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NH2-PEG-NH2雙端氨基聚乙二醇,應用于多肽,蛋白等藥物分子修飾

2023-01-03 15:55 作者:WEIHUASW1  | 我要投稿

NH2-PEG-NH2氨基聚乙二醇氨基儲存條件2-8°C,溶解度:溶于大部分有機溶劑,不溶于水

形態(tài):白色固體粉末狀,或粘稠液體取決于PEG分子量。

NH2-PEG-NH2是一類同雙官能團修飾劑,可用于靶向藥物研究并廣泛應用于蛋白載體及配基的交聯(lián)等。產品的氨基端,對于?;噭┗钚员攘u基高,它很容易進行還原氨基化反應。應用氨基的反應活性,容易進行還原氨基化反應,生成穩(wěn)定的化學鍵如酰胺鍵,氨基甲酸酯鍵,脲鍵和仲胺鍵等,把另一些分子和其連接。廣泛應用于多肽,蛋白等藥物分子的修飾。

為華生物NH2-PEG-NH2氨基聚乙二醇氨基可用于:制備帶有生物活性化合物的配體;多肽合成時的載體;制備高分子接枝物等等。

注意事項:NH2-PEG-NH2氨基聚乙二醇氨基易吸潮,取用前需放置室溫后再打開包裝取用防止吸潮,吸潮后活性會降低直至完全失去活性,請務必保持干燥,同時盡量避免頻繁的溶解和凍干。

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為華生物NH2-PEG-NH2結構式


Nh2-peg-nh2 amino polyethylene glycol amino storage conditions 2-8 ° C, solubility: soluble in most organic solvents, insoluble in water

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Form: white solid powder, or viscous liquid, depending on the molecular weight of PEG.

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Nh2-peg-nh2 is a kind of bifunctional modifier, which can be used in targeted drug research and widely used in protein carrier and ligand crosslinking. The amino end of the product is more active than the hydroxyl group for the acylation reagent, and it is easy to carry out the reductive amino reaction. Using the reactive activity of amino groups, it is easy to carry out reductive amino reactions, generate stable chemical bonds such as amide bonds, carbamate bonds, urea bonds and secondary amine bonds, and connect other molecules with them. It is widely used in the modification of drug molecules such as polypeptides and proteins.

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The nh2-peg-nh2 amino polyethylene glycol amino group of sinobio can be used to: prepare ligands with bioactive compounds; Carrier for polypeptide synthesis; Preparation of polymer grafts and the like.

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Precautions: nh2-peg-nh2 amino polyethylene glycol amino group is easy to absorb moisture. Before taking it, it needs to be placed at room temperature before opening the package to prevent moisture absorption. After moisture absorption, the activity will decrease until it completely loses its activity. Please keep it dry and avoid frequent dissolution and lyophilization.


NH2-PEG-NH2雙端氨基聚乙二醇,應用于多肽,蛋白等藥物分子修飾的評論 (共 條)

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