簡(jiǎn)介

在免疫系統(tǒng)自然應(yīng)對(duì)潛在有害物質(zhì)和環(huán)境的反應(yīng)中，激肽釋放酶和抗菌化合物如抗菌肽起著非常重要的作用。它們可以誘導(dǎo)白細(xì)胞介素(interleukins,IL)的釋放，但是過量的白細(xì)胞介素可能導(dǎo)致面部皮膚發(fā)紅和毛細(xì)血管擴(kuò)張。紅斑及血管擴(kuò)張性皮膚病，如紅斑痤瘡，LL-37的表達(dá)都異常的高，它一旦被激活后大量的炎性反應(yīng)會(huì)導(dǎo)致促炎性代謝物的增加，其中就包括IL-6和IL-8。細(xì)胞外基質(zhì)如膠原蛋白被MMPs 水解后，真皮的連接組織會(huì)被破壞掉。因此皮膚發(fā)紅的區(qū)域會(huì)變得更明顯易見，毛細(xì)血管變得脆弱和通透性增強(qiáng)，發(fā)炎更容易導(dǎo)致血管擴(kuò)大。乙酰四肽-40降低由于LL-37活化和白細(xì)胞介素釋放引起的面部發(fā)紅及相關(guān)皮膚問題。它還具有光保護(hù)的效應(yīng)，降低細(xì)胞受損程度和皮膚發(fā)炎導(dǎo)致的不良反應(yīng)。

INCI ?乙酰四肽-40

機(jī)理

?乙酰四肽-40可以降低由抗菌肽LL-37誘導(dǎo)的白細(xì)胞介素IL-6和IL-8的過度釋放。它可以減少由于過度炎癥引起的不良反應(yīng)如皮膚發(fā)紅，血管擴(kuò)張，組織降解和發(fā)炎后色素過度沉積和皮膚暗淡。另外乙酰四肽-40還具有光保護(hù)的效應(yīng)，降低細(xì)胞受損程度和皮膚發(fā)炎導(dǎo)致的不良反應(yīng)。

Acetyltetrapeptide-40 can reduce the excessive release of IL-6 and IL-8 induced by Cathelicidin LL-37. It can reduce adverse reactions caused by excessive inflammation, such as skin redness, vascular dilation, tissue degradation, and excessive pigmentation and skin dullness after inflammation. In addition, acetyltetrapeptide-40 also has a photoprotective effect, reducing the degree of cell damage and adverse reactions caused by skin inflammation.

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美容功效

乙酰四肽-40是一種新型四肽，它能降低LL-37誘導(dǎo)的IL-6和IL-8釋放，減少體內(nèi)外的膠原蛋白降解，改善膚質(zhì)，在體內(nèi)僅7天便能顯著減少面部紅斑和紅血絲現(xiàn)象。同時(shí)，它具有細(xì)胞光保護(hù)作用，減少肌膚色素沉著（改善可能與炎癥有關(guān)的post-inflammatory hyperpigmentation,PIH），改善膚色均勻性和暗沉外觀。

Acetyltetrapeptide-40 is a new type of tetrapeptide that can reduce the release of IL-6 and IL-8 induced by LL-37, reduce collagen degradation in vitro and in vivo, improve skin quality, and significantly reduce facial erythema and redness in just 7 days in the body. At the same time, it has a cellular photoprotective effect, reducing skin pigmentation (improving post inflammatory hyperpigmentation (PIH) that may be related to inflammation), improving skin tone uniformity and dull appearance.