貨號(hào)：DHC90711

產(chǎn)品鏈接：http://www.atagenix.com/product_detail-75427.html

別名：hA20 / IMMU-106, CAS: 728917-18-8

簡(jiǎn)介：

Veltuzumab (IMMU-106) 是一種人源化抗 CD20 單克隆抗體。Veltuzumab 在 Daudi 細(xì)胞系中的 EC50 值較低，為 0.08-0.09 μg/mL。Veltuzumab 可用于癌癥的研究，如非霍奇金淋巴瘤 (NHL)。

形態(tài)：Liquid

保存：0.01M PBS, pH 7.4.

濃度：1 mg/ml

純度：>95%

克隆性：Monoclonal

亞型：IgG1-kappa

應(yīng)用：Research Grade Biosimilar

靶點(diǎn)：hA20 / IMMU-106

應(yīng)用范圍：類似物，陽(yáng)性對(duì)照抗體

產(chǎn)地：France

標(biāo)記物：Unconjugate

品牌：AntibodySystem

抗原來(lái)源：Mammalian cells

適應(yīng)物種：Human

標(biāo)識(shí)物：Unconjugate

保存條件：Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -336°C long term.

參考文獻(xiàn)：

Veltuzumab (humanized anti-CD20 monoclonal antibody): characterization, current clinical results, and future prospects. PMID: 20214444

Rituximab in B-Cell Hematologic Malignancies: A Review of 20 Years of Clinical Experience. PMID: 28983798

Systematic Review of Safety and Efficacy of Second- and Third-Generation CD20-Targeting Biologics in Treating Immune-Mediated Disorders. PMID: 35185862

Novel therapies for immune-mediated inflammatory diseases: What can we learn from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, psoriasis, Crohn's disease and ulcerative colitis? PMID: 28765121

Subcutaneous veltuzumab, a humanized anti-CD20 antibody, in the treatment of refractory pemphigus vulgaris. PMID: 25133328

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Immunotherapy in indolent Non-Hodgkin's Lymphoma. PMID: 35663281

Subcutaneous injections of low-dose veltuzumab (humanized anti-CD20 antibody) are safe and active in patients with indolent non-Hodgkin's lymphoma. PMID: 21173095

Low-dose anti-CD20 veltuzumab given intravenously or subcutaneously is active in relapsed immune thrombocytopenia: a phase I study. PMID: 23829485

Humanized anti-CD20 antibody, veltuzumab, in refractory/recurrent non-Hodgkin's lymphoma: phase I/II results. PMID: 19451441

Veltuzumab, an anti-CD20 mAb for the treatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and immune thrombocytopenic purpura. PMID: 19330725

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Bullous Diseases. PMID: 29131038

Comparison of two dosing schedules for subcutaneous injections of low-dose anti-CD20 veltuzumab in relapsed immune thrombocytopenia. PMID: 27515248

Milatuzumab and veltuzumab induce apoptosis through JNK signalling in an NF-κB dependent human transformed follicular lymphoma cell line. PMID: 24386925

Rituximab resistance. PMID: 21658619

The combination of milatuzumab, a humanized anti-CD74 antibody, and veltuzumab, a humanized anti-CD20 antibody, demonstrates activity in patients with relapsed and refractory B-cell non-Hodgkin lymphoma. PMID: 25847298

Therapy of advanced B-lymphoma xenografts with a combination of 90Y-anti-CD22 IgG (epratuzumab) and unlabeled anti-CD20 IgG (veltuzumab). PMID: 18829494

Anti-CD22 90Y-epratuzumab tetraxetan combined with anti-CD20 veltuzumab: a phase I study in patients with relapsed/refractory, aggressive non-Hodgkin lymphoma. PMID: 25150258

Pretargeted versus directly targeted radioimmunotherapy combined with anti-CD20 antibody consolidation therapy of non-Hodgkin lymphoma. PMID: 19223402

Treatment Update of Autoimmune Blistering Diseases. PMID: 30850044

B-cell depletion in immune thrombocytopenia. PMID: 23664523

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CD20-targeted tetrameric interferon-alpha, a novel and potent immunocytokine for the therapy of B-cell lymphomas. PMID: 19710501

Novel agents for chronic lymphocytic leukemia. PMID: 23680477

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Multiple signaling pathways induced by hexavalent, monospecific, anti-CD20 and hexavalent, bispecific, anti-CD20/CD22 humanized antibodies correlate with enhanced toxicity to B-cell lymphomas and leukemias. PMID: 20628151

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Anti-CD22/CD20 Bispecific antibody with enhanced trogocytosis for treatment of Lupus. PMID: 24841238

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Epratuzumab-SN-38: a new antibody-drug conjugate for the therapy of hematologic malignancies. PMID: 22039078

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[Novel B-cell directed strategies for the treatment of rheumatic diseases]. PMID: 19513729

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Bispecific anti-CD20/22 antibodies inhibit B-cell lymphoma proliferation by a unique mechanism of action. PMID: 18025153

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Dual-targeting immunotherapy of lymphoma: potent cytotoxicity of anti-CD20/CD74 bispecific antibodies in mantle cell and other lymphomas. PMID: 22271448

Complicated Diagnosis and Treatment of HA20 due to Contiguous Gene Deletions involving 6q23.3. PMID: 34032947

Improving the treatment of non-Hodgkin lymphoma with antibody-targeted radionuclides. PMID: 20127947

Variable contribution of monoclonal antibodies to ADCC in patients with chronic lymphocytic leukemia. PMID: 19562616

A bispecific antibody-IFNalpha2b immunocytokine targeting CD20 and HLA-DR is highly toxic to human lymphoma and multiple myeloma cells. PMID: 20876805

Hepatocyte paraffin 1 immunoexpression in esophageal brush samples. PMID: 15918175

Three different B-cell depletion (anti-CD20 monoclonal antibodies) treatments for severe resistant systemic lupus erythematosus. PMID: 20534646

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