貨號(hào)：RVV02822

產(chǎn)品鏈接：http://www.antibodysystem.com/product/14139.html

物種反應(yīng)性：Human respiratory syncytial virus A (strain A2)

形式：Liquid

存儲(chǔ)緩沖區(qū)：0.01M PBS, pH 7.4.

濃度：1 mg/ml

純度：>95% by SDS-PAGE.

克隆性：Monoclonal

應(yīng)用：ELISA

靶點(diǎn)：F/Fusion glycoprotein F0

儲(chǔ)存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.

參考文獻(xiàn)：

Identification of subgroups of bovine respiratory syncytial virus. PMID: 1583108
Infectivity of a human respiratory syncytial virus lacking the SH, G, and F proteins is efficiently mediated by the vesicular stomatitis virus G protein. PMID: 12610153

Transmembrane Domain Dissociation Is Required for Hendra Virus F Protein Fusogenic Activity. PMID: 31462574
Development of liposomes and pseudovirions with fusion activity for efficient gene delivery. PMID: 22023472
Molecular Features of the Measles Virus Viral Fusion Complex That Favor Infection and Spread in the Brain. PMID: 34061592
Mutations in the parainfluenza virus 5 fusion protein reveal domains important for fusion triggering and metastability. PMID: 24089572
The electrophysiological net response ('F-complex') to spatial fusion of speech elements forming an auditory object. PMID: 12738428
Triggering of the newcastle disease virus fusion protein by a chimeric attachment protein that binds to Nipah virus receptors. PMID: 21460213

呼吸道合胞病毒（respiratory syncytial virus）是一種單股負(fù)鏈RNA病毒，是引起嬰幼兒急性下呼吸道感染最常見(jiàn)的病毒病原體，冬春季高發(fā)，在全球范圍內(nèi)均有流行。據(jù)估計(jì)，2005年呼吸道合胞病毒在全球造成69 000～199 000例兒童患者死亡，99%的病例發(fā)生在發(fā)展中國(guó)家。呼吸道合胞病毒疫苗研發(fā)十分困難，到目前為止，尚未有一種疫苗被批準(zhǔn)上市。為有效控制該病毒的流行，世界衛(wèi)生組織在全球流感監(jiān)測(cè)項(xiàng)目的基礎(chǔ)上，于2017年建立了全球呼吸道合胞病毒的監(jiān)測(cè)網(wǎng)絡(luò)，并將其疫苗列入全球優(yōu)先研發(fā)的傳染病疫苗之一。

呼吸道合胞病毒在<2歲兒童中感染風(fēng)險(xiǎn)很高，并且與患兒以后的喘息發(fā)作和哮喘關(guān)系密切；其在老年人和免疫功能低下的高危人群中也有較高發(fā)病率，可延長(zhǎng)患者的住院時(shí)間并導(dǎo)致死亡率增高。研究提示，及時(shí)識(shí)別呼吸道合胞病毒感染的危險(xiǎn)因素對(duì)臨床治療和預(yù)后判斷具有重要價(jià)值。但到目前為止，與此相關(guān)的研究還十分有限，本研究依托北京市呼吸道病原監(jiān)測(cè)系統(tǒng)（Respiratory Pathogen Surveillance System, RPSS)，面向不同類(lèi)型醫(yī)院，收集全年齡組范圍的呼吸道合胞病毒肺炎患者，以探索重癥呼吸道合胞病毒肺炎的獨(dú)立危險(xiǎn)因素。