國際獸醫(yī)癲癇工作組共識建議：歐洲犬癲癇的藥物治療

Sofie F.M. Bhatti1*, Luisa De Risio2 , Karen Mu?ana3 , Jacques Penderis4 , Veronika M. Stein5 , Andrea Tipold5 , Mette Berendt6 , Robyn G. Farquhar7 , Andrea Fischer8 , Sam Long9 , Wolfgang L?scher10, Paul J.J. Mandigers11, Kaspar Matiasek12, Akos Pakozdy13, Edward E. Patterson14, Simon Platt15, Michael Podell16, Heidrun Potschka17, Clare Rusbridge18,19 and Holger A. Volk20

Abstract

摘要

In Europe, the number of antiepileptic drugs (AEDs) licensed for dogs has grown considerably over the last years.Nevertheless, the same questions remain, which include, 1) when to start treatment, 2) which drug is best used initially, 3) which adjunctive AED can be advised if treatment with the initial drug is unsatisfactory, and 4) when treatment changes should be considered. In this consensus proposal, an overview is given on the aim of AED treatment, when to start long-term treatment in canine epilepsy and which veterinary AEDs are currently in use for dogs. The consensus proposal for drug treatment protocols, 1) is based on current published evidence-based literature, 2) considers the current legal framework of the cascade regulation for the prescription of veterinary drugs in Europe, and 3) reflects the authors’ experience. With this paper it is aimed to provide a consensus for the management of canine idiopathic epilepsy. Furthermore, for the management of structural epilepsy AEDs are inevitable in addition to treating the underlying cause, if possible.

在歐洲，獲得許可的犬用抗癲癇藥物(AEDs)的數(shù)量在過去數(shù)年里有了相當(dāng)大的增長。

但是仍然存在類似的問題，包括：

1）什么時候開始治療，

2）最初使用哪種藥物最好，

3）如果使用初始藥物治療效果不理想，可以建議使用哪種輔助抗癲癇藥物, ?

4）什么時候應(yīng)考慮改變治療方法。

在本共識建議中，概述了抗癲癇藥物治療的目的，什么時候開始犬癲癇的長期治療，以及目前有哪些獸醫(yī)用抗癲癇藥物用于犬類。

關(guān)于藥物治療方案的本共識的建議，

1）基于當(dāng)前已發(fā)表的循證文獻，

2)考慮了歐洲獸藥處方級聯(lián)監(jiān)管的現(xiàn)行法律框架，

3)反映了作者們的經(jīng)驗。

本文旨在為犬特發(fā)性癲癇的治療提供一個共識。

此外，對于結(jié)構(gòu)性癲癇的管理，除了治療潛在的原因，如果可能的話，抗癲癇藥物是難免需要使用的。

Keywords:?

Dog, Epileptic seizure, Epilepsy, Treatment

關(guān)鍵字：

犬，癲癇性抽搐發(fā)作，癲癇，治療