受體(FcμR)是否由先天免疫細(xì)胞表達(dá)。

256.Translational fidelity and growth of Arabidopsis require stress-sensitive diphthamide biosynthesis.

擬南芥的翻譯保真度和生長需要對壓力敏感的雙硫脒生物合成。

257.Machine learning-based tissue of origin classification for cancer of unknown primary diagnostics using genome-wide mutation features.

基于機(jī)器學(xué)習(xí)的原發(fā)組織分類，利用全基因組突變特征對未知原發(fā)癌癥進(jìn)行診斷。

258.Blocking glycine utilization inhibits multiple myeloma progression by disrupting glutathione balance.

阻斷甘氨酸利用通過破壞谷胱甘肽平衡抑制多發(fā)性骨髓瘤的進(jìn)展。

259.Regulation of AUXIN RESPONSE FACTOR condensation and nucleo-cytoplasmic partitioning.

AUXIN RESPONSE FACTOR凝結(jié)和核-質(zhì)體分配的調(diào)節(jié)。

260.Chromatin sequesters pioneer transcription factor Sox2 from exerting force on DNA.

染色質(zhì)封存先鋒轉(zhuǎn)錄因子Sox2，使其無法對DNA施力。

261.Compulsive alcohol drinking in rodents is associated with altered representations of behavioral control and seeking in dorsal medial prefrontal cortex.

嚙齒動物的強(qiáng)迫性飲酒與背內(nèi)側(cè)前額葉皮層的行為控制和尋求的表征改變有關(guān)。

262.Interchromosomal interaction of homologous Stat92E alleles regulates transcriptional switch during stem-cell differentiation.

同源的Stat92E等位基因的染色體間相互作用調(diào)節(jié)了干細(xì)胞分化過程中的轉(zhuǎn)錄轉(zhuǎn)換。

263.Precision digital mapping of endogenous and induced genomic DNA breaks by INDUCE-seq.

INDUCE-seq對內(nèi)源性和誘導(dǎo)性基因組DNA斷裂的精確數(shù)字圖譜。

264.Programmable CRISPR-Cas9 microneedle patch for long-term capture and real-time monitoring of universal cell-free DNA.

可編程CRISPR-Cas9微針貼片用于長期捕獲和實(shí)時監(jiān)測通用無細(xì)胞DNA。

265.Clinical characteristics and immune profile alterations in vaccinated individuals with breakthrough Delta SARS-CoV-2 infections.

突破性三角洲SARS-CoV-2感染的疫苗接種者的臨床特征和免疫概況改變。

266.Variance-quantitative trait loci enable systematic discovery of gene-environment interactions for cardiometabolic serum biomarkers.

變異定量性狀位點(diǎn)能夠系統(tǒng)發(fā)現(xiàn)心臟代謝血清生物標(biāo)志物的基因-環(huán)境相互作用。

267.ADAMTS18+ villus tip telocytes maintain a polarized VEGFA signaling domain and fenestrations in nutrient-absorbing intestinal blood vessels.

ADAMTS18+絨毛頂端端細(xì)胞維持著極化的VEGFA信號域和吸收營養(yǎng)的腸道血管中的柵欄。

268.Mechanism of fertilization-induced auxin synthesis in the endosperm for seed and fruit development.

受精誘導(dǎo)的輔助素在胚乳中合成種子和果實(shí)發(fā)育的機(jī)制。

269.A Nodal enhanced micropeptide NEMEP regulates glucose uptake during mesendoderm differentiation of embryonic stem cells.

一種Nodal增強(qiáng)型微肽NEMEP調(diào)控胚胎干細(xì)胞中胚層分化過程中的葡萄糖攝取。

270.Probing strigolactone perception mechanisms with rationally designed small-molecule agonists stimulating germination of root parasitic weeds.

用合理設(shè)計(jì)的小分子激動劑探究刺激根寄生雜草發(fā)芽的糙米內(nèi)酯感知機(jī)制。

271.Acetyl-CoA-Carboxylase 1-mediated de novo fatty acid synthesis sustains Lgr5+ intestinal stem cell function.

乙酰-CoA-羧基酶1介導(dǎo)的從頭脂肪酸合成維持Lgr5+腸道干細(xì)胞的功能。

272.Ciliary transition zone proteins coordinate ciliary protein composition and ectosome shedding.

睫狀體過渡區(qū)蛋白協(xié)調(diào)睫狀體蛋白的組成和外植體的脫落。

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