“Sodium thioethamyl”

sodium isoamylethylthiobarbiturate

The basal narcotic known as sodium thioethamyl was submitted by manufacturers(Messrs.Parke,Davis and Co.)to the joint Anaesthetics?Section of the Research Council and the Anaethetics Section of the Royal Society of Medicine,through the Therapeutic Trials Committee of the Medical Research Council.

異戊硫巴比妥鈉作為常用麻醉劑由派克戴維斯公司(Messrs.Parke,Davis and Co.)研發(fā)生產(chǎn)。經(jīng)英國醫(yī)學研究學會治療試驗委員會(Therapeutic?Trials?Committee?of the?Medical Research?Council)批準作為麻醉科研究委員會(Anaesthetics?Section?of the?Research Council)和英國皇家醫(yī)學會麻醉科(Anaethetics Section of the?Royal Society?of Medicine)的交接項目。

Composition and Prooerties?構成及藥用價值

Sodium thioethamyl is the trade name for sodium isoamylethylthiobarbiturate.This preparation is therefore the sulphur homologue of sodium isoamylethylbarbiturate(sodium amytal).It is supplied as a yellow powder in 1.5 gramme glass capsules.

異戊硫巴比妥鈉是異戊基-乙硫基-巴比妥類-鈉的商品名。因而該制劑是異戊硫巴比妥鈉(異戊巴比妥鈉)的硫同系物。 一般制成黃色粉劑裝在1.5克玻璃膠囊里。

The powder is readily soluble in water,giving off a gas smelling of sulphuretted hydrogen and yielding a clear straw-coloured solutions.

該粉劑可溶于水。溶解后表現(xiàn)為透明的淡黃色溶液，并釋放出硫化氫氣味的氣體。

The recommended concentration is a 10 percent.solution,so that? 15 c.cm. of distilled water are required for each ampoule of powder.

配劑時濃度應控制在10％，單個安瓿瓶裝粉末應使用流量為15cc/min的蒸餾水進行稀釋。

I found it better,however,to dissolve the contents of each ampoule in 20 c.cm.of distilled water:not only is this more convenient,but the resulting 7.5 persent.solution appeared to cause less depression of the respiratory and circulatory system.

然而，經(jīng)對照發(fā)現(xiàn)，20cc/min的蒸餾水更適合作為溶劑：不僅更便利，而且7.5％濃度制劑對呼吸和循環(huán)系統(tǒng)的抑制相對較小。

Pharmacology 藥理學

The pharmacology and toxicity of sodium thioethamyl have been investigated in America by Gruber(1937a,1937b),Gruhzit et al.(1937),and Burstein and Rovenstine(1938).It is concluded that the substance behaves in a very similar manner to the other well-known short-acting barbiturates,and that in cats the safety factor(ratio of minimal lethal dose to minimal anaesthetic dose)is 3.75 to 1.

對異戊硫巴比妥鈉的藥理及毒理學研究已由Gruber(1937a,1937b),Gruhzit研究組(1937),Burstein,Rovenstine(1938).完成。結論為該制劑的作用方式與其他同類常用短效巴比妥制劑非常類似，進行動物實驗時，安全系數(shù)（最小致死劑量與最小麻醉劑量之比）為 3.75 比 1。

Administration in Man 禁忌事項

A freshly prepared 7.5 per cent.solution is injected intravenously in exactly the same way,and observing the same precautions,as in the case of evipan sodium and pentothal sodium.

預制7.5%溶液和環(huán)己巴比妥、硫噴妥鈉同采用間歇靜脈注射，并遵守相同的預防措施。

About 100 administrations were given(by Dr.J.Hunter,Dr.C.Langton Hewer,and Dr.E.Landau),and it would appear that the effects are almost indistinguishable from those obtained with sodium ethyl[1-methylbutyl] thiobarbiturate(pentothal sodium).

（Dr.J.Hunter,Dr.C.Langton Hewer,and Dr.E.Landau)給出了100個禁忌事項，幾乎完全與乙基鈉[1-甲基丁酯]硫巴比妥〔酸〕鹽(硫噴妥鈉)一致。

in a view of the fact that similar results with sodium thioethamyl have already been recorded in America(by Cullen and Rovenstine,1938),it seemed unecessary to make a more extensive investigation or to prepare a more detailed report.

鑒于類似結論已由美國學者(Cullen&Rovenstine,1938)得出，之于異戊硫巴比妥鈉的詳細調查報告已經(jīng)不甚必要了。

The conclusion was reached that,so far as our present knowledge extends,sodium thioethamyl is a useful drug,and can satisfactorily be used as a short-acting barbiturate by intravenous injection.Its greatest use is for basal narcosis immediately preceding general anaesthesia or as repeated doses.

結論指出，就我們目前所知，異戊硫巴比妥鈉可作為用以靜脈注射的短效巴比妥藥物。作為基礎麻醉劑或二次麻醉劑進行全身麻醉前同樣有顯著功效。

Since the drug contains a sulphur atom in its molecule it should not be used on patient receving sulphanilamide preparations.This contraindication should be added to those already well known as applying to the short-acting barbiturates generally.

由于該藥物分子中含有硫原子，因此不適用于正在攝入磺胺類藥物的患者。這一禁忌應添加常用短效巴比妥類藥物的禁忌事項中。

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