腸道菌群對(duì)藥物代謝的影響

The metabolic effect of gut microbiota on Drugs

腸道菌群對(duì)藥物的代謝作用。

Drug Metabolism Reviews(IF4.518)Pub Date : 2020-03-02, DOI:10.1080/03602532.2020.1718691

Yuan Xie1, 2, Fangdi Hu1, Dawei Xiang2, Hui Lu2, Wenbin Li2, Anpeng Zhao2, Longji Huang1, 2, Rong Wang1, 2

Affiliation

人的腸道內(nèi)存在1000多種微生物，其中約有1014種微生物。腸道菌群作為人類的隱形器官，通?？梢酝ㄟ^(guò)產(chǎn)生特定的酶（例如還原酶和水解酶）參與藥物代謝，從而影響藥物的功效，毒性和生物利用度。已顯示至少30種市售藥物是腸道微生物衍生的酶的底物，越來(lái)越多的藥物可能在改善釋放系統(tǒng)或不良溶解性/通透性的幫助下與遠(yuǎn)端腸道接觸，更多的藥物預(yù)計(jì)將通過(guò)腸道菌群代謝。通過(guò)收集參與合成藥物和中藥成分代謝的腸道菌群實(shí)例，本文為將來(lái)的研究者研究腸道菌群的藥物代謝提供了全面的參考。值得注意的是，腸道菌群的組成和數(shù)量因人而異，并可能受到某些藥物管理（例如抗生素）或環(huán)境變化（急性高原缺氧）的影響。這似乎表明腸道菌群有可能成為新的藥物靶標(biāo)，從而影響可被腸道菌群代謝的藥物的功效。因此，了解腸道菌群對(duì)藥物代謝的影響并闡明藥物轉(zhuǎn)化過(guò)程，對(duì)于指導(dǎo)合理的臨床使用，個(gè)體化使用，毒理學(xué)評(píng)價(jià)，促進(jìn)藥物發(fā)現(xiàn)和開(kāi)發(fā)具有重要意義。腸道菌群的組成和數(shù)量因人而異，并可能受到某些藥物管理（例如抗生素）或環(huán)境變化（急性高原缺氧）的影響。這似乎表明腸道菌群有可能成為新的藥物靶標(biāo)，從而影響可被腸道菌群代謝的藥物的功效。因此，了解腸道菌群對(duì)藥物代謝的影響并闡明藥物轉(zhuǎn)化過(guò)程，對(duì)于指導(dǎo)合理的臨床使用，個(gè)體化使用，毒理學(xué)評(píng)價(jià)，促進(jìn)藥物發(fā)現(xiàn)和開(kāi)發(fā)具有重要意義。腸道菌群的組成和數(shù)量因人而異，并可能受到某些藥物管理（例如抗生素）或環(huán)境變化（急性高原缺氧）的影響。這似乎表明腸道菌群可能會(huì)成為新的藥物靶標(biāo)，從而影響可被腸道菌群代謝的藥物的功效。因此，了解腸道菌群對(duì)藥物代謝的影響并闡明藥物轉(zhuǎn)化過(guò)程，對(duì)于指導(dǎo)合理的臨床使用，個(gè)體化使用，毒理學(xué)評(píng)價(jià)以及促進(jìn)藥物發(fā)現(xiàn)和開(kāi)發(fā)具有重要意義。這似乎表明腸道菌群可能會(huì)成為新的藥物靶標(biāo)，從而影響可被腸道菌群代謝的藥物的功效。因此，了解腸道菌群對(duì)藥物代謝的影響并闡明藥物轉(zhuǎn)化過(guò)程，對(duì)于指導(dǎo)合理的臨床使用，個(gè)體化使用，毒理學(xué)評(píng)價(jià)，促進(jìn)藥物發(fā)現(xiàn)和開(kāi)發(fā)具有重要意義。這似乎表明腸道菌群有可能成為新的藥物靶標(biāo)，從而影響可被腸道菌群代謝的藥物的功效。因此，了解腸道菌群對(duì)藥物代謝的影響并闡明藥物轉(zhuǎn)化過(guò)程，對(duì)于指導(dǎo)合理的臨床使用，個(gè)體化使用，毒理學(xué)評(píng)價(jià)以及促進(jìn)藥物發(fā)現(xiàn)和開(kāi)發(fā)具有重要意義。

The metabolic effect of gut microbiota on Drugs.

There are more than 1000 species of microbes reside in the human gut, umbering～1014 microbes. As the invisible organ of human beings, gut microbiota can usually participate in Drug metabolism by producing specific enzymes, such as reductase and hydrolytic enzyme, thus affecting the efficacy, toxicity, and bioavailability of Drugs. At least 30 commercially available Drugs have been shown to be substrates of gut microbes-derived enzymes, and an increasing number of Drugs may have the potential to contact with the distal gut with the help of improved release systems or poor solubility/permeability, more Drugs are expected to be found to be metabolized through the gut flora. By collecting examples of intestinal flora participating in the metabolism of synthetic Drugs and traditional Chinese medicine components, this article provides a comprehensive reference for future researchers to study Drug metabolism by intestinal flora. Noticeably, the composition and quantity of intestinal flora varies among individuals, and can be affected by some Drug administration (such as antibiotics) or environmental changes (acute plateau hypoxia). This seems to suggest that intestinal flora could have the potential to be a new Drug target to affect the efficacy of Drugs which can be metabolized by Intestinal flora. Accordingly, understanding the impact of intestinal flora on Drug metabolism and clarifying the Drug transformation process is of great significance for?guiding rational clinical use, individualized use, toxicological evaluation, and promoting Drug discovery and development.

發(fā)布于 2022-05-24 21:08