A highly sensitive biomarker for the production of Aβ 1-42 derived from the βAPP-like protein APLP1. The peptide is generated by the same proteolytic mechanism as Aβ42. Non-amyloidogenic APL1β28 can be detected in the CSF and its levels correlate with Aβ42 production. Its ratio to total APL1β (APL1β25, APL1β27, and APL1β28) is significantly increased in familial and sporadic cases of AD.

從β app樣蛋白APLP1衍生的Aβ 1-42生產的高度敏感的生物標志物。該肽的產生機制與Aβ42相同。在腦脊液中可以檢測到非淀粉樣性APL1β28，其水平與Aβ42的產生相關。它與總APL1β (APL1β25、APL1β27和APL1β28)的比值在家族性和散發(fā)性AD病例中顯著增加。

編號: 110157
中文名稱: APL1β28
英文名: APL1β28
英文同義詞: APLP1-derived Aβ-like peptide (1-28)
CAS號: 1233876-42-0
單字母: H2N-DELAPAGTGVSREAVSGLLIMGAGGGSL-OH
三字母: H2N-Asp-Glu-Leu-Ala-Pro-Ala-Gly-Thr-Gly-Val-Ser-Arg-Glu-Ala-Val-Ser-Gly-Leu-Leu-Ile-Met-Gly-Ala-Gly-Gly-Gly-Ser-Leu-COOH
氨基酸個數(shù): 28
分子式: C109H185N31O39S1
平均分子量: 2585.88
精確分子量: 2584.32
等電點(PI): 3.93
pH=7.0時的凈電荷數(shù): -2.02
平均親水性: -0.14
疏水性值: 0.53
來源: 人工化學合成，僅限科學研究使用，不得用于人體。
儲存條件: 負80℃至負20℃
標簽: 淀粉樣肽(Amyloid Peptides)