摘要

B細(xì)胞生物學(xué)的多個(gè)檢查點(diǎn)中，通過B細(xì)胞受體(BCR)傳導(dǎo)的信號(hào)起著關(guān)鍵作用。比如，BCR在骨髓(BM)的早期發(fā)育過程中扮演守門人的角色；在克隆刪除和受體編輯等觸發(fā)機(jī)制中也不可替代，能消除自身反應(yīng)性B細(xì)胞；外周循環(huán)時(shí)，最重要的一項(xiàng)功能是作為受體識(shí)別各種細(xì)胞外抗原，包括應(yīng)對(duì)細(xì)菌和病毒感染，來增強(qiáng)宿主防御能力（BCR對(duì)抗原的識(shí)別是獲得T細(xì)胞幫助幼稚B細(xì)胞向漿細(xì)胞、生發(fā)中心B細(xì)胞和記憶B細(xì)胞分化的第一步）；此外，類似于在B細(xì)胞發(fā)育早期發(fā)揮的作用，BCR信號(hào)在防止自身反應(yīng)性B細(xì)胞的異常激活中也意義重大，因?yàn)楫惓＜せ羁烧T導(dǎo)次級(jí)淋巴器官相關(guān)的自身免疫生成。BCR對(duì)于B細(xì)胞正確地激發(fā)免疫反應(yīng)必不可少，通過BCR的信號(hào)也受到細(xì)胞內(nèi)正負(fù)調(diào)控因子的嚴(yán)格控制。在這一章中，根據(jù)最新的研究，我們對(duì)BCR信號(hào)的激活和抑制機(jī)制進(jìn)行了綜述。

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關(guān)鍵詞

#B cell receptor #Calcium signal #NF-κB #MAPK #PI3K #SHP #SHIP

#B細(xì)胞受體 #鈣信號(hào) #NF-κB #MAPK #PI3K #SHP #SHIP

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