【文獻速遞】【Nature】【2022年】【3月】
聲明：本專欄主要對生命科學(xué)領(lǐng)域的一些期刊文章標題進行翻譯，所有內(nèi)容均由本人手工整理翻譯。由于本人專業(yè)為生物分析相關(guān)，其他領(lǐng)域如果出現(xiàn)翻譯錯誤請諒解。
增強酶
Biaryl compounds, which contain two connected aromatic rings, are common throughout chemistry, medicine and materials science. Joining together the individual molecular components to form these compounds can be a challenge. In this week’s issue, Alison Narayan and her colleagues report the design and engineering of enzyme biocatalysts that help to connect the necessary building blocks through their carbon–hydrogen bonds. The researchers used engineered forms of cytochrome P450 enzymes as the catalyst, and as a result were able to transform a low-yielding, unselective reaction into one that efficiently joined phenols to form biaryl compounds with control over both which C–H bonds are coupled and the stereochemistry of the products.
含有兩個相連芳環(huán)的聯(lián)芳基化合物在化學(xué)、醫(yī)學(xué)和材料科學(xué)中很常見。 將各個分子成分連接在一起以形成這些化合物可能是一項挑戰(zhàn)。 在本周的期刊中，Alison Narayan 和她的同事報告了酶生物催化劑的設(shè)計和工程，這些酶生物催化劑有助于通過碳氫鍵連接必要的構(gòu)建塊。 研究人員使用工程形式的細胞色素 P450 酶作為催化劑，因此能夠?qū)⒌彤a(chǎn)率、非選擇性的反應(yīng)轉(zhuǎn)化為有效連接酚類以形成聯(lián)芳基化合物的反應(yīng)，同時控制 C-H 鍵的偶聯(lián)和 產(chǎn)物的立體化學(xué)。
預(yù)測過去
Inscriptions provide an invaluable insight into the ancient world. But over the centuries, many inscriptions have been damaged and exist in fragmented or semi-legible forms, making the job of reading and interpreting them extremely difficult. In this week’s issue, Yannis Assael, Thea Sommerschield and their team introduce Ithaca, a deep neural network designed to help historians restore and understand ancient Greek inscriptions. Working alone, Ithaca is able to restore damaged texts with a 62% accuracy, but when historians use Ithaca, their accuracy on the same task rises to 72%. Ithaca can also determine the original geographical location of inscriptions with 71% accuracy, and can date them to within 30 years from the date ranges proposed by historians. The researchers say that such cooperation between artificial intelligence and historians could help transform studies of the ancient world.
銘文提供了對古代世界的寶貴見解。 但幾個世紀以來，許多銘文已被損壞，并以支離破碎或半清晰的形式存在，這使得閱讀和解釋它們的工作變得極其困難。 在本周的期刊中，Yannis Assael、Thea Sommerschield 和他們的團隊介紹了 Ithaca，這是一種深度神經(jīng)網(wǎng)絡(luò)，旨在幫助歷史學(xué)家修復(fù)和理解古希臘銘文。 單獨工作時，Ithaca能夠以 62% 的準確率恢復(fù)損壞的文本，但當歷史學(xué)家使用Ithaca時，他們在同一任務(wù)上的準確率上升到 72%。 Ithaca還可以以 71% 的準確度確定銘文的原始地理位置，并且可以將它們追溯到歷史學(xué)家提出的日期范圍的 30 年以內(nèi)。 研究人員表示，人工智能與歷史學(xué)家之間的這種合作可能有助于改變對古代世界的研究。
基因精靈
For more than 50 years, scientists have been trying to understand the relationship between DNA sequence, gene-expression phenotype and fitness to decipher principles of gene regulatory evolution. In this week’s issue, Eeshit Dhaval Vaishnav, Carl de Boer, Aviv Regev and their colleagues present a framework for understanding and engineering regulatory DNA sequences that takes a step towards this goal. The researchers built this framework around an ‘oracle’ they developed using a deep neural network model that predicts gene expression given a promoter DNA sequence. The neural network was trained using the expression measurements for tens of millions of promoter sequences. The result was an AI oracle that predicts expression from sequence well enough to study the evolutionary history and future evolvability of regulatory DNA sequences, as well as to design regulatory DNA sequences for synthetic biology applications. The cover offers a visual representation of the evolutionary properties of sequences at the extremes of the evolvability spectrum.
50 多年來，科學(xué)家們一直試圖了解 DNA 序列、基因表達表型和適應(yīng)性之間的關(guān)系，以破譯基因調(diào)控進化的原理。 在本周的期刊中，Eeshit Dhaval Vaishnav、Carl de Boer、Aviv Regev 及其同事提出了一個框架，用于理解和工程化調(diào)控 DNA 序列，朝著這一目標邁出了一步。 研究人員圍繞他們使用深度神經(jīng)網(wǎng)絡(luò)模型開發(fā)的“oracle”構(gòu)建了這個框架，該模型可以預(yù)測給定啟動子 DNA 序列的基因表達。 使用數(shù)千萬啟動子序列的表達測量來訓(xùn)練神經(jīng)網(wǎng)絡(luò)。 其結(jié)果是一個 AI oracle，它可以很好地預(yù)測序列的表達，以研究調(diào)節(jié) DNA 序列的進化歷史和未來的進化能力，以及為合成生物學(xué)應(yīng)用設(shè)計調(diào)節(jié) DNA 序列。 封面提供了進化譜極端序列的進化特性的可視化表示。
星際約會者的銀河系指南
The cover image shows a view of the Milky Way captured at Nambung National Park in Western Australia. To understand how the Galaxy formed requires precision age dating of the stars that it contains. In this week’s issue, Maosheng Xiang and Hans-Walter Rix of the Max Planck Institute for Astronomy in Heidelberg, Germany, present an analysis of the birth dates for nearly 250,000 stars in their subgiant evolutionary phase, when they can serve as precise stellar clocks. The researchers found that the individual ages of the stars ranged from about 1.5 billion to more than 13 billion years old. Tripling the age-dating precision for such a large stellar sample allowed the researchers to infer the sequence of events that initiated our Galaxy’s formation. Using this information, Xiang and Rix were able to determine that the oldest part of our Galaxy’s disk had already begun to form about 13 billion years ago, just 800 million years after the Big Bang, and that the formation of the inner Galactic halo was completed some 2 billion years later.
封面圖片展示了在西澳大利亞州南邦國家公園拍攝的銀河景觀。 要了解銀河系是如何形成的，需要對它所包含的恒星進行精確的年齡測定。 在本周的期刊中，德國海德堡馬克斯普朗克天文學(xué)研究所的 Maosheng Xiang 和 Hans-Walter Rix 對近 250,000 顆處于亞巨星演化階段的恒星的誕生日期進行了分析，當它們可以作為精確的恒星時鐘時。 研究人員發(fā)現(xiàn)，恒星的個體年齡從大約 15 億歲到超過 130 億歲不等。 將如此大的恒星樣本的年齡測定精度提高三倍，使研究人員能夠推斷出引發(fā)我們銀河系形成的事件順序。 利用這些信息，Xiang 和 Rix 能夠確定我們銀河系最古老的部分在大約 130 億年前就已經(jīng)開始形成，也就是大爆炸之后的 8 億年，并且銀河系內(nèi)暈的形成已經(jīng)完成 大約 20 億年后。
電話連接
The cover shows Yournina Akinyi using her mobile phone at her produce stand in Matasia village, Kenya. In this week’s issue, Joshua Blumenstock and his colleagues show how big data derived from mobile phone networks can improve the targeting of humanitarian aid. Rapid identification of those in greatest need is a significant challenge during a crisis. Blumenstock and his team used conventional survey data to train machine-learning algorithms to recognize patterns of poverty in mobile phone data. Their method was then used in Togo to distribute millions of dollars in COVID-19 relief. The researchers found that compared with more conventional targeting methods, their machine-learning approach reduced the proportion of individuals in need who missed out on aid by 4–21%, suggesting that data sources such as phones could enhance aid distribution in times of crisis.
封面展示了 Yournina Akinyi 在肯尼亞 Matasia 村的農(nóng)產(chǎn)品攤位上使用她的手機。 在本周的期刊中，約書亞·布盧門斯托克 (Joshua Blumenstock) 和他的同事們展示了來自移動電話網(wǎng)絡(luò)的大數(shù)據(jù)如何提高人道主義援助的針對性。 快速識別最需要幫助的人是危機期間的一項重大挑戰(zhàn)。 Blumenstock 和他的團隊使用傳統(tǒng)的調(diào)查數(shù)據(jù)來訓(xùn)練機器學(xué)習(xí)算法，以識別手機數(shù)據(jù)中的貧困模式。 他們的方法隨后在Togo被用于分發(fā)數(shù)百萬美元的 COVID-19 救濟金。 研究人員發(fā)現(xiàn)，與更傳統(tǒng)的定位方法相比，他們的機器學(xué)習(xí)方法將錯過援助的有需要的人的比例降低了 4-21%，這表明電話等數(shù)據(jù)源可以在危機時期加強援助分配。
1.Mechanism underlying a risk gene in neurodegeneration
神經(jīng)退行性中的潛在風(fēng)險基因機制
2.Plasmas primed for rapid pulse production
等離子體用于快速脈沖產(chǎn)生
3.From the archive
來自檔案
4.Isotopes tracked on a sub-nanometre scale using electron spectroscopy
使用電子光譜法以亞納米量表跟蹤的同位素
5.Light-dependent development is tailored in visual neurons
光依賴性發(fā)育是在視覺神經(jīng)元中量身定制的
6.Lung microbes mediate spinal-cord autoimmunity
肺微生物介導(dǎo)脊柱自身免疫性
7.Progress and prospects in magnetic topological materials
磁拓撲材料的進度和前景
8.A persistent ultraviolet outflow from an accreting neutron star binary transient
從中子恒星二進制瞬變中持續(xù)的紫外線流出
9.Recovery time of a plasma-wakefield accelerator
等離子體效率加速器的恢復(fù)時間
10.High-density switchable skyrmion-like polar nanodomains integrated on silicon
集成在硅上的高密度可切換的類似skyrmion的極性納米域
11.Imaging of isotope diffusion using atomic-scale vibrational spectroscopy
使用原子尺度振動光譜學(xué)對同位素擴散的成像
12.All-perovskite tandem solar cells with improved grain surface passivation
全綠化晶狀體串聯(lián)太陽能電池，具有改善的晶粒表面鈍化
13.Biocatalytic oxidative cross-coupling reactions for biaryl bond formation
雙芳香鍵形成的生物催化氧化交叉偶聯(lián)反應(yīng)
14.A wet heterogeneous mantle creates a habitable world in the Hadean
一個濕的異質(zhì)地幔在哈迪恩創(chuàng)造了一個可居住的世界
15.The Mesozoic terminated in boreal spring
中生代在北方春季終止
16.Genetic associations of protein-coding variants in human disease
人類疾病中蛋白質(zhì)編碼變體的遺傳關(guān)聯(lián)
17.Determinants of emissions pathways in the coupled climate–social system
結(jié)合氣候 - 社會系統(tǒng)中排放途徑的決定因素
18.A global timing mechanism regulates cell-type-specific wiring programmes
全球定時機制調(diào)節(jié)細胞類型特定的接線程序
19.A biophysical account of multiplication by a single neuron
單個神經(jīng)元繁殖的生物物理說明
20.TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A
TDP-43抑制FTD – ALS基因UNC13A中的隱性外顯子包含
21.TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A
TDP-43損失和ALS風(fēng)險SNP驅(qū)動UNC13A的錯誤拼接和耗盡
22.The lung microbiome regulates brain autoimmunity
肺微生物組調(diào)節(jié)腦自身免疫性
23.The cGAS–STING pathway drives type I IFN immunopathology in COVID-19
Covid-19中CGA-sting途徑驅(qū)動I型IFN的免疫病理學(xué)
24.Twin study reveals non-heritable immune perturbations in multiple sclerosis
雙胞胎研究揭示了多發(fā)性硬化癥中無遺物的免疫擾動
25.Low-dose metformin targets the lysosomal AMPK pathway through PEN2
低劑量二甲雙胍通過PEN2靶向AMPK途徑溶菌酶
26.Effective drug combinations in breast, colon and pancreatic cancer cells
乳腺癌，結(jié)腸和胰腺癌細胞中的有效藥物組合
27.Structure and receptor recognition by the Lassa virus spike complex
LASSA病毒尖峰復(fù)合物的結(jié)構(gòu)和受體識別
28.Structural architecture of the human NALCN channelosome
人類NALCN通道體的結(jié)構(gòu)
29.Self-assembly of molecules triggered by electricity
由電觸發(fā)的分子的自組裝
30.Epstein–Barr virus sparks brain autoimmunity in multiple sclerosis
Epstein–Barr病毒在多發(fā)性硬化癥中激發(fā)腦自身免疫性
31.Light arrays measure up on a chip the size of a fingertip
光陣列在指尖大小的芯片上測量
32.Letters and cards telling people about local police reduce crime
信件和卡告訴人們當?shù)鼐斓男畔p少犯罪
33.AI minds the gap and fills in missing Greek inscriptions
AI注意到差距并填補了缺少的希臘銘文
34.AGN as potential factories for eccentric black hole mergers
AGN作為偏心黑洞合并的潛在工廠
35.Ultra-narrow optical linewidths in rare-earth molecular crystals
稀土分子晶體中的超窄光線寬度
36.Structure of the moiré exciton captured by imaging its electron and hole
通過成像其電子和孔捕獲的Moiré激子的結(jié)構(gòu)
37.A large-scale microelectromechanical-systems-based silicon photonics LiDAR
大規(guī)模微電機電系統(tǒng)基于硅光子劑激光雷達
38.Vertical MoS2 transistors with sub-1-nm gate lengths
垂直MOS2晶體管，具有亞1-nm柵極長度
39.Electron-catalysed molecular recognition
電子催化分子識別
40.Au–Pd separation enhances bimetallic catalysis of alcohol oxidation
Au – Pd分離增強了酒精氧化的雙金屬催化
41.Weak cubic CaSiO3 perovskite in the Earth’s mantle
地幔上的薄弱立方CaSiO3鈣鈦礦
42.Restoring and attributing ancient texts using deep neural networks
使用深神經(jīng)網(wǎng)絡(luò)恢復(fù)和歸屬古代文本
43.Innovative ochre processing and tool use in China 40,000 years ago
40，000年前，中國創(chuàng)新的Ocher加工和工具使用
44.Ancient DNA and deep population structure in sub-Saharan African foragers
撒哈拉以南非洲覓食者的古代DNA和深層人口結(jié)構(gòu)
45.Knowledge about others reduces one’s own sense of anonymity
對他人的知識減少了自己的匿名感
46.Differential mechanisms underlie trace and delay conditioning in Drosophila
差異機制是果蠅中的痕量和延遲調(diào)節(jié)的基礎(chǔ)
47.Molecular hallmarks of heterochronic parabiosis at single-cell resolution
單細胞分辨率的異核拋物線的分子標志
48.The bacterial toxin colibactin triggers prophage induction
細菌大腸菌素觸發(fā)噬菌體誘導(dǎo)
49.Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM
多發(fā)性硬化癥中的克隆膨脹的B細胞結(jié)合EBV EBNA1和GlialCAM
50.A trispecific antibody targeting HER2 and T cells inhibits breast cancer growth via CD4 cells
靶向HER2和T細胞的三抗抗體通過CD4細胞抑制乳腺癌的生長
51.Silent mutations reveal therapeutic vulnerability in RAS Q61 cancers
無聲突變揭示了RAS Q61癌癥中的治療脆弱性
52.Structural basis for mismatch surveillance by CRISPR–Cas9
CRISPR – CAS9的不匹配監(jiān)視的結(jié)構(gòu)基礎(chǔ)
53.Aquaculture will continue to depend more on land than sea
水產(chǎn)養(yǎng)殖將繼續(xù)更多地依賴土地而不是海洋
54.Savannahs store carbon despite frequent fires
盡管經(jīng)常發(fā)生火災(zāi)，熱帶稀樹草原仍然儲存碳
55.Methane might be made by all living organisms
甲烷可能是所有生物體制造的
56.Superfluid confines exotic atoms without disrupting precision measurements
超流體限制外來原子而不會破壞精度測量
57.AI predicts the effectiveness and evolution of gene promoter sequences
AI預(yù)測基因啟動子序列的有效性和演變
58.The land-to-ocean loops of the global carbon cycle
全球碳循環(huán)的土地到海洋循環(huán)
59.High-resolution laser resonances of antiprotonic helium in superfluid 4He
超氟4HE中抗磷酸氦的高分辨率激光共振
60.Unbiasing fermionic quantum Monte Carlo with a quantum computer
公正的費米量子蒙特卡洛與量子計算機
61.Steady Floquet–Andreev states in graphene Josephson junctions
石墨烯Josephson連接中的穩(wěn)定的floquet -andreev狀態(tài)
62.Wind dispersal of battery-free wireless devices
無電池?zé)o線設(shè)備的風(fēng)散
63.Flat-surface-assisted and self-regulated oxidation resistance of Cu(111)
Cu（111）的平表面輔助和自調(diào)節(jié)的氧化抗性
64.A kinase-cGAS cascade to synthesize a therapeutic STING activator
激酶-cGAS級聯(lián)反應(yīng)，以合成治療性STING激活劑
65.Limited increases in savanna carbon stocks over decades of fire suppression
數(shù)十年來的滅火，稀樹草納碳儲備的增加有限
66.New land-use-change emissions indicate a declining CO2 airborne fraction
新的土地利用變化排放表明二氧化碳的空氣降低分數(shù)下降
67.The evolution, evolvability and engineering of gene regulatory DNA
基因調(diào)節(jié)DNA的進化，發(fā)展性和工程化
68.Cortical processing of flexible and context-dependent sensorimotor sequences
柔性和上下文依賴的感覺運動序列的皮質(zhì)處理
69.FSH blockade improves cognition in mice with Alzheimer’s disease
FSH封鎖改善了阿爾茨海默氏病小鼠的認知
70.A non-canonical tricarboxylic acid cycle underlies cellular identity
非經(jīng)典三羧酸周期是細胞身份的基礎(chǔ)
71.Methane formation driven by reactive oxygen species across all living organisms
甲烷形成由所有生物體中的活性氧驅(qū)動
72.T cell responses to SARS-CoV-2 spike cross-recognize Omicron
T 細胞對 SARS-CoV-2 刺突的反應(yīng)交叉識別 Omicron
73.Vaccines elicit highly conserved cellular immunity to SARS-CoV-2 Omicron
疫苗對SARS-COV-2 Omicron產(chǎn)生高度保守的細胞免疫力
74.Establishment of fetomaternal tolerance through glycan-mediated B cell suppression
通過聚糖介導(dǎo)的B細胞抑制建立胎兒耐受性
75.Ribosome collisions induce mRNA cleavage and ribosome rescue in bacteria
核糖體碰撞誘導(dǎo)細菌中的mRNA裂解和核糖體救援
76.Bacterial ribosome collision sensing by a MutS DNA repair ATPase paralogue
細菌核糖體通過MutS DNA修復(fù)ATP酶旁系同源物感測碰撞
77.Discovery of a Ni2+-dependent guanidine hydrolase in bacteria
在細菌中發(fā)現(xiàn)Ni2+依賴性鳥嘌呤水解酶
78.Overcoming universal restrictions on metal selectivity by protein design
克服蛋白質(zhì)設(shè)計對金屬選擇性的普遍限制
79.Structure determination of high-energy states in a dynamic protein ensemble
在動態(tài)蛋白質(zhì)組裝中的高能狀態(tài)的結(jié)構(gòu)測定
80.The size of the land carbon sink in China
中國土地碳匯的大小
81.Reply to: The size of the land carbon sink in China
回復(fù)：中國的土地碳匯的大小
82.On the role of atmospheric model transport uncertainty in estimating the Chinese land carbon sink
大氣模型傳輸不確定性在估算中國陸地碳匯中的作用
83.Reply to: On the role of atmospheric model transport uncertainty in estimating the Chinese land carbon sink
回復(fù)：大氣模型傳輸不確定性在估算中國陸地碳匯中的作用
84.Trade-offs between stability and manoeuvrability in bird flight
在鳥類飛行中的穩(wěn)定性與可操作性之間的權(quán)衡
85.A stellar clock reveals the assembly history of the Milky Way
恒星時鐘揭示了銀河系的組裝歷史
86.Immune cells alter genetic decoding in cancer
免疫細胞改變癌癥中的遺傳解碼
87.Promising reversible protein inhibitors kept on target
保持在靶標上的潛力可逆蛋白抑制劑
88.A smart sensor that can be woven into everyday life
可以編織到日常生活的智能傳感器
89.Human genetic and immunological determinants of critical COVID-19 pneumonia
人類遺傳和免疫決定covid-19肺炎的關(guān)鍵
90.A time-resolved picture of our Milky Way’s early formation history
我們銀河系早期形成歷史的時間分辨圖片
91.Optimal metrology with programmable quantum sensors
具有可編程量子傳感器的最佳計量器
92.Emergence of Fermi arcs due to magnetic splitting in an antiferromagnet
由于反鐵磁體中的磁分裂引起的費米弧的出現(xiàn)
93.Single fibre enables acoustic fabrics via nanometre-scale vibrations
單光纖通過納米尺度振動啟用聲學(xué)織物
94.High-brightness all-polymer stretchable LED with charge-trapping dilution
高亮度全聚合物可拉伸的帶電荷陷阱稀釋LED
95.Metastable hexagonal close-packed palladium hydride in liquid cell TEM
液池 TEM 中的亞穩(wěn)態(tài)六方密排氫化鈀
96.Boron clusters as broadband membrane carriers
硼簇作為寬帶膜載體
97.Geophysical imaging of the Yellowstone hydrothermal plumbing system
黃石水熱管系統(tǒng)的地球物理成像
98.Birds can transition between stable and unstable states via wing morphing
鳥可以通過機翼變形在穩(wěn)定狀態(tài)和不穩(wěn)定狀態(tài)之間過渡
99.Reproducible brain-wide association studies require thousands of individuals
可再現(xiàn)的腦范圍協(xié)會研究需要數(shù)千個人
100.Frontal neurons driving competitive behaviour and ecology of social groups
額葉神經(jīng)元推動社會群體的競爭行為和生態(tài)
101.Cortical ensembles orchestrate social competition through hypothalamic outputs
皮質(zhì)組裝通過下丘腦輸出協(xié)調(diào)社會競爭
102.Immune regulation by fungal strain diversity in inflammatory bowel disease
通過真菌菌株多樣性在炎癥性腸病中的免疫調(diào)節(jié)
103.Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa
南部非洲SARS-COV-2 Omicron變體的快速流行病擴展
104.SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters
SARS-COV-2 Omicron病毒導(dǎo)致小鼠和倉鼠衰弱疾病
105.Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron
SARS-COV-2 B.1.1.529 Omicron的衰減復(fù)制和致病性
106.Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant
SARS-COV-2 Omicron變體的減毒融合性和致病性
107.Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
SARS-COV-2 Omicron使用的TMPRSS2改變了感染力和融合性
108.SARS-CoV-2 Omicron variant replication in human bronchus and lung ex vivo
SARS-COV-2 Omicron變體在人支氣管和離體肺中的復(fù)制
109.Tryptophan depletion results in tryptophan-to-phenylalanine substitutants
色氨酸耗竭會導(dǎo)致色氨酸作為苯丙氨酸取代基
110.A genome-scale screen for synthetic drivers of T cell proliferation
T細胞增殖的合成驅(qū)動因素的基因組規(guī)模篩選
111.Regulation of liver subcellular architecture controls metabolic homeostasis
肝臟亞細胞體系結(jié)構(gòu)的調(diào)節(jié)控制代謝穩(wěn)態(tài)
112.Activation mechanism of the class D fungal GPCR dimer Ste2
D類真菌GPCR二聚體Ste2的激活機制
113.[{Th(C8H8)Cl2}3]2? is stable but not aromatic
[{Th(C8H8)Cl2}3]2-是穩(wěn)定但不是芳香的
114.Reply to: [{Th(C8H8)Cl2}3]2? is stable but not aromatic
回復(fù)：[{Th(C8H8)Cl2}3]2-是穩(wěn)定但不是芳香的
115.Models of flow through sponges must consider the sponge tissue
海綿的流動模型必須考慮海綿組織
116.Reply to: Models of flow through sponges must consider the sponge tissue
回復(fù)：海綿的流動模型必須考慮海綿組織
117.Bacteria swim faster when obstacles keep them in line
當障礙使它們排隊時，細菌游泳更快
118.Mobile mantle could explain volcanic hotspot locations
移動地?？梢越忉尰鹕綗狳c位置
119.Mucus secretion blocked at its source in the lungs
粘液分泌在其肺部的來源阻塞
120.From the archive: fishy business in 1972 and 1922
來自檔案：1972年和1922年的魚腥生意
121.Constrained human genes under scrutiny
受到審查的受約束人基因
122.Critical advances and future opportunities in upcycling commodity polymers
升級再造商品聚合物的關(guān)鍵進展和未來機會
123.A highly magnified star at redshift 6.2
紅移 6.2的高度放大恒星
124.The colloidal nature of complex fluids enhances bacterial motility
復(fù)合液的膠體性質(zhì)增強了細菌運動能力
125.Catalogue of flat-band stoichiometric materials
平板化學(xué)計量材料目錄
126.Orbital-resolved visualization of single-molecule photocurrent channels
單分子光電流通道的軌道分辨可視化
127.Observing polymerization in 2D dynamic covalent polymers
觀察2D動態(tài)共價聚合物中的聚合
128.Trends in Europe storm surge extremes match the rate of sea-level rise
歐洲暴風(fēng)雨極端的趨勢與海平面上升的速度相匹配
129.Assembly of the basal mantle structure beneath Africa
非洲下基礎(chǔ)地幔結(jié)構(gòu)的組裝
130.Subaqueous foraging among carnivorous dinosaurs
食肉恐龍中的水下覓食
131.Reduced reproductive success is associated with selective constraint on human genes
繁殖成功率降低與對人類基因的選擇性約束有關(guān)
132.Machine learning and phone data can improve targeting of humanitarian aid
機器學(xué)習(xí)和電話數(shù)據(jù)可以改善人道主義援助的目標
133.The development and evolution of inhibitory neurons in primate cerebrum
靈長類動物大腦中抑制性神經(jīng)元的發(fā)展和演變
134.A multidimensional coding architecture of the vagal interoceptive system
迷走神經(jīng)內(nèi)感受系統(tǒng)的多維編碼體系結(jié)構(gòu)
135.A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk
人類腦血管的地圖集揭示了阿爾茨海默氏癥風(fēng)險的各種介體
136.Single-cell dissection of the human brain vasculature
人腦脈管系統(tǒng)的單細胞解剖
137.Bacterial inhibition of Fas-mediated killing promotes neuroinvasion and persistence
FAS介導(dǎo)的殺傷的細菌抑制可促進神經(jīng)侵襲和持久性
138.Human gut bacteria produce ΤΗ17-modulating bile acid metabolites
人腸道細菌產(chǎn)生ΤΗ17調(diào)節(jié)膽汁酸代謝物
139.ACE2 binding is an ancestral and evolvable trait of sarbecoviruses
ACE2結(jié)合是sarbecoviruses的祖先和可發(fā)展的特征
140.Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants
來自三重疫苗的記憶B細胞針對不同的SARS-CoV-2變體
141.A single-cell atlas of human and mouse white adipose tissue
人和小鼠白色脂肪組織的單細胞地圖集
142.GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas
H3K27M突變的彌漫性中線神經(jīng)膠質(zhì)瘤的GD2-CAR T細胞療法
143.Nivolumab plus chemotherapy or ipilimumab in gastro-oesophageal cancer
胃癌中Nivolumab加化學(xué)療法或ipilimumab
144.Inhibition of calcium-triggered secretion by hydrocarbon-stapled peptides
通過碳氫化合物肽抑制鈣觸發(fā)的分泌
