[ 摘要 ] 注射劑作為一種特殊的藥物劑型，具有起效快、定位準等優(yōu)點，因而被廣泛應用于臨床。隨著臨床應用需求的增多，在傳統(tǒng)注射劑的
基礎上，許多新型注射劑應運而生。脂質體、混懸劑、納米粒、微球和包合物等注射給藥系統(tǒng)的出現，不僅減少了藥物在體內外的降解，還具
有緩釋、控釋的優(yōu)點，受到研究人員密切關注。重點介紹了幾種新型注射劑的特點，并對國內外已上市和在研的新型注射劑進行簡要介紹，旨
在為其深度開發(fā)提供參考。
[ 關鍵詞 ] 新型注射劑；緩控釋給藥系統(tǒng)；脂質體；納米粒

[Abstract] As a special pharmaceutical dosage form, injectable products have the advantages of quick onset of action and accurate positioning,
and ?thus ?have ?been ?widely ?used ?in ?clinical ?practice. With ?increased ?clinical ?demand, ?many ?novel ?injections ?have ?been ?developed ?on ?the ?basis ?
of ?traditional ?injections. The ?emergence ?of ?novel ?injection ?delivery ?systems ?such ?as ?liposomes, ?suspensions, ?nanoparticles, ?microspheres ?and ?
inclusion ?complexes ?not ?only ?reduces ?drug ?degradation ?in ?vitro ?and ?in ?vivo ?but ?also ?achieves ?sustained ?and ?controlled ?release, ?receiving ?close ?
attention from researchers. This article focuses on the characteristics of several novel injections and briefly introduces novel injections that have
been marketed or under clinical development at home and abroad, so as to provide reference for their further development.
[Key words] novel injection; sustained- and controlled-release drug delivery system; liposome; nanoparticle