聲明：本專(zhuān)欄主要對(duì)生命科學(xué)領(lǐng)域的一些期刊文章標(biāo)題進(jìn)行翻譯，所有內(nèi)容均由本人手工整理翻譯。由于本人專(zhuān)業(yè)為生物分析相關(guān)，其他領(lǐng)域如果出現(xiàn)翻譯錯(cuò)誤請(qǐng)諒解。

1.Peritumoural immunomodulatory scaffolds. This issue highlights an anti-CD98 antibody with pH-dependent binding for antitumour therapy, cytotoxic CAR T cells derived from human induced pluripotent stem cells with enhanced proliferation and persistency in solid tumours, intragastrically delivered polymeric micelles releasing butyrate for the restoration of barrier-protective responses in mouse models of gut inflammation, peritumourally implanted immunomodulatory macroporous scaffolds providing systemic antitumour immunity, and pathogen-mimicking polymer nanoparticles inducing T-helper-17-cell-mediated antitum.

瘤周免疫調(diào)節(jié)支架。本期重點(diǎn)介紹了用于抗腫瘤治療的具有 pH 依賴(lài)性結(jié)合的抗 CD98 抗體、源自人誘導(dǎo)多能干細(xì)胞的細(xì)胞毒性 CAR T 細(xì)胞（在實(shí)體瘤中具有增強(qiáng)的增殖和持久性）、胃內(nèi)遞送的聚合膠束釋放丁酸鹽以恢復(fù)屏障保護(hù)腸道炎癥小鼠模型中的反應(yīng)、瘤周植入的免疫調(diào)節(jié)大孔支架提供全身抗腫瘤免疫，以及誘導(dǎo) T-helper-17 細(xì)胞介導(dǎo)的抗腫瘤的模擬病原體聚合物納米顆粒。

2.An anti-CD98 antibody displaying pH-dependent Fc-mediated tumour-specific activity against multiple cancers in CD98-humanized mice.

一種抗 CD98 抗體，在 CD98 人源化小鼠中表現(xiàn)出針對(duì)多種癌癥的 pH 依賴(lài)性 Fc 介導(dǎo)的腫瘤特異性活性。

3.Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells.

源自人類(lèi)誘導(dǎo)多能干細(xì)胞的 CAR T 細(xì)胞增殖和持久性的優(yōu)化。

4.Treatment of peanut allergy and colitis in mice via the intestinal release of butyrate from polymeric micelles.

通過(guò)聚合膠束在腸道中釋放丁酸鹽來(lái)治療小鼠花生過(guò)敏和結(jié)腸炎。

5.Systemic enhancement of antitumour immunity by peritumourally implanted immunomodulatory macroporous scaffolds.

通過(guò)瘤周植入免疫調(diào)節(jié)大孔支架全身增強(qiáng)抗腫瘤免疫力。

6.Induction of T-helper-17-cell-mediated anti-tumour immunity by pathogen-mimicking polymer nanoparticles.

通過(guò)模仿病原體的聚合物納米粒子誘導(dǎo) T 輔助細(xì)胞 17 細(xì)胞介導(dǎo)的抗腫瘤免疫。

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1.A soft robotic ventilator for assisting inspiration. This issue highlights an intravascular infused biomaterial for treating inflammation, an implantable soft robotic ventilator, the intraoperative histology of bone tissue via photoacoustic microscopy and deep learning, neural organoids for spinal-cord regeneration, piezoelectric nanoparticles for deep brain stimulation, receptor agonists with enhanced pharmacokinetics, and alterations in chromatin organization in disease.

用于輔助吸氣的軟體機(jī)器人呼吸機(jī)。本期重點(diǎn)介紹用于治療炎癥的血管內(nèi)灌注生物材料、植入式軟機(jī)器人呼吸機(jī)、通過(guò)光聲顯微鏡和深度學(xué)習(xí)進(jìn)行骨組織的術(shù)中組織學(xué)、用于脊髓再生的神經(jīng)類(lèi)器官、用于深部腦刺激的壓電納米粒子、具有增強(qiáng)藥代動(dòng)力學(xué)的受體激動(dòng)劑，以及疾病中染色質(zhì)組織的改變。

2.Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues.

血管內(nèi)注入細(xì)胞外基質(zhì)作為生物材料，用于靶向和治療發(fā)炎組織。

3.An implantable soft robotic ventilator augments inspiration in a pig model of respiratory insufficiency.

植入式軟機(jī)器人呼吸機(jī)可增強(qiáng)呼吸功能不全的豬模型的吸氣能力。

4.Label-free intraoperative histology of bone tissue via deep-learning-assisted ultraviolet photoacoustic microscopy.

通過(guò)深度學(xué)習(xí)輔助紫外光聲顯微鏡對(duì)骨組織進(jìn)行無(wú)標(biāo)記術(shù)中組織學(xué)分析。

5.A hydrogel-based mechanical metamaterial for the interferometric profiling of extracellular vesicles in patient samples.

一種基于水凝膠的機(jī)械超材料，用于對(duì)患者樣本中的細(xì)胞外囊泡進(jìn)行干涉分析。

6.Deep brain stimulation by blood–brain-barrier-crossing piezoelectric nanoparticles generating current and nitric oxide under focused ultrasound.

通過(guò)跨越血腦屏障的壓電納米顆粒在聚焦超聲下產(chǎn)生電流和一氧化氮來(lái)刺激深部腦部。

7.Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions.

通過(guò)將大環(huán)肽移植到片段可結(jié)晶區(qū)域來(lái)設(shè)計(jì)具有增強(qiáng)藥代動(dòng)力學(xué)的受體激動(dòng)劑。

8.Aberrant chromatin reorganization in cells from diseased fibrous connective tissue in response to altered chemomechanical cues.

患病纖維結(jié)締組織細(xì)胞中響應(yīng)化學(xué)機(jī)械線索改變的異常染色質(zhì)重組。

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1.Hepatocyte-targeting nanoparticles for enhanced hepatobiliary MRI. This issue highlights that hepatobiliary MRI can be enhanced by an ultrasmall nanoparticle targeting hepatocytes, that transmembrane water-efflux rate is a sensitive biomarker of the expression of aquaporin-4, a hydrogel-based metamaterial for profiling extracellular vesicles in patient samples, a near-infrared fluorophore for the imaging of aggregates of amyloid-β and tau through the skull of mice, nanoparticles producing ultrasound-induced afterglow luminescence, a library of renally cleared fluorescence probes for the tracking of tumour-infiltrating leukocytes, liposomal nanoparticles for spatially mapping light in deep tissue via MRI, and a tomographic method for the location of photon pairs produced from high-energy X-rays.

用于增強(qiáng)肝膽 MRI 的肝細(xì)胞靶向納米顆粒。本期強(qiáng)調(diào)，肝膽 MRI 可以通過(guò)靶向肝細(xì)胞的超小納米顆粒得到增強(qiáng)，跨膜水流出率是水通道蛋白 4 表達(dá)的敏感生物標(biāo)志物，水通道蛋白 4 是一種基于水凝膠的超材料，用于分析患者樣本中的細(xì)胞外囊泡，這是一種近乎用于通過(guò)小鼠頭骨對(duì)淀粉樣蛋白-β 和 tau 蛋白聚集體進(jìn)行成像的紅外熒光團(tuán)、產(chǎn)生超聲誘導(dǎo)余輝發(fā)光的納米顆粒、用于跟蹤腫瘤浸潤(rùn)白細(xì)胞的腎清除熒光探針庫(kù)、用于在空間映射光的脂質(zhì)體納米顆粒通過(guò) MRI 探測(cè)深層組織，以及用于定位高能 X 射線產(chǎn)生的光子對(duì)的斷層掃描方法。

2.A hepatocyte-targeting nanoparticle for enhanced hepatobiliary magnetic resonance imaging.

用于增強(qiáng)肝膽磁共振成像的肝細(xì)胞靶向納米顆粒。

3.Transmembrane water-efflux rate measured by magnetic resonance imaging as a biomarker of the expression of aquaporin-4 in gliomas.

通過(guò)磁共振成像測(cè)量跨膜水流出率作為神經(jīng)膠質(zhì)瘤中 aquaporin-4 表達(dá)的生物標(biāo)志物。

4.Generation of neural organoids for spinal-cord regeneration via the direct reprogramming of human astrocytes.

通過(guò)人類(lèi)星形膠質(zhì)細(xì)胞的直接重編程生成用于脊髓再生的神經(jīng)類(lèi)器官。

5.Near-infrared fluorescence lifetime imaging of amyloid-β aggregates and tau fibrils through the intact skull of mice.

通過(guò)小鼠完整頭骨對(duì)淀粉樣蛋白-β 聚集體和 tau 纖維進(jìn)行近紅外熒光壽命成像。

6.Activatable near-infrared probes for the detection of specific populations of tumour-infiltrating leukocytes in vivo and in urine.

可激活的近紅外探針，用于檢測(cè)體內(nèi)和尿液中特定腫瘤浸潤(rùn)白細(xì)胞群。

7.Nanoparticles with ultrasound-induced afterglow luminescence for tumour-specific theranostics.

具有超聲誘導(dǎo)余輝發(fā)光的納米顆粒，用于腫瘤特異性治療診斷。

8.Mapping light distribution in tissue by using MRI-detectable photosensitive liposomes.

使用 MRI 可檢測(cè)的光敏脂質(zhì)體繪制組織中的光分布圖。

9.Tomographic detection of photon pairs produced from high-energy X-rays for the monitoring of radiotherapy dosing.

對(duì)高能 X 射線產(chǎn)生的光子對(duì)進(jìn)行斷層掃描檢測(cè)，用于監(jiān)測(cè)放射治療劑量。

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1.Bioresorbable optoelectronic neural interfaces. This issue includes a focus on neurotechnologies for the treatment of conditions of the central and peripheral nervous systems, with emphasis on neural interfaces and on motor and visual neural.

生物可吸收光電神經(jīng)接口。本期重點(diǎn)關(guān)注用于治療中樞和周?chē)窠?jīng)系統(tǒng)疾病的神經(jīng)技術(shù)，重點(diǎn)關(guān)注神經(jīng)接口以及運(yùn)動(dòng)和視覺(jué)神經(jīng)。

2.Bioresorbable thin-film silicon diodes for the optoelectronic excitation and inhibition of neural activities.

用于神經(jīng)活動(dòng)的光電激發(fā)和抑制的生物可吸收薄膜硅二極管。

3.A one-photon endoscope for simultaneous patterned optogenetic stimulation and calcium imaging in freely behaving mice.

一種單光子內(nèi)窺鏡，用于在自由行為的小鼠中同時(shí)進(jìn)行圖案化光遺傳學(xué)刺激和鈣成像。

4.A low-power stretchable neuromorphic nerve with proprioceptive feedback.

具有本體感覺(jué)反饋的低功率可拉伸神經(jīng)形態(tài)神經(jīng)。

5.Ultraflexible electrode arrays for months-long high-density electrophysiological mapping of thousands of neurons in rodents.

超靈活的電極陣列，可對(duì)嚙齒類(lèi)動(dòng)物的數(shù)千個(gè)神經(jīng)元進(jìn)行長(zhǎng)達(dá)數(shù)月的高密度電生理圖繪制。

6.A prototype closed-loop brain–machine interface for the study and treatment of pain.

用于研究和治療疼痛的閉環(huán)腦機(jī)接口原型。

7.Rapid adaptation of brain–computer interfaces to new neuronal ensembles or participants via generative modelling.

通過(guò)生成模型，腦機(jī)接口快速適應(yīng)新的神經(jīng)元集合或參與者。

8.Closed-loop optogenetic control of the dynamics of neural activity in non-human primates.

非人類(lèi)靈長(zhǎng)類(lèi)動(dòng)物神經(jīng)活動(dòng)動(dòng)力學(xué)的閉環(huán)光遺傳學(xué)控制。

9.Closed-loop enhancement and neural decoding of cognitive control in humans.

人類(lèi)認(rèn)知控制的閉環(huán)增強(qiáng)和神經(jīng)解碼。

10.A soft neuroprosthetic hand providing simultaneous myoelectric control and tactile feedback.

柔軟的神經(jīng)假手可同時(shí)提供肌電控制和觸覺(jué)反饋。