本質(zhì)上光敏的視網(wǎng)膜神經(jīng)節(jié)細胞（ipRGCs）含有黑素。ipRGC具有驚人的長過程，參與對光和暗的感知，是晝夜節(jié)律的決定因素。親和純化的抗黑色素蛋白（UF008）對小鼠ipRGCs具有非常高的特異性。

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親和純化的抗黑色素蛋白（UF008）是針對小鼠黑色素蛋白酶的15個N端胞外氨基酸而產(chǎn)生的。這種抗體不會與其他物種的黑素蛋白發(fā)生交叉反應(yīng)，它對小鼠非常特異。

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Advanced Targeting Systems/ATSbio艾美捷兔黑色素蛋白多克隆，親和純化抗體：

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圖：使用AB-N39在1:4000的平板小鼠視網(wǎng)膜和AlexaFluor-568二級抗體中從單個z系列獲得的2-光子共焦顯微鏡圖像。這張圖像是通過神經(jīng)節(jié)細胞層的單個視平面，也顯示了一些近端RGC樹突。圖片由Matthew Van Hook博士提供。?

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Advanced Targeting Systems/ATSbio艾美捷兔黑色素蛋白多克隆，親和純化抗體應(yīng)用包括免疫熒光（1μg/ml）和靶向（黑色素蛋白SAP中的靶向劑，目錄號IT-44）。這種抗體在橫截面染色和平板染色中都有效。

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Advanced Targeting Systems/ATSbio?艾美捷其它熱門抗體研究：

AB-N39?Melanopsin Rabbit Polyclonal, affinity-purified?黑視素(Melanopsin)

AB-N01AP?NGFr (mu p75) Rabbit Polyclonal, affinity-purified?NGFr (mu p75)

AB-N07?NGFr (ME20.4, p75) Mouse Monoclonal?NGFr (ME20.4, p75)

AB-N33AP?NK-1 Receptor Rabbit Polyclonal, affinity-purified?NK-1受體

AB-N03?trkA Rabbit Polyclonal?trkA

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Advanced Targeting Systems/ATSbio艾美捷兔黑色素蛋白多克隆抗體相關(guān)文獻：

Examination of zinc in the circadian system.

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Moshirpour M, Nakashima AS, Sehn N, Smith VM, Thackray SE, Dyck RH, Antle MC (2020) Examination of zinc in the circadian system. Neuroscience 432:15-29. doi: 10.1016/j.neuroscience.2020.02.016

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Objective: To examine the anatomical and functional aspects of zinc in the circadian system.

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Summary: Neither enhancement nor chelation of free zinc at either the SCN or IGL altered circadian responses to phase-shifting light in hamsters.

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Usage: Retinal immunohistochemistry (1:5000) included a 20-min wash in 4% PFA prior to initiation of the IHC protocol.

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Related Products: Melanopsin Rabbit Polyclonal (Cat. #AB-N38)

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nGnG amacrine cells and Brn3b-negative M1 ipRGCs are specifically labeled in the ChAT-ChR2-EYFP mouse.

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Cui LJ, Chen WH, Liu AL, Han X, Jiang SX, Yuan F, Zhong YM, Yang XL, Weng SJ (2020) nGnG amacrine cells and Brn3b-negative M1 ipRGCs are specifically labeled in the ChAT-ChR2-EYFP mouse. Invest Ophthalmol Vis Sci 61(2):14. doi: 10.1167/iovs.61.2.14

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Summary: The authors speculated that type II cells might be ipRGCs. This was later verified by the strong immunostaining of type II cells in response to the melanopsin antibody UF006 (100%, 141 of 141 cells collected from 5 retinas, Figs. 6B1–B3), which probes multiple ipRGC subtypes.

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Usage: Immunostaining 1:10000

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Related Products: Melanopsin Rabbit Polyclonal (Cat. #AB-N38)

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Advanced Targeting Systems(ATSbio)主要研究領(lǐng)域包含神經(jīng)靶向毒素，神經(jīng)生物學(xué)研究方面的抗體/蛋白，靶向劑內(nèi)化水平檢測工具等。艾美捷科技是ATSbio的中國代理商，為科研工作者提供優(yōu)質(zhì)的產(chǎn)品與服務(wù)。